<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">JCC</journal-id><journal-title-group><journal-title>Journal of Computer and Communications</journal-title></journal-title-group><issn pub-type="epub">2327-5219</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/jcc.2018.64007</article-id><article-id pub-id-type="publisher-id">JCC-84207</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Computer Science&amp;Communications</subject></subj-group></article-categories><title-group><article-title>
 
 
  Classification of Hematological Data Using Data Mining Technique to Predict Diseases
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Fahmida</surname><given-names>Akter</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Md</surname><given-names>Altab Hossin</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Golam</surname><given-names>Moktader Daiyan</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Md.</surname><given-names>Motaher Hossain</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Department of Computer Science and Engineering, Coxbazar International University, Chittagong, Bangladesh</addr-line></aff><aff id="aff4"><addr-line>Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh</addr-line></aff><aff id="aff3"><addr-line>Department of Computer Science and Engineering, East Delta University, Chittagong, Bangladesh</addr-line></aff><aff id="aff2"><addr-line>Department of Information Management and Ecommerce, University of Electronic Science and Technology of China, Chengdu, China</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>altabbd@163.com(MAH)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>19</day><month>04</month><year>2018</year></pub-date><volume>06</volume><issue>04</issue><fpage>76</fpage><lpage>83</lpage><history><date date-type="received"><day>30,</day>	<month>March</month>	<year>2018</year></date><date date-type="rev-recd"><day>25,</day>	<month>April</month>	<year>2018</year>	</date><date date-type="accepted"><day>28,</day>	<month>April</month>	<year>2018</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  Over the years, the amount of information about patients and medical information has grown substantially. Moreover, due to an increase of blood diseases patients, conventional diagnostic tests have been using by the medical pathologists which are low in cost and result in an inaccurate diagnosis. To recognize optimal disease pattern from hematological data, a reliable prediction methodology is needed for medical professionals. Data mining approaches permit users to examine data from various dimensions, group it and sum up the relationships identified. Classification is a vital data mining technique with extensive applications. Classification algorithms are applied to categorize every item in a set of data into one of a known set of classes. The objective of this paper is to compare different classification algorithms using Waikato Environment for Knowledge Analysis and to find out a most effective algorithm for end-user functioning on hematological data. The most efficient algorithm found is Random Forest having accurateness at 96.47% and the overall time is taken to construct the model is 0.16 seconds which is more efficient than different existing works. On the contrary, Multilayer Perceptron classifier has the lowest accuracy of 75.29% with 1.92 seconds to construct the model.
 
</p></abstract><kwd-group><kwd>Data Mining</kwd><kwd> Random Forest</kwd><kwd> Multilayer Perception</kwd><kwd> Bayesian Network</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Data mining is the process of finding useful and relevant information from the various types of databases. Different approaches to data mining were suggested to face the challenges of storing and processing all types of data [<xref ref-type="bibr" rid="scirp.84207-ref1">1</xref>] . Nowadays data mining has increasing applications in Medical Science, Railway and so on [<xref ref-type="bibr" rid="scirp.84207-ref2">2</xref>] . Data mining provides doctors to provide necessary treatments, and thus patients are treated better along with more cheap health services, becoming popular day by day [<xref ref-type="bibr" rid="scirp.84207-ref3">3</xref>] [<xref ref-type="bibr" rid="scirp.84207-ref4">4</xref>] [<xref ref-type="bibr" rid="scirp.84207-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.84207-ref6">6</xref>] . In pathology, it has become familiar with a strong technique in dealing with enormous pathological information to search knowledge that is given. Additionally, comparison of different classification techniques using WEKA (Waikato Environment for knowledge analysis) for blood-related data is a demanding task in medical science research. To find out better classification algorithms, it is hard to compare different classification algorithms in different collections of data [<xref ref-type="bibr" rid="scirp.84207-ref7">7</xref>] . The main concern is the classification of hematological data to predict diseases. With this purpose to perform better, hematological data analysis is divided into three phases: Hematological data collection, classification algorithms and evaluation of results and performance. Major data mining techniques are three which are known as regression, classification and clustering. The application of data mining now goes towards clinical research such as AML (Acute Myeloid Leukemia) where predictive model plays an important role [<xref ref-type="bibr" rid="scirp.84207-ref8">8</xref>] [<xref ref-type="bibr" rid="scirp.84207-ref9">9</xref>] [<xref ref-type="bibr" rid="scirp.84207-ref10">10</xref>] [<xref ref-type="bibr" rid="scirp.84207-ref11">11</xref>] .</p><p>The remainder of this paper is organized as follows. Section 2 reviews the related works. Section 3 describes material and methods. Dataset and preprocessing are explained in Section 4. In Section 5, experimental results and discussion are illustrated. At Section 6, the conclusion is given.</p></sec><sec id="s2"><title>2. Related Works</title><p>Several types of research have been made to evaluate the performance of data mining classification algorithms using WEKA. In the study [<xref ref-type="bibr" rid="scirp.84207-ref3">3</xref>] [<xref ref-type="bibr" rid="scirp.84207-ref12">12</xref>] , the researchers evaluated the performance of data mining classification algorithm in WEKA. Another research in [<xref ref-type="bibr" rid="scirp.84207-ref1">1</xref>] compared different classification techniques using different datasets. The research in [<xref ref-type="bibr" rid="scirp.84207-ref2">2</xref>] compared the various clustering algorithms of WEKA tools. Moreover, performance analysis and evaluation of various data mining algorithms used for cancer cell classification had done [<xref ref-type="bibr" rid="scirp.84207-ref13">13</xref>] . This is also used in artificial intelligence and predicting abnormality in peripheral blood smear [<xref ref-type="bibr" rid="scirp.84207-ref14">14</xref>] [<xref ref-type="bibr" rid="scirp.84207-ref15">15</xref>] . Data mining classifiers were used in the study [<xref ref-type="bibr" rid="scirp.84207-ref16">16</xref>] to develop an automated diagnosis of thalassemia [<xref ref-type="bibr" rid="scirp.84207-ref17">17</xref>] . Also, analysis of various clustering algorithms of data mining on health informatics was performed [<xref ref-type="bibr" rid="scirp.84207-ref18">18</xref>] . The area of bioinformatics has also used data mining tools and various classification techniques which were compared [<xref ref-type="bibr" rid="scirp.84207-ref19">19</xref>] - [<xref ref-type="bibr" rid="scirp.84207-ref24">24</xref>] . Data mining techniques were also used to differentiate between the patients with a normal blood disease and patients with blood tumor [<xref ref-type="bibr" rid="scirp.84207-ref25">25</xref>] . Another study highlighted on contrasting of two classification techniques J48 and Random tree by means of WEKA to classify Sickle Cell Diseases (SCD). More recently, anemia has foreseen using different data mining classification algorithms [<xref ref-type="bibr" rid="scirp.84207-ref12">12</xref>] [<xref ref-type="bibr" rid="scirp.84207-ref26">26</xref>] [<xref ref-type="bibr" rid="scirp.84207-ref27">27</xref>] where J48 algorithm confirmed its best performance in classifying types of anemia [<xref ref-type="bibr" rid="scirp.84207-ref28">28</xref>] . Besides, WEKA has been used in this experiment as hidden predictive information can be extracted using this algorithm from large database [<xref ref-type="bibr" rid="scirp.84207-ref29">29</xref>] . In addition, the experiment has been conducted for CBC (Compete Blood Count), which is quite rational to extract data using the intended algorithm as the WEKA is being employed for data mining widely.</p></sec><sec id="s3"><title>3. Material and Methods</title><p>In this study, an open to all data mining tool WEKA (version 3.8.0) has been used. Two dissimilar data sets have been utilized and the performance of classification algorithms (classifiers) has been examined. The analysis has been carried out by SONY VIAO Windows version 8 with Intel&#174; Core™ i3 Central Processing Unit, 1.70 Gigahertz Processor and 4 Gigabyte RAM. The data sets have been selected so that they vary in size, predominantly with the number of attributes. The hematological parameters consist of White blood cell o (WBC), Red blood cell count (RBC), Hemoglobin (Hb), Hematocrit (Hct), Mean corpuscular volume (MCV), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC), Platelet count (PLT), Neutrophil count (NEU), Lymphocyte (LYMP), Monocyte (MONO), Eosinophil (EO), and Basophil (BASO) (SysMex 1000i Sysmexcorporation, Kobe, Japan). Hematological data were evaluated by the hand of a medical technologist. Data which are collected are allocated to multiple tags: indicative of anaemia of unceasing disorder, Eosinophilia, Microcytic hypochromic anaemia, Normocytic anaemia, Neutrophil leucocytosis, Neutrophilia, Non-specific findings, High ESR.</p></sec><sec id="s4"><title>4. Dataset and Preprocessing</title><p>The dataset of experiment1 comprises of 425 samples and dataset of experiment 2 consists of 298 samples. The attributes characterize the Complete Blood Count (CBC) features as in <xref ref-type="table" rid="table1">Table 1</xref>.</p><p>In the preprocessing of the dataset, irrelevant attributes were eliminated, refilled the missing values and removed/refilled the outlier values on the outlier samples. <xref ref-type="table" rid="table2">Table 2</xref> represents the dataset attributes which are used in this investigation.</p></sec><sec id="s5"><title>5. Result and Discussion</title><p>In this study, the experiment that employs the data mining classifiers will be separated into two branches: the experimentation with full and reduced features. The outcomes from these two branches and in-depth classification accuracy analysis highlighting on the classification errors will be displayed in following sections. Three experiments were conducted in each type: the first one is to measure the performance of the Random Forest Tree classifier; the second one is to measure the performance of the Bayesian Network classifier, the third one to measure the performance of the Neural network (Multilayer Perceptron). The</p><table-wrap id="table1" ><label><xref ref-type="table" rid="table1">Table 1</xref></label><caption><title> CBC test features</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Shortcut</th><th align="center" valign="middle" >Term</th><th align="center" valign="middle" >Male normal value</th><th align="center" valign="middle" >Female normal value</th></tr></thead><tr><td align="center" valign="middle" >WBC (cmm)</td><td align="center" valign="middle" >White Blood Cell</td><td align="center" valign="middle" >4000 ? 11,000</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >RBC (million/cmm)</td><td align="center" valign="middle" >Red Blood Cell</td><td align="center" valign="middle" >5.0 &#177; 0.5</td><td align="center" valign="middle" >4.3 &#177; 0.5</td></tr><tr><td align="center" valign="middle" >HB (g/dl)</td><td align="center" valign="middle" >Hemoglobin</td><td align="center" valign="middle" >15.0 &#177; 2.0</td><td align="center" valign="middle" >13.5 &#177; 1.5</td></tr><tr><td align="center" valign="middle" >HCT (I/I)</td><td align="center" valign="middle" >Hemoglobin</td><td align="center" valign="middle" >0.45 &#177; 0.05</td><td align="center" valign="middle" >0.41 &#177; 0.005</td></tr><tr><td align="center" valign="middle" >MCV (ft)</td><td align="center" valign="middle" >Mean Cellular Volume</td><td align="center" valign="middle" >92 &#177; 9</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >MCH (pg)</td><td align="center" valign="middle" >Mean Cellular Hemoglobin</td><td align="center" valign="middle" >29.5 &#177; 2.5</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >MCHC (g/dl)</td><td align="center" valign="middle" >Mean Cellular Hemoglobin Concentration</td><td align="center" valign="middle" >33.0 &#177; 1.5</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PLT (/Cmm)</td><td align="center" valign="middle" >Platelet Count</td><td align="center" valign="middle" >150,000 ? 400,000</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >NEU</td><td align="center" valign="middle" >Neutrophils (%)</td><td align="center" valign="middle" >40 - 75</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >LYMP</td><td align="center" valign="middle" >Lymphocytes (%)</td><td align="center" valign="middle" >20 - 40</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >MONO</td><td align="center" valign="middle" >Monocytes (%)</td><td align="center" valign="middle" >2 - 10</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >EO</td><td align="center" valign="middle" >Eosinophils (%)</td><td align="center" valign="middle" >2 - 6</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >BO</td><td align="center" valign="middle" >Basophils (%)</td><td align="center" valign="middle" >&lt;1.0</td><td align="center" valign="middle" ></td></tr></tbody></table></table-wrap><table-wrap id="table2" ><label><xref ref-type="table" rid="table2">Table 2</xref></label><caption><title> Dataset attributes</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Attribute</th><th align="center" valign="middle" >Data type</th><th align="center" valign="middle" >Attribute role</th></tr></thead><tr><td align="center" valign="middle" >SEX</td><td align="center" valign="middle" >Binomial</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >WBC</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >RBC</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >HB</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >HCT</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >MCB</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >MCH</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >MCHC</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >PLT</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >NEU</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >LYMP</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >MONO</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >EO</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >BO</td><td align="center" valign="middle" >Integer</td><td align="center" valign="middle" >Regular</td></tr><tr><td align="center" valign="middle" >Hematological Comments</td><td align="center" valign="middle" >Nominal</td><td align="center" valign="middle" >Label</td></tr></tbody></table></table-wrap><p>feed-forward back-propagation neural network classifier was regulated with 500 training cycles, learning rate 0.3, and momentum 0.2.</p><sec id="s5_1"><title>5.1. Experiment with Full Features</title><p>In these experiments, whole traces aspects of each sample were used. The Random Forest tree classifier gives an accuracy of 96.47%, the Neural Network (Multilayer Perceptron) presents accuracy of 75.29%, and finally, the Bayesian network classifier provides accuracy of 84.70% as shown in <xref ref-type="fig" rid="fig1">Figure 1</xref> and in <xref ref-type="table" rid="table3">Table 3</xref>.</p></sec><sec id="s5_2"><title>5.2. Experiment with Reduced Feature</title><p>The results from these experiments are given in <xref ref-type="table" rid="table4">Table 4</xref>. The Random Forest Tree classifier puts the accuracy of 86.44%, while the Neural Network classifier provides accuracy of 52.54% and the Bayesian Network classifier gives an accuracy of 74.57% as shown in <xref ref-type="fig" rid="fig2">Figure 2</xref> and in <xref ref-type="table" rid="table4">Table 4</xref>.</p><p>After considering <xref ref-type="fig" rid="fig1">Figure 1</xref>, <xref ref-type="fig" rid="fig2">Figure 2</xref> and <xref ref-type="table" rid="table5">Table 5</xref>, it is seen that the maximum accuracy is 96.47% and the minimum accuracy is 52.54%. It can be concluded that Random Forest tree classifier is better than other classifiers considered.</p></sec></sec><sec id="s6"><title>6. Conclusion</title><p>This paper evaluated and investigated three preferred classification algorithms based on WEKA. By utilizing the hematological data, the superlative algorithm found is Random Forest Classifier with an accuracy of 96.47% and the total time taken to build the model is at 0.16 s. Neural Network has the accuracy of 52.54% which is the lowest accuracy in comparison with others, which is an affirmative side of this study. These results will aid the researchers to get competent results for a particular dataset. The finding will help users to analyze disease in minimal time which is a good contribution of this study.</p><table-wrap id="table3" ><label><xref ref-type="table" rid="table3">Table 3</xref></label><caption><title> Dataset attributes</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Algorithm (Total Instances 425)</th><th align="center" valign="middle" >Correctly Classified Instances % (Value)</th><th align="center" valign="middle" >Incorrectly Classified Instances % (Value)</th><th align="center" valign="middle" >Time Taken (Second)</th><th align="center" valign="middle" >Kappa Statistic</th></tr></thead><tr><td align="center" valign="middle" >Random Forest Tree</td><td align="center" valign="middle" >96.47% (82)</td><td align="center" valign="middle" >3.53% (3)</td><td align="center" valign="middle" >0.16</td><td align="center" valign="middle" >0.9535</td></tr><tr><td align="center" valign="middle" >Neural Network</td><td align="center" valign="middle" >75.29% (64)</td><td align="center" valign="middle" >24.71% (21)</td><td align="center" valign="middle" >2.06</td><td align="center" valign="middle" >0.6772</td></tr><tr><td align="center" valign="middle" >Bayesian Network</td><td align="center" valign="middle" >84.70% (72)</td><td align="center" valign="middle" >15.30% (13)</td><td align="center" valign="middle" >0.1</td><td align="center" valign="middle" >0.7985</td></tr></tbody></table></table-wrap><table-wrap id="table4" ><label><xref ref-type="table" rid="table4">Table 4</xref></label><caption><title> Simulation result of experiment 2</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Algorithm (Total Instances 425)</th><th align="center" valign="middle" >Correctly Classified Instances % (Value)</th><th align="center" valign="middle" >Incorrectly Classified Instances % (Value)</th><th align="center" valign="middle" >Time Taken (Second)</th><th align="center" valign="middle" >Kappa Statistic</th></tr></thead><tr><td align="center" valign="middle" >Random Forest Tree</td><td align="center" valign="middle" >86.447% (51)</td><td align="center" valign="middle" >13.56% (8)</td><td align="center" valign="middle" >0.16</td><td align="center" valign="middle" >0.9535</td></tr><tr><td align="center" valign="middle" >Neural Network</td><td align="center" valign="middle" >52.54% (31)</td><td align="center" valign="middle" >47.46% (28)</td><td align="center" valign="middle" >1.53</td><td align="center" valign="middle" >0.3363</td></tr><tr><td align="center" valign="middle" >Bayesian Network</td><td align="center" valign="middle" >74.57% (44)</td><td align="center" valign="middle" >25.43% (15)</td><td align="center" valign="middle" >0.2</td><td align="center" valign="middle" >0.6456</td></tr></tbody></table></table-wrap><table-wrap id="table5" ><label><xref ref-type="table" rid="table5">Table 5</xref></label><caption><title> Comparison of various classifiers</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Name of the Classifier</th><th align="center" valign="middle" >Experiment 1</th><th align="center" valign="middle" >Experiment 2</th></tr></thead><tr><td align="center" valign="middle" >Random Forest Tree</td><td align="center" valign="middle" >96.47</td><td align="center" valign="middle" >86.44</td></tr><tr><td align="center" valign="middle" >Neural Network</td><td align="center" valign="middle" >75.29</td><td align="center" valign="middle" >52.54</td></tr><tr><td align="center" valign="middle" >Bayesian Network</td><td align="center" valign="middle" >84.70</td><td align="center" valign="middle" >74.57</td></tr></tbody></table></table-wrap></sec><sec id="s7"><title>Cite this paper</title><p>Akter, F., Hossin, M.A., Daiyan, G.M. and Hossain, M.M. (2018) Classification of Hematological Data Using Data Mining Technique to Predict Diseases. Journal of Computer and Communications, 6, 76-83. https://doi.org/10.4236/jcc.2018.64007</p></sec></body><back><ref-list><title>References</title><ref id="scirp.84207-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Kaur, P., Singh, M. and Josan, G.S. (2015) Classification and Prediction Based Data Mining Algorithms to Predict Slow Learners in Education Sector. Procedia Computer Science, 57, 500-508. https://doi.org/10.1016/j.procs.2015.07.372</mixed-citation></ref><ref id="scirp.84207-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Zierk, J., Hirschmann, J., Toddenroth, D., Prokosch, H.U., Rauh, M. and Metzler, M. (2016) A Bioinformatics Approach to Pediatric Hematology Reference Intervals. 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