TITLE:
Diffuse Large B-Cell Lymphoma with Synchronous Breast and Ovarian Localization: A Rare and Misleading Presentation
AUTHORS:
Mohamed Mrida, Milene Tshibola Nkashama, Soukaina Daoudi, Wijdane Amine, Oumaima Wajih, Youness Bencherifi, Mustapha Benhessou, Mohamed Ennachit, Mohamed El Karroumi
KEYWORDS:
Breast Lymphoma, Ovarian Lymphoma, Extranodal Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma, R-CHOP Chemotherapy, Pelvic Mass, Breast Tumor
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.16 No.7,
July
21,
2026
ABSTRACT: Primary extranodal lymphomas are rare diseases arising outside the lymphatic system, with breast and ovarian involvement representing exceptional sites of occurrence. We report the case of a 32-year-old woman who presented with a right breast mass associated with non-cyclic pelvic pain. Radiological investigations revealed multiple bilateral breast lesions with axillary lymphadenopathy, as well as a large left latero-uterine pelvic mass with central necrosis. Histological examination of a breast lesion concluded to diffuse large B-cell non-Hodgkin lymphoma. Ovarian involvement was strongly suspected based on imaging findings, with a normal CA-125 level. A multidisciplinary approach led to diagnostic excision of the breast lesion and lymph node, followed by systemic chemotherapy without surgical intervention of the pelvic mass. The patient received R-CHOP chemotherapy, with complete clinical and radiological regression of both breast and pelvic lesions. This case illustrates the diagnostic complexity of extranodal breast and ovarian lymphomas, which may mimic epithelial tumors, and emphasizes the importance of histopathological analysis and a multidisciplinary approach.