<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">AAR</journal-id><journal-title-group><journal-title>Advances in Aging Research</journal-title></journal-title-group><issn pub-type="epub">2169-0499</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/aar.2017.62004</article-id><article-id pub-id-type="publisher-id">AAR-74555</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biomedical&amp;Life Sciences</subject><subject> Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  An Innovative Antiseptic, Antiperspirant and Deodourant Diaper for the Older and Frail Older People Suffering from Urinary Incontinence
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Elaine</surname><given-names>Wat</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Alex</surname><given-names>W. L. Lin</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Cyrus</surname><given-names>Mak</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ivan</surname><given-names>Lam</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Clara</surname><given-names>Bik-San Lau</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Frency</surname><given-names>Sau-Fun Ng</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Patrick</surname><given-names>Chi-Leung Hui</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ping-Chung</surname><given-names>Leung</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib></contrib-group><aff id="aff4"><addr-line>Partner State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Hong Kong</addr-line></aff><aff id="aff3"><addr-line>Neighbourhood Advice-Action Council, Harmony Manor, Hong Kong</addr-line></aff><aff id="aff2"><addr-line>Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong</addr-line></aff><aff id="aff1"><addr-line>Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong</addr-line></aff><pub-date pub-type="epub"><day>06</day><month>03</month><year>2017</year></pub-date><volume>06</volume><issue>02</issue><fpage>29</fpage><lpage>37</lpage><history><date date-type="received"><day>January</day>	<month>9,</month>	<year>2017</year></date><date date-type="rev-recd"><day>Accepted:</day>	<month>March</month>	<year>3,</year>	</date><date date-type="accepted"><day>March</day>	<month>6,</month>	<year>2017</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  
    Background: Urinary Incontinence is a common symptom among the older and frail older people. Apart from affecting the quality of life and skin complications, the demand on assistance could be too high for any sufferer. While conservative means of treatment do not work, special incontinence apparel could be a good compromise. Objective: To create an absorbent, antiseptic, antiperspirant and deodourant diaper for the older and dependent people suffering from urinary incontinence. Material and Methods: Antiperspirant and antiseptic medicinal materials have been reported in Traditional Chinese Medicine and two herbs were screened out to provide the required effects. A combination of Fraxini Cortex, Calamine and Zinc oxide made in powder forms was impregnated into a pocket of the diaper. Laboratory tests were performed to confirm the antiseptic, antiperspirant and deodourant effects of the materials. A self-control clinical trial on the diaper was organized in an elderly home. Results: Antibacterial effects against Staphylococcus, 
   E. coli and Candida were proven. Antiperspirant effects were confirmed using acetylcholinesterase inhibitor testings. Volunteers using the Sudoscan machine further demonstrated the weak antiperspirant effects of the herbs. A pilot study on 31 dependent diaper users gave positive feedbacks of more comfort, less leakage, odour and better skin conditions. The overall satisfaction reached 79%. Conclusion: A special diaper with antiseptic, antiperspirant and deodourant effects could be created with inexpensive herbal powder impregnated and could be recommended to the older and frail older people with urinary incontinence. 
  
 
</p></abstract><kwd-group><kwd>Urinary Incontinence</kwd><kwd> Older And Frail Older</kwd><kwd> Toilet Assistance</kwd><kwd> Rehabilitation</kwd><kwd> Adult Diaper</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Older and frail older people often suffer from incontinence. This problem is most common among frail older people living in elderly homes which might not be provided with sufficient carers. Overnight wetting of diapers which serve as compromising treatment frequently leads to perineal dermatitis and the poor micro-environment often leads to contacting pressure injuries (ulcers). Despite consequences of unhealthiness and deteriorating quality of life, these frail older people are not given special attention over the incontinence [<xref ref-type="bibr" rid="scirp.74555-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.74555-ref2">2</xref>] .</p><p>When the apparently simple “wetting” phenomenon is seriously analysed, many specific problems are revealed. They are:</p><p>i) Overflow of urine, which is the source of discomfort and demand for much manpower support in tedious apparel care.</p><p>ii) Perineal dermatitis, which could result from the poor micro-environment, bacterial and fungal infections.</p><p>iii) Pressure injuries, which are consequences of dermatitis leading to skin abrasions and ulcerations resulting even from minor rubs and contact stretches [<xref ref-type="bibr" rid="scirp.74555-ref3">3</xref>] .</p><p>iv) Local infections, which are particularly prone in the perineal region because of the faecal outlet [<xref ref-type="bibr" rid="scirp.74555-ref3">3</xref>] .</p><p>v) Foul odour production resulting from the combination of bacterial and fungal flora, putrefaction activities arising from the unhygienic environment and sweat gland irritations [<xref ref-type="bibr" rid="scirp.74555-ref4">4</xref>] .</p><p>vi) Sweat gland hyperactivity reacting to the poor microenvironment [<xref ref-type="bibr" rid="scirp.74555-ref5">5</xref>] .</p><p>A pilot study was therefore planned and the aim was to create a special diaper for the older and frail older people suffering from urinary incontinence to prevent complications arising from over-night and persistent wetting of the perineal region. Topical Traditional Chinese Medicine could be considered since many medicinal herbs have been reported to be antiseptic, antiperspirant and anti-allergic. Herbal products more over are not expensive.</p><p>The innovative Diaper should therefore possess the following properties: effectively absorbent, antiseptic, antiperspirant and deodourant.</p><p>With regard to the absorbent ability of the diaper, the material involved, its fabrication and design would require the critical analysis of the textile and apparel experts.</p><p>With regard to the other requirements, we looked forward to medicinal herbs that had been reported to be antibacterial and antiperspirant. They needed to be tested in biological platforms and then in clinical applications. The deodouring effects could be tested in reputable special laboratories and in the subsequent clinical trials. The medicinal herbs, in extract powder form, were to be implanted into the diapers which would be given to volunteers in a clinical pilot study.</p></sec><sec id="s2"><title>2. Medicinal Materials</title><p>Traditional Chinese medicine has reported a number of medicinal material (including herbs) having antiseptic, antiperspirant and deodourant effects.</p><p>The selected material included two herbs and two solid powders.</p><p>The medicinal herbs are:</p><p>i) Mori Follium (Mulberry leaves) is the leaves of the mulberry tree have been reported since the Ming Dynasty in China to be an effective antiperspirant (本草?目李?珍Li Shi-Zhen, Compendium of Materia Medica) when used as an oral concoction. Using Mori Follium as a local agent has not been reported [<xref ref-type="bibr" rid="scirp.74555-ref6">6</xref>] .</p><p>ii) Fraxini Cortex. The cortex of the plant has been used systemically as an antiperspirant. In the laboratory, special extracts of Fraxinus Rhynchophylla have been proven to have antiperspirant effects through fluorescence tests using the protein constitutions of human skin and comparing with a potent in-organic antiperspirant aluminum polychloride [<xref ref-type="bibr" rid="scirp.74555-ref7">7</xref>] .</p><p>The solid powders are:</p><p>iii) Calamine powder. Although calamine lotion has been known as a common inert and perhaps anti-allergic topical agent among family physicians dermatologists, calamine powder in Traditional Chinese medicine is advocated as an anti-inflammatory, anti-allergic, deodourant and antiperspirant agent. The powder is obtained from a soft stone and is found to contain silicone and traces of Zinc Oxide [<xref ref-type="bibr" rid="scirp.74555-ref8">8</xref>] .</p><p>iv) Zinc oxide powder. The Zinc oxide cream or paste has been widely used in clinical practice as an inert cleaning material for irritable skin among babies and dependents requiring diapers. Zinc oxide has also been utilized in Traditional medicine as a dry powder created from a soft stone for itchy skin and dermatitis. It is antiseptic and anti-allergic [<xref ref-type="bibr" rid="scirp.74555-ref9">9</xref>]</p><sec id="s2_1"><title>2.1. The Diaper</title><p>A heavy duty absorbent diaper of mixed cotton and synthetic material was chosen (<xref ref-type="fig" rid="fig1">Figure 1</xref>). The medicinal herbs were prepared as aqueous extracts in the standard way (boiling for two hours followed by filtering out). After dehydration and drying processes, the extracts were converted to the powder form.</p><p>A special window was created behind the inner layer of the diaper leading the way into a pocket which held 1 gram each of the powders, viz, of Mori Follium, Fraxini Cortex, Calamine and Zinc oxide. The medicinal powders were well concealed so that there would be no direct contact with the perineal skin. After</p><fig id="fig1"  position="float"><label><xref ref-type="fig" rid="fig1">Figure 1</xref></label><caption><title> The Diaper before and after application for six hours</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/1-2420215x2.png"/></fig><p>full soaking with urine, the powders would diffuse out to achieve direct interactions with the micro-environment [<xref ref-type="bibr" rid="scirp.74555-ref10">10</xref>] [<xref ref-type="bibr" rid="scirp.74555-ref11">11</xref>] .</p></sec><sec id="s2_2"><title>2.2. Design of the Study</title><p>The study is designed to consist of preliminary Laboratory platform experiments to confirm the antiseptic, antiperspirant and deodourant effects of the medicinal materials; thence clinical studies to test the antiperspirant effects and the overall improvements in the quality of life of the dependent users.</p><sec id="s2_2_1"><title>2.2.1. Laboratory Studies</title><p>i) Prevention of Sepsis:</p><p>Bacteriological tests for the common pathogens of the perineal region [<xref ref-type="bibr" rid="scirp.74555-ref12">12</xref>] .</p><p>ii) Control of Sweating:</p><p>Sweating involves complex mechanisms dependent on the sensitivity and activity of cellular tissues within the sweat glands which also responds to neurological messages sent from the cerebrum along the autonomic nerves. Platform study therefore includes (a) Direct explorations on the direct effects of the medicinal agents on the cellular activities, and (b) Explorations on the cholinergic responses of the glandular cells to neurological messages [<xref ref-type="bibr" rid="scirp.74555-ref13">13</xref>] [<xref ref-type="bibr" rid="scirp.74555-ref14">14</xref>] .</p><p>iii) Deodourant effects:</p><p>Special laboratory tests were performed to verify the deodouring effects of the agents against specific odours of ammonia, acetic acid, hydrogen sulphide and methyl mercaptan [<xref ref-type="bibr" rid="scirp.74555-ref15">15</xref>] [<xref ref-type="bibr" rid="scirp.74555-ref16">16</xref>]</p></sec><sec id="s2_2_2"><title>2.2.2. Clinical Testings</title><p>i) Antiperspirant effects of the medicinal herbs</p><p>A convenient sweating assessment machine―the Sudoscan, was utilized as an objective tool to assess the state of sweating in the soles of volunteers before and after they bathed their feet in a warm pool of herbal extracts [<xref ref-type="bibr" rid="scirp.74555-ref17">17</xref>] [<xref ref-type="bibr" rid="scirp.74555-ref18">18</xref>] .</p><p>ii) A pilot clinical trial on dependent older and severely disabled people using the innovative herbal extract impregnated diapers.</p><p>Volunteers belonging to the frail older group and disable were recruited in an elderly home to try the special diaper for a fixed period of six hours per day for five days, comparing the different experiences of comfort, skin situations, and odour, between the old and new diapers [<xref ref-type="bibr" rid="scirp.74555-ref19">19</xref>] .</p></sec></sec></sec><sec id="s3"><title>3. Results</title><sec id="s3_1"><title>3.1. Laboratory Studies</title><p>Prevention of Sepsis―both Mori Follium and Fraxini Cortex extracts effectively killed strains of Staphylococcus aureus, E. Coli and Candida Fungus. (Special laboratory report from Bacteriological Laboratory of Faculty of Medicine Jinan University Guangzhou using the standard bacteriological cultural requirements) [<xref ref-type="bibr" rid="scirp.74555-ref20">20</xref>] .</p><p>Control of Sweating. Sweating is initiated through the release of acetylcholine (ACH) via a central control transmitted along the sympathic system. ACH is deactivated by a specific enzyme ACH esterase. The cellular activity of sweat gland can be revealed through the assessment of ACH esterase activities under the influence of herbal agents (i.e. Mori Follium and Fraxini Cortex) [<xref ref-type="bibr" rid="scirp.74555-ref21">21</xref>] .</p><p>The results showed that the herbal extracts enhanced ACH esterase activities. Full report is being prepared for publication.</p><p>Deodorant Effects. Results done in “Expert Japanese Laboratory for deodorization testing” in Shanghai showed very good deodouring effects in Ammonia, Acetic acid, Hydrogen Sulphide and Methyl mercaptan chambers [<xref ref-type="bibr" rid="scirp.74555-ref16">16</xref>] . <xref ref-type="fig" rid="fig2">Figure 2</xref> showed the test results.</p></sec><sec id="s3_2"><title>3.2. Clinical Studies</title><p>Sweating Control using the Sudoscan</p><p>Sudoscan uses low Direct Current Stimulation to stimulate topical sweating from hands and feet, then chloride ions are extracted from the sweat to create a current when the electrically charged ions encounter specific electrodes. Sudoscan then measures the electrochemical skin conductance (ESC) of the hands and feet through reverse iontophoresis, and the ESC readings indicate the extensiveness of sweating [<xref ref-type="bibr" rid="scirp.74555-ref22">22</xref>] . In the trial, comparing with pre-treatment with the herbal extracts, Sudoscan tests showed a 15.3% reduction in sweat production after 15 minutes of topical immersion in the herbal bath. A full report has been published. [<xref ref-type="bibr" rid="scirp.74555-ref22">22</xref>] .</p><p>A pilot trial recruited 31 severely disabled volunteers who required over-night diapers. They wore the medicinal herbs bearing diapers in the Elderly Rehabilitation Home for 5 days, six hours per day and subjectively compared their experience on the special apparel. Feedback and questionnaires were obtained from the volunteers themselves and their immediate attendants. Compared with the diapers they used to wear, majority of volunteers appreciated the trial diapers</p><fig id="fig2"  position="float"><label><xref ref-type="fig" rid="fig2">Figure 2</xref></label><caption><title> Dedorant effects of the Herbal Formulae (In Japanese)</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/1-2420215x3.png"/></fig><p>which absorbed urine well, reduced unpleasant odour, gave better perineal comfort and less itching. No ulceration in the perineal region was found.</p><p><xref ref-type="table" rid="table1">Table 1</xref> gives a summary of the results of the clinical trial.</p><p>One additional safe-guard measure has been done to eliminate the possibility of allergic reactions arising from the medicinal herbs in topical skin contacts. Using test Kits (Mattek Corporation) and (Epi Derm, EPI 200) to verify whether the extracts could cause allergic reactions showed no allergic responses to the herbal extracts</p></sec></sec><sec id="s4"><title>4. Discussion</title><p>Urinary incontinence has been defined by the International Society as “any urinary leakage” [<xref ref-type="bibr" rid="scirp.74555-ref1">1</xref>] and it is a common symptom not only among old people but</p><table-wrap id="table1" ><label><xref ref-type="table" rid="table1">Table 1</xref></label><caption><title> 31 subjects in a self-control study: overall results of evaluation after completion of the trial use of special diapers</title></caption><table><tbody><thead><tr><th align="center" valign="middle" ></th><th align="center" valign="middle" >Special Diaper</th><th align="center" valign="middle" >Diaper without Medicinal Material</th></tr></thead><tr><td align="center" valign="middle" >Leakage</td><td align="center" valign="middle" >5%</td><td align="center" valign="middle" >90%</td></tr><tr><td align="center" valign="middle" >Comfort</td><td align="center" valign="middle" >90%</td><td align="center" valign="middle" >50%</td></tr><tr><td align="center" valign="middle" >Foul smelling</td><td align="center" valign="middle" >20%</td><td align="center" valign="middle" >70%</td></tr><tr><td align="center" valign="middle" >Healthy skin condition</td><td align="center" valign="middle" >90%</td><td align="center" valign="middle" >60%</td></tr><tr><td align="center" valign="middle" >Overall Satisfaction</td><td align="center" valign="middle" >Much Better 79%</td><td align="center" valign="middle" ></td></tr></tbody></table></table-wrap><p>also among those suffering from paraplegia. It has been estimated that 30% - 40% people over 65 years of age living in their own accommodations suffer from incontinence, while those living in nursing homes have an even higher prevalence [<xref ref-type="bibr" rid="scirp.74555-ref2">2</xref>] . The problem affects the quality of life of sufferers and causes dependency, sleep disturbances and downgrades the person’s dignity and mood [<xref ref-type="bibr" rid="scirp.74555-ref23">23</xref>] . In the busy, possibly crowded settings of old peoples’ home, incontinence tends to significantly affect the environmental hygiene and careers’ moral [<xref ref-type="bibr" rid="scirp.74555-ref4">4</xref>] . Frail older persons often suffer from co-existing illnesses and co-morbidities which require intensive assistance from health care staff and further deprive them of available caring time.</p><p>Under such adverse reality, the creation of rehabilitation devices that could improve the quality of life of the old people with incontinence and possibly relieve the workload of the carers would be very much appreciated. Among community-dwelling older persons, although incontinence pads (diapers) and toileting programs have been commonly used, but the results are disappointing [<xref ref-type="bibr" rid="scirp.74555-ref2">2</xref>] .</p><p>The creation of a diaper that would prevent leakage, prevent common skin complications like infection and allergy and improve the odour arising from incontinence is an innovative endeavor. The practical value of the diaper needs to be proven through clinical tests and the cost of production must be affordable to the general public.</p><p>There are medicinal herbs used in Traditional Medicine for the control of sweating and other medicinal powder for the protection of skin hygiene. When such simple medicinal materials are impregnated into the fabric of a diaper, there is good chance that the perineal skin could be better protected because of the improved dryer micro-environment, the better antiseptic, antiperspirant and deodouring effects [<xref ref-type="bibr" rid="scirp.74555-ref6">6</xref>] [<xref ref-type="bibr" rid="scirp.74555-ref7">7</xref>] [<xref ref-type="bibr" rid="scirp.74555-ref10">10</xref>] .</p><p>We have started our research in two stages. Firstly the herbal products were subjected to bacterial and biochemical platforms to investigate their antiseptic, antiperspirant and deodourant effects which were all proven effective. Then, a pilot trial conducted in an elderly home to obtain users information directly from the incontinent sufferers and their attendants. The results have been highly encouraging.</p></sec><sec id="s5"><title>5. Conclusion</title><p>A simple diaper with good absorbent abilities and antiseptic, antiperspirant and deodourant effects could be made with the incorporation of simple medicinal powders used in Traditional Medicine. Its value on the quality of life of the incontinent people has been proven among a small group of volunteer users. It is also expected that this simple device would also simplify the supportive role of the carers.</p></sec><sec id="s6"><title>Acknowledgements</title><p>Special gratitude is given to the “8765 Diabetes” Clinical Services which kindly arranged the application of the SUDOSCAN. We also thank the Neighbourhood Advice-Action Council, Harmony Manor and its staff which provided clinical support for the medicinal herbs bearing diapers study.</p></sec><sec id="s7"><title>Funding</title><p>The work was supported by Innovation and Technology Fund of the Government of Hong Kong Special Administrative Region (Project Code: ITS/370/14).</p></sec><sec id="s8"><title>Cite this paper</title><p>Wat, E., Lin, A.W.L., Mak, C., Lam, I., Lau, C.B.-S., Ng, F.S.-F., Hui, P.C.-L. and Leung, P.-C. (2017) An Innovative Antiseptic, Antiperspirant and Deodourant Diaper for the Older and Frail Older People Suffering from Urinary Incontinence. 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