There is increased biotic pressure due to excessive increase in human population and over harvesting of nature and natural resource, resulting in increased attention to bio-prospecting [1] . The potential for physical flora collection to support scientific research is being enhanced by rapid development of information technology and remotely available digital database. India possesses rich floristic wealth and diversified genetic resources of medicinal plants. Several plants are used in traditional medicine for the treatment of vector borne diseases including malaria in many parts of the world [2] . Modern drugs have been deducted from folklore and traditional medicines [3] and hence the search for additional antimalarials from higher plants must continue to fight the deadly disease.

About 36% of world population is at risk of malaria. Around 2.5 million malaria cases are reported annually from South East Asia and 76% of it is in India (WHO, 2011). In the Tarai region of Eastern UP the spreading of vector borne diseases become uncontrolled especially during rainy seasons [4] . The need of the hour is to find new variety of drugs to combat the attack of mosquitoes who have found resistance to almost all old drugs. GIS provides the architecture and analysis tools to perform spatio-temporal modeling of disease transmission, and other factors relevant to the understanding of impacts and risk associated with malaria [5] . The effort has to be finding an alternative form of malaria control. Cost effective, practical and accessible interventions to be integrated into most malaria control programs. And thus investigation of insecticidal properties of plant-derived materials is environmentally safe, degradable and target specific.

Based on the parameters, like the recorded uses of medicinal plants, rarity and threat factors plant species and area can be identified to develop GIS based mapping using available software for visualizing, analyzing, creat- ing, and managing data with a geographic component. Most data has a component that can be tied to a place us- ing global positioning system (GPS) co-ordinates. GIS has been used as a “map maker” [6] . GIS supports multi- disciplinary analysis using a systematic approach and provides the ability to perform predictions of disease out- breaks based on available information. Later, plant density can also be calculated using image analysis algorithm applied on satellite data, and it can be cross validated with the available government data of forest of that area.

The trade in herbs and medicinal plants in UP at present stands at $1000 million per annum approximately. The growth rate has increased from 7% to 15% in the last couple of years, but export from the state is extremely inferior. In UP, over 250,000 hectare land comes under cultivation of herbs. The demand for herbal and natural products is escalating globally. The international market of herbal products is estimated above $62 billion while India’s share in the global market of export is merely 0.5% (Economic policy Business Standard 2009) [7] . The demand for the high time is to explore several means and launch various bio-prospecting projects to harvest natural wealth of the country sustainably. State government of UP has taken various initiatives towards meeting herbal and medicinal needs of people including cultivation of antimalarial medicinal plant Artemisia annua by Central Institute of Medicinal and Aromatic Plants (CIMAP) Lucknow. It is used to extract artemisinin, a compound which is most widely used compound in the development of antimalarial drug.

Ethnobotanical exploration with respect to food value has been done for north-eastern tarai region of UP and found 27 underutilized edible fruits consumed by ethnic people [8] . It widens the scope of bio-prospection and has established database of these fruits may be helpful in for achieving food security and environmental sustainability. For north east India all the antimalarial plants have been enlisted to emphasize the need for an alternative drug for malaria for developing new indigenous antiplasmodic plants [9] . It has also been highlighted total herbal plants used for the treatment of malaria and found that many of these plants are being used since ancient times for the treatment of malaria throughout the world [10] .

The current work is an amalgamation of data collection and its cross validation. It is based on two sources namely “Flora Gorakhpurensis” & “Flora of Upper Gangetic Plains” and cross validated with available literature survey (Figure 1). This is done to evaluate future prospects of all antimalarials prevalent in the region. Available literature amounts to numerous research papers and journals related such work of compilation of antimalarial plants and GIS applications. From the study area 48 antimalarial plants were reported. GPS coordinates were recorded for marked locations and under GIS environment maps of antimalarials are generated to highlight geographical distribution of such plants. Further, these are analysed with respect to various natural plant habitats. Having life in close vicinity of the nature, traditional societies have acquired unique knowledge about the use of flora and fauna in wild, most of which are still unknown to the common masses. The traditional knowledge, skills and practices thus developed are freely exchanged, cared for and nourished as a common property of the

communities [11] . The current work has highlighted the geographical location (habitat) of antimalarial plants along with other details like plant species, plant family and local name.

The objective of the current study is to carry out inter-disciplinary work by integrating ethno-medicinal findings with GIS tools to develop spatio-temporal maps covering antimalarial plants prevalent in three rural districts of eastern UP, India. Further, the aim is to adapt and apply map design principles to minimize cognitive and perceptual burden of exploring complex data sets. Spatial distribution of malaria using GIS happens to be a de novo approach in defining plants of a given locality and the advancement in information technology will certainly give an edge to this emerging field of research.

The work is not purely ethnobotanical in nature but amalgamation of ethnobotany & GIS. It is the work of ethnography. The native communities have been using their unique traditional knowledge system, culture, indigenous skills and expertise since the ancient times. India has witnessed its legacy from the time of Charaka & Susruta for traditional knowledge system (TKS) of medicinal plants. The GIS map has facilitated easy access of plant’s natural habitat. Further, it depicts the importance and method of application of these plants towards treatment in case of malaria, fever and intermittent fever. Applying GIS mapping will catalyse the process of extraction of artemisinin & quinine derivatives from the antimalarial plants and it will be a novice idea especially with the growing importance of information technology and advancement in satellite imagery techniques. This region has monsoonal rainfall that makes it favourable for vector borne diseases and hence the traditional knowledge coupled with new technology makes this study highly useful for basic amenity stressed regions.

Geographical distribution has been fragmented to eight habitat types (Table 2) of waste land (WL-15 plants), railway tracks (RL-6 plants), forest area (FA-5 plants), Roadside (RD-9 plants), Marshy/Moist Places (MM-9), crop fields (CF-7 plants), Garden/Orchard/Settlement (GOS-16 plants), water body/nallas/canals (WB-9 plants),

WL = Waste Land, RL = Railway Tracks, FA = Forest Area, RD = Roadside, MM = Marshy/Moist Places, CF = Crop Fields, GOS = Garden/Or- chard/Settlement, WB = Water Body/Nallas/Canals, WR = Whole Region.

whole region (WR-3 plants). There are many plants found in more than one habitat type. Largest number of plants is found in gardens, orchard and settlements while as many as 15 plants are found in waste lands. There are three plants Solanum indicum, Streblus asper and Tinospora cordifolia which are found throughout the study area & in abundance (Figure 5). In the study area two species namely Nagarmotha (Cyperus scariosus) and Goma or Drona pushpi (Leucas aspera) are at the verge of extinction mainly due to the change in water reservoir structure i.e. because of loss of water bodies like ponds and other reservoirs for the former and because of change in land-use pattern for the latter. Further, due to ruthless exploitation, many important medicinal plants species are becoming rare and some of them are critically endangered (As per the IUCN, Switzerland Red List Criteria). It is estimated that 10% of all plant species are currently endangered in India [19] .

Herbal medicines have good values in malaria treatment and because of its potential in many countries scientific investigations are undergoing and nearly 85% traditional medicines are plant derived [23] . Conservation of natural resources as well as its sustainable use is important in preservation of traditional knowledge.

Series of works have been done on ethno-botany work and ethno-ecology. However, GIS based mapping is indeed a novice idea. Spatial distribution using GIS happens to be new field of research and can be used in defining plants of a given region. Geo-visualization research in last 15 years directed considerable effort towards enhancing dynamic and interactive maps [24] . There are many remote places which are restricted for any physical reach for identification of plants. In this peculiar circumstance GIS could be a tool to address all these complexities using extrapolation techniques. Study area in the work happens to be least developed part of one of the poorest State in India. Thus, working for low socio-economic profile region will certainly be useful at larger scale and will bear extended benefits when the work will be thoroughly evaluated. The geographical maps (Fig- ures 4-7, Figure 9) are primarily drawn on the basis of GPS co-ordinates collected during field visit. But there are many remote points which remained unreachable because of rainy seasons and geographical terrain and hence for such regions extrapolation was done. Using the map results one can directly approach for any particular plant and assesses its geographical health. It gives precise location of plants in the identified geographical territory.

The work would help researchers to find out the novel antimalarials towards open source drug discovery projects. GIS maps serve the purpose of emphasizing spatial distribution of plants. GIS mapping has got potential application in field of traditional knowledge mapping in times to come. Much work in this promising field has yet to be done. Integrating legends (of plant botanical names) with maps enhance readability of maps and it can be easily understood for the geographical features of the study region. The GIS based technique can be used to trace a given antimalarial geographically in a speedy manner. There exists alarming need to conserve and protect these important species for sustainable harvesting. A serious endeavor has to be taken to save these natural resources for the generations to come.

The work carried out in the region reveals that the plants recorded are highly valuable for antimalarial application and in future; bio-prospecting projects can be further initiated for sustainable harvesting towards developing antimalarial drug for curing malaria at large. A GIS based national mapping of antimalarials can be aimed and the task can be integrated with on-going umbrella projects bio-prospection of CSIR, New Delhi under domain of open source drug discovery for malaria (OSDDm). Some plants are nearly extinct in the region, the reason being change in land use pattern and shrinking of water bodies along with overharvesting of herbs. The bio-depletion of these antimalarials is due to the burgeoning population.

The GIS based approach can be made microscopic further by accommodating geographical features linked to growth of an antimalarial plant in a given area. Developing a link between information technology and ethno- botany will be a novice idea especially when world technology is changing rapidly. GIS has touched all walks of human interfaces and thus application of GIS in the research paper has been done to map antimalarial plants of any given locality. Traditional plant knowledge and plant spatial distribution can be linked further and its understanding is enhanced with GIS mappings. It is anticipated that in times to come GIS will be a dominant tool to understand ethnography.

We are highly indebted to the Open Source Drug Discovery Project for malaria of CSIR, New Delhi for providing financial assistance which kept constant high motivation throughout the work. We also acknowledge the computer laboratory facility at School of Computational & Integrative Sciences and Centre for the Study of Regional Development, Jawaharlal Nehru University, New Delhi and is equally indebted to the Ministry of Environment & Forest, MoEF Govt. of India for its continuous support towards making this work plausible.

None declared.

Not required.