Application of Clayton Copula-Based Bivariate Weibull and Exponential Models to Type II Censored Medical Data ()
1. Introduction
In clinical research, disease progression often involves multiple correlated event times. For kidney disease patients, the times of first and second infections after catheter implantation not only reflect disease recurrence patterns but may also be dependent [1]. Similarly, in organ transplantation and tumor recurrence, joint analysis of multiple event times is crucial for understanding disease evolution and guiding treatment [2]. However, such bivariate survival data face two challenges: potential non-independent dependence between event times [3], and the presence of censored observations due to limited follow-up [4].
Traditional methods for bivariate survival data, such as frailty models or multivariate risk regression, often impose strong parametric assumptions on the dependence structure. Copula functions offer greater flexibility by separating marginal distributions from the dependence structure. Nelsen systematically presented the mathematical properties and statistical applications of Copulas in his classic work [5]. Clayton first introduced Copula concepts into bivariate life table analysis [6], with his model capturing lower-tail dependence—making it particularly suitable for analyzing associations between early events.
The success of Copula methods in survival analysis has driven their extension to more complex censored data. Under Type II censoring, the trial terminates upon observing a predetermined r-th event—a design widely used in reliability testing and medical follow-up [7]. To support practical applications, Sun and Ding developed the CopulaCenR package, which enables Copula-based regression for bivariate censored data, supporting Clayton, Gumbel, Frank copulas, and Weibull, log-logistic marginal models [8].
The Weibull distribution is widely used in survival analysis because its shape parameter can flexibly fit monotonically increasing, decreasing, or constant hazard rate functions. The exponential distribution, as a special case of the Weibull distribution (with the shape parameter equal to 1), assumes a constant hazard rate and has a more parsimonious model structure [9]. In recent years, El-Sherpieny et al. [10] investigated parameter estimation for bivariate Weibull distributions based on different Copula functions under progressive Type II censoring. Wang and Yan [11] explored reliability and dependence parameter estimation for a three-variable stress-strength model based on the Clayton Copula under progressive Type II censoring, employing method of moments, maximum likelihood estimation, and Bayesian methods for comparative analysis. Although the properties of these two marginal distributions under univariate censored data have been thoroughly studied, a systematic comparison between the bivariate Weibull model and the bivariate exponential model linked by the Clayton Copula under the Type II censoring framework has not yet been reported in the literature. The differences between the two models in terms of parameter estimation accuracy, interval estimation reliability, and capability to characterize dependence structures remain unclear.
Parametric and semi-parametric models, particularly the Cox proportional hazards model, have long been the cornerstone of survival analysis, offering interpretable estimation of covariate effects without baseline hazard assumptions [12]. Recent advances in machine learning, including random survival forests and DeepSurv, have demonstrated superior predictive performance in large clinical datasets by adaptively capturing complex nonlinearities and interactions [13]. However, many machine learning methods struggle with small samples or high censoring rates [14], and semi-parametric approaches lack a direct framework for modeling dependence structures among variables. By contrast, copula-based parametric models explicitly characterize event-time dependence, jointly estimate marginal and dependence parameters, and provide full uncertainty quantification [15]—advantages that are especially critical in small-sample or heavily censored medical studies. Thus, rather than competing, the proposed method complements existing approaches: machine learning excels in prediction with abundant data, while fully parametric copula models offer a principled framework for dependence quantification and interpretable inference in small-sample settings, with each approach occupying a distinct niche under different data regimes and analytical goals.
This paper is situated within the Type-II censoring scheme, where the experiment is terminated upon the occurrence of a predetermined number r of events. This censoring mechanism is particularly valuable in reliability experiments and certain clinical follow-up studies, as it ensures a fixed number of complete observations, thus providing adequate information for parameter estimation. Although the proposed estimation framework for the two Clayton copula-based models is developed under Type-II censoring, it can be straightforwardly generalized to Type-I or random right-censoring settings by adjusting the censoring terms in the likelihood function.
To address this gap, we construct bivariate Clayton Weibull (BCW) and bivariate Clayton exponential (BCE) models under Type II censoring, using both maximum likelihood estimation and Bayesian MCMC methods. Monte Carlo simulations evaluate point estimation accuracy, interval reliability, and Copula dependence estimation under various censoring levels, comparing Weibull and exponential marginal distributions for Type II censored data. The proposed models are then applied to the kidney catheter infection data of McGilchrist and Aisbett to demonstrate their validity and practicality on real medical data, offering a methodological reference for analyzing dependent survival data.
2. Copula Theory
This section delineates the essential components of bivariate copula theory: 1) the definition of two dependence measures, Spearman’s
and Kendall’s
; 2) the theoretical framework of the Clayton copula function; and 3) Sklar’s theorem, which underpins the entire copula theory.
Let
and
be continuous random variables with marginal distribution functions
and
, respectively, and let their joint distribution be given by the copula function
, where
for
. The population Kendall’s tau, denoted
, is defined as the probability of concordance minus the probability of discordance, and can be expressed in terms of the copula as:
where
is the copula density function. The population Spearman’s rho, denoted
, is defined as the correlation between the probability-transformed variables and is given by:
The Archimedean copula family is a class of copulas characterized by an explicit generator, among which the Clayton copula is one of the most widely used. Proposed by Clayton [6] in 1978, the Clayton copula has the generator:
. For the association parameter
, the cumulative distribution function (cdf) of the bivariate Clayton copula is given by:
In the limit
,
, corresponding to independence; as
, the variables become perfectly positively dependent, and the copula approaches the Fréchet-Hoeffding upper bound. Thus, the Clayton copula is characterized by lower-tail dependence, indicating stronger association in the lower tail of the joint distribution.
The probability density function (pdf) of the Clayton copula is given by:
The relationship between
and the copula parameter
is given by:
Thus, when
, we have
, corresponding to independence
between the variables; when
, we have
, corresponding to perfect positive dependence.
Sklar’s theorem, proposed by Sklar in 1959 [16], is the foundational core of copula theory. The theorem states that for any random variables
and
with marginal cumulative distribution functions
and
, and marginal probability density functions
and
, there exists a unique copula
such that their joint distribution function can be written as:
where
is the dependence parameter that quantifies the dependence structure between the variables. If the marginal distributions are continuous, the joint probability density function is given by:
where
denotes the copula density function.
3. Bivariate Distributions
This section introduces two bivariate distributions constructed by linking the exponential distribution and Weibull distribution with the Clayton copula function separately.
3.1. Bivariate Clayton Exponential Distribution (BCE)
The cumulative distribution function (cdf) and probability density function (pdf) of the exponential distribution are, respectively:
Its reliability function and hazard rate function are, respectively:
The joint pdf and joint cdf of the bivariate Clayton exponential (BCE) model are given, respectively, by:
where
,
, with
.
The respective reliability functions of the marginal distributions are:
The joint reliability function of the bivariate copula is:
. Therefore, the reliability function of the BCE distribution is given by:
The expression of the bivariate failure rate function is
. [17] Consequently, the hazard function of the BCE distribution is given by:
with
and
.
Figure 1 and Figure 2 show the joint density and joint hazard surfaces of the BCE model under different parameter combinations. As the Copula parameter
increases, the lower-tail dependence strengthens, and the peaks of both surfaces concentrate near the origin, exhibiting a sharp peaking pattern. This reflects the amplifying effect of lower-tail dependence on early system failure risk.
Figure 1. Joint density plots of BCE under some parameter values.
Figure 2. Joint hazard rate plots of BCE under some parameter values.
3.2. Bivariate Clayton Weibull Distribution (BCW)
The Weibull distribution is a continuous distribution defined by Fréchet [18] in 1927, and the cdf and the pdf of it are respectively presented as:
where
is the shape parameter and
is the scale parameter. When
, the distribution becomes an exponential distribution.
Individually, the reliability function and the hazard rate function of it are:
Here are the joint pdf and joint cdf of the BCW distribution:
where
,
.
Separately, the reliability functions belonging to the marginal distributions are:
Then the reliability function of the BCW distribution is given by the following formula:
The expression of the hazard function of the BCW distribution is as follows:
where
,
.
Figure 3 and Figure 4 illustrate the joint probability density and joint hazard rate surfaces of the BCW model under various parameter settings. It can be observed that as
increases, the lower-tail dependence between variables intensifies, leading to a more pronounced concentration of the joint density and hazard rate near the origin, with the surface shape evolving from smooth to sharp-peaked.
Figure 3. Joint density plots of BCW under some parameter values.
Figure 4. Joint hazard rate plots of BCW under some parameter values.
4. Inferential Analysis for Uncensored and Censored Samples
This section presents the maximum likelihood estimation (MLE) and Bayesian parameter estimation for the bivariate models. To facilitate clarity, the BCW model is used as an example for the mathematical derivations; the estimation for the BCE model follows similarly.
4.1. MLE with Full Samples
MLE is a classical approach to parameter estimation, which seeks the parameter values that maximize the probability of the observed data. Under complete sampling, let
, for
, be independent and identically distributed observations from a bivariate distribution
, with
denoting the parameter vector. The likelihood function for
based on the complete sample is given by:
where
is the density function of the Clayton copula that connects the two marginal distributions.
Given observed data pairs
from the Weibull distribution, the likelihood function for parameter
is:
where
,
in which
,
.
Let
denote the log-likelihood function of the BCW distribution, which is given by:
where
By calculating the partial derivatives of
, we obtain:
where
The maximum likelihood estimates are obtained by numerically solving the nonlinear system resulting from setting the partial derivatives to zero.
4.2. MLE under Type-II Censoring
In practice, complete lifetime data are often unavailable due to limited observation periods or cost constraints, leading to censored data. Type-II censoring is a typical mechanism: in an experiment with
samples, the test terminates when the
-th failure (
) is observed, yielding
complete failures and
censored observations.
Consider bivariate random samples
for
from a bivariate Weibull distribution, with joint cdf
and pdf
. Let
be the order statistics of
, and let
be the concomitant of the
-th order statistic [19]. Under Type-II censoring, only the first
(
) pairs
for
are observed. The likelihood function is given by Balakrishnan and Kim [20] and Kim et al. [21]:
where
denotes the Clayton copula density evaluated at the marginal cumulative distribution functions
and
. The log-likelihood function of the BCW distribution, denoted by
, is then given by:
where
Differentiating
partially with respect to
leads to:
where
Equating the partial derivatives to zero gives a nonlinear system in
. Since
has no closed-form solution, it is obtained numerically using nonlinear optimization.
4.3. Bayesian Estimation
In contrast to frequentist methods that treat parameters as fixed, Bayesian methods consider them as random variables described by prior distributions. Priors, based on historical or domain knowledge, are updated with sample data to produce posterior distributions, thereby combining prior and data information. For reliability analysis with scarce data, this framework enhances estimation accuracy and stability, making prior selection critical. We adopt independent Gamma priors for
, chosen for their positive support
and distributional flexibility [22]. Under the mean squared error loss function, the Bayesian posterior estimates are given by the following priors:
Then the joint prior distribution is:
The hyperparameters
are calibrated using the moment matching approach. Suppose that for each parameter
(
), a total of
MLE estimates
are obtained from
independent simulated datasets. The sample mean and sample variance of these estimates are then calculated as:
By matching the theoretical moments of the Gamma prior distribution—specifically, its mean
and variance
—to their sample counterparts
and
, we obtain the following closed-form solutions for the hyperparameters:
The correspondence between the parameters and the
notation is established as:
,
,
,
,
.
Let
denote the joint posterior distribution. By Bayes’ theorem, the posterior is proportional to the prior times the likelihood. For the BCW model, the joint posterior is given by:
Under the squared error loss function, the Bayes estimator is the posterior mean. However, due to the lack of a closed-form solution, we resort to MCMC methods for posterior sampling. MCMC constructs a Markov chain with the target posterior as its stationary distribution. After convergence, the sampled draws are used to compute the Bayesian estimates. The full conditional posterior distributions for each parameter are derived as follows:
Given the complexity of the full conditional distributions, direct sampling is infeasible. We thus employ the Metropolis-Hastings (MH) algorithm, using a normal proposal distribution, to approximate the posterior distribution through an acceptance-rejection sampling scheme. The MH algorithm with a normal proposal is a well-established approach in Bayesian inference for obtaining parameter estimates and credible intervals [23].
5. Interval Estimation
This section presents two types of interval estimates for the BCW model parameters
: confidence intervals and credible intervals. The construction procedures are detailed below.
5.1. Asymptotic Confidence Intervals
Based on the asymptotic normality property of maximum likelihood estimation, confidence intervals for the unknown parameters can be constructed using the Fisher information matrix. Let
denote the maximum likelihood estimator. The Fisher information matrix
, evaluated at
, quantifies the information contained in the observed data. The asymptotic variance-covariance matrix of the estimator is obtained by inverting
, i.e.,
. The explicit form of
is given by:
In accordance with the asymptotic normality of MLEs, the
confidence interval for each parameter
is formulated as:
where
is the
-th parameter estimate,
is the upper
quantile of the standard normal distribution, and
is the
-th diagonal element of
, representing the asymptotic variance of
.
5.2. Confidence Intervals
Bayesian credible intervals for the individual parameters are constructed via the following numerical procedure [24]. Let
denote the parameter vector sampled at the
-th MCMC iteration. After discarding the burn-in period, extract the marginal samples for each parameter, yielding sequences of length
:
where
is the effective number of MCMC samples after burn-in. Sorting the
samples of each parameter in ascending order yields the corresponding order statistics:
Based on these ordered samples, the percentile method is adopted to construct the
symmetric Bayesian credible intervals. For a given significance level
, the lower and upper bounds are taken as the
-th and
-th order statistics, respectively, where
denotes the floor function. Thus, the credible intervals for the individual parameters are:
Setting
yields the 95% symmetric credible intervals for all unknown parameters.
6. Numerical Simulation Experiments
In this section, Monte Carlo simulations are conducted to evaluate the statistical performance of the BCE and BCW models, with a focus on point estimation accuracy, interval estimation reliability, and the effectiveness of copula dependence parameter estimation. Following the conditional distribution method proposed by Nelsen [5], bivariate random samples are generated under the Clayton copula framework, and the performance of the models is systematically compared under different censoring levels.
Two sets of true parameter values are considered:
1)
;
2)
;
3)
.
Under fixed sample sizes
and
, we evaluate both complete and Type-II censored samples, with censoring levels
for
and
for
, where
is the number of observed failures. For each parameter-censoring combination, 250 independent replications are carried out to ensure robust simulation results. Parameter estimation is carried out using Markov chain Monte Carlo (MCMC) methods within the Bayesian framework, with MCMC chains generated using the coda package in R, each running for 12,000 iterations and discarding the first 2000 as burn-in to ensure convergence to the stationary distribution. For comparison, point estimates are also obtained via MLE using the Newton-Raphson algorithm implemented in the maxLik package.
The simulation results for the parameters
,
,
,
,
, along with the dependence measures
and
, are summarized in Tables 1-3 for both MLE and Bayesian estimation approaches. The performance of the estimators is evaluated using the following metrics: MSEs (mean squared errors), Abias (average bias), LACI (average length of asymptotic confidence intervals), and LCCI (average length of credible intervals).
Table 1. The estimation results for parameters
,
,
,
,
.
n |
r |
|
MLE |
Bayes |
BCE |
BCW |
BCE |
BCW |
Abias |
MSEs |
LACI |
Abias |
MSEs |
LACI |
Abias |
MSEs |
LCCI |
Abias |
MSEs |
LCCI |
45 |
27 |
|
0.0451 |
0.0361 |
0.6890 |
0.0922 |
0.0970 |
1.0432 |
0.0066 |
0.1262 |
0.5541 |
0.0474 |
0.2308 |
0.9461 |
|
|
|
|
0.0433 |
0.0207 |
0.4782 |
|
|
|
0.0339 |
0.1512 |
0.4969 |
|
0.0498 |
0.0489 |
0.9239 |
0.1229 |
0.1930 |
1.6507 |
0.0198 |
0.1535 |
0.6997 |
0.1427 |
0.3612 |
1.5309 |
|
|
|
|
0.0323 |
0.0105 |
0.3727 |
|
|
|
0.0122 |
0.0936 |
0.3690 |
|
0.1409 |
0.2474 |
1.6691 |
0.1120 |
0.3030 |
2.0198 |
0.0077 |
0.1800 |
1.0512 |
−0.0534 |
0.5507 |
2.0223 |
|
0.0136 |
0.0107 |
0.3566 |
0.0020 |
0.0141 |
0.4276 |
−0.0010 |
0.0404 |
0.2414 |
−0.0408 |
0.1458 |
0.4849 |
|
0.0138 |
0.0069 |
0.2874 |
0.0054 |
0.0089 |
0.3446 |
−0.0003 |
0.0324 |
0.1920 |
−0.0277 |
0.1113 |
0.3775 |
36 |
|
0.0430 |
0.0243 |
0.5890 |
0.0710 |
0.0586 |
0.9017 |
0.0189 |
0.1149 |
0.5051 |
0.0406 |
0.2067 |
0.8233 |
|
|
|
|
0.0169 |
0.0104 |
0.3824 |
|
|
|
0.0175 |
0.0978 |
0.3801 |
|
0.0578 |
0.0440 |
0.7170 |
0.1289 |
0.1570 |
1.3154 |
0.0093 |
0.1309 |
0.5869 |
0.0919 |
0.2945 |
1.1936 |
|
|
|
|
0.0184 |
0.0066 |
0.3068 |
|
|
|
0.0028 |
0.0682 |
0.2952 |
|
0.0960 |
0.1660 |
1.4820 |
0.1043 |
0.2348 |
1.7866 |
0.0007 |
0.1771 |
1.0038 |
−0.0005 |
0.4722 |
1.8056 |
|
0.0089 |
0.0075 |
0.3239 |
0.0058 |
0.0102 |
0.3831 |
−0.0026 |
0.0405 |
0.2318 |
−0.0207 |
0.1210 |
0.4239 |
|
0.0092 |
0.0049 |
0.2601 |
0.0075 |
0.0066 |
0.3083 |
−0.0016 |
0.0324 |
0.1842 |
−0.0130 |
0.0932 |
0.3324 |
45 |
|
0.0229 |
0.0167 |
0.5104 |
0.0338 |
0.0417 |
0.7943 |
0.0130 |
0.1087 |
0.4587 |
0.0282 |
0.1886 |
0.7739 |
|
|
|
|
0.0284 |
0.0079 |
0.3191 |
|
|
|
0.0048 |
0.0742 |
0.3016 |
|
0.0149 |
0.0220 |
0.5593 |
0.0239 |
0.0714 |
1.0310 |
0.0123 |
0.1173 |
0.5046 |
0.0558 |
0.2339 |
1.0080 |
|
|
|
|
0.0172 |
0.0051 |
0.2687 |
|
|
|
0.0068 |
0.0664 |
0.2601 |
|
0.0641 |
0.1403 |
1.3475 |
0.0440 |
0.1740 |
1.5657 |
−0.0047 |
0.1695 |
0.9575 |
0.0471 |
0.4105 |
1.6381 |
|
0.0034 |
0.0068 |
0.3006 |
−0.0046 |
0.0093 |
0.3490 |
−0.0036 |
0.0388 |
0.2222 |
−0.0035 |
0.0951 |
0.3728 |
|
0.0046 |
0.0043 |
0.2406 |
−0.0012 |
0.0058 |
0.2790 |
−0.0024 |
0.0310 |
0.1765 |
−0.0005 |
0.0750 |
0.2951 |
140 |
105 |
|
−0.1474 |
0.0499 |
0.2419 |
−0.2382 |
0.0961 |
0.3469 |
0.0060 |
0.0846 |
0.3289 |
0.0199 |
0.1324 |
0.4919 |
|
|
|
|
0.0312 |
0.0074 |
0.2070 |
|
|
|
0.0021 |
0.0522 |
0.2191 |
|
−0.0897 |
0.0206 |
0.3502 |
−0.1554 |
0.0489 |
0.5335 |
0.0146 |
0.1054 |
0.4071 |
0.0186 |
0.1827 |
0.7020 |
|
|
|
|
0.0459 |
0.0041 |
0.1790 |
|
|
|
0.0016 |
0.0431 |
0.1737 |
|
−0.0195 |
0.0474 |
0.8259 |
−0.0921 |
0.0716 |
0.9019 |
−0.0214 |
0.1976 |
0.8307 |
0.0184 |
0.2474 |
1.0086 |
|
−0.0087 |
0.0026 |
0.1728 |
−0.0278 |
0.0042 |
0.2371 |
−0.0085 |
0.0472 |
0.1988 |
−0.0009 |
0.0541 |
0.2296 |
|
−0.0062 |
0.0016 |
0.1442 |
−0.0210 |
0.0026 |
0.1801 |
−0.0062 |
0.0374 |
0.1570 |
0.0001 |
0.0435 |
0.1829 |
130 |
|
−0.0545 |
0.0114 |
0.2745 |
−0.0583 |
0.0193 |
0.4225 |
0.0095 |
0.0760 |
0.2941 |
−0.0874 |
0.0451 |
0.6605 |
|
|
|
|
0.0097 |
0.0026 |
0.1817 |
|
|
|
0.0167 |
0.0139 |
0.4268 |
|
−0.0333 |
0.0093 |
0.3187 |
−0.0240 |
0.0212 |
0.5723 |
0.0041 |
0.0858 |
0.3328 |
−0.0139 |
0.0029 |
0.2082 |
|
|
|
|
0.0154 |
0.0015 |
0.1559 |
|
|
|
0.0442 |
0.0256 |
0.6309 |
|
0.0182 |
0.0448 |
0.7606 |
0.0107 |
0.0504 |
0.8881 |
0.0135 |
0.1948 |
0.7660 |
0.0241 |
0.1182 |
1.3526 |
|
0.0003 |
0.0023 |
0.1756 |
−0.0019 |
0.0025 |
0.2094 |
−0.0003 |
0.0447 |
0.1771 |
−0.0012 |
0.0014 |
0.1631 |
|
0.0009 |
0.0015 |
0.1381 |
−0.0008 |
0.0016 |
0.1612 |
0.0004 |
0.0357 |
0.1409 |
−0.0002 |
0.0012 |
0.1455 |
140 |
|
0.0084 |
0.0050 |
0.2845 |
0.0163 |
0.0135 |
0.4527 |
0.0057 |
0.0708 |
0.2813 |
0.0097 |
0.1128 |
0.4461 |
|
|
|
|
0.0046 |
0.0019 |
0.1743 |
|
|
|
0.0001 |
0.0457 |
0.1710 |
|
0.0114 |
0.0075 |
0.3164 |
0.0247 |
0.0225 |
0.5875 |
0.0128 |
0.0812 |
0.3146 |
0.0152 |
0.1460 |
0.5787 |
|
|
|
|
0.0071 |
0.0013 |
0.1495 |
|
|
|
0.0019 |
0.0384 |
0.1478 |
|
0.0287 |
0.0328 |
0.7431 |
0.0438 |
0.0570 |
0.8815 |
0.0314 |
0.1939 |
0.7530 |
0.0064 |
0.2136 |
0.8715 |
|
0.0038 |
0.0016 |
0.1651 |
0.0054 |
0.0026 |
0.2037 |
0.0040 |
0.0428 |
0.1714 |
−0.0025 |
0.0482 |
0.2001 |
|
0.0035 |
0.0010 |
0.1320 |
0.0051 |
0.0017 |
0.1579 |
0.0038 |
0.0344 |
0.1368 |
−0.0013 |
0.0386 |
0.1593 |
Table 2. The estimation results for parameters
,
,
,
,
.
n |
r |
|
MLE |
Bayes |
BCE |
BCW |
BCE |
BCW |
Abias |
MSEs |
LACI |
Abias |
MSEs |
LACI |
Abias |
MSEs |
LCCI |
Abias |
MSEs |
LCCI |
45 |
27 |
|
0.1622 |
0.4818 |
2.5603 |
0.1020 |
0.1777 |
1.4899 |
−0.0028 |
0.2652 |
1.5362 |
0.0323 |
0.3847 |
1.5216 |
|
|
|
|
0.1024 |
0.1170 |
1.1653 |
|
|
|
0.0594 |
0.2840 |
1.1040 |
|
0.0734 |
0.1043 |
1.3295 |
0.0296 |
0.0221 |
0.5701 |
0.0169 |
0.1660 |
0.8694 |
0.0225 |
0.1533 |
0.5953 |
|
|
|
|
0.1581 |
0.2753 |
1.7357 |
|
|
|
0.0820 |
0.4141 |
1.6066 |
|
0.2300 |
0.4574 |
2.2547 |
0.1854 |
0.7702 |
3.1927 |
0.0060 |
0.2455 |
1.4281 |
0.0395 |
0.7809 |
3.1474 |
|
0.0125 |
0.0038 |
0.2205 |
−0.0021 |
0.0080 |
0.3174 |
−0.0013 |
0.0265 |
0.1570 |
−0.0158 |
0.0948 |
0.3554 |
|
0.0147 |
0.0036 |
0.2137 |
0.0032 |
0.0070 |
0.3035 |
−0.0008 |
0.0253 |
0.1482 |
−0.0100 |
0.0844 |
0.3238 |
|
36 |
|
0.1609 |
0.3293 |
2.1586 |
0.0849 |
0.1093 |
1.2845 |
0.0317 |
0.2587 |
1.4567 |
0.0362 |
0.3361 |
1.2974 |
|
|
|
|
0.0395 |
0.0603 |
0.9091 |
|
|
|
0.0294 |
0.2233 |
0.8995 |
|
0.0860 |
0.0914 |
1.0640 |
0.0331 |
0.0153 |
0.4306 |
0.0067 |
0.1588 |
0.7625 |
0.0164 |
0.1143 |
0.4429 |
|
|
|
|
0.0790 |
0.1322 |
1.3267 |
|
|
|
0.0253 |
0.3032 |
1.2735 |
|
0.1636 |
0.3158 |
2.0606 |
0.1806 |
0.5649 |
2.7681 |
0.0098 |
0.2527 |
1.3820 |
0.0747 |
0.6716 |
2.7623 |
|
0.0086 |
0.0030 |
0.2071 |
0.0035 |
0.0054 |
0.2755 |
−0.0010 |
0.0271 |
0.1514 |
−0.0064 |
0.0751 |
0.3008 |
|
0.0103 |
0.0028 |
0.1999 |
0.0070 |
0.0049 |
0.2648 |
−0.0005 |
0.0259 |
0.1431 |
−0.0026 |
0.0695 |
0.2784 |
45 |
|
0.0795 |
0.2077 |
1.8059 |
0.0303 |
0.0848 |
1.1608 |
0.0225 |
0.2661 |
1.3527 |
0.0234 |
0.2970 |
1.2024 |
|
|
|
|
0.0645 |
0.0430 |
0.7597 |
|
|
|
0.0086 |
0.1793 |
0.7202 |
|
0.0286 |
0.0474 |
0.8154 |
0.0815 |
0.0084 |
0.3584 |
0.0118 |
0.1423 |
0.6645 |
0.0088 |
0.0894 |
0.3702 |
|
|
|
|
0.0767 |
0.0043 |
1.1006 |
|
|
|
0.0184 |
0.2712 |
1.0629 |
|
0.0969 |
0.2708 |
1.8997 |
0.0570 |
0.3785 |
2.3735 |
0.0005 |
0.2306 |
1.3270 |
0.1360 |
0.6215 |
2.4944 |
|
0.0026 |
0.0027 |
0.1978 |
−0.0058 |
0.0046 |
0.2528 |
−0.0017 |
0.0250 |
0.1462 |
0.0031 |
0.0636 |
0.2595 |
|
0.0043 |
0.0024 |
0.1894 |
−0.0026 |
0.0040 |
0.2398 |
−0.0012 |
0.0238 |
0.1381 |
0.0057 |
0.0605 |
0.2442 |
140 |
105 |
|
−0.5788 |
0.6435 |
0.9635 |
−0.4152 |
0.3104 |
0.6225 |
0.0025 |
0.3110 |
1.2039 |
0.0139 |
0.1980 |
0.7457 |
|
|
|
|
0.0707 |
0.0405 |
0.4871 |
|
|
|
0.0039 |
0.1232 |
0.5242 |
|
−0.1930 |
0.0843 |
0.4842 |
−0.0864 |
0.0142 |
0.2144 |
0.0188 |
0.1538 |
0.6013 |
0.0005 |
0.0700 |
0.2614 |
|
|
|
|
0.1690 |
0.0820 |
0.7339 |
|
|
|
0.0089 |
0.1853 |
0.7664 |
|
−0.0309 |
0.0938 |
1.1520 |
−0.1585 |
0.2233 |
1.3761 |
−0.0135 |
0.2587 |
1.1388 |
0.0369 |
0.3861 |
1.5484 |
|
−0.0064 |
0.0011 |
0.1433 |
−0.0246 |
0.0029 |
0.1836 |
−0.0037 |
0.0292 |
0.1274 |
−0.0005 |
0.0391 |
0.1659 |
|
−0.0054 |
0.0010 |
0.1312 |
−0.0216 |
0.0025 |
0.1620 |
−0.0030 |
0.0275 |
0.1200 |
0.0005 |
0.0377 |
0.1571 |
130 |
|
−0.1224 |
0.1046 |
1.0006 |
−0.0874 |
0.0451 |
0.6605 |
0.0300 |
0.2685 |
1.0544 |
0.0136 |
0.1792 |
0.6791 |
|
|
|
|
0.0167 |
0.0139 |
0.4268 |
|
|
|
0.0200 |
0.1287 |
0.4465 |
|
−0.0312 |
0.0160 |
0.4676 |
−0.0139 |
0.0029 |
0.2082 |
0.0070 |
0.1239 |
0.4884 |
0.0043 |
0.0570 |
0.2159 |
|
|
|
|
0.0442 |
0.0256 |
0.6309 |
|
|
|
0.0237 |
0.1689 |
0.6423 |
|
0.0464 |
0.0868 |
1.0829 |
0.0241 |
0.1182 |
1.3526 |
0.0266 |
0.2687 |
1.0783 |
0.0005 |
0.3638 |
1.3745 |
|
0.0023 |
0.0009 |
0.1254 |
−0.0012 |
0.0014 |
0.1631 |
0.0006 |
0.0290 |
0.1171 |
−0.0043 |
0.0400 |
0.1506 |
|
0.0029 |
0.0008 |
0.1168 |
−0.0002 |
0.0012 |
0.1455 |
0.0011 |
0.0277 |
0.1112 |
−0.0030 |
0.0377 |
0.1420 |
140 |
|
0.0245 |
0.0669 |
1.0064 |
0.0226 |
0.0290 |
0.6689 |
0.0182 |
0.2495 |
0.9941 |
0.0045 |
0.1755 |
0.6723 |
|
|
|
|
0.0155 |
0.0112 |
0.4124 |
|
|
|
−0.0013 |
0.1094 |
0.4050 |
|
0.0110 |
0.0135 |
0.4570 |
0.0050 |
0.0028 |
0.2072 |
0.0166 |
0.1143 |
0.4534 |
0.0008 |
0.0539 |
0.2070 |
|
|
|
|
0.0053 |
0.0261 |
0.6043 |
|
|
|
0.0002 |
0.1587 |
0.5975 |
|
0.0496 |
0.0623 |
1.0554 |
0.0402 |
0.0996 |
1.3319 |
0.0508 |
0.2785 |
1.0634 |
0.0358 |
0.3416 |
1.3335 |
|
0.0034 |
0.0007 |
0.1071 |
0.0012 |
0.0011 |
0.1428 |
0.0031 |
0.0290 |
0.1135 |
0.0003 |
0.0356 |
0.1428 |
|
0.0037 |
0.0006 |
0.1055 |
0.0019 |
0.0010 |
0.1361 |
0.0035 |
0.0279 |
0.1083 |
0.0011 |
0.0341 |
0.1356 |
Table 3. The estimation results for parameters
,
,
,
,
.
n |
r |
|
MLE |
Bayes |
BCE |
BCW |
BCE |
BCW |
Abias |
MSEs |
LACI |
Abias |
MSEs |
LACI |
Abias |
MSEs |
LCCI |
Abias |
MSEs |
LCCI |
45 |
27 |
|
0.0894 |
0.1435 |
1.3845 |
0.0861 |
0.1115 |
1.1663 |
0.0019 |
0.1886 |
0.9495 |
0.0212 |
0.1926 |
0.9304 |
|
|
|
|
0.0726 |
0.0587 |
0.8186 |
|
|
|
0.0252 |
0.1257 |
0.6002 |
|
0.1069 |
0.2285 |
1.9942 |
0.0587 |
0.0862 |
1.1552 |
0.0188 |
0.2272 |
1.2573 |
0.0324 |
0.2010 |
0.9517 |
|
|
|
|
0.1039 |
0.1141 |
1.1827 |
|
|
|
0.0290 |
0.1705 |
0.8204 |
|
0.1839 |
0.3287 |
1.9293 |
0.1468 |
0.4861 |
2.5498 |
0.0087 |
0.2125 |
1.2267 |
0.0333 |
0.1821 |
1.3299 |
|
0.0141 |
0.0061 |
0.2829 |
−0.0001 |
0.0106 |
0.3736 |
−0.0012 |
0.0338 |
0.1975 |
−0.0014 |
0.0288 |
0.2139 |
|
0.0153 |
0.0048 |
0.2478 |
0.0047 |
0.0079 |
0.3259 |
−0.0004 |
0.0291 |
0.1698 |
−0.0007 |
0.0248 |
0.1839 |
36 |
|
0.0870 |
0.0970 |
1.1735 |
0.0699 |
0.0686 |
1.0093 |
0.0264 |
0.1811 |
0.8868 |
0.0184 |
0.1838 |
0.8275 |
|
|
|
|
0.0280 |
0.0300 |
0.6459 |
|
|
|
0.0180 |
0.1172 |
0.5222 |
|
0.1277 |
0.2059 |
1.5701 |
0.0687 |
0.0645 |
0.8842 |
0.0084 |
0.2204 |
1.1111 |
0.0259 |
0.1768 |
0.7728 |
|
|
|
|
0.0558 |
0.0634 |
0.9346 |
|
|
|
0.0104 |
0.1427 |
0.7172 |
|
0.1272 |
0.2275 |
1.7405 |
0.1389 |
0.3630 |
2.2234 |
0.0057 |
0.2145 |
1.1831 |
0.0110 |
0.1942 |
1.2836 |
|
0.0090 |
0.0048 |
0.2614 |
0.0046 |
0.0075 |
0.3283 |
−0.0018 |
0.0343 |
0.1908 |
−0.0004 |
0.0315 |
0.2054 |
|
0.0101 |
0.0037 |
0.2282 |
0.0076 |
0.0057 |
0.2868 |
−0.0009 |
0.0294 |
0.1639 |
0.0002 |
0.0270 |
0.1768 |
45 |
|
0.0441 |
0.0638 |
1.0008 |
0.0283 |
0.0523 |
0.9063 |
0.0183 |
0.1788 |
0.8210 |
0.0039 |
0.1674 |
0.7665 |
|
|
|
|
0.0471 |
0.0222 |
0.5425 |
|
|
|
0.0074 |
0.0963 |
0.4385 |
|
0.0378 |
0.1042 |
1.2110 |
0.0030 |
0.0352 |
0.7348 |
0.0167 |
0.2041 |
0.9805 |
0.0090 |
0.1430 |
0.6513 |
|
|
|
|
0.0558 |
0.0445 |
0.7998 |
|
|
|
0.0152 |
0.1456 |
0.6440 |
|
0.0794 |
0.1936 |
1.5939 |
0.0501 |
0.2564 |
1.9292 |
−0.0013 |
0.1999 |
1.1319 |
0.0377 |
0.1997 |
1.2518 |
|
0.0029 |
0.0043 |
0.2466 |
−0.0058 |
0.0067 |
0.3019 |
−0.0026 |
0.0322 |
0.1837 |
0.0038 |
0.0314 |
0.1969 |
|
0.0046 |
0.0032 |
0.2136 |
−0.0021 |
0.0048 |
0.2607 |
−0.0016 |
0.0276 |
0.1577 |
0.0038 |
0.0271 |
0.1702 |
140 |
105 |
|
0.0087 |
0.0249 |
0.6604 |
0.0050 |
0.0190 |
0.5663 |
0.0081 |
0.1395 |
0.5926 |
0.0127 |
0.1347 |
0.5381 |
|
|
|
|
0.0169 |
0.0115 |
0.3761 |
|
|
|
0.0038 |
0.0748 |
0.3360 |
|
0.0082 |
0.0579 |
0.8960 |
0.0038 |
0.0203 |
0.5167 |
0.0170 |
0.1791 |
0.7896 |
−0.0018 |
0.1269 |
0.4976 |
|
|
|
|
0.0313 |
0.0235 |
0.5405 |
|
|
|
0.0052 |
0.1078 |
0.4757 |
|
0.0063 |
0.0590 |
0.9646 |
−0.0029 |
0.1008 |
1.2127 |
−0.0063 |
0.1663 |
0.8323 |
0.0153 |
0.1891 |
0.9783 |
|
−0.0024 |
0.0015 |
0.1556 |
−0.0062 |
0.0027 |
0.1957 |
−0.0027 |
0.0274 |
0.1357 |
0.0004 |
0.0295 |
0.1558 |
|
−0.0012 |
0.0011 |
0.1336 |
−0.0041 |
0.0020 |
0.1681 |
−0.0019 |
0.0233 |
0.1164 |
0.0009 |
0.0255 |
0.1344 |
|
130 |
|
0.0234 |
0.0232 |
0.5873 |
0.0190 |
0.0197 |
0.5295 |
0.0140 |
0.1288 |
0.5392 |
0.0115 |
0.1215 |
0.4914 |
|
|
|
|
0.0097 |
0.0069 |
0.3188 |
|
|
|
0.0126 |
0.0783 |
0.2935 |
|
0.0282 |
0.0412 |
0.7366 |
0.0140 |
0.0144 |
0.4423 |
0.0048 |
0.1571 |
0.6670 |
0.0117 |
0.1042 |
0.4210 |
|
|
|
|
0.0158 |
0.0153 |
0.4655 |
|
|
|
0.0162 |
0.1008 |
0.4226 |
|
0.0295 |
0.0553 |
0.9018 |
0.0287 |
0.0892 |
1.1167 |
0.0184 |
0.1754 |
0.7956 |
−0.0057 |
0.1965 |
0.9103 |
|
0.0016 |
0.0014 |
0.1430 |
−0.0003 |
0.0022 |
0.1767 |
0.0011 |
0.0282 |
0.1274 |
0.0032 |
0.0320 |
0.1471 |
|
0.0021 |
0.0010 |
0.1233 |
0.0008 |
0.0016 |
0.1524 |
0.0014 |
0.0242 |
0.1097 |
−0.0022 |
0.0273 |
0.1264 |
140 |
|
−0.0051 |
0.0180 |
0.5517 |
−0.0074 |
0.0155 |
0.5143 |
0.0068 |
0.1222 |
0.5181 |
0.0025 |
0.1177 |
0.4839 |
|
|
|
|
0.0087 |
0.0062 |
0.2941 |
|
|
|
−0.0002 |
0.0682 |
0.2700 |
|
0.0001 |
0.0294 |
0.6767 |
−0.0017 |
0.0113 |
0.4185 |
0.0208 |
0.1496 |
0.6311 |
0.0001 |
0.0986 |
0.3988 |
|
|
|
|
0.0195 |
0.0136 |
0.4431 |
|
|
|
0.0032 |
0.0986 |
0.4028 |
|
0.0026 |
0.0487 |
0.8723 |
−0.0043 |
0.0655 |
1.0637 |
0.0350 |
0.1800 |
0.7851 |
0.0080 |
0.1827 |
0.8883 |
|
−0.0024 |
0.0013 |
0.1408 |
−0.0045 |
0.0017 |
0.1721 |
0.0038 |
0.0280 |
0.1241 |
−0.0007 |
0.0290 |
0.1423 |
|
−0.0014 |
0.0009 |
0.1208 |
−0.0030 |
0.0013 |
0.1477 |
0.0037 |
0.0242 |
0.1072 |
−0.0001 |
0.0250 |
0.1226 |
In terms of estimation performance, the Bayesian method generally surpasses MLE across all scenarios, producing smaller bias, lower MSE, and shorter interval estimates, indicating that prior information effectively improves estimation accuracy. Regarding model comparison, the BCW model exhibits greater flexibility and robustness than the BCE model due to its shape parameters, and achieves superior performance across all metrics despite its higher parameter dimensionality. As sample size increases from 45 to 140, estimation precision improves for all parameters, with reduced bias, MSE, and interval lengths. Complete samples yield the best estimates, and reducing the censoring rate from 40% to 20% consistently improves precision, with the Clayton copula parameter η being the most sensitive to censoring.
7. Empirical Study
To evaluate the applicability and effectiveness of the proposed model, a case study is conducted using the kidney disease patient data from McGilchrist and Aisbett [25]. The dataset comprises 30 patients on portable dialysis who required long-term treatment. Catheter site infections are common during dialysis, affecting treatment continuity and potentially causing severe complications. For each patient, two time points are recorded: the time from catheter implantation to the first infection (
) and the time from the second implantation to the second infection (
), both in days. The data are presented in Table 4.
Table 4. Inter-infection times in kidney disease patients.
|
8 |
23 |
22 |
447 |
30 |
24 |
7 |
511 |
53 |
15 |
7 |
141 |
96 |
149 |
536 |
152 |
402 |
13 |
39 |
12 |
113 |
132 |
34 |
2 |
130 |
17 |
185 |
292 |
22 |
15 |
|
16 |
13 |
28 |
318 |
12 |
245 |
9 |
30 |
196 |
154 |
333 |
8 |
38 |
70 |
25 |
362 |
24 |
66 |
46 |
40 |
201 |
156 |
30 |
25 |
26 |
4 |
117 |
114 |
159 |
108 |
Figure 5 shows a bivariate scatter plot matrix of
. Diagonal panels display histograms with kernel density estimates; the off-diagonal panel shows the joint scatter plot with a locally smoothed fit. Both variables are right-skewed, with observations concentrated at lower values and extended tails, consistent with a Weibull distribution. The joint plot indicates clear dependence between
and
, violating independence and supporting the use of the Clayton copula.
Figure 5. Scatter plot matrix of the data.
Table 5 shows that the exponential distribution is rejected for
at the 5% significance level, whereas the Weibull distribution passes the Kolmogorov-Smirnov (K-S) test for both
and
. The Akaike information criterion (AIC) and Hannan-Quinn information criterion (HQIC) values further confirm that the Weibull model outperforms the exponential model for
. Therefore, the Weibull distribution is chosen as the marginal distribution for both infection interval datasets.
Based on the data characteristics and goodness-of-fit results, the Weibull distribution is chosen as the marginal distribution and the Clayton copula is used to model the dependence structure, i.e., the BCW model is adopted for further analysis.
Table 5. Goodness-of-fit test results for sample data.
|
|
|
Est |
StEr |
K-S |
p-value |
AIC |
HQIC |
|
Exponential |
|
0.0083 |
0.0015 |
0.2577 |
0.0372 |
349.7309 |
352.1792 |
Weibull |
|
0.0099 |
0.0026 |
0.1456 |
0.5484 |
346.9844 |
351.8809 |
|
0.7514 |
0.1055 |
|
|
|
|
|
Exponential |
|
0.0101 |
0.0018 |
0.1721 |
0.3364 |
337.7678 |
340.2160 |
Weibull |
|
0.0104 |
0.0022 |
0.1458 |
0.5462 |
339.5149 |
344.4114 |
|
0.9319 |
0.1326 |
|
|
|
|
To evaluate the BCW model’s fitting performance on the kidney disease patient infection data, it is compared with several models from [26], including BCPL, BGPL, and BFPL. Table 6 summarizes the parameter estimates and goodness-of-fit metrics for each model. In the table, Est is the parameter estimate, and StEr is the standard error, measuring estimation precision. The negative log-likelihood
indicates model fit, with smaller values being better. AIC and HQIC are model selection criteria that balance fit and complexity; smaller values indicate a better model.
Table 6. Parameter estimates and goodness-of-fit for different models.
|
|
|
|
|
|
|
|
AIC |
HQIC |
BCW |
Est |
0.0100 |
0.7396 |
0.0105 |
0.9139 |
0.4792 |
338.4692 |
686.9384 |
689.1797 |
StEr |
0.0026 |
0.1044 |
0.0022 |
0.1325 |
0.3806 |
|
|
|
BFPL |
Est |
0.5538 |
0.1596 |
0.6633 |
0.1020 |
0.8184 |
338.9452 |
687.8905 |
694.8964 |
StEr |
0.0657 |
0.0528 |
0.0802 |
0.0398 |
1.0106 |
|
|
|
BCPL |
Est |
0.5489 |
0.1634 |
0.6546 |
0.1068 |
0.4187 |
338.5119 |
687.0239 |
694.0299 |
StEr |
0.0657 |
0.0541 |
0.0807 |
0.0419 |
0.3633 |
|
|
|
BGPL |
Est |
0.5525 |
0.1686 |
0.4333 |
0.4501 |
1.0463 |
371.7617 |
753.5235 |
760.5295 |
StEr |
0.0661 |
0.0607 |
0.0505 |
0.0984 |
0.1100 |
|
|
|
BFXL |
Est |
0.0162 |
|
0.0193 |
|
0.8682 |
361.3897 |
728.7794 |
732.9830 |
StEr |
0.0021 |
|
0.0026 |
|
0.7539 |
|
|
|
CBPL |
Est |
0.0157 |
|
0.0181 |
|
0.2274 |
359.1277 |
724.2553 |
728.4589 |
StEr |
0.0020 |
|
0.0025 |
|
0.1154 |
|
|
|
BGXL |
Est |
0.0181 |
|
0.0365 |
|
1.0219 |
432.1889 |
870.3779 |
874.5815 |
StEr |
0.0024 |
|
0.0031 |
|
0.0242 |
|
|
|
BFGMV |
Est |
0.7521 |
100.5887 |
0.9298 |
95.8087 |
0.3984 |
338.9352 |
687.8704 |
694.8764 |
StEr |
0.1054 |
25.8636 |
0.1323 |
19.9343 |
0.4979 |
|
|
|
BFGMF |
Est |
22.7499 |
0.7287 |
27.9035 |
0.8661 |
0.6121 |
340.7127 |
691.4254 |
698.4314 |
StEr |
6.1236 |
0.0979 |
6.2978 |
0.1175 |
0.5614 |
|
|
|
BFGMG |
Est |
0.6761 |
0.0056 |
0.9288 |
0.0094 |
0.3781 |
339.4908 |
688.9817 |
695.9877 |
StEr |
0.1478 |
0.0018 |
0.2089 |
0.0028 |
0.4839 |
|
|
|
BFGMGE |
Est |
0.6595 |
0.0062 |
0.9224 |
0.0096 |
0.4100 |
339.5462 |
689.0924 |
696.0984 |
StEr |
0.1481 |
0.0017 |
0.2174 |
0.0024 |
0.4849 |
|
|
|
Table 6 shows that the BCW model has the lowest negative log-likelihood, AIC, and HQIC among all competing models, indicating the best fit. Moreover, its parameter estimates have relatively small standard errors, suggesting stability. Overall, the BCW model exhibits the best fitting performance on this dataset, confirming the effectiveness of the proposed model.
To evaluate the BCW model’s estimation performance under Type-II censoring, three scenarios are considered: complete samples (
) and censored samples (
). Table 7 presents the MLE and Bayesian results. As censoring increases (effective sample size decreases from 30 to 20), the parameter estimates show small fluctuations, but their standard errors increase, indicating greater estimation uncertainty. Under the same censoring level, Bayesian standard errors are generally smaller than those of MLE, demonstrating higher estimation accuracy under small-sample Type-II censoring. Moreover, the copula parameter
is positive across all censoring levels, confirming a positive dependence between the two infection intervals.
Table 7. MLE and Bayesian estimation results for the BCW model.
|
|
|
|
Est |
StEr |
Est |
StEr |
Est |
StEr |
BCW |
MLE |
|
0.7431 |
0.1051 |
0.7215 |
0.1143 |
0.7027 |
0.1268 |
|
0.0101 |
0.0026 |
0.0102 |
0.0030 |
0.0097 |
0.0034 |
|
0.9145 |
0.1329 |
0.8784 |
0.1361 |
0.8381 |
0.1534 |
|
0.0106 |
0.0022 |
0.0109 |
0.0026 |
0.0110 |
0.0032 |
|
0.4468 |
0.3814 |
0.4627 |
0.4835 |
0.3341 |
0.7586 |
Bayes |
|
0.7344 |
0.0912 |
0.7044 |
0.1011 |
0.6783 |
0.1044 |
|
0.0102 |
0.0022 |
0.0103 |
0.0024 |
0.0099 |
0.0026 |
|
0.8798 |
0.1191 |
0.8503 |
0.1254 |
0.7948 |
0.1265 |
|
0.0106 |
0.0021 |
0.0107 |
0.0022 |
0.0109 |
0.0026 |
|
0.6738 |
0.2368 |
0.7468 |
0.2772 |
0.7376 |
0.3090 |
Figure 6 shows the MCMC trace plots for each parameter under three Type-II censoring scenarios. The sampling sequences of all parameters display stable random fluctuations in the later iterations, with no obvious trends, clustering, or drift, indicating good convergence of the Markov chains. This confirms that posterior sampling is effective under Type-II censored data, and the Bayesian estimates are statistically reliable.
Figure 6. MCMC trace plots.
8. Conclusion
In this paper, we construct the bivariate Clayton Weibull (BCW) and bivariate Clayton exponential (BCE) models under Type-II censoring, with parameters estimated via maximum likelihood estimation (MLE) and Bayesian Markov chain Monte Carlo (MCMC) methods. Monte Carlo simulations reveal that Bayesian estimation consistently outperforms MLE, that larger sample sizes enhance estimation precision, and that the BCW model is more robust than the BCE model. When applied to kidney infection data, BCW yields the best fit, as evidenced by the lowest AIC and HQIC values among competing models. The estimated shape parameters for both infection times are below 1, indicating a declining risk of infection over time, and the positive Clayton copula parameter confirms a positive dependence between the two event times, thereby supporting patient risk stratification. The simulation results further inform the selection of sample sizes and follow-up cutoffs in clinical trial design. While the Clayton copula is specifically designed to capture lower-tail dependence and medical data may present more heterogeneous dependence patterns, the proposed estimation framework can be straightforwardly extended to other copula families to accommodate diverse data structures. Overall, the proposed methodology offers a practical and robust statistical framework for analyzing dependent survival data under Type-II censoring.