<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">OJO</journal-id><journal-title-group><journal-title>Open Journal of Orthopedics</journal-title></journal-title-group><issn pub-type="epub">2164-3008</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/ojo.2017.74012</article-id><article-id pub-id-type="publisher-id">OJO-75722</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  Clinical Outcome of Percutaneous Endoscopic Lumbar Surgery (PELS) in Treatment of Lumbar Disc Herniation
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Mangal</surname><given-names>P. Hirachan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Zengxin</surname><given-names>Gao</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Yucheng</surname><given-names>Lin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ratish</surname><given-names>Singh</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Department of Spine Surgery, Zhongda Hospital Affiliated to Southeast University, Nanjing, China</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>552366015@qq.com(ZG)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>28</day><month>04</month><year>2017</year></pub-date><volume>07</volume><issue>04</issue><fpage>99</fpage><lpage>109</lpage><history><date date-type="received"><day>March</day>	<month>22,</month>	<year>2017</year></date><date date-type="rev-recd"><day>Accepted:</day>	<month>April</month>	<year>25,</year>	</date><date date-type="accepted"><day>April</day>	<month>28,</month>	<year>2017</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  Lumbar disc herniation is a spinal problem seen in both young and old people causing pain in the back with pain and numbness in lower extremity leading to disability limiting daily activities. When conservative treatments are ineffective, then it is treated by surgeries, more recently with minimal invasive percutaneous endoscopic lumbar surgery (PELS). One of the mostly accepted PELS by spinal surgeons is percutaneous transforaminal endoscopic lumbar discectomy, which can be performed for any age. The main aim of this review was to evaluate clinical outcome and safety based on the Oswestry Disable Index (ODI), Visual Analog Scale (VAS) and MacNab criteria and complications of PELS surgery and its advantages in clinical basis.
 
</p></abstract><kwd-group><kwd>Lumbar Disc Herniation (LDH)</kwd><kwd> Percutaneous Endoscopic Lumbar Surgery (PELD)</kwd><kwd> Percutaneous Transforaminal Endoscopic Lumbar Discectomy (PTELD)</kwd><kwd> Interlaminar Percutaneous Endoscopic Lumbar Discectomy (ILPELD)</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Lumbar disc herniation is one of the common causes of low back pain with sciatica in young and adult with huge economic burden to family and society [<xref ref-type="bibr" rid="scirp.75722-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.75722-ref2">2</xref>] [<xref ref-type="bibr" rid="scirp.75722-ref3">3</xref>] . Point prevalence of lumber disc herniation is 37.1%, 1-year prevalence of 76.0%, and lifetime prevalence of 85.5% [<xref ref-type="bibr" rid="scirp.75722-ref4">4</xref>] . About 70% - 80% of population experiences back pain in lifetime. It’s reported that the prevalence of herniated discs are higher among people 35 - 45 years old [<xref ref-type="bibr" rid="scirp.75722-ref5">5</xref>] . Not all herniated disc need operative treatment but when sign and symptoms such as back with or without radicular leg pain progressively increase despite of conservative treatment for more than 6 weeks, neurological deficits as foot drop, cauda equine, etc. are seen then has to undergo for surgery. Currently, there are numerous surgical interventions for lumber disc herniation. They can be broadly classified as posterior open discectomies and percutaneous techniques. Posterior open discectomies include open laminectomy and discectomy, micro discectomy, micro endoscopic discectomy, hemi laminectomy with discectomy, among which micro discectomy remains the standard surgery for lumber disc herniation. Whereas, percutaneous techniques include chemonucleolysis, nucleoplasty, intradiscal electrothermal therapy, percutaneous laser discectomy and percutaneous endoscopic lumbar surgery (PELS) [<xref ref-type="bibr" rid="scirp.75722-ref6">6</xref>] [<xref ref-type="bibr" rid="scirp.75722-ref7">7</xref>] [<xref ref-type="bibr" rid="scirp.75722-ref8">8</xref>] . Except PELS, all of the percutaneous techniques are blind procedure, whereas, PELS is performed under direct endoscopic vision.</p><p>Percutaneous endoscopic lumbar surgery is one of the latest emerging techniques in treatment of lumbar disc herniation. Kambin and Gellman in 1973 and Hijikatain 1975 first introduced non-visualized percutaneous central nucleotomy via posterolateral approach [<xref ref-type="bibr" rid="scirp.75722-ref9">9</xref>] [<xref ref-type="bibr" rid="scirp.75722-ref10">10</xref>] . After introduction of direct visualization of intervertebral disc space with modified arthroscopy by Forest and Housman in 1983, this technique has been widely practiced for treatment of lumber disc herniation [<xref ref-type="bibr" rid="scirp.75722-ref7">7</xref>] . In 1992 Kambin P. further defined removal of protruded disc passing through Kambin’s triangle, considered to be a safe site in posterolateral region [<xref ref-type="bibr" rid="scirp.75722-ref11">11</xref>] . Recently, there are 2 techniques widely used for percutaneous endoscopic surgery: 1) transforaminal approach described by Yeung (Yeung Endoscopic spinal surgery, YESS) in 1997 and Hoogland (Transforaminal endoscopic spine surgery system, TESSYS) in 1994 [<xref ref-type="bibr" rid="scirp.75722-ref12">12</xref>] [<xref ref-type="bibr" rid="scirp.75722-ref13">13</xref>] ; 2) Interlaminar approach described by Ruetten in 2008 [<xref ref-type="bibr" rid="scirp.75722-ref14">14</xref>] . The indications for transforaminal endoscopic treatment are the same as classical discectomy procedures. Now due to advancement of instrumentation and skill of surgeon indication has broadened.</p></sec><sec id="s2"><title>2. Surgical Technique</title><p>If the surgery is indicative then all pre-operation evaluation and preparation are performed; this surgery can be done in two positions; prone or lateral decubitus position. If the patient is placed in prone position then hip and knee are flexed and pillow is placed between lower abdominal and chest so that abdomen is hanged freely. For lateral decubitus position, pillow is placed under the waist, which will open up the foramen and allow the Dura to fall down to the contra-lateral side avoiding damage on introduction of the cannula and the also reduced intra-abdominal pressure and decrease bleeding. Then under guidance of C-arm, entry point is marked 8 - 16 cm from midline of vertebra to lateral side according to the disc interval at an angle of 15 - 25 degrees in horizontal plane [<xref ref-type="bibr" rid="scirp.75722-ref15">15</xref>] [<xref ref-type="bibr" rid="scirp.75722-ref16">16</xref>] . Under all aseptic condition and local anesthesia (1%lidocane), and under anteroposterior (AP) and lateral view, a 25 cm 18 gauge needle is inserted in the level of herniated disc through the posterolateral approach. Intraoperative discogram is then performed with a 2 mL mixture of contrast medium and methylene blue at the ratio of 9:1 and help of c-arm. If the dye is seen in the epidural space nucleus then it indicates the herniated fragment. Then guide wire is inserted and the needle is removed leaving the guide wire in situ. A small skin incision of 8 mm is then given over the guide wire entry point. A 2 mm conical rod is introduced over the guiding wire, and then sequentially the first, second and third sleeves were inserted dilating the soft tissues up to 6.5 mm. Then the reamer is introduced anti clockwise, to avoid damage to the spinal muscles and continuously under the guidance of image intensifier reamed to 1 or 2 mm inside the medial pedicular line. The procedure is repeated with each of the sequentially larger rods, tubes and reamers. Then working cannula is introduced over the third conical rod and its tip should be located on the herniated disc. Then image intensifier is removed and working endoscope set introduced and herniated disc is removed under direct visualization as in <xref ref-type="fig" rid="fig1">Figure 1</xref>. After complete decompression, the dural sac and the lumber exiting nerve root is checked for freely movable with the valsalva maneuver. Bleeding of the small vessels is controlled with a flexible bipolar radio frequency probe. Communication with patients is maintained throughout the procedure. Though the technique is considered to be much safer but it involves several technical challenges, such as the critical narrow access through the foraminal triangular window and the limited intradiscal and epidural working space.</p></sec>
<sec id="s3">
<title>3. Discussion</title>
<p>In recent time, percutaneous endoscopic lumbar surgery specially transforaminal approach is widely used to treat lumber disc herniation due to its comparable significant outcome as shown in <xref ref-type="table" rid="table1">Table 1</xref>. This transforaminal approach can be approached by two techniques YESS and TYSSYS. The standard indication for percutaneous transforaminal endoscopic lumber discectomy (PTELD) is limited to soft (non calcified) and contained LDH, which caused discogenic leg pain that</p>
<fig id="fig1"  position="float"><label><xref ref-type="fig" rid="fig1">Figure 1</xref></label><caption><title> Procedure for percutaneous endoscopic lumbar surgery. (a) positioning of patient in operating table, (b) Insertion of 25 cm 18-gauge needle, (c) discogram with mixture of contrast medium and methylene blue, (d) reaming over dilator, (e) removal of content under direct vision with endoscope and (f) free nerve root after discectomy</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/1-2010472x2.png"/></fig></sec></body>
<back><ref-list><title>References</title><ref id="scirp.75722-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Fan, G., et al. (2015) Significant Improvement of Puncture Accuracy and Fluoroscopy Reduction in Percutaneous Transforaminal Endoscopic Discectomy with Novel Lumbar Location System: Preliminary Report of Prospective Hello Study. Medicine, 94, e2189. https://doi.org/10.1097/MD.0000000000002189</mixed-citation></ref><ref id="scirp.75722-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Liu, C. and Zhou, Y. (2017) Percutaneous Endoscopic Lumbar Diskectomy and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Recurrent Lumbar Disk Herniation. World Neurosurgery, 98, 14-20. https://doi.org/10.1016/j.wneu.2016.10.056</mixed-citation></ref><ref id="scirp.75722-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Liu, W.G., et al. (2009) Long-Term Outcomes of Percutaneous Lumbar Discectomy and Microendoscopic Discectomy for Lumbar Disc Herniation. National Medical Journal of China, 89, 750-753.</mixed-citation></ref><ref id="scirp.75722-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Torun, F., Dolgun, H., Tuna, H., Attar, A., Uz, A. and Erdem, A. (2006) Morphometric Analysis of the Roots and Neural Foramina of the Lumbar Vertebrae. Surgical Neurology, 66, 148-151. https://doi.org/10.1016/j.surneu.2006.02.041</mixed-citation></ref><ref id="scirp.75722-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Arslan, M., et al. (2012) Nerve Root to Lumbar Disc Relationships at the Intervertebral Foramen from a Surgical Viewpoint: An Anatomical Study. Clinical Anatomy, 25, 218-223. https://doi.org/10.1002/ca.21213</mixed-citation></ref><ref id="scirp.75722-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Pan, L., Zhang, P. and Yin, Q. (2014) Comparison of Tissue Damages Caused by Endoscopic Lumbar Discectomy and Traditional Lumbar Discectomy: A Randomised Controlled Trial. International Journal of Surgery, 12, 534-537.https://doi.org/10.1016/j.ijsu.2014.02.015</mixed-citation></ref><ref id="scirp.75722-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Ying, J., et al. (2016) The Effect and Feasibility Study of Transforaminal Percutaneous Endoscopic Lumbar Discectomy via Superior Border of Inferior Pedicle Approach for Down-Migrated Intracanal Disc Herniations. Medicine, 95, e2899.</mixed-citation></ref><ref id="scirp.75722-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Li, X., et al. (2016) Percutaneous Endoscopic Lumbar Discectomy for Recurrent Lumbar Disc Herniation. International Journal of Surgery, 27, 8-16.https://doi.org/10.1016/j.ijsu.2016.01.034</mixed-citation></ref><ref id="scirp.75722-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Lee, D.Y., Shim, C.S., Ahn, Y., Choi, Y.G., Kim, H.J. and Lee, S.H. (2009) Comparison of Percutaneous Endoscopic Lumbar Discectomy and Open Lumbar Microdiscectomy for Recurrent Disc Herniation. Journal of Korean Neurosurgical Society, 46, 515-521. https://doi.org/10.3340/jkns.2009.46.6.515</mixed-citation></ref><ref id="scirp.75722-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">Wang, K., et al. (2015) Evaluation of Transforaminal Endoscopic Lumbar Discectomy in the Treatment of Lumbar Disc Herniation. International Orthopaedics, 39, 1599-1604. https://doi.org/10.1007/s00264-015-2747-1</mixed-citation></ref><ref id="scirp.75722-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Ahn, Y., et al. (2004) Percutaneous Endoscopic Lumbar Discectomy for Recurrent Disc Herniation: Surgical Technique, Outcome, and Prognostic Factors of 43 Consecutive Cases. Spine, 29, E326-E332. https://doi.org/10.1097/01.brs.0000134591.32462.98</mixed-citation></ref><ref id="scirp.75722-ref12"><label>12</label><mixed-citation publication-type="other" xlink:type="simple">Sinkemani, A., et al. (2015) Outcomes of Microendoscopic Discectomy and Percutaneous Transforaminal Endoscopic Discectomy for the Treatment of Lumbar Disc Herniation: A Comparative Retrospective Study. Asian Spine Journal, 9, 833-840.https://doi.org/10.4184/asj.2015.9.6.833</mixed-citation></ref><ref id="scirp.75722-ref13"><label>13</label><mixed-citation publication-type="other" xlink:type="simple">Li, Z.-Z., Hou, S.-X., Shang, W.-L., Cao, Z. and Zhao, H.-L. (2016) Percutaneous Lumbar Foraminoplasty and Percutaneous Endoscopic Lumbar Decompression for Lateral Recess Stenosis through Transforaminal Approach: Technique Notes and 2 Years Follow-Up. Clinical Neurology and Neurosurgery, 143, 90-94. https://doi.org/10.1016/j.clineuro.2016.02.008</mixed-citation></ref><ref id="scirp.75722-ref14"><label>14</label><mixed-citation publication-type="other" xlink:type="simple">Lee, S.-H., et al. (2006) Comparative Radiologic Evaluation of Percutaneous Endoscopic Lumbar Discectomy and Open Microdiscectomy: A Matched Cohort Analysis. The Mount Sinai Journal of Medicine, 73, 795-801.</mixed-citation></ref><ref id="scirp.75722-ref15"><label>15</label><mixed-citation publication-type="other" xlink:type="simple">Gadjradj, P.S., et al. (2016) Clinical Outcomes after Percutaneous Transforaminal Endoscopic Discectomy for Lumbar Disc Herniation: A Prospective Case Series. Neurosurgical Focus, 40, E3. https://doi.org/10.3171/2015.10.FOCUS15484</mixed-citation></ref><ref id="scirp.75722-ref16"><label>16</label><mixed-citation publication-type="other" xlink:type="simple">Choi, K.-C. and Park, C.-K. (2016) Percutaneous Endoscopic Lumbar Discectomy for L5-S1 Disc Herniation: Consideration of the Relation between the Iliac Crest and L5-S1 Disc. Pain Physician, 19, E301-E308.</mixed-citation></ref><ref id="scirp.75722-ref17"><label>17</label><mixed-citation publication-type="other" xlink:type="simple">Lee, J.-S., Kim, H.-S., Jang, J.-S. and Jang, I.-T. (2016) Structural Preservation Percutaneous Endoscopic Lumbar Interlaminar Discectomy for L5-S1 Herniated Nucleus Pulposus. BioMed Research International, 2016, Article ID: 6250247. https://doi.org/10.1155/2016/6250247</mixed-citation></ref><ref id="scirp.75722-ref18"><label>18</label><mixed-citation publication-type="other" xlink:type="simple">Tzaan, W. (2007) Transforaminal Percutaneous Endoscopic Lumbar Discectomy. Chang Gung Medical Journal, 30, 226.</mixed-citation></ref><ref id="scirp.75722-ref19"><label>19</label><mixed-citation publication-type="other" xlink:type="simple">Ahn, Y., Lee, S.H., Chung, S.E., Park, H.S. and Shin, S.W. (2005) Percutaneous Endoscopic Cervical Discectomy for Discogenic Cervical Headache Due to Soft Disc Herniation. Neuroradiology, 47, 924-930. https://doi.org/10.1007/s00234-005-1436-y</mixed-citation></ref><ref id="scirp.75722-ref20"><label>20</label><mixed-citation publication-type="other" xlink:type="simple">McCaffery, M. and Pasero, C. (2001) Using the 0-to-10 Pain Rating Scale: Nine Common Problems Solved. The American Journal of Nursing, 101, 81-82. https://doi.org/10.1097/00000446-200110000-00031</mixed-citation></ref><ref id="scirp.75722-ref21"><label>21</label><mixed-citation publication-type="other" xlink:type="simple">Fairbank, J.C.T. and Pynsent, P.B. (2000) The Oswestry Disability Index. Spine, 25, 2940-2953. https://doi.org/10.1097/00007632-200011150-00017</mixed-citation></ref><ref id="scirp.75722-ref22"><label>22</label><mixed-citation publication-type="other" xlink:type="simple">Pan, Z., Ha, Y., Yi, S. and Cao, K. (2016) Efficacy of Transforaminal Endoscopic Spine System (TESSYS) Technique in Treating Lumbar Disc Herniation. Medical Science Monitor, 22, 530-539. https://doi.org/10.12659/MSM.894870</mixed-citation></ref><ref id="scirp.75722-ref23"><label>23</label><mixed-citation publication-type="other" xlink:type="simple">Eun, S.S., Lee, S.H. and Sabal, L.A. (2016) Long-Term Follow-Up Results of Percutaneous Endoscopic Lumbar Discectomy. Pain Physician, 19, E1161.</mixed-citation></ref><ref id="scirp.75722-ref24"><label>24</label><mixed-citation publication-type="other" xlink:type="simple">Ahn, S.-S., Kim, S.-H., Kim, D.-W. and Lee, B.-H. (2016) Comparison of Outcomes of Percutaneous Endoscopic Lumbar Discectomy and Open Lumbar Microdiscectomy for Young Adults: A Retrospective Matched Cohort Study. World Neurosurgery, 86, 250-258. https://doi.org/10.1016/j.wneu.2015.09.047</mixed-citation></ref><ref id="scirp.75722-ref25"><label>25</label><mixed-citation publication-type="other" xlink:type="simple">Liao, Z., Chen, W. and Wang, C.H. (2014) Transforaminal Percutaneous Endoscopic Surgery for Far Lateral Lumbar Intervertebral Disk Herniation. Orthopedics, 37, e717-e727. https://doi.org/10.3928/01477447-20140728-58</mixed-citation></ref><ref id="scirp.75722-ref26"><label>26</label><mixed-citation publication-type="other" xlink:type="simple">Ruetten, S., Komp, M., Merk, H. and Godolias, G. (2008) Full-Endoscopic Interlaminar and Transforaminal Lumbar Discectomy versus Conventional Microsurgical Technique: A Prospective, Randomized, Controlled Study. Spine, 33, 931-939. https://doi.org/10.1097/BRS.0b013e31816c8af7</mixed-citation></ref><ref id="scirp.75722-ref27"><label>27</label><mixed-citation publication-type="other" xlink:type="simple">Hoogland, T., et al. (2006) Transforaminal Posterolateral Endoscopic Discectomy with or without the Combination of a Low-Dose Chymopapain: A Prospective Randomized Study in 280 Consecutive Cases. Spine, 31, E890-E897. https://doi.org/10.1097/01.brs.0000245955.22358.3a</mixed-citation></ref><ref id="scirp.75722-ref28"><label>28</label><mixed-citation publication-type="other" xlink:type="simple">Yeung, A.T. and Tsou, P.M. (2002) Posterolateral Endoscopic Excision for Lumbar Disc Herniation: Surgical Technique, Outcome, and Complications in 307 Consecutive Cases. Spine, 27, 722-731. https://doi.org/10.1097/00007632-200204010-00009</mixed-citation></ref><ref id="scirp.75722-ref29"><label>29</label><mixed-citation publication-type="other" xlink:type="simple">Kambin, P. (1992) Arthroscopic Microdiscectomy. Arthroscopy: The Journal of Arthroscopic &amp; Related Surgery, 8, 287-295. https://doi.org/10.1016/0749-8063(92)90058-J</mixed-citation></ref><ref id="scirp.75722-ref30"><label>30</label><mixed-citation publication-type="other" xlink:type="simple">Kambin, P. and Gellman, H. (1983) Percutaneous Lateral Discectomy of the Lumbar Spine. A Preliminary Report. Clinical Orthopaedics and Related Research, 174, 127-132.</mixed-citation></ref><ref id="scirp.75722-ref31"><label>31</label><mixed-citation publication-type="other" xlink:type="simple">Hijikata, S. (1989) Percutaneous Nucleotomy. A New Concept Technique and 12 Years’ Experience. Clinical Orthopaedics and Related Research, No. 238, 9-23. https://doi.org/10.1097/00003086-198901000-00003</mixed-citation></ref><ref id="scirp.75722-ref32"><label>32</label><mixed-citation publication-type="other" xlink:type="simple">Smith, L. (1964) Enzyme Dissolution of the Nucleus Pulposus in Humans. JAMA, 187, 137-140. https://doi.org/10.1001/jama.1964.03060150061016</mixed-citation></ref><ref id="scirp.75722-ref33"><label>33</label><mixed-citation publication-type="other" xlink:type="simple">Forst, R. and Hausmann, B. (1983) Nucleoscopy—A New Examination Technique. Archives of Orthopaedic and Trauma Surgery, 101, 219-221. https://doi.org/10.1007/BF00436774</mixed-citation></ref><ref id="scirp.75722-ref34"><label>34</label><mixed-citation publication-type="other" xlink:type="simple">Mixter, W.J. and Ayer, J.B. (1935) Herniation or Rupture of the Intervertebral Disc into the Spinal Canal—Report of Thirty-Four Cases. The New England Journal of Medicine, 213, 385-393. https://doi.org/10.1056/NEJM193508292130901</mixed-citation></ref><ref id="scirp.75722-ref35"><label>35</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Heliovaara</surname><given-names> M. </given-names></name>,<etal>et al</etal>. (<year>1987</year>)<article-title>Occupation and Risk of Herniated Lumbar Intervertebral Disc or Sciatica Leading to Hospitalization</article-title><source> Journal of Chronic Diseases</source><volume> 40</volume>,<fpage> 259</fpage>-<lpage>264</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.75722-ref36"><label>36</label><mixed-citation publication-type="other" xlink:type="simple">Schmidt, C.O., et al. (2007) Back Pain in the German Adult Population: Prevalence, Severity, and Sociodemographic Correlates in a Multiregional Survey. Spine, 32, 2005-2011. https://doi.org/10.1097/BRS.0b013e318133fad8</mixed-citation></ref><ref id="scirp.75722-ref37"><label>37</label><mixed-citation publication-type="other" xlink:type="simple">Dagenais, S., Caro, J. and Haldeman, S. (2008) A Systematic Review of Low Back Pain Cost of Illness Studies in the United States and Internationally. The Spine Journal, 8, 8-20. https://doi.org/10.1016/j.spinee.2007.10.005</mixed-citation></ref><ref id="scirp.75722-ref38"><label>38</label><mixed-citation publication-type="other" xlink:type="simple">Maetzel, A. and Li, L. (2002) The Economic Burden of Low Back Pain: A Review of Studies Published between 1996 and 2001. Best Practice &amp; Research: Clinical Rheumatology, 16, 23-30. https://doi.org/10.1053/berh.2001.0204</mixed-citation></ref><ref id="scirp.75722-ref39"><label>39</label><mixed-citation publication-type="other" xlink:type="simple">Dewing, C.B., et al. (2008) The Outcomes of Lumbar Microdiscectomy in a Young, Active Population: Correlation by Herniation Type and Level. Spine, 33, 33-38. https://doi.org/10.1097/BRS.0b013e31815e3a42</mixed-citation></ref></ref-list></back></article>