The use of negative pressure wound therapy has become massive in recent years. Management of complex wounds both acute and chronic, particularly in diabetic foot ulcers, post-traumatic wounds and vascular ulcers, has been extensively performed using this system by almost every surgical specialty. Unfortunately recent systemic reviews have not been able to demonstrate high level of evidence supporting the superiority of negative wound therapy over conventional treatment [1] [2] . In addition, many adverse effects such as infection, skin irritation, foreign body waste, skin necrosis, painful dressing changes, difficult daily wound evaluation, fistula development, massive bleeding and a possible increased in the rate of mortality have been reported [3] -[6] . In this brief communication, we present a case report where another serious complication occurred and may be related to vacuum assisted closure.

A 22-year-old male patient with a history of soft tissue high grade fusocellular sarcoma of the right thigh measuring 23 × 10 × 9 cm, was resected with negative margins in 2009 at another institution. A local recurrence was detected in 2010 and the patient underwent a new surgical resection and adjuvant radiotherapy completing 5000 cGray in daily sessions of 200 cGray for 2 months. He was admitted at our hospital in January 2012 with severe malnutrition and a new local tumor recurrence. The Cancer Committee decided a new surgical resection that required femoral vessels excision followed by femoro-popliteal by-pass with PTFE prosthesis and primary wound closure. Posterior biopsy demonstrated negative surgical margins for tumor. In the early postoperative period the patient developed mid and distal wound dehiscence with partial exposure of the vascular prosthesis and the plastic surgery team was consulted.

Considering the poor general conditions of the patient, flap closure was delay and negative pressure wound therapy was set in a continuous manner between 100 or 120 mmHg with changes every 4 to 5 days. After 6 weeks of multidisciplinary management including nutritional support, physical therapy, negative pressure wound therapy and psychiatric surveillance, adequate general and local conditions were achieved and surgery was plan in order to cover the remaining defect. But the patient started to present increased wound exudates, local pain and an exaggerated and friable proliferation during the following 2 weeks (Figure 1). Biopsy of the proliferating tissue revealed a new tumor recurrence and lower extremity amputation with hip disarticulation was performed by the orthopedic team.

At present there is no evidence of malignant recurrence after negative pressure wound therapy, on the contrary, the use of this type of treatment for the management of complicated wound healing in sarcoma patients following tumor surgery has been reported to be safe and effective [7] . However, if the physiologic and molecular bases of negative pressure and tissue expansion are analyzed, we would realize that its use may be hazardous in

oncologic patients. The mechanical stress imposed by negative pressure generates mechano-transduction signals from different kinds of membrane proteins that promote the expression of genes that regulate cell proliferation [8] . In other words, stretching cells stimulate them to grow and multiply [9] . While this effect may be welcome in acute or chronic wounds promoting healing, in oncology patients the stimulation of cellular hyperplasia in tissues that have lost self-control can be dangerous. The use of negative pressure in this setting may stimulate the appearance of a rapid local recurrence despite of negative margins, as in the case reported.

Although we cannot determine with certainty a full causative relationship between vacuum assisted closure and cancer recurrence in this case, we can say that it at least help in the fast development of a recurrent tumor. In our opinion, it seems prudent to advise cautious use of negative pressure wound therapy in oncologic related wound beds.

None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this manuscript.