Osteoporosis is defined as a skeletal disease condition characterized by low bone mass which precipitates the fracture risk [1] . Bone density decreases after menopause due to decreased levels of estrogen hormone. Osteoporosis may also occur due to number of diseases or treatments like alcoholism, anorexia, hyperthyroidism, renal diseases. Anti-seizure medications, chemotherapy, proton pump inhibitors, selective serotonin reuptake inhibitors and glucocorticoids also increase the risk of developing osteoporosis. Lack of exercises and smoking are also risk factors [2] . Osteoporosis is defined as a bone density of 2.5 standard derivatives below that of a young adult. This is typically measured by dual energy x-ray absorptiometry (DEXA) scan [3] . The commonest fragility fracture due to osteoporosis is vertebral compression fractures (Figure 1) affecting 25% of post menopausal women and more than 200 million individually worldwide [4] . Despite proper conservative treatment, some patients continue to develop severe pain, vertebral compression and kyphotic deformity [5] . Nowadays, OVCF are being increasingly treated with minimally invasive bone augmentation technique like Percutaneous Vertebroplasty.

The thoracic spine is typically made up of 12 vertebrae. These vertebrae have a body, pedicles, laminae, spinous processes, and facet joints (Figure 2). Additionally, they have prominent lateral processes that form the articulation with the paired 12 ribs on either side. The 12 vertebrae, 24 ribs, and sternum together form the chest cavity, allowing negative-pressure respiration and providing protection of the chest wall. The thoracic spine is highly immobile [6] .

The lumbar spine is the next mobile segment of the spine, typically consisting

of 5 large vertebrae with classic features, including body, pedicles, lamina, spinous processes, facet joints, and lateral processes (Figure 3). The lumbar spine is mobile with all articulations, contributing to flexion-extension, bending, and rotation. The lumbar spine allows truncal mobility [6] .

Percutaneous vertebroplasty is a safe and efficient procedure for treating osteoporotic vertebral compression fractures [8] . Percutaneous vertebroplasty is one of the widely accepted treatments for VCFs of various causes. These procedures are associated with a decrease in the morbidity rates after VCFs. However, complications also have been reported [9] . Vertebroplasty is a minimally invasive, image-guided therapy used to relieve pain from a vertebral body fracture. It has been used for osteoporotic or malignant fractures. Initially, the major indication was treatment of spinal hemangiomas, as described in 1987 by Galibert et al. [10] . Vertebroplasty can increase patient mobility, decrease narcotic needs, and prevent further vertebral collapse. Percutaneous vertebroplasty (PVP) usually involves percutaneous injection of a cement, polymethylmethacrylate (PMMA), into the vertebral bodies [6] .

The indications and contraindications of PVP are listed as above in Table 1. The common indications for PVP are painful OVCF [6] , Spinal tumors [11] and vertebral hemangiomas [12] . Although PVP is a safe and efficient procedure for treating OVCF, it has some limitations PVP in contraindicated in cases like asymptomatic vertebral fractures, active osteomyelitis of vertebra, coagulopathies, allergy to the cement used, Significant central canal narrowing and epidural tumors [13] .

・ After obtaining informed consent, the patients were placed in the prone position at operating table (Figure 4(a)).

・ Under aseptic precautions, the skin and paravertebral soft tissues were anesthetized with 1% lidocaine.

・ The pedicle of fractured vertebra is localized using biplanar fluoroscopy (Figure 4(b)).

・ 11 guaze needle for L-spine or 13 guaze needle for T-spine were inserted at the anterior and middle one third region of the fractured vertebral body (Figure 4(c)).

・ Polymethylmethacrylate (PMMA) mixed with barium was then injected into the vertebral body under fluoroscopic guidance.

・ Cement injection is stopped when the posterior one fourth of the vertebra is filled or if any signs of leakage are seen (Figure 5).

・ Wound cleaned and aseptic dressing applied.

The Kaplan-Meier estimator also called the product limit estimator is known as a non parametric used to estimate the survival function from lifetime data. It is often used to measure the fraction of patients living for a certain amount of time after treatment in medical research [14] .

The review of various related articles was done focusing on the adjacent vertebral compression fractures in post PVP patients. The search engines like PUBMED, GOOGLE SCHOLAR, EMBRASE and SCOPUS were used to search the articles related to the adjacent vertebral compression fracture in post PVP patients. Around 68 adjacent level vertebral compression fracture articles out of which 57 articles were excluded as the author used balloon kyphoplasty as their mainstay method of treatment. Among 11 reviewed articles due to fewer numbers of patients and due to inadequate data, 2 more articles were excluded.

Percutaneous Vertebroplasty is a safe and effective procedure for alleviating pain and it also allows patients to resume their normal daily life earlier with compared to the conservative management. Till date, there are numerous published data on vertebroplasty in large population of patients [16] [23] [24] . Despite of its beneficial advantages over primary conservative managements, adjacent level vertebral compression fracture remains the challenge for surgeons. Despite the benefits of PVP, there are some complications following surgery: Hematoma, Infection, Adjacent vertebral fracture, neurological deficit. The aim of this review is more concerned on adjacent vertebral fracture, so there is more focus on it.

A study done in 2004 by S. H. Kim, H. S. Kang et al. [15] on 106 patients in with 212 percutaneous vertebroplasties in a period of 3 years (Table 2). They analysed five superior vertebrae and inferior to the treated vertebra. Seventy-two (7.9%) new fractures were found with the Kaplan-Meier estimate of the 1-year fracture-free rate 93.1%.

For evaluation of risk factors and the development of new symptomatic OVCFs after PVPs, Wan Soo Lee
et al. [16] performed a retrospective study from September 1999 to December 2001 (Table 2). A total of 244 cases of PVP for symptomatic OVCFs at 382 levels was performed. Overall, 38 among 244 treated patients (15.6%) had experienced newly developed symptomatic OVCF(s) during the follow up period. The Kaplan-Meier estimate of the 1-year fracture-free rate was 92.2%.

A.T Trout et al. [17] in year 2006 (Table 2) performed a retrospective analysis calculating the risks and timing of adjacent vertebral compression fractures after

PVP. A total of 432 patients were included, out of which Seventy-seven (41.4%) adjacent vertebral fractures were noted in patients with previously treated with vertebroplasty. The median time to diagnosis of an incident adjacent-level fracture was 55.0 days

A retrospective cohort study done by Kang Lu et al. [18] between January 2007 and December 2008 (Table 2). Forty-three (27.7%) of the 155 patients had subsequent vertebral compression fractures within 2 years of percutaneous vertebroplasty.

A study performed by Wen-Jer Chen et al. [22] in year 2008 (Table 2) showed 18.9% (22) new adjacent vertebral fractures out of 106 patients previously treated with PVP. This study revealed that the Cement leakage outside the vertebral body during vertebroplasty is one of the complications for adjacent vertebral fractures and is usually clinically asymptomatic.

Young-Joon Rho et al. [8] in a retrospective analysis, in year 2011 (Table 2) found out that out of 147 patients treated with pvp, 18.4% (27 patients) had adjacent level vertebral compression fractures. The Kaplan meier1-yearfracture free interval of this study is 85.0%.

In 2011, Ying Chou Sun et al. [21] performed a study showing correlation between the morphological extent of bone cement during vertebroplasty with the adjacent level vertebral compression fracture after PVP (Table 2). This study showed out of 162 vertebras treated with pvp, 25% (41) new symptomatic adjacent vertebral fractures were noted. The mean interval between the vertebroplasty and the earliest radiographic demonstration of adjacent vertebral fracture was 134 ± 225 days (median 24 days, range 2 - 1038 days). 53% of these adjacent fractures were seen within 1 month after vertebroplasty. About 86% were found within 1 year, and 96% within 18 months after vertebroplasty.

A retrospective study in 2011 (Table 2) done by Myung-Ho Kim et al. [20] showed that out of 104 post pvp patients , 51.9% (54) adjacent vertebral compression fracture were seen within 1 year follow up. In this analysis, Age of the patient, lumbar lordotic angle, sacral slope, pelvic tilt, pelvic incidence, bone mineral density (BMD), preexisting fracture, and intradiscal cement leakage were recorded for all 104 study subjects.

Kyung-Ah Lee et al. [19] found new adjacent fractures in 36 (10.3%) out of 351 patients after vertebroplasty surgery in follow up mean time of 6.8 months (range 1 - 47 months) (Table 2).