The chemistry of coordination compounds is well known and widely studied, yet many new developments are continuously taking place in this area of inorganic chemistry. The preparative work of Jorgenson, Werner and many others during the turn of the century opened up new vistas in the coordination chemistry of transition metals. It was Alfred Werner1 who systematized the subject coordination chemistry, by propounding theory in 1893, for which he awarded Nobel Prize in 1913. These ideas have considerably enriched the understanding of the nature of metal-ligand bonds, structure, and chemistry of metal complexes, their stabilities and liabilities and other properties. It is now the need of time that new ligands of specified design should be synthesized, which could lead to metal complexes with special desired and possible predictable properties. The steady improvement in synthetic methodology allows us to foresee coordinating chemistry entering a phase of creative chemistry [1]. Schiff base complexes with transition metal have played a central role in the development of coordination chemistry. Because Schiff base ligands are capable of forming stable complexes with metal ions. Metal complexes play an important role in agriculture, pharmaceutical and industrial chemistry [2]. It is well know that azomethine of the general formula (–C=N-) has a great attention as precursor in huge organic synthesis and biological applications such as cycloaddition reaction [3] [4], optoelectronic properties [5], dyes and pharmaceuticals, antimicrobial activity [6], liquid membrane technology [7], anti-inflammatory [8], anticonvulsant [9], anti-tumour [10], antihypertensive activity [10] and anti-HIV activities [11]. Moreover, the reactions of azomethine throughout ring-closing to generation a wide range of five, six and seven members ring of heterocyclic organic molecules such as 4-thiazolidinone derivatives [12], 1,2-Dihydro-1-arylnaphtho[1,2-e][1,3] oxazine-3-one derivatives [6] [13] and [14] and 1,3-oxazepinediones [15]. All of these derivatives of heterocyclic compounds have importance as pharmaceutical drugs, active substances in biological systems [3] [14] [16] and liquid-crystalline compounds [15]. Therefore the synthesis of these kinds of organic compounds has become interesting.

Benzidine (4,4'-diaminobiphenyl), other names for benzidine are [1,1'-Biphenyl]- 4,4'-diamine, 4,4-diamino-biphenyl, 4,4-bianiline, 4,4-diphenyldi-amine is a greyish- red, yellowish, or white-coloured, very toxic, crystalline aromatic amine that darkens when exposed to air and light. Benzidine has been widely used for the detection of blood. A reagent in the manufacture of dyes. Ingestion of benzidine causes cyanosis, headache, mental confusion, nausea and vomiting. The azo dyes derived from benzidine are important because they are unlike simpler classes of azo dyes, they become strongly fixed to cotton without a mordant [17] [18]. Its use is now limited because of the strong association between exposure to benzidine and an increased risk of bladder cancer in humans [19]. The chemical or enzymatic oxidation of benzidine proceeds via a radical cation detectable by electron spin resonance. Peroxidase-catalyzed oxidation of benzidine generates reactive electrophiles which readily form adducts with phenol and thiol compounds. The structures of these novel metabolites are described. Peroxidases, including prostaglandin synthase, catalyze benzidine binding to protein and nucleic acid; the nature of the resulting adducts is unknown. The relevance of these processes to benzidine carcinogenesis in vivo is the subject of research and debate [20]. Benzidine is prepared in a two-step process from nitrobenzene. First, the nitrobenzene is converted to 1, 2-diphenylhydrazine, usually using iron powder as the reducing agent. Treatment of this hydrazine with mineral acids induces a rearrangement reaction to 4, 4'-benzidine. Smaller amounts of other isomers are also formed. The benzidine rearrangement, which proceeds intramolecularly, is a classic mechanistic puzzle in organic chemistry. Benzidine, the trivial name for 4, 4'-diaminobiphenyl, is the solid organic compound with the formula (C₆H₄NH₂)₂. This aromatic amine is a component of a test for cyanide and also in the production of dyes. Benzidine has been linked to bladder and pancreatic cancer. Since August 2010 benzidine dyes are included in the EPA’s List of Chemicals of Concern [21]. Benzidine is no longer produced in the United States, although benzidine-based dyes may be imported into this country. No information is available on the acute (short-term) effects of benzidine in humans by inhalation exposure, but benzidine is considered to be very acutely toxic to humans by ingestion. Chronic (long-term) exposure to benzidine in humans may result in injury to the bladder. Epidemiological studies have shown occupational exposure to benzidine to result in an increased risk of bladder cancer. Animal studies have reported various tumour types at multiple sites from benzidine exposure via oral, inhalation, and injection exposure. EPA has classified benzidine as a Group A, known human carcinogen [21] [22].

Benzidine has been used since the 1850s as the reagent base for the production of a large number of dyes, particularly azo dyes for wool, cotton, and leather. However, because benzidine was found in the 1970s to be carcinogenic to humans, there has been a considerable decline in the use of the benzidine dyes. Benzidine is used for the quantitative determination of sulfuric acid and the detection and determination of numerous anions and metal ions. The reaction of benzidine with pyridine in the presence of elemental chlorine is suitable for detecting traces of free chlorine or pyridine in drinking-water. The green to blue colouration that occurs when benzidine reacts with hydrogen peroxide in the presence of peroxidases can be used to detect blood. Benzidinstill plays a role in many chemical syntheses [23]. In the past, benzidine also has been used as a rubber compounding agent, in the manufacture of plastic films, for detection of hydrogen peroxide in milk, and quantitative determination of nicotine. Most of these uses have been discontinued, although some dyes that may contain benzidine as an impurity are still used as stains for microscopy and similar laboratory applications [24]. Archana et al. [25] synthesised and investigated four Schiff base chelates of Cu(II), Co(II), Ni(II) and Zn(II) formed from the reaction of 2-hydroxy benzaldehyde and benzidine. Metal complexes are reported and characterized using several analytical and spectroscopic techniques; the reaction is shown in Figure 1.

In present work, The complexes of Cr(III) and Fe(II) ions with the Schiff bases derived from the condensation of 2-methoxy benzaldehyde and benzidine were synthesised and characterised by different techniques, in particular, elemental analysis and molar conductance measurements as well as IR and electronic spectroscopy.

In the present work, appropriate aldehyde derivatives were reacted with benzidine to give the corresponding Schiff base which confirmed by several analysis methods, and two coordination compounds of Cr(III) and Fe(II) with this Schiff base were prepared and confirmed with several analysis methods. This area of research is an open area, and other coordination compounds can be prepared using this Schiff base which we think it is a new Schiff base and aldehydes derivatives can also be used.

The authors declare no conflicts of interest regarding the publication of this paper.

Amer, Y.O.B., El-Daghare, R.N., Hammouda, A.N., El- Ferjani, R.M. and Elmagbari, F.M. (2020) Synthesis and Characterization of Cr(III) & Fe(II) Bis(2-Methoxybenzylidene)Biphenyl- 4,4'-Diamine Complexes. Open Journal of Inorganic Chemistry, 10, 6-14. https://doi.org/10.4236/ojic.2020.101002