<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">CRCM</journal-id><journal-title-group><journal-title>Case Reports in Clinical Medicine</journal-title></journal-title-group><issn pub-type="epub">2325-7075</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/crcm.2017.611033</article-id><article-id pub-id-type="publisher-id">CRCM-80308</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  Spontaneous Respiration with Dexmedetomidine for Removal of Subglottic Airway Foreign Body in an Infant: A Case Report
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Jinhong</surname><given-names>Wu</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Lijun</surname><given-names>Wang</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Department of Anesthesiology, Ear Eye Nose and Throat Hospital, Fudan University, Shanghai, China</addr-line></aff><pub-date pub-type="epub"><day>14</day><month>11</month><year>2017</year></pub-date><volume>06</volume><issue>11</issue><fpage>291</fpage><lpage>294</lpage><history><date date-type="received"><day>26,</day>	<month>September</month>	<year>2017</year></date><date date-type="rev-recd"><day>12,</day>	<month>November</month>	<year>2017</year>	</date><date date-type="accepted"><day>15,</day>	<month>November</month>	<year>2017</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  Anesthesia risks for surgery of airway foreign body removal are very high. A safe way to anaesthetize the patients is important. This report presented a case of an infant with a foreign body in the subglottic area, which was ultimately removed by rigid laryngoscopy under spontaneous respiratory using dexmedetomidine (DEX). A loading dose of DEX 4 μg&amp;middotkg
  <sup>-1</sup> and sevoflurane 2 MAC could provide adequate depth of anesthesia during inserting the rigid bronchoscopy, and DEX 3 μg&amp;middotkg
  <sup>-1</sup>&amp;middoth
  <sup>-1</sup> was suitable for the maintance of anethesia with spontaneous respiratory. We considered that the maintenance of spontaneous respiration is one of the key points.
 
</p></abstract><kwd-group><kwd>Airway Foreign Body</kwd><kwd> Anesthesia</kwd><kwd> Rigid Bronchoscopy</kwd><kwd> Dexmedetomidine</kwd><kwd> Spontaneous Respiration</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Children younger than 3 years’ old are at high risk of airway foreign body (FB) aspiration [<xref ref-type="bibr" rid="scirp.80308-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.80308-ref2">2</xref>] . A time series observation of children undergoing rigid bronchoscopy for an inhaled foreign body revealed that the incidence of pneumothorax and death was 0.3% and 0.1% [<xref ref-type="bibr" rid="scirp.80308-ref3">3</xref>] . Subglottic airway foreign body is especially a life-threatening emergency. Rigid bronchoscopy under general anesthesia is the usual surgical technique for foreign body removal [<xref ref-type="bibr" rid="scirp.80308-ref4">4</xref>] [<xref ref-type="bibr" rid="scirp.80308-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.80308-ref6">6</xref>] . Anesthesia risks for surgery of airway foreign body removal are very high, and also the mortality is very high. Haemorrhage, post-procedure laryngeal oedema and tracheo-bronchial lacerations can occur during rigid bronchoscopy [<xref ref-type="bibr" rid="scirp.80308-ref7">7</xref>] . Tension pneumothorax is one of the most serious consequences of rigid bronchoscopy [<xref ref-type="bibr" rid="scirp.80308-ref8">8</xref>] . The baby would die within several minutes if not handled promptly when tension pneumothorax occurred. Spontaneous respiratory has lower risk to cause tension pneumothorax compared with manual jet ventilation. Here we reported a sharp subglottic airway foreign body removed undergoing rigid bronchoscopy under spontaneous respiratory with DEX.</p></sec><sec id="s2"><title>2. Clinical Presentation</title><p>A 10 kg 9-month-old boy was undergoing rigid bronchoscopy because of sticking a fish bone for four days. X-ray indicated the foreign body was just lodged subglottic (<xref ref-type="fig" rid="fig1">Figure 1</xref>(A)). The baby was breathlessness and wheezing, and both of his lungs were filled with rales during auscultation.</p><p>After the baby entered the operating room, he was continuously monitored for heart rate (HR), pulse oxygen saturation (SpO<sub>2</sub>), and noninvasive blood pressur (Bp) every 5 minutes. After monitor being connected, it showed HR128 bpm, Bp 88/50 mmHg and SpO<sub>2</sub> 98%. The anesthetic circuit was precharged with 8% sevoflurane in 100% oxygen at 8 L∙min<sup>−</sup><sup>1</sup> for 2 minutes. Then the baby was induced with 5% sevoflurane in 100% oxygen at 5 L∙min<sup>−</sup><sup>1</sup> and intravenous access was obtained. DEX 4 μg∙kg<sup>−</sup><sup>1</sup> was intravenously injected within 10 minutes and then the dose was changed to 3 μg∙kg<sup>−</sup><sup>1</sup>∙h<sup>−</sup><sup>1</sup>. Methylprednisolone 20 mg and atropine 0.05 mg were also intravenously administered. The baby maintained spontaneous breath with the tidal volume ranged from 40 - 60 mL and the respiratory rate ranged from 25 - 30 bpm. After a loading dose of DEX infusion was completed and sevoflurane was above 2 MAC, a rigid bronchoscope was successfully inserted.</p><p>Stop inhalation of sevoflurane and anesthesia was continued with DEX still at the rate of 3 μg∙kg<sup>−</sup><sup>1</sup>∙h<sup>−</sup><sup>1</sup>. 100% oxygen was delivered at a flow rate of 8 L∙min<sup>−</sup><sup>1</sup> by connecting the respiratory circuit to the side arm of the bronchoscope. The fish bone was very sharp and the otolaryngologists tried carefully to avoid scratching the airway. It was difficult to pull it out. The otolaryngologist repeatedly adjusted the bronchoscope for three times and the surgery lasted for 23 minutes. The baby maintained spontaneous breath during the surgery and SpO<sub>2</sub> maintained above 95%. After the fish bone was removed and the bronchoscope was with draw an, the baby was placed in lateral position and closely monitored. All the vital signs were normal. After 35 minutes, the baby woke up and returned to the ward safely.</p><p>This case showed an urgent subglottic airway foreign body (fish bone) (<xref ref-type="fig" rid="fig1">Figure 1</xref>(B)) and the bone was successfully removed undergoing rigid bronchoscopy with spontaneous respiratory. Spontaneous respiratory effort is particularly helpful in identifying the presence of tracheal obstruction because respiratory excursion and breath sounds are minimal or absent if such obstruction is present. With spontaneous ventilation, there is less chance of pushing a foreign body into the distal airway [<xref ref-type="bibr" rid="scirp.80308-ref9">9</xref>] . So in this case, we chose spontaneous ventilation</p><p>instead of other ventilation mode. However, if the anesthetic depth is inadequate, intraoperative body movement, breath holding, bronchospasm, and laryngospasm may occur [<xref ref-type="bibr" rid="scirp.80308-ref10">10</xref>] , while deep anesthesia increases the risk of respiratory depression. DEX produces sedation, analgesia and amnestic effects, and has antisialagogue properties [<xref ref-type="bibr" rid="scirp.80308-ref11">11</xref>] . DEX uniquely provides analgesia without causing respiratory depression [<xref ref-type="bibr" rid="scirp.80308-ref12">12</xref>] . It has been reported DEX provides appropriately deep anesthesia and ideal conditions for rigid bronchoscopy for airway foreign body removal without respiratory depression or hemodynamic instability [<xref ref-type="bibr" rid="scirp.80308-ref13">13</xref>] . This case showed a loading dose of DEX 4 μg∙kg<sup>−</sup><sup>1</sup> and sevoflurane 2 MAC could provide adequate depth of anesthesia during inserting the rigid bronchoscopy and DEX 3 μg∙kg<sup>−</sup><sup>1</sup>∙h<sup>−</sup><sup>1</sup> was suitable for the maintance of anesthesia with spontaneous ventilation. This case may be helpful for the anesthesia of urgent subglottic airway foreign body removal in clinic.</p></sec><sec id="s3"><title>3. Conclusion</title><p>Spontaneous respiratory could lower anesthesia risks associated with airway foreign body removal surgery, especially the risk of tension pneumothorax which could cause the baby die within minutes if not handled promptly. DEX combined with induction with sevoflurane could well keep spontaneous respiration during airway foreign body removal surgery.</p></sec><sec id="s4"><title>Cite this paper</title><p>Wu, J.H. and Wang, L.J. (2017) Spontaneous Respiration with Dexmedetomidine for Removal of Subglottic Airway Foreign Body in an Infant: A Case Report. Case Reports in Clinical Medicine, 6, 291-294. https://doi.org/10.4236/crcm.2017.611033</p></sec></body><back><ref-list><title>References</title><ref id="scirp.80308-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Kim, J.P., Kwon, O.J., Shim, H.S., Kim, R.B., Kim, J.H. and Woo, S.H. (2015) Analysis of Clinical Feature and Management of Fish Bone Ingestion of Upper Gastrointestinal Tract. Clinical and Experimental Otorhinolaryngology, 8, 261-267. https://doi.org/10.3342/ceo.2015.8.3.261</mixed-citation></ref><ref id="scirp.80308-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Woo, S.H. and Kim, K.H. (2015) Proposal for Methods of Diagnosis of Fish Bone Foreign Body in the Esophagus. The Laryngoscope, 125, 2472-2475. https://doi.org/10.1002/lary.25340</mixed-citation></ref><ref id="scirp.80308-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Zhang, X., Li, W.X. and Cai, Y.R. (2015) A Time Series Observation of Chinese Children Undergoing Rigid Bronchoscopy for an Inhaled Foreign Body: 3,149 Cases in 1991-2010. Chinese Medical Journal (Engl), 128, 504-509. https://doi.org/10.4103/0366-6999.151104</mixed-citation></ref><ref id="scirp.80308-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Kadmon, G., Stern, Y., Bron-Harlev, E., Nahum, E., Battat, E. and Schonfeld, T. (2008) Computerized Scoring System for the Diagnosis of Foreign Body Aspiration in Children. Annals of Otology, Rhinology &amp; Laryngology, 117, 839-843. https://doi.org/10.1177/000348940811701108</mixed-citation></ref><ref id="scirp.80308-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Eren, S., Balci, A.E., Dikici, B., Doblan, M. and Eren, M.N. (2003) Foreign Body Aspiration in Children: Experience of 1160 Cases. Annals of Tropical Paediatrics, 23, 31-37. https://doi.org/10.1179/000349803125002959</mixed-citation></ref><ref id="scirp.80308-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Zhijun, C., Fugao, Z., Niankai, Z. and Jingjing, C. (2008) Therapeutic Experience from 1428 Patients with Pediatric Tracheobronchial Foreign Body. Journal of Pediatric Surgery, 43, 718-721. https://doi.org/10.1016/j.jpedsurg.2007.10.010</mixed-citation></ref><ref id="scirp.80308-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Hasdiraz, L., Oguzkaya, F., Bilgin, M. and Bicer, C. (2006) Complications of Bronchoscopy for Foreign Body Removal: Experience in 1,035 Cases. Annals of Saudi Medicine, 26, 283-287. https://doi.org/10.5144/0256-4947.2006.283</mixed-citation></ref><ref id="scirp.80308-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Harar, R.P., Pratap, R., Chadha, N. and Tolley, N. (2005) Bilateral Tension Pneumothorax Following Rigid Bronchoscopy: A Report of an Epignathus in a Newborn Delivered by the EXIT Procedure with a Fatal Outcome. The Journal of Laryngology &amp; Otology, 119, 400-402. https://doi.org/10.1258/0022215053945813</mixed-citation></ref><ref id="scirp.80308-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Vane, D.W., Pritchard, J., Colville, C.W., West, K.W., Eigen, H. and Grosfeld, J.L. (1988) Bronchoscopy for Aspirated Foreign Bodies in Children. Experience in 131 Cases. Archives of Surgery, 123, 885-888. https://doi.org/10.1001/archsurg.1988.01400310099017</mixed-citation></ref><ref id="scirp.80308-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">Vardhan, V., Singh, M., Reddy, S., Shetty, A.B. and Hemant, R.H. (2005) Airway Foreign Body in Pediatric Patient: A Fishy Experience. Journal of Cardiothoracic and Vascular Anesthesia, 19, 90-92. https://doi.org/10.1053/j.jvca.2004.11.018</mixed-citation></ref><ref id="scirp.80308-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Abdelmalak, B., Makary, L., Hoban, J. and Doyle, D.J. (2007) Dexmedetomidine as Sole Sedative for Awake Intubation in Management of the Critical Airway. Journal of Clinical Anesthesia, 19, 370-373. https://doi.org/10.1016/j.jclinane.2006.09.006</mixed-citation></ref><ref id="scirp.80308-ref12"><label>12</label><mixed-citation publication-type="other" xlink:type="simple">Hammer, G.B., Philip, B.M., Schroeder, A.R., Rosen, F.S. and Koltai, P.J. (2005) Prolonged Infusion of Dexmedetomidine for Sedation Following Tracheal Resection. Pediatric Anesthesia, 15, 616-620. https://doi.org/10.1111/j.1460-9592.2005.01656.x</mixed-citation></ref><ref id="scirp.80308-ref13"><label>13</label><mixed-citation publication-type="other" xlink:type="simple">Cai, Y., Li, W. and Chen, K. (2013) Efficacy and Safety of Spontaneous Ventilation Technique Using Dexmedetomidine for Rigid Bronchoscopic Airway Foreign Body Removal in Children. Pediatric Anesthesia, 23, 1048-1053. https://doi.org/10.1111/pan.12197</mixed-citation></ref></ref-list></back></article>