JCDSAJournal of Cosmetics, Dermatological Sciences and Applications2161-4105Scientific Research Publishing10.4236/jcdsa.2020.101004JCDSA-99022ArticlesMedicine&Healthcare Effect of a Cosmetic Use with 2% Isostearyl-L-Ascorbic Acid Gel for Postinflammatory Hyperpigmentation and Postinflammatory Erythema in Acne Vulgaris IchiroKurokawa1*MasakoWatanabe2KazuhitoHayashibe3Department of Dermatology, Meiwa Hospital, Nishinomiya, Hyogo, JapanHayashibe Skin Clinic, Sanda, JapanKobayashi Skin Clinic, Kobe, Japan220120201001283229, February 202020, March 2020 23, March 2020© Copyright 2014 by authors and Scientific Research Publishing Inc. 2014This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/

Postinflammatory hyperpigmentation (PIH) and postinflammatory erythema (PIE) in acne vulgaris are important and refractory complications for patients with acne vulgaris. To clarify the effects of 2% isostearyl-L-ascorbic acid (ISAA) against PIH and PIE in acne vulgaris, a clinical pilot study with topical 2% ISAA gel was performed in 25 acne patients with PIH and PIE. Topical ISAA gel was applied on the whole face with PIH and PIE in acne vulgaris twice a day for 3 months. Regarding PIH and PIE, investigator’s global improvement rating (IGIR) was evaluated in 7-point scales according to the reduced area of PIH and PIE before and after the study. Remarkable improvement in PIH was observed in 7 patients (28.0%) and in PIE in 12 (48%) of the 25 patients. No adverse reactions were observed during the treatment. Topical ISAA application can be an alternative, non-invasive available treatment for PIH and PIE in acne vulgaris.

Acne Vitamin C Postinflammatory Hyperpigmentation Postinflammatory ErythemaFunding Acknowledgement

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Conflicts of Interest

The authors declare no conflict of interest in preparing this article.

Cite this paper

Kurokawa, I., Watanabe, M. and Hayashibe, K. (2020) Effect of a Cosmetic Use with 2% Isostearyl-L-Ascorbic Acid Gel for Postinflammatory Hyperpigmentation and Postinflammatory Erythema in Acne Vulgaris. Journal of Cosmetics, Dermatological Sciences and Applications, 10, 28-32. https://doi.org/10.4236/jcdsa.2020.101004

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