WJNSWorld Journal of Neuroscience2162-2000Scientific Research Publishing10.4236/wjns.2020.101005WJNS-97918ArticlesBiomedical&Life Sciences Book Review: I-Cubed and <i>The Autoimmune Brain</i>, A Five-Step Plan DavidS. Younger1*Department of Clinical Medicine, CUNY School of Medicine at City College, New York, USA291120191001293626, December 201913, January 2020 16, January 2020© Copyright 2014 by authors and Scientific Research Publishing Inc. 2014This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/

The Autoimmune Brain 1 explains I-Cubed, a shorthand for post-infectious autoimmunity that results from the multiplier effect of infection, immunity and inflammation , when protective immunity becomes the source of autoimmunity, conditioned by applicable environmental and genetic predisposing factors. In keeping with the post-infectious autoimmune nature of I-Cubed, neurologic and psychiatric symptoms evolve beyond a standard of care course of antibiotic therapy. Extensive serologic, electrophysiological and neuroradiographic diagnostic testing provide s clues to areas of central, peripheral and autonomic nervous system , and systemic involvement that guide therapy. A multimodality therapeutic approach employing immune modulatory (Ig) therapy that addresses the underlying mechanisms and not just the symptoms of Cubed disorders is most effective. Representative cases of post-infectious autoimmunity associated with Lyme disease and PANDAS are presented .

Neuropsychiatry Lyme Disease PANDAS I-Cubed Post-Infectious AutoimmunityConclusion

By treating the underlying mechanism of post-infectious autoimmunity and not just the symptoms alone, neurologic and neuropsychiatric I-Cubed disorders can be effectively managed and even cured.

Conflicts of Interest

The author denies any conflicts of interest.

Cite this paper

Younger, D.S. (2020) Book Review: I-Cubed and The Autoimmune Brain, A Five-Step Plan. World Journal of Neuroscience, 10, 29-36. https://doi.org/10.4236/wjns.2020.101005

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