During the study period, 8113 patients were admitted to the pediatric surgery and urology-andrology departments, including 80 UTA cases (1%). The average age was 6.1 ± 4.6 years old (0 - 17 years old). There was a male predominance with 76 boys and 4 girls.

Clinically, the circumstances of discovery were: ectopic urethral meatus in 53 cases (66.2%), vesical urine retention and dysuria in 15 cases (18.7%), lumbar spine pain in 5 cases (6.3%), urinary incontinence in 4 cases (5.0%), female external genitalia abnormality in 2 cases (2.5%) and abdominal bloating in 1 case (1.3%).

Ultrasound of the urinary tract (Table 1) was performed in 24 children (30%), RUC in 24 (30%) and IVU in 8 (10%). Ultrasonography revealed bilateral ureterohydronephrosis and fight bladder in 13 cases (54.2%), hydronephrosis with cortical thinning in 3 cases (21.1%). In 4 cases (16.4%), ultrasound findings were normal.

Diagnoses

The discharge diagnoses are shown in Table 2.

Hypospadias was the most common disease with 47 cases (58.7%) and the average age at the time of diagnosis was 5.6 years old (0 - 17 years old).

Associated malformations

Five children (6.3%) had other congenital conditions associated with UTA. Symphyseal disjunction occurred in 2 children with bladder exstrophy, bifid clitoris in 2 children, and anorectal malformation with vaginal hypoplasia in one child.

Complications at the time of diagnosis

The main complications found were urinary tract infection in 9 children (4 E. coli, 3 Klebsiella and 2 Candida albicans infections), bladder stones in 3 children and renal failure in 2 children (serum creatinine 50 and 58 mg/L).

Seventy-seven (96.2%) patients were treated including two patients with renal cystic dysplasia who were monitored and one patient died before surgery. Surgical treatment was performed in 62 cases (81.2%) depending on the disease; and 15 (17.5%) patients had instrumental treatment by destruction of the posterior urethral valves either by laminating or with Beniqué probe. The different types of surgeries performed are shown in Table 3.

*For hypospadias or epispadias repair.

The mean length of hospitalization was 13.7 days ± 8.6 days (3 to 45 days).

The postoperative follow-up of patients was appreciated during hospitalization. Fifty-five (68.7%) patients had simple postoperative follow-up. Twenty patients (42.5%) who had surgery for hypospadias had fistula in the postoperative follow-up. Two (1.3%) patients had vesico-parietal fistula after bladder repair for bladder exstrophy, and we noted a case of severe sepsis (1.3%).

A 6-year-old patient with chronic renal failure with a bilateral mute kidney at the IVU complicating posterior urethral valves, died before the operation.

In our study, UTA represent 1% of all admissions to the service. This frequency is lower than those observed in Conakry [9] with 4%. For Kahloul et al. [10], this rate is 3%, in a study conducted in a pediatric ward where admissions are higher than ours. Most authors agree that uropathies are frequent in boys like observed in our study [9] [10] [11]; it cans be explained by the high frequency of malformations of the male urethra, especially hypospadias and epispadias.

The average age of children in our study is 6.1 years old (0 to 17 years old) at the time of diagnosis. This result is close to that reported by Asinobi et al. [6] in Nigeria while in western countries postnatal discovery is earlier, particularly with an average age of 11 months in Germany [12], 10.6 months in Poland [13]. This diagnostic delay in our hospital practice +can be explained by the virtual absence of antenatal diagnosis on the one hand and by socio-cultural reasons on the other. While in developed countries, the antenatal screening rate for UTA is 60% to 70% [5] [14] from a routine obstetrical ultrasound; which allows early management of patients.

Circumstances of discovery

The majority of patients (66.2%) were admitted for external urologic malformation, including urethral meatus position abnormality, anterior abdominal wall defect, others for clinical manifestations such as dysuria or acute retention of urine, abdominal and/or lumbar pain, abdominal mass with lumbar contact. While others have been discovered by complications: urinary tract infection (11.2%), urolithiasis (3.7%), or even renal failure (2.5%). Urinary tract infection is the most commonly reported circumstance in the literature [2] [10]; indeed, the occurrence of urine infection which that is the age remains a mode of revelation very frequent. For Solomon [15], congenital abnormalities of the urinary tract are the leading cause of chronic renal failure in children.

Hypospadias

Hypospadias is one of the most common congenital anomalies of the urethral spongiosum, the ventral prepuce and in more severe cases penile chordee. It is the most common urinary tract anomaly in our series with a mean age at the time of diagnosis of 67.2 months. While in developed countries, the average age at diagnosis varies from 16 to 24 months [16] [17] [18] [19]. This difference is related to several socio-cultural and economic factors in developing countries. Indeed, in developing countries, ignorance, poverty and traditional beliefs are diagnosis delay factors. The operative technique used was a function of the type of hypospadias and the habits of the surgeon. In clinical practice, many factors influence the choice of surgical technique, including ‘‘personal taste, upbringing, situation-al preference, training, experience and personal success’’ [20]. There are five sequential steps for the successful repair of hypospadias: penile straightening, urethroplasty, meatoplasty and glanuloplasty, scrotoplasty and skin coverage. The major technical advances in hypospadias surgery that have improved surgical outcomes are preservation of the urethral plate, incision of the urethral plate, dorsal midline plication, epithelized urethroplasty dartos flap coverage, and two stage alternative techniques [21]. Fistula is the most common complication after urethroplasty [22]; in our study, we noted 42.5% of fistula after uretrhoplasty.

Posterior urethral valves

During our study, we found 16 cases in 10 years, with a hospital frequency of 1.6 cases/years. They constitute the second cause of UTA with 20% of cases. The incidence of posterior urethral valves is variously reported in the literature ranging from 1 to 4/1000 births [22] [23]. Urinary disorders such as dysuria or urine retention are constant [22] [23]. Ante-natal ultrasound allows the early management of this disease from birth [6]. Fogarty probe [24] is still the most commonly used technique in our hospital practice, although currently the standard treatment of the posterior urethral valves is endoscopic resection as soon as possible to avoid the occurrence complications [25] [26].

Pyelo-ureteral junction syndrome

In our series, it represents 7.6% of UTA; this rate is variable according to some authors, more important in developed countries especially in England with 38% [27] and lower in developing countries with 14% in Tunisia [10] and 3.2% in Mali [28]. This difference can be explained by the absence or insufficiency of antenatal diagnosis and by low health coverage in our countries where the diagnosis is generally suspected during abdominal mass or complications including urinary infections. [10] [28]. In our series, treatment consisted of conventional pyeloplasty using the Anderson-Hynes technique [29] in 2 patients and the 3rd had a total nephrectomy due to destruction of the renal parenchyma.

Bladder exstrophy accounts for 5% of UTA. This rate is identical to that found by N’diaye in Mali [30]. Initial treatment consisted of a plasty of the bladder, bladder neck, urethra and anterior abdominal wall associated with posterior iliac osteotomy; depending on the evolution, an enlargement can be proposed or a urinary derivation type Mitrofanoff [31].

Isolated epispadias with 3 cases remains a rare malformation; it was a penile continent epispadias in most cases and treated by urethroplasty [32].

Cystic dysplasia was diagnosed in 2 patients (2.5%) and their management consisted of clinical and ultrasound surveillance as recommended in the literature [33].