IJCMInternational Journal of Clinical Medicine2158-284XScientific Research Publishing10.4236/ijcm.2018.93016IJCM-83260ArticlesMedicine&Healthcare Antibiotics Friend and Foe: “From Wonder Drug to Causing Mitochondrial Dysfunction, Disrupting Human Microbiome and Promoting Tumorigenesis” RobertL. Elliott1*XianP. Jiang2CatherineBaucom2ZuzannaLomnicka1Sallie Astor Burdine Breast Foundation, Baton Rouge, USAElliott Mastology Center, Baton Rouge, USA* E-mail:drrobertelliott@cox.net(RLE);06032018090318218622, February 201823, March 2018 26, March 2018© Copyright 2014 by authors and Scientific Research Publishing Inc. 2014This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/

Mitochondria are evolutionary bacteria that are dynamic intracellular organelles involved in many vital cellular functions. However, modern medicine has fallen prey to misuse and over-usage of antibiotics. This misuse can damage the mitochondrion, alter host antibiotic interactions, and cause serious pathophysiologic conditions. We believe this leads to mitochondrial dysfunction, which may promote tumorigenesis and neurodegeneration. This opinion commentary’s goal is to bring awareness of this important hot topic to the medical community before induced modern plagues are irreversible.

Mitochondrial Dysfunction Microbiome Tumorigenesis Endosymbiotic Warburg EffectCite this paper

Elliott, R.L., Jiang, X.P., Baucom, C. and Lomnicka, Z. (2018) Antibiotics Friend and Foe: “From Wonder Drug to Causing Mitochondrial Dysfunction, Disrupting Human Microbiome and Promoting Tumorigenesis”. International Journal of Clinical Medicine, 9, 182-186. https://doi.org/10.4236/ijcm.2018.93016

ReferencesElliott, R.L., Jiang, X.P. and Baucom, C.C. (2017) Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis. Journal of Cancer Treatment and Research, 5, 62-65. https://doi.org/10.11648/j.jctr.20170504.11Blaser, M.J. (2014) Missing Microbes: (How the Overusage of Antibiotics Is Fueling Our Modern Plagues) Henry Holt.Warburg, O., Wind, F. and Negleis, E. (1930) On the Metabolism of Tumors in the Body. In: Warburg, Ed., The Metabolism of Tumors Constable, Princeton, 254-270.Warburg, O. (1956) On the Origin of Cancer Cells. Science, 123, 309-314. https://doi.org/10.1126/science.123.3191.309Margulis, L. (1970) Origin of Eukaryotic Cells. Yale University Press, New Haven.Gray, M.W. (2012) Mitochondrial Evolution. Cold Spring Harbor Perspectives in Biology, 4, 1403. https://doi.org/10.1101/cshperspect.a011403Barnhill, A.E., Brewer, M.T. and Carlson, S.A. (2012) Adverse Effects of Antimicrobials via Predictable or Idiosyncratic Inhibition of Host Mitochondrial Components. Antimicrobial Agents and Chemotherapy, 56, 4046-4051. https://doi.org/10.1128/AAC.00678-12