<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">OJPed</journal-id><journal-title-group><journal-title>Open Journal of Pediatrics</journal-title></journal-title-group><issn pub-type="epub">2160-8741</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/ojped.2019.94029</article-id><article-id pub-id-type="publisher-id">OJPed-96632</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  State of Shock: Epidemiological, Etiological and Therapeutic Aspects at the Pediatric Unit of the Medical and Surgical Emergencies of the Donka National Hospital
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Diallo</surname><given-names>Mohamed Lamine</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Barry</surname><given-names>Ibrahima Koolo</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Camara</surname><given-names>Emmanuel</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ondima</surname><given-names>Hermann Laurent Marion</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Sossouadouno</surname><given-names>Elisabeth Sita</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Diallo</surname><given-names>Saliou Bella</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib></contrib-group><aff id="aff2"><addr-line>Institute of Nutrition and Child Health (INSE), Donka National Hospital, Conakry, Guinea</addr-line></aff><aff id="aff1"><addr-line>Emergencies Pediatric, Donka National Hospital, Conakry, Guinea</addr-line></aff><aff id="aff3"><addr-line>Pediatric Department, Donka National Hospital, Conakry, Guinea</addr-line></aff><pub-date pub-type="epub"><day>29</day><month>10</month><year>2019</year></pub-date><volume>09</volume><issue>04</issue><fpage>302</fpage><lpage>308</lpage><history><date date-type="received"><day>2,</day>	<month>February</month>	<year>2019</year></date><date date-type="rev-recd"><day>24,</day>	<month>November</month>	<year>2019</year>	</date><date date-type="accepted"><day>27,</day>	<month>November</month>	<year>2019</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  <u>Introduction</u>
  : The objective of this study was to write the epidemiological, etiological and therapeutic aspects of shock in children in the paediatric medico-surgical emergency unit of the National Donka Hospital. <u>Method</u>: This was a forward-looking, descriptive 6-month study, including all children aged 0 to 15 who were received in the paediatric medico-surgical emergency unit at The Donka National Hospital, where the shock diagnosis was retained and 
  the 
  patients received care. <u>Results</u>: In our study, 26 out of 1123 patients were received in a state of shock. Hypovolemic shock was more common at 24 (92%). Vascular filling by Ringer’s milk was the basic treatment. The 6 to 11 month age group was the most affected and the sex-ratio M/F was 1.6. The acute febrile gastroenteritis and dehydration status were the most frequent causes. The outcome was favorable in 25 patients (96%). <u>Conclusion</u>: Rapid and effective management would improve the vital and functional prognosis of children in shock.
 
</p></abstract><kwd-group><kwd>Choc</kwd><kwd> Children</kwd><kwd> Urgences</kwd><kwd> Paediatrics</kwd><kwd> Donka</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Shock is a vital emergency due to acute circulatory insufficiency characterized by inadequate supply and oxygen requirements. It can result either from a decrease in the oxygen supply, or from a lack of oxygen utilization by the cell, or from a combination of both [<xref ref-type="bibr" rid="scirp.96632-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.96632-ref2">2</xref>].</p><p>Several etiologies can be at the origin of a state of shock. However, regardless of the etiology and mechanism of this state of shock, it is characterized by hypo-infusion or inadequate tissue perfusion with hypoxia, or even cellular anoxia, resulting in the metabolism of the aerobic pathway to the body anaerobic pathway with a defect in the production of adenosine triphosphate, the main energy source of the cell [<xref ref-type="bibr" rid="scirp.96632-ref2">2</xref>].</p><p>In the United-States, a survey by Watson found an incidence [<xref ref-type="bibr" rid="scirp.96632-ref3">3</xref>] of 0.56 cases per 1000 children per year and an e-hospital mortality rate of 10% which corresponded to 6 deaths per 100,000 children under 18 years a year. Among the causes of death, severe sepsis accounted for 7% of cases, a value well above cancer-related mortality [<xref ref-type="bibr" rid="scirp.96632-ref3">3</xref>] [<xref ref-type="bibr" rid="scirp.96632-ref4">4</xref>].</p><p>In Western Europe and North America, hemorrhagic shock is the most common cause among other shock conditions in children [<xref ref-type="bibr" rid="scirp.96632-ref5">5</xref>]; in France the hypovolemic shock is the first cause of shock in the child among other states of shock [<xref ref-type="bibr" rid="scirp.96632-ref6">6</xref>].</p><p>In sub-Saharan Africa, specifically in Senegal, the prevalence of shock among hospitalized newborns is 9% [<xref ref-type="bibr" rid="scirp.96632-ref7">7</xref>].</p><p>The state of shock is a vital emergency; its diagnosis is based solely on the clinic. The identification of nature is based on a group of essentially anamnestic and clinical arguments. The para-clinical examinations provide only additional information to clarify the mechanism [<xref ref-type="bibr" rid="scirp.96632-ref2">2</xref>]. The efficiency of treatment depends on rapid recognition of the judgment and the triggering factor was taken into etiological load. Therapeutic delay is a risk factor for poor prognosis [<xref ref-type="bibr" rid="scirp.96632-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.96632-ref7">7</xref>].</p><p>The aim of this study was to write epidemiological, aetiological and therapeutic aspects of the state of shock in children at the pediatric unit of the medical-surgical emergencies of Donka National Hospital.</p></sec><sec id="s2"><title>2. Method</title><p>This is a transversal, prospective type descriptive six months, from March 9 to September 9, 2015. We included all children aged 0 to s 15 years in which the diagnosis of shock has was retained and treated at the pediatric unit of the medical and surgical departments of the National Donka Hospital during the period.</p><p>The epidemiological data (age, gender), clinical (reasons for consultation, physical signs, diagnosis) etiological (hypovolemic shock, or septic shock) and therapeutic (drugs) were studied. Informed consent was obtained from any parent of the patient before inclusion of the patient in the study.</p><p>Have been defined as cases of shock, any patient with Tachycardia, TRC &gt; 3 seconds, a small pulse or shooting, hypothermia, cold extremities, agitation, respiratory distress, Hypoxia, Oliguria.</p><p>The research was conducted according to the principles of the Helsinski Declaration.</p></sec><sec id="s3"><title>3. Results</title><p>We collected 26 cases of shock on 1123 children admitted to consultation during the study (2.3%), including 16 boys (61.54%), 10 girls (38.46%) and a sex ratio. M/F of 1.6. The average age was 33 months with extremes of 5 and 180 months (Tables 1-3).</p><p>24 cases (92%) of hypovolemic shock were recorded against 2 cases (8%) of septic shock.</p><p>We recorded 24 cases (2%) of acute febrile gastroenteritis with dehydration associated with severe malaria and meningitis; 1 case (4%) of haemorrhage due to open collarbone fracture with frontal wound and 1 case (4%) of septicemia due to abscess of the right thigh with anal wound.</p><p>Among the emergency checkups, a blood glucose, a hemoglobin level, a thick drop with parasite density, a TDR and white blood cells were realized in cases (100%); Lumbar puncture in 11 cases (42%) and blood grouping/Rh factor in 1 case (4%) (<xref ref-type="table" rid="table4">Table 4</xref>).</p><table-wrap id="table1" ><label><xref ref-type="table" rid="table1">Table 1</xref></label><caption><title> Breakdown of 26 patients in a state of shock based on epidemiological characteristics in the Pediatric Unit of the National Donka Hospital</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Characteristics</th><th align="center" valign="middle" >n</th><th align="center" valign="middle" >%</th></tr></thead><tr><td align="center" valign="middle"  colspan="3"  >Age group (months)</td></tr><tr><td align="center" valign="middle" >0 - 5</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" >2 7</td></tr><tr><td align="center" valign="middle" >6 - 11</td><td align="center" valign="middle" >12</td><td align="center" valign="middle" >46</td></tr><tr><td align="center" valign="middle" >12 - 23</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td></tr><tr><td align="center" valign="middle" >24 - 59</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >1 5</td></tr><tr><td align="center" valign="middle" >60 - 119</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >4</td></tr><tr><td align="center" valign="middle" >120 - 180</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >8</td></tr><tr><td align="center" valign="middle"  colspan="3"  >Reasons for consultation</td></tr><tr><td align="center" valign="middle" >Vomiting</td><td align="center" valign="middle" >23</td><td align="center" valign="middle" >88</td></tr><tr><td align="center" valign="middle" >Fever</td><td align="center" valign="middle" >21</td><td align="center" valign="middle" >81</td></tr><tr><td align="center" valign="middle" >Diarrhea</td><td align="center" valign="middle" >18</td><td align="center" valign="middle" >69</td></tr><tr><td align="center" valign="middle" >Sweats</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >12</td></tr><tr><td align="center" valign="middle" >Agitations</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >8</td></tr><tr><td align="center" valign="middle" >Loss of consciousness</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >8</td></tr><tr><td align="center" valign="middle" >Bleeding</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >8</td></tr><tr><td align="center" valign="middle" >Inability to suck</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >8</td></tr><tr><td align="center" valign="middle" >Respiratory distress</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >4</td></tr></tbody></table></table-wrap><table-wrap id="table2" ><label><xref ref-type="table" rid="table2">Table 2</xref></label><caption><title> Frequency of clinical signs in 26 patients in shock in the Pediatric Unit of hospital National Donka</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Clinical signs</th><th align="center" valign="middle" >n</th><th align="center" valign="middle" >%</th></tr></thead><tr><td align="center" valign="middle"  colspan="3"  >Cardiovascular</td></tr><tr><td align="center" valign="middle" >Tachycardia</td><td align="center" valign="middle" >20</td><td align="center" valign="middle" >77</td></tr><tr><td align="center" valign="middle" >Bradycardia</td><td align="center" valign="middle" >17</td><td align="center" valign="middle" >65</td></tr><tr><td align="center" valign="middle" >TRC Peripheral &gt; 3 s</td><td align="center" valign="middle" >16</td><td align="center" valign="middle" >62</td></tr><tr><td align="center" valign="middle" >Running pulses</td><td align="center" valign="middle" >14</td><td align="center" valign="middle" >54</td></tr><tr><td align="center" valign="middle" >Small pulse</td><td align="center" valign="middle" >11</td><td align="center" valign="middle" >42</td></tr><tr><td align="center" valign="middle" >Cold end</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >15</td></tr><tr><td align="center" valign="middle" >Cyanosis</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >4</td></tr><tr><td align="center" valign="middle"  colspan="3"  >Neurological</td></tr><tr><td align="center" valign="middle" >Obnubilation</td><td align="center" valign="middle" >12</td><td align="center" valign="middle" >46</td></tr><tr><td align="center" valign="middle" >Coma</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >15</td></tr><tr><td align="center" valign="middle" >Agitation</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >12</td></tr><tr><td align="center" valign="middle" >Drowsiness</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >4</td></tr><tr><td align="center" valign="middle"  colspan="3"  >Respiratory</td></tr><tr><td align="center" valign="middle" >Polypnoea Respiratory distress</td><td align="center" valign="middle" >15 10</td><td align="center" valign="middle" >58 38</td></tr><tr><td align="center" valign="middle" >Bradypnea</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >23</td></tr><tr><td align="center" valign="middle" >Hypoxia</td><td align="center" valign="middle" >5</td><td align="center" valign="middle" >19</td></tr><tr><td align="center" valign="middle"  colspan="3"  >Urinary, cutaneous and general</td></tr><tr><td align="center" valign="middle" >Oliguria</td><td align="center" valign="middle" >9</td><td align="center" valign="middle" >3 5</td></tr><tr><td align="center" valign="middle" >Hyperthermia</td><td align="center" valign="middle" >21</td><td align="center" valign="middle" >8 1</td></tr><tr><td align="center" valign="middle" >Hypothermia</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >4</td></tr><tr><td align="center" valign="middle" >Dryness of the mucous membranes</td><td align="center" valign="middle" >22</td><td align="center" valign="middle" >8 5</td></tr><tr><td align="center" valign="middle" >Pallor</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" >2 7</td></tr></tbody></table></table-wrap><table-wrap id="table3" ><label><xref ref-type="table" rid="table3">Table 3</xref></label><caption><title> Distribution of the 26 patients by age according to the pathologies encountered in the paediatric unit of the National Donka hospital</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Age (month)</th><th align="center" valign="middle" >Malaria Serious</th><th align="center" valign="middle" >Meningitis</th><th align="center" valign="middle" >Open fracture</th><th align="center" valign="middle" >Septicemia</th><th align="center" valign="middle" >Total</th></tr></thead><tr><td align="center" valign="middle" >0 - 5</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >7</td></tr><tr><td align="center" valign="middle" >6 - 11</td><td align="center" valign="middle" >8</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >12</td></tr><tr><td align="center" valign="middle" >12 - 23</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td></tr><tr><td align="center" valign="middle" >24 - 59</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >3</td></tr><tr><td align="center" valign="middle" >60 - 119</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td></tr><tr><td align="center" valign="middle" >120 - 180</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >3</td></tr><tr><td align="center" valign="middle" >Total</td><td align="center" valign="middle" >13</td><td align="center" valign="middle" >11</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >26</td></tr></tbody></table></table-wrap><table-wrap id="table4" ><label><xref ref-type="table" rid="table4">Table 4</xref></label><caption><title> Distribution of 26 patients undergoing treatment in the pediatric unit of the National Donka Hospital</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Treatment</th><th align="center" valign="middle" >Effective</th><th align="center" valign="middle" >Percentage</th></tr></thead><tr><td align="center" valign="middle" >Lactated Ringer</td><td align="center" valign="middle" >26</td><td align="center" valign="middle" >100</td></tr><tr><td align="center" valign="middle" >Saline serum</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >8</td></tr><tr><td align="center" valign="middle" >Haemaccel</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >8</td></tr><tr><td align="center" valign="middle" >Transfusion</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >4</td></tr><tr><td align="center" valign="middle" >Paracetamol</td><td align="center" valign="middle" >21</td><td align="center" valign="middle" >81</td></tr><tr><td align="center" valign="middle" >Vogal&#232;ne</td><td align="center" valign="middle" >16</td><td align="center" valign="middle" >62</td></tr><tr><td align="center" valign="middle" >Ceftriaxone</td><td align="center" valign="middle" >9</td><td align="center" valign="middle" >35</td></tr><tr><td align="center" valign="middle" >Ampicillin</td><td align="center" valign="middle" >5</td><td align="center" valign="middle" >19</td></tr><tr><td align="center" valign="middle" >Dexam&#233;tazone</td><td align="center" valign="middle" >5</td><td align="center" valign="middle" >19</td></tr><tr><td align="center" valign="middle" >Diazepam</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >12</td></tr><tr><td align="center" valign="middle" >Metronidazole</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >4</td></tr></tbody></table></table-wrap><p>Two (02) patients were transferred respectively to pediatric and trauma services for adapted care after managing the medical emergency (vascular filling, antipyretic perfusable, antiemetic, antibiotic and corticosteroid).</p></sec><sec id="s4"><title>4. Discussion</title><p>The weakness of equipments of the technical platform, and the non-realization of certain para-clinical investigations (ionogram and blood gasometry) were limits to the study without compromising the results.</p><p>From 09 March to 09 September 2015, we carried out a prospective cross-sectional study of the descriptive type at the pediatric unit of the medical and surgical departments of the National Donka Hospital on the state of shock of the child. It represented 2.3% of consultations of this period. This low result could be explained by the epidemic of Ebola virus disease that erupted during this period, leading to a decline in patient attendance in the service. The 6 to 11 month age group was the most affected followed by the 0 to 5 month age group. Our results are similar to those of Touzani [<xref ref-type="bibr" rid="scirp.96632-ref1">1</xref>] in 2010 in Morocco who found that the 2 - 10 month period was the most affected.</p><p>In addition, vomiting, fever and diarrhea were common reasons for consultation. These same causes were also mentioned by Nada [<xref ref-type="bibr" rid="scirp.96632-ref8">8</xref>] and Touzani [<xref ref-type="bibr" rid="scirp.96632-ref1">1</xref>] in their studies. T his finding may explain the vulnerability of our patients (children under 15) face this triad POUVA cause severe water loss leading to dehydration and hypovolemic shock.</p><p>Tachycardia, TRC &gt; 3 s, pulse rate, obstruction, polypnea and fever were the most common signs of shock in this study. This observation, similar to the suggestive signs reported by literature data [<xref ref-type="bibr" rid="scirp.96632-ref9">9</xref>], is explained by the causal mechanism of shock.</p><p>Among the types of shock encountered in this study, hypovolemic shock was by far the most represented. This observation is explained by the presence of absolute hypovolemia in the majority of our patients due to digestive losses reported at the time of admission (diarrhea, vomiting).</p><p>The treatment was based first on the vascular filling and this was done mainly with Ringer Lactate. This conduct is similar to that stated in the Nada [<xref ref-type="bibr" rid="scirp.96632-ref8">8</xref>], Paut [<xref ref-type="bibr" rid="scirp.96632-ref1">1</xref>] and Soummer [<xref ref-type="bibr" rid="scirp.96632-ref2">2</xref>]. The predominant use of solute is due to its availability and low cost in our midst.</p><p>Ts antipyretic, antiemetic and antibiotic were administered in more than half of patients. This support is superimposable to that of art work Touzani [<xref ref-type="bibr" rid="scirp.96632-ref5">5</xref>] which used in the treatment of patients anti-diarrheal them (77%), anti-emetics (61%) and antibiotics (13.8%). This would be explained in our context by the prevalence of fever and vomiting in our patients.</p></sec><sec id="s5"><title>5. Conclusions</title><p>The shock is a medical emergency which is a frequent reason for admission in pediatrics and intensive care. The diagnosis is essentially clinical.</p><p>The treatment is based on vascular filling with solutes, antibiotic therapy, corticosteroid therapy, analgesics, antiemetics.</p><p>The quick and effective support would improve the vital and functional prognosis of children in shock.</p></sec><sec id="s6"><title>Conflicts of Interest</title><p>The authors declare no conflicts of interest regarding the publication of this paper.</p></sec><sec id="s7"><title>Cite this paper</title><p>Lamine, D.M., Koolo, B.I., Emmanuel, C., Marion, O.H.L., Sita, S.E. and Bella, D.S. (2019) State of Shock: Epidemiological, Etiological and Therapeutic Aspects at the Pediatric Unit of the Medical and Surgical Emergencies of the Donka National Hospital. Open Journal of Pediatrics, 9, 302-308. https://doi.org/10.4236/ojped.2019.94029</p></sec></body><back><ref-list><title>References</title><ref id="scirp.96632-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Nada Tazi, E.P. (2011) The Practical Guide of the Main Pediatric Emergencies CHU Hassan II of Fès [Thesis]. UniversitySidi Mohammed Ben Abdellah, Fez.</mixed-citation></ref><ref id="scirp.96632-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Paut, O., Ughetto, F. and Labenne, M. (2010) Pediatric Peculiarities of the State of Shock. Refresh Conferences, 52nd National Congress of Anesthesia and Resuscitation Doctors, 1-50.</mixed-citation></ref><ref id="scirp.96632-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Watson, R.S., Carcillo, J.A. and Linde-Zwirble, W.T. (2003) The Epidemiology of Severe Sepsis in Children in the United States. American Journal of Respiratory and Critical Care Medicine, 167, 695-701. https://doi.org/10.1164/rccm.200207-682OC</mixed-citation></ref><ref id="scirp.96632-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Orliaguet, G., Gauvin, F., Hume, H., Lacroix, J., et al. (2007) Haemorrhagic Shock. In: Emergency and Pediatric Intensive Care, CHU Sainte-Justine and Elsevier-Masson, Montreal, 167-186.</mixed-citation></ref><ref id="scirp.96632-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Touzani, F. (2010) Acute Gastroenteritis Rotavirus in Infants (About 42 Cases) [Thesis]. Sidi Mohammed Ben Abdellah University, Fès.</mixed-citation></ref><ref id="scirp.96632-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Faye, B.F., Sylla, A., Seck, M., Sall, A., et al. (2013) Diagnostic and Evolutionary Aspects of Haemorrhagic Syndromes of the Newborn in Dakar. Pediatric Archive, 20, 164-170. https://doi.org/10.1016/j.arcped.2012.11.010</mixed-citation></ref><ref id="scirp.96632-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Boot, A. and Leclerc, F. (2009) Initial Management of Shock in Children. Emergency Medicine, 31, 361-372.</mixed-citation></ref><ref id="scirp.96632-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Coste, Ph., Dumont, R., Benatia, P., Allal, H., et al. (2006) Shock Hypovolé Nomic by Lower Gastrointestinal Bleeding in an Infant. Emergency Medicine, 28, 113-116.</mixed-citation></ref><ref id="scirp.96632-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Watson, R.S. and Carcillo, J.A. (2005) Scope and Epidemiology of Pediatric Sepsis. Pediatric Critical Care Medicine, 6, 3-5.  
https://doi.org/10.1097/01.PCC.0000161289.22464.C3</mixed-citation></ref></ref-list></back></article>