<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">FNS</journal-id><journal-title-group><journal-title>Food and Nutrition Sciences</journal-title></journal-title-group><issn pub-type="epub">2157-944X</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/fns.2014.511116</article-id><article-id pub-id-type="publisher-id">FNS-46940</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>MEDICINE &amp; HEALTHCARE</subject><subject>BIOMEDICAL &amp; LIFE SCIENCES</subject><subject>CHEMISTRY &amp; MATERIALS SCIENCE</subject></subj-group></article-categories><title-group><article-title>Cardiovascular Risk of Community-Dwelling Elderly from a City in Northeastern Brazil: Correlations with Vitamin D and Parathormone</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Lídia</surname><given-names>Ribeiro de Carvalho</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Cecília</surname><given-names>Maria R. G. de Carvalho</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Sandra</surname><given-names>M. L. Ribeiro</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ivone</surname><given-names>F. de Oliveira C. Nunes</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Raquel</surname><given-names>Galvão Figueredo</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Amanda</surname><given-names>Marreiro Barbosa</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Francisco</surname><given-names>Erasmo de Oliveira</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Dilina</surname><given-names>do Nascimento Marreiro</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Marcos</surname><given-names>David Figueiredo de Carvalho</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>José</surname><given-names>Machado Moita Neto</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group>


<aff id="aff3">
<addr-line>Laboratório Med Imagem, Teresina, Brazil</addr-line>
</aff>
<aff id="aff1">
<addr-line>Federal University of Piaui (UFPI), Teresina, Brazil</addr-line
></aff>
<aff id="aff2">
<addr-line>School of Arts, Sciences and Humanities, University of S?o Paulo, S?o Paulo, Brazil
</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>smlribeiro@usp.br(SMLR)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>26</day><month>05</month><year>2014</year></pub-date><volume>05</volume><issue>11</issue><fpage>1056</fpage><lpage>1064</lpage><history><date date-type="received"><day>6</day>	<month>April</month>	<year>2014</year></date><date date-type="rev-recd"><day>7</day>	<month>May</month>	<year>2014</year>	</date><date date-type="accepted"><day>16</day>	<month>May</month>	<year>2014</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
	We investigated the
cardiovascular disease (CVD) risk of the elderly in a city in northeastern Brazil,
and the correlation of this risk with vitamin D and PTH status. We studied 359
elderly, both genders, from Piauí-Teresina-Brazil. Variables investigated: body
mass index, waist circumference, systolic and diastolic blood pressure. A
subsample (n = 100) was investigated for biochemical analyses: PTH and
25(OH)-vitamin D levels; total, HDL and LDL-cholesterol; and fasting glucose.
High blood pressure, abdominal obesity, sedentarism, high total cholesterol, high
triacylglycerol levels, as well as low vitamin D levels, were, among the
investigated variables, the most prevalent. Visceral adiposity and low vitamin
D were found to be more prevalent in women than in men, whilst alcohol intake
and smoking were more prevalent in men. The correlation between vitamin D, PTH
and the investigated risk variables, under our study conditions, were not
significant.
</p></abstract><kwd-group><kwd>Cardiovascular Diseases</kwd><kwd> Risk Factors</kwd><kwd> Elderly</kwd><kwd> Vitamin D</kwd><kwd> PTH</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Aging processes enhance the risk to chronic diseases, such as obesity, hypertension, type II diabetes mellitus, dyslipidemias, and cardiovascular diseases. In this way, we can find a number of published articles investigating risk factors and different strategies to manage the associated diseases [<xref ref-type="bibr" rid="scirp.46940-ref1">1</xref>] -[<xref ref-type="bibr" rid="scirp.46940-ref3">3</xref>] .</p><p>Recent researches have shown an important role of vitamin D in the development of many chronic diseases. This vitamin binds to its receptors (vitamin D receptors-VDR), constituting a complex capable of modifying path- ways of gene expression, or other non-genomic pathways, in a number of tissues [<xref ref-type="bibr" rid="scirp.46940-ref4">4</xref>] -[<xref ref-type="bibr" rid="scirp.46940-ref6">6</xref>] . Several systems, directly or indirectly related to cardiovascular function seem to be influenced by the binding of vitamin D to its re- ceptors. For instance, we can count effects on the renin-angiotensin-aldosterone system; effects on vascular endothelial growth factor and cytokine production; effects on endothelial cell function and myocyte calcium influx [<xref ref-type="bibr" rid="scirp.46940-ref7">7</xref>] -[<xref ref-type="bibr" rid="scirp.46940-ref14">14</xref>] . In addition, low vitamin D levels are associated with high parathormone (PTH) levels, which in turn are associated with left ventricular hypertrophy and heart failure [<xref ref-type="bibr" rid="scirp.46940-ref15">15</xref>] .</p><p>With regard to nutritional deficiencies that are typical of aging, many studies have shown low levels of vitamin D in elderly people. Classic studies have suggested the prevalence of vitamin D deficiency in these individuals to be close to 40% [<xref ref-type="bibr" rid="scirp.46940-ref16">16</xref>] -[<xref ref-type="bibr" rid="scirp.46940-ref18">18</xref>] . Brazilian studies have shown a prevalence varying from 5% to 25% [<xref ref-type="bibr" rid="scirp.46940-ref17">17</xref>] . Ta- king into account the institutionalized elderly, this prevalence can reach 71.2% [<xref ref-type="bibr" rid="scirp.46940-ref11">11</xref>] . Therefore, the aging pro- cess can result in a combination of some risk factors for CVD.</p><p>Despite the importance of investigating vitamin D and associated diseases, there are still few regional studies in Brazil, particularly in some cities of northeastern of the country. As such, the aim of this study was to investigate the CVD risk in elderly from Teresina-PI-Brazil, and the correlation of this risk with vitamin D and PTH status. Considering the fast population aging [<xref ref-type="bibr" rid="scirp.46940-ref19">19</xref>] , this kind of study may contribute to the management of the high cost of diseases associated with this population’s group.</p></sec><sec id="s2"><title>2. Material and Methods</title><sec id="s2_1"><title>2.1. Subjects</title><p>This is an observational, descriptive, and cross-sectional study. The participants were elderly (above 60-years old), of both genders, and were community-dwelling in Teresina, Piau&#237;-Brazil. Subjects were selected using data from a Brazilian Ministry Health Program (Health Family Strategy). The sample size was calculated from the standard deviation estimative of 28.5 ng/mL of 25(OH)-D [<xref ref-type="bibr" rid="scirp.46940-ref11">11</xref>] , with a confidence level of 95% and sample error of 5.6 ng/mL. We excluded subjects that were bedridden, those that used a wheelchair, those with hearing or talking impairments, those who were taking vitamin D or calcium supplements and those with diseases related to vitamin D metabolism (for instance, kidney or liver diseases). The guidelines for human studies were followed according to the Declaration of Helsinki. The volunteers elected to the study signed their informed consent, and the project was approved by the Ethics Committee of the Federal University of Piau&#237;, protocol number 0386.0.045.000-10.</p></sec><sec id="s2_2"><title>2.2. Assessments</title><p>Data were obtained during a house interview, adopting a questionnaire that had been pre-tested in a previous pilot experiment. Data were collected from February to June, 2011. The anthropometric measurements were: body weight (Plenna scale, 150 Kg), knee height-measured with a caliper consisting of an adjustable measuring stick with a blade attached to each end, at a 90˚ angle [<xref ref-type="bibr" rid="scirp.46940-ref20">20</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref21">21</xref>] —and waist circumference (WC), measured with an inelastic fiberglass tape. From the measurements, we estimated the height [<xref ref-type="bibr" rid="scirp.46940-ref20">20</xref>] , and calculated the body mass index [BMI = weight/(height)<sup>2</sup>]. To classify the nutritional status according to BMI, we adopted the recommendation of the Pan-American Health Organization; normality when BMI was between 23 - 28 kg/m<sup>2</sup>, overweight when 28 kg/m<sup>2</sup> ≤ BMI &lt; 30 kg/m<sup>2</sup> and obesity when BMI ≥ 30 Kg/m<sup>2</sup> [<xref ref-type="bibr" rid="scirp.46940-ref22">22</xref>] . To identify cardiovascular risk from the waist circumference, we adopted standards proposed by the WHO [<xref ref-type="bibr" rid="scirp.46940-ref23">23</xref>] , where waist circumference ≥ 102 cm for men and ≥ 88 cm for women constituted cardiovascular risk.</p><p>Blood pressure was measured following the VI Brazilian Guidelines for Hypertension (BD sphygmomanometer). According to these guidelines, hypertension was defined as systolic blood pressure (SBP) ≥ 140 mm/hg and/or diastolic blood pressure (DBP) ≥ 90 mm/Hg. The values were obtained by calculating the average of two measurements [<xref ref-type="bibr" rid="scirp.46940-ref24">24</xref>] . For participants with diabetes, hypertension was defined when SBP was ≥ 130 and/or DBP 80 ≥ mmHg. In addition, participants who referred to taking medicines for hypertension were also considered as having high blood pressure [<xref ref-type="bibr" rid="scirp.46940-ref25">25</xref>] .</p></sec><sec id="s2_3"><title>2.3. Biochemistry</title><p>For blood sample collection, the participants were required to attend the Health Unit on a scheduled day, during the morning, after fasting and rest of between 8 - 12 hours. In case of any difficulty, the researcher went to the participant’s house to carry out blood withdrawal. The blood was centrifuged and the plasma was frozen until analysis. Biochemical analyses were performed at the Hospital Med Imagem, Teresina, Piau&#237;, Brazil. PTH and 25(OH)-D levels were analyzed by chemiluminescence method (IMMULITE 200 and Diasorin LIAISON<sup>TM</sup>, USA, respectively). The reference range for PTH was 12 to 72 pg/mL, and the classification of vitamin D levels followed that proposed by Holick et al. [<xref ref-type="bibr" rid="scirp.46940-ref26">26</xref>] : ≤ 20 ng/mL-vitamin D deficiency; 21 to 29.9 ng/mL-insufficient level; ≥ 30 ng/mL to 100 ng/mL-adequate levels. Plasma lipids were analyzed by automation (ViteK Systems Clinline 150-Biomerieux). HDL-cholesterol and triacylglycerol were measured by enzymatic colorimetry, and LDL-cholesterol was calculated according to the Friedwald equation [<xref ref-type="bibr" rid="scirp.46940-ref27">27</xref>] . We adopted reference values according to the IV Brazilian Guidelines on dyslipidemia and arterosclerosis prevention [<xref ref-type="bibr" rid="scirp.46940-ref28">28</xref>] . Fasting blood glucose was measured by enzymatic colorimetric method, and the reference values followed those of the Brazilian Society of Diabetes [<xref ref-type="bibr" rid="scirp.46940-ref29">29</xref>] . Participants with blood glucose values ≥ 126 mg/dL and those with normal values, but under pharmacological treatment, were considered as diabetic.</p></sec><sec id="s2_4"><title>2.4. Data Analysis and Statistical Methods</title><p>Numeric data were presented as mean and standard deviation. The categorical variables were presented as percentages. The Kolmogorov-Smirnov test revealed that none of the investigated variables presented normal distribution. Therefore, we adopted non-parametric tests (Mann-Whitney test and Kruskal-Wallis test). The association between categorical variables was investigated by the Chi-square test (c<sup>2</sup>), and cases where more than 25% of the cells presented n &lt; 5 we adopted the Fisher exact-test. Some data were correlated by Spearman test. We considered a p-value &lt; 0.05 as significant for all analyses and the analyses were performed with the Statistical Package for Social Sciences (SPSS<sup>&#174;</sup>), version 18.0.</p></sec></sec><sec id="s3"><title>3. Results</title><sec id="s3_1"><title>3.1. Sociodemographic and Clinical Aspects</title><p><xref ref-type="table" rid="table1">Table 1</xref> depicts the variables investigated and <xref ref-type="table" rid="table2">Table 2</xref> presents the prevalence of cardiovascular risk, for both genders. With regard to demographic data, the majority of the participants declared living with a partner; most of them reported low schooling and low income.</p><p>Both men and women presented a low prevalence of total obesity, as evaluated by BMI values. However, abdominal obesity, evaluated by WC, suggested that the majority of women presented CVD risk, but not the majority of men. Both genders presented an elevated prevalence of high blood pressure.</p><p>Biochemical analysis suggested low levels of 25(OH)-D for both genders, but women presented lower values than men. PTH values were between normality ranges for the majority of both men and women. High fasting glucose was relatively low in prevalence both in men and women, although the mean values were higher in men. The prevalence of high total cholesterol and triacylglycerol was elevated in both genders, without any difference between genders. In turn, the prevalence of both high LDL-cholesterol and low HDL-cholesterol was lower than other markers of blood lipids, although women showed a higher prevalence than men. Alcohol intake and smoking were referred by a small percentage of the participants; men reported these habits more than women. In addition, a sedentary lifestyle was referred by the majority of participants, of both genders.</p><p>In order to turn our study broader, we investigated cardiovascular risk by taking into account other independent variables. With regard to schooling, total obesity was higher in the subjects with higher schooling level. In contrast, a sedentary lifestyle was more common in subjects with lower schooling (illiterate = 7.2% and 81.3% for total obesity and sedentary lifestyle, respectively; fundamental level = 12.4% and 73.3% respectively; intermediate level and above: 16.9% and 55.9% respectively; p &lt; 0.05 for all the comparisons). Biochemical variables and blood pressure values did not present any significant association with regard to schooling. Considering marital status, high blood pressure, abdominal obesity and low HDL-cholesterol were more prevalent in the</p><table-wrap id="table1"  position="float"><object-id pub-id-type="pii">Table 1</object-id><label>Table 1</label><caption><p>. Distribution of the variables investigated, according to gender<sup>*</sup></p></caption><table><thead><tr><th align="center" valign="middle" >Demographic variables</th><th align="center" valign="middle" >Male (n = 138) N (%)</th><th align="center" valign="middle" >Female (n = 221) N (%)</th><th align="center" valign="middle" ></th><th align="center" valign="middle" >Total (n = 359) N (%)</th></tr></thead><tbody><tr><td align="center" valign="middle" >Age group</td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >60 - 69 y</td><td align="center" valign="middle" >66 (47.8)</td><td align="center" valign="middle" >117 (52.9)</td><td align="center" valign="middle" >c<sup>2</sup> = 0.98</td><td align="center" valign="middle" >183 (51.0)</td></tr><tr><td align="center" valign="middle" >70 - 79 y</td><td align="center" valign="middle" >49 (35.5)</td><td align="center" valign="middle" >73 (33.0)</td><td align="center" valign="middle" >p = 0.61</td><td align="center" valign="middle" >122 (34.0)</td></tr><tr><td align="center" valign="middle" >≥80 y</td><td align="center" valign="middle" >23 (16.7)</td><td align="center" valign="middle" >31 (14.0)</td><td align="center" valign="middle" ></td><td align="center" valign="middle" >54 (15.0)</td></tr><tr><td align="center" valign="middle" >Marital status</td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >Without partner</td><td align="center" valign="middle" >20 (14.5)</td><td align="center" valign="middle" >114 (51.6)</td><td align="center" valign="middle" >c<sup>2</sup> = 49.96</td><td align="center" valign="middle" >134 (37.3)</td></tr><tr><td align="center" valign="middle" >With partner</td><td align="center" valign="middle" >118 (85.5)</td><td align="center" valign="middle" >107 (48.4)</td><td align="center" valign="middle" >p &lt; 0.001</td><td align="center" valign="middle" >225 (62.7)</td></tr><tr><td align="center" valign="middle" >Schooling</td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >Illiterate</td><td align="center" valign="middle" >52 (37.7)</td><td align="center" valign="middle" >87 (39.4)</td><td align="center" valign="middle" ></td><td align="center" valign="middle" >139 (38.7)</td></tr><tr><td align="center" valign="middle" >Fundamental level<sup>1</sup></td><td align="center" valign="middle" >65 (47.1)</td><td align="center" valign="middle" >96 (43.3)</td><td align="center" valign="middle" >c<sup>2</sup> = 0.52 p = 0.77</td><td align="center" valign="middle" >161 (44.8)</td></tr><tr><td align="center" valign="middle" >Intermediate level or above<sup>1</sup></td><td align="center" valign="middle" >21 (15.2)</td><td align="center" valign="middle" >38 (17.2)</td><td align="center" valign="middle" ></td><td align="center" valign="middle" >59 (16.4)</td></tr><tr><td align="center" valign="middle" >Family Income</td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >&lt;2 MS<sup>2</sup></td><td align="center" valign="middle" >71 (51.4)</td><td align="center" valign="middle" >142 (64.2)</td><td align="center" valign="middle" >c<sup>2</sup> = 10.42</td><td align="center" valign="middle" >213 (59.3)</td></tr><tr><td align="center" valign="middle" >2 - 5 MS</td><td align="center" valign="middle" >44 (31.9)</td><td align="center" valign="middle" >64 (29.0)</td><td align="center" valign="middle" >p = 0.005</td><td align="center" valign="middle" >108 (30.1)</td></tr><tr><td align="center" valign="middle" >&gt;5 MS</td><td align="center" valign="middle" >23 (16.7)</td><td align="center" valign="middle" >15 (6.8)</td><td align="center" valign="middle" ></td><td align="center" valign="middle" >38 (10.6)</td></tr><tr><td align="center" valign="middle" >Anthopometric and  BP variables</td><td align="center" valign="middle" >Male (n = 138) Mean (SD)</td><td align="center" valign="middle" >Female (n = 221) Mean (SD)</td><td align="center" valign="middle" >p-value<sup>*</sup></td><td align="center" valign="middle" >Total (n = 359) Mean (SD)</td></tr><tr><td align="center" valign="middle" >BMI<sup>3</sup> (kg/m<sup>2</sup>)</td><td align="center" valign="middle" >24.6 (3.8)</td><td align="center" valign="middle" >25.2 (4.4)</td><td align="center" valign="middle" >0.065</td><td align="center" valign="middle" >25.0 (4.2)</td></tr><tr><td align="center" valign="middle" >WC (cm)</td><td align="center" valign="middle" >96.8 (10.3)</td><td align="center" valign="middle" >98.2 (12.5)</td><td align="center" valign="middle" >0.072</td><td align="center" valign="middle" >97.7 (11.7)</td></tr><tr><td align="center" valign="middle" >SBP<sup>4</sup> (mmHg)</td><td align="center" valign="middle" >131.7 (19.0)</td><td align="center" valign="middle" >131.6 (22.2)</td><td align="center" valign="middle" >0.679</td><td align="center" valign="middle" >131.6 (21.0)</td></tr><tr><td align="center" valign="middle" >DBP<sup>5</sup> (mmHg)</td><td align="center" valign="middle" >78.3 (11.0)</td><td align="center" valign="middle" >77.6 (11.7)</td><td align="center" valign="middle" >0.391</td><td align="center" valign="middle" >77.9 (11.5)</td></tr><tr><td align="center" valign="middle" >Biochemical Variables</td><td align="center" valign="middle" >Male (n = 42) Mean (SD)</td><td align="center" valign="middle" >Female (n = 38) Mean (SD)</td><td align="center" valign="middle" >p-value<sup>*</sup></td><td align="center" valign="middle" >Total (n = 100) Mean (SD)</td></tr><tr><td align="center" valign="middle" >25(OH)-D (ng/mL)</td><td align="center" valign="middle" >25.7 (9.2)</td><td align="center" valign="middle" >20.2 (6.2)</td><td align="center" valign="middle" >0.001</td><td align="center" valign="middle" >22.5 (8.0)</td></tr><tr><td align="center" valign="middle" >PTH (pg/mL)</td><td align="center" valign="middle" >42.0 (22.5)</td><td align="center" valign="middle" >39.3 (19.7)</td><td align="center" valign="middle" >0.555</td><td align="center" valign="middle" >40.7 (20.9)</td></tr><tr><td align="center" valign="middle" >Fasting Glucose (mg/dL)</td><td align="center" valign="middle" >108.0 (23.6)</td><td align="center" valign="middle" >98.4 (22.7)</td><td align="center" valign="middle" >0.024</td><td align="center" valign="middle" >102.4 (23.4)</td></tr><tr><td align="center" valign="middle" >Total Cholesterol (mg/dL)</td><td align="center" valign="middle" >239.2 (36.8)</td><td align="center" valign="middle" >251.8 (55.8)</td><td align="center" valign="middle" >0.346</td><td align="center" valign="middle" >246.5 (48.9)</td></tr><tr><td align="center" valign="middle" >LDL-Cholesterol (mg/dL)</td><td align="center" valign="middle" >145.0 (25.7)</td><td align="center" valign="middle" >158.6 (50.9)</td><td align="center" valign="middle" >0.335</td><td align="center" valign="middle" >152.9 (75.6)</td></tr><tr><td align="center" valign="middle" >HDL-Cholesterol (mg/dL)</td><td align="center" valign="middle" >51.6 (9.4)</td><td align="center" valign="middle" >51.1 (6.9)</td><td align="center" valign="middle" >0.922</td><td align="center" valign="middle" >51.3 (8.0)</td></tr><tr><td align="center" valign="middle" >Triacylglycerol (mg/dL)</td><td align="center" valign="middle" >231.1 (95.9)</td><td align="center" valign="middle" >210.3 (57.4)</td><td align="center" valign="middle" >0.444</td><td align="center" valign="middle" >211.5 (75.6)</td></tr></tbody></table></table-wrap><p><sup>*</sup>Category variables were compared by Chi-squared test (c<sup>2</sup>), and numeric variables were compared by Mann-Whitney Test. <sup>1</sup>Complete or incomplete; <sup>2</sup>MS = Minimal salary; <sup>3</sup>BMI = body mass index; <sup>4</sup>SBP = systolic blood pressure; <sup>5</sup>DBP = diastolic blood pressure.</p><table-wrap id="table2"  position="float"><object-id pub-id-type="pii">Table 2</object-id><label>Table 2</label><caption><p>. Prevalence of cardiovascular risk, according to the investigated parameters</p></caption><table><thead><tr><th align="center" valign="middle"  rowspan="2"  >Anthropometric and BP parameters</th><th align="center" valign="middle" >Total n = 359</th><th align="center" valign="middle" >Male n = 138</th><th align="center" valign="middle" >Female n = 221</th><th align="center" valign="middle"  rowspan="2"  >p</th></tr></thead><tbody><tr><td align="center" valign="middle" >%</td><td align="center" valign="middle" >%</td><td align="center" valign="middle" >%</td></tr><tr><td align="center" valign="middle" >High blood pressure</td><td align="center" valign="middle" >71.3</td><td align="center" valign="middle" >66.7</td><td align="center" valign="middle" >74.2</td><td align="center" valign="middle" >0.124</td></tr><tr><td align="center" valign="middle" >Total obesity</td><td align="center" valign="middle" >11.1</td><td align="center" valign="middle" >9.4</td><td align="center" valign="middle" >12.2</td><td align="center" valign="middle" >0.688</td></tr><tr><td align="center" valign="middle" >Abdominal obesity</td><td align="center" valign="middle" >65.2</td><td align="center" valign="middle" >30.4</td><td align="center" valign="middle" >86.9</td><td align="center" valign="middle" >&lt;0.001</td></tr><tr><td align="center" valign="middle" >Alcohol intake</td><td align="center" valign="middle" >22.6</td><td align="center" valign="middle" >34.8</td><td align="center" valign="middle" >14.9</td><td align="center" valign="middle" >&lt;0.001</td></tr><tr><td align="center" valign="middle" >Smoking</td><td align="center" valign="middle" >11.7</td><td align="center" valign="middle" >15.2</td><td align="center" valign="middle" >9.5</td><td align="center" valign="middle" >&lt;0.001</td></tr><tr><td align="center" valign="middle" >Sedentary</td><td align="center" valign="middle" >73.5</td><td align="center" valign="middle" >74.6</td><td align="center" valign="middle" >72.9</td><td align="center" valign="middle" >0.709</td></tr><tr><td align="center" valign="middle"  rowspan="2"  >Biochemical parameters</td><td align="center" valign="middle" >n = 100</td><td align="center" valign="middle" >n = 42</td><td align="center" valign="middle" >n = 58</td><td align="center" valign="middle"  rowspan="2"  >p</td></tr><tr><td align="center" valign="middle" >%</td><td align="center" valign="middle" >%</td><td align="center" valign="middle" >%</td></tr><tr><td align="center" valign="middle" >Low vitamin D</td><td align="center" valign="middle" >82.0</td><td align="center" valign="middle" >66.7</td><td align="center" valign="middle" >93.1</td><td align="center" valign="middle" >0.001</td></tr><tr><td align="center" valign="middle" >Low PTH</td><td align="center" valign="middle" >4.0</td><td align="center" valign="middle" >4.8</td><td align="center" valign="middle" >3.4</td><td align="center" valign="middle" >0.355</td></tr><tr><td align="center" valign="middle" >High fasting glucose</td><td align="center" valign="middle" >22.0</td><td align="center" valign="middle" >28.6</td><td align="center" valign="middle" >17.2</td><td align="center" valign="middle" >0.177</td></tr><tr><td align="center" valign="middle" >High total cholesterol</td><td align="center" valign="middle" >88.0</td><td align="center" valign="middle" >85.7</td><td align="center" valign="middle" >89.7</td><td align="center" valign="middle" >0.549</td></tr><tr><td align="center" valign="middle" >High LDL-c</td><td align="center" valign="middle" >34.0</td><td align="center" valign="middle" >23.8</td><td align="center" valign="middle" >41.4</td><td align="center" valign="middle" >0.067</td></tr><tr><td align="center" valign="middle" >Low HDL-c</td><td align="center" valign="middle" >30.0</td><td align="center" valign="middle" >11.9</td><td align="center" valign="middle" >43.1</td><td align="center" valign="middle" >0.001</td></tr><tr><td align="center" valign="middle" >Hypertriacylglycerol</td><td align="center" valign="middle" >88.0</td><td align="center" valign="middle" >88.1</td><td align="center" valign="middle" >87.9</td><td align="center" valign="middle" >0.980</td></tr></tbody></table></table-wrap><p>participants living without a partner (with partner = 65.3%, 56.9% and 23.2%, respectively; p &lt; 0.05 for all comparisons; without partner = 81.3%, 79.1% and 45.2%, respectively). In turn, alcohol intake was higher in participants living with a partner (27.1%, versus 14.9%; p &lt; 0.05). There were no differences in any of the risk factors when stratified for income. When grouping the participants according to age intervals (60 - 69, 70 - 79 and above 80 years), the only variable that was significantly different in the groups was alcohol intake (29.5%, 15.6% and 14.8% respectively, p &lt; 0.05).</p></sec><sec id="s3_2"><title>3.2. Correlation between Vitamin D and Parathormone with Cardiovascular Risk</title><p><xref ref-type="table" rid="table3">Table 3</xref> shows the correlation between vitamin D and variables related to cardiovascular risk, and <xref ref-type="table" rid="table4">Table 4</xref> shows the correlation between PTH and the same variables. We did not observe any significant correlation of vitamin D levels and any of the variables. With regard to PTH, only DBP presented significant correlation with this factor.</p></sec></sec><sec id="s4"><title>4. Discussion</title><p>We investigated some variables related to CVD risk of elderly individuals in a city in the northeastern Brazil, and the correlation between those variables and vitamin D and PTH status. We observed that the most prevalent risk factors were: high blood pressure, abdominal obesity, sedentarism, high total cholesterol, high triacylglycerol, and low vitamin D. We also found that abdominal adiposity and low vitamin D were variables that were more prevalent in women than in men, whilst alcohol intake and smoking were more prevalent in men. However, we did not find significant correlation between vitamin D, PTH and any risk variables investigated.</p><p>The correlation investigated in the present study show divergences in literature. With regard to adiposity, Kimmons et al. [<xref ref-type="bibr" rid="scirp.46940-ref30">30</xref>] , in agreement with the present study, found no significant correlation between PTH and BMI, while Ahlstr&#246;m et al. [<xref ref-type="bibr" rid="scirp.46940-ref31">31</xref>] and Premaor &amp; Furnanetto [<xref ref-type="bibr" rid="scirp.46940-ref17">17</xref>] found positive and significant correlations between these variables. The authors attributed these significant results to the ability of adipocytes to store vitamin</p><table-wrap id="table3"  position="float"><object-id pub-id-type="pii">Table 3</object-id><label>Table 3</label><caption><p>. Correlation (spearman) between variables related to cardiovascular risk and 25(OH)-vitamin D levels</p></caption><table><thead><tr><th align="center" valign="middle" >Variables</th><th align="center" valign="middle" >r-value</th><th align="center" valign="middle" >p-value</th></tr></thead><tbody><tr><td align="center" valign="middle" >SBP with use of medicine</td><td align="center" valign="middle" >0.009</td><td align="center" valign="middle" >0.948</td></tr><tr><td align="center" valign="middle" >DBP with medicine</td><td align="center" valign="middle" >−0.057</td><td align="center" valign="middle" >0.673</td></tr><tr><td align="center" valign="middle" >SBP without use of medicine</td><td align="center" valign="middle" >−0.152</td><td align="center" valign="middle" >0.337</td></tr><tr><td align="center" valign="middle" >DBP without medicine</td><td align="center" valign="middle" >−0.105</td><td align="center" valign="middle" >0.509</td></tr><tr><td align="center" valign="middle" >Fasting blood glucose</td><td align="center" valign="middle" >−0.042</td><td align="center" valign="middle" >0.680</td></tr><tr><td align="center" valign="middle" >Body mass index</td><td align="center" valign="middle" >−0.144</td><td align="center" valign="middle" >0.154</td></tr><tr><td align="center" valign="middle" >Waist Circumference</td><td align="center" valign="middle" >−0.173</td><td align="center" valign="middle" >0.085</td></tr><tr><td align="center" valign="middle" >Total-Cholesterol</td><td align="center" valign="middle" >−0.126</td><td align="center" valign="middle" >0.210</td></tr><tr><td align="center" valign="middle" >LDL-Cholesterol</td><td align="center" valign="middle" >−0.114</td><td align="center" valign="middle" >0.261</td></tr><tr><td align="center" valign="middle" >HDL-Cholesterol</td><td align="center" valign="middle" >−0.017</td><td align="center" valign="middle" >0.863</td></tr><tr><td align="center" valign="middle" >Triacylglycerol</td><td align="center" valign="middle" >−0.120</td><td align="center" valign="middle" >0.234</td></tr></tbody></table></table-wrap><table-wrap id="table4"  position="float"><object-id pub-id-type="pii">Table 4</object-id><label>Table 4</label><caption><p>. Correlation (spearman) between variables related to cardio- vascular risk and PTH levels</p></caption><table><thead><tr><th align="center" valign="middle" >Variables</th><th align="center" valign="middle" >r-value</th><th align="center" valign="middle" >p-value</th></tr></thead><tbody><tr><td align="center" valign="middle" >SBP (mmHg)</td><td align="center" valign="middle" >−0.124</td><td align="center" valign="middle" >0.218</td></tr><tr><td align="center" valign="middle" >DBP (mmHg)</td><td align="center" valign="middle" >−0.201</td><td align="center" valign="middle" >0.045</td></tr><tr><td align="center" valign="middle" >Fasting blood glucose (ml/dL)</td><td align="center" valign="middle" >−0.078</td><td align="center" valign="middle" >0.443</td></tr><tr><td align="center" valign="middle" >Body Mass Index (kg/m&#178;)</td><td align="center" valign="middle" >0.023</td><td align="center" valign="middle" >0.818</td></tr><tr><td align="center" valign="middle" >Waist Circumference (cm)</td><td align="center" valign="middle" >0.027</td><td align="center" valign="middle" >0.787</td></tr><tr><td align="center" valign="middle" >Total Cholesterol (ml/dL)</td><td align="center" valign="middle" >−0.175</td><td align="center" valign="middle" >0.081</td></tr><tr><td align="center" valign="middle" >LDL-Cholesterol (ml/dL)</td><td align="center" valign="middle" >−0.145</td><td align="center" valign="middle" >0.149</td></tr><tr><td align="center" valign="middle" >HDL-Cholesterol (ml/dL)</td><td align="center" valign="middle" >−0.010</td><td align="center" valign="middle" >0.918</td></tr><tr><td align="center" valign="middle" >Triacylglycerol (ml/dL)</td><td align="center" valign="middle" >−0.137</td><td align="center" valign="middle" >0.175</td></tr></tbody></table></table-wrap><p>D, which makes this vitamin biologically unavailable [<xref ref-type="bibr" rid="scirp.46940-ref10">10</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref32">32</xref>] -[<xref ref-type="bibr" rid="scirp.46940-ref34">34</xref>] . As such, low levels of vitamin D and consequently high levels of PTH contribute to the elevation of intracellular calcium in adipocytes, stimulating lipogenesis.</p><p>Data from 15 088 individuals from a study by NHANES III showed an inverse association between obesity and vitamin D [<xref ref-type="bibr" rid="scirp.46940-ref10">10</xref>] . Studies have found a significant association between vitamin D and visceral obesity [<xref ref-type="bibr" rid="scirp.46940-ref34">34</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref35">35</xref>] , whilst others have not [<xref ref-type="bibr" rid="scirp.46940-ref8">8</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref36">36</xref>] . Cigolini et al. [<xref ref-type="bibr" rid="scirp.46940-ref8">8</xref>] , in a case-control study, did not find differences in body fat, when comparing individuals with or without vitamin D deficiency.</p><p>Regarding blood pressure, data from NHANES III (USA) showed an inverse correlation between SBP and vitamin D [<xref ref-type="bibr" rid="scirp.46940-ref12">12</xref>] , and other studies have shown similar associations [<xref ref-type="bibr" rid="scirp.46940-ref37">37</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref38">38</xref>] . The role of vitamin D in the renin- angiotensin-aldosterone system is the most plausible explanation for the results [<xref ref-type="bibr" rid="scirp.46940-ref13">13</xref>] . However, other authors, similarly to us, failed to find significant correlations between SBP and DBP with vitamin D [<xref ref-type="bibr" rid="scirp.46940-ref35">35</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref36">36</xref>] .</p><p>In agreement with our study, neither Ahlstr&#246;n et al. [<xref ref-type="bibr" rid="scirp.46940-ref30">30</xref>] nor Hjelmesaeth et al. [<xref ref-type="bibr" rid="scirp.46940-ref38">38</xref>] found any significant correlation between PTH and blood glucose, or between PTH and LDL-cholesterol. However, Ahlstr&#246;n et al. [<xref ref-type="bibr" rid="scirp.46940-ref31">31</xref>] , as well as Hjelmesaeth et al. [<xref ref-type="bibr" rid="scirp.46940-ref39">39</xref>] found a negative and significant correlation between PTH and HDL- cholesterol, and also a positive and significant correlation between PTH and triacylglycerol.</p><p>Ponda et al. [<xref ref-type="bibr" rid="scirp.46940-ref40">40</xref>] showed an inverse correlation between vitamin D and total cholesterol and LDL-cholesterol, and others with triacylglycerol [<xref ref-type="bibr" rid="scirp.46940-ref8">8</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref10">10</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref36">36</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref40">40</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref41">41</xref>] . Some studies have also suggested a positive association between vitamin D and HDL-cholesterol [<xref ref-type="bibr" rid="scirp.46940-ref40">40</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref41">41</xref>] , but other studies did not find any significant association with HDL-c, LDL-c and total cholesterol [<xref ref-type="bibr" rid="scirp.46940-ref8">8</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref10">10</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref36">36</xref>] . As vitamin D contributes to vascular endothelial growth factor and cytokine production, understanding the role of this vitamin in CVD risk remains important [<xref ref-type="bibr" rid="scirp.46940-ref13">13</xref>] .</p><p>Studies have found an inverse correlation between vitamin D and blood glucose, in both genders [<xref ref-type="bibr" rid="scirp.46940-ref42">42</xref>] or only in men [<xref ref-type="bibr" rid="scirp.46940-ref36">36</xref>] . Animal studies showed that low levels of vitamin D lead to low insulin synthesis by pancreatic tissues. It has been postulated that the binding of vitamin D and VDR present in pancreatic islets triggers a genomic pathway related to insulin secretion [<xref ref-type="bibr" rid="scirp.46940-ref43">43</xref>] [<xref ref-type="bibr" rid="scirp.46940-ref44">44</xref>] . Despite those findings in literature, we did not find significant correlation between blood glucose and vitamin D.</p><p>It is important to highlight some limitations of the present study. It should be pointed out that there exist a number of potential confounding factors in observational studies on vitamin D, and some of these confounder were present in our study; age, obesity, smoking, sedentary lifestyle, chronic inflammation, medication, genetics, or even assay heterogeneity [<xref ref-type="bibr" rid="scirp.46940-ref7">7</xref>] . In addition, any disease state makes the individual more sedentary, with less exposure to sunlight, signifying reverse causality [<xref ref-type="bibr" rid="scirp.46940-ref10">10</xref>] . Additionally, the investigation of inflammation markers, and also genetic polymorphisms of vitamin D receptor, could allow a better understanding of our results. It’s also important to highlight the regional feature of our work. Although it’s important to understand Brazilian specificity, our results could not be extrapolated to other locations.</p></sec><sec id="s5"><title>5. Conclusion</title><p>Under our study conditions, we found low levels of vitamin D, and the prevalence of a number of risk factors for CVD. Associations between vitamin D, PTH and CVD risk did not present significance, probably due to the nu- merous confounders existing in elderly studies. 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