<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">WJCD</journal-id><journal-title-group><journal-title>World Journal of Cardiovascular Diseases</journal-title></journal-title-group><issn pub-type="epub">2164-5329</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/wjcd.2016.611045</article-id><article-id pub-id-type="publisher-id">WJCD-72218</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  Epidemiology of Cardiovascular Diseases in Children at the Teaching Hospital of Brazzaville, Congo
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Anne</surname><given-names>Berthe M’pemba Loufoua-Lemay</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Alphonse</surname><given-names>Massamba</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Department of Pediatrics, University of Brazzaville Hospital, Brazzaville, Congo</addr-line></aff><aff id="aff2"><addr-line>Laboratory of Health, Exercise Physiology and Biomechanics, Superior Institute of Physical Education, University Marien Ngouabi, Braz-zaville, Congo</addr-line></aff><pub-date pub-type="epub"><day>03</day><month>11</month><year>2016</year></pub-date><volume>06</volume><issue>11</issue><fpage>410</fpage><lpage>424</lpage><history><date date-type="received"><day>October</day>	<month>16,</month>	<year>2016</year></date><date date-type="rev-recd"><day>Accepted:</day>	<month>November</month>	<year>21,</year>	</date><date date-type="accepted"><day>November</day>	<month>24,</month>	<year>2016</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  Context: Several studies were conducted throughout the world on heart diseases in children; no data is available in Congolese child. 
  Objective: To evaluate epidemiological profile of Congolese children and teenager carrying cardiovascular diseases. 
  Methods: A descriptive and prospective study was carried out during 4 years in the pediatric department of teaching hospital of Brazzaville, near the children received in consultation of pediatric cardiology. 
  Results: On 41,472 patients admitted in pediatric service, 526 patients were received in consultation for suspicion of heart diseases. Among them, 444 had cardiopathy (incidence of 10.7‰). It was about a congenital heart disease to 316 (60%) incidence of 7.6‰; Acquired heart disease to 128 (24.4%) incidence of 3.1‰. Among congenital heart defects observed frequency of patients with ASD was 20.3%, isolated in 10.1% of cases, and associated with ECD (11.8%). The VSD was observed in 30.1% of cases, and the Tetralogy of Fallot in 10.1% of cases. Among the acquired heart diseases, severe hypo kinetic dilated cardiomyopathy (DCM) was noted in 24.4% of cases. The rheumatic heart diseases accounted for 41.4% of cases. It was mitral regurgitation (33.6%), a mitral stenosis (1.6%). Pericarditis was objectified at 10.1% of the patients. The evolution was favorable for 43.3% of patients. An aggravation of symptoms was observed to 2.7% of patients. Mortality was 11.9% and 71.9% of deaths were observed to not operate carriers of congenital heart disease. 69.9% of dead patients were carrying a cyanogen heart disease. Left to right shunt represented 21.7% of the deaths. 
  Conclusion: Heart diseases are real problem of public health for Congolese children.
 
</p></abstract><kwd-group><kwd>Congenital Heart Diseases</kwd><kwd> Acquired Heart Diseases</kwd><kwd> Children</kwd><kwd> Brazzaville</kwd><kwd> Sub-Saharan Africa</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>The heart diseases are various origins. Being able congenital or to be acquired, they touch nearly 1% of the population with regard to congenital heart diseases and 5% of the children in others countries as regards the acquired forms [<xref ref-type="bibr" rid="scirp.72218-ref1">1</xref>] . In the tropical countries, they became a major problem of infant and youthful health. Indeed, the cardiac child is a true problem of public health in the countries in the process of development, concerning up to 3% to 4% of children with diseases very invalidating and very expensive for their family and the society [<xref ref-type="bibr" rid="scirp.72218-ref1">1</xref>] . In sub-Saharan Africa, the prevalence of heart diseases in youth medium is estimated at approximately 8 per thousand alive births for the congenital heart diseases and at least 1 to 14 per thousand for the rheumatic heart diseases. However, these data remain approximate, the relevant statistical data are usually vague, or do not exist [<xref ref-type="bibr" rid="scirp.72218-ref2">2</xref>] . The situation for sub-Saharan is linked to pernicious environmental conditions like poverty, infections, and poor health habits might exert a deleterious influence [<xref ref-type="bibr" rid="scirp.72218-ref1">1</xref>] . In addition, these cardiac pathologies, during the growth, are increasingly frequent in Congo, with established associated forms. Their prevalence seems to rise of ignorance or refusal of an awakening of certain medical pathologies, like the AIDS and the anginas with streptococcus. With that, the archaism or the absence of medical resources is added, then multiplying the harmful effects of these diseases. Moreover, the prevalence of infectious and parasitic diseases relegates to the second rank the cardiac pathology of the child. It is in this context that heart diseases are described very little in Congo where there exist few publications on cardiovascular pathology of the child. Also, we therefore investigated epidemiologic aspects of cardiac pathologies observed in pediatric department of the teaching hospital of Brazzaville. The objectives specifically assigned to this study are to evaluate the prevalence of heart diseases in Congolese child and teenager and to specify type of heart diseases observed.</p></sec><sec id="s2"><title>2. Material and Methods</title><sec id="s2_1"><title>2.1. Topics</title><p>The study, descriptive and prospective, was carried out with the teaching hospital of Brazzaville. Patients aged 0 - 15 years received in consultation of pediatric cardiology during the period of 1st June 2009-1st June 2013. The population of Brazzaville, for this period, was 1,373,382 inhabitants.</p></sec><sec id="s2_2"><title>2.2. Methods</title><p>The present work reports on 526 consecutive Congolese young patients admitted or followed up in teaching hospital of Brazzaville. The two-dimensional echocardiography, carried out with an apparatus portable Doppler color (Mr.-Turbo Sonosite, Bothell, USA) was done for all the patients. The interest data were age, gender, reason for consultation, type of cardiopathy, existence or not of an operational indication, existence or not of a surgical assumption of responsibility and evolution.</p></sec><sec id="s2_3"><title>2.3. Statistical Analysis</title><p>They were noted on individual record sheets of collection. We used Epi Info version 6.5.1 (WHO &amp; CDC) to enter and clean the data, and SPSS (Statistical Package for Social Science) version 16.0 (SPSS Inc, Chicago, IL, USA) to analyze the data. The p-value, less than 0.05, was regarded as the statistical threshold of significance. The quantitative information was expressed on average accompanied by the standard deviation, the frequencies in the form of percentages. Chi square and Sokal tests were used for comparing categorical and qualitative variables. The comparisons between various groups of heart diseases, like between sex and groups of ages, were carried out using the test of the χ<sup>2</sup> of Spearman when indicated.</p></sec></sec><sec id="s3"><title>3. Results</title><sec id="s3_1"><title>3.1. Distribution of the Patients by Age and Gender (<xref ref-type="table" rid="table1">Table 1</xref>)</title><p>For the period of study, the number of consultations to the teaching hospital rose with 68,352 patients, including 41,472 patients in pediatry (60.7%). On the whole, 526 patients were received in pediatric consultations of cardiology (1.3%). The present serie comprised 284 (54%) girls and 242 (46%) boys (sex ratio of 0.85). The average age of the patients was 2053 days, either 5 years 7 months (2109 days or 8 months for the girls; 1997 days either or 5 months for the boys) with range: 4 days - 5400 days (15 years). The distribution of the patients according to the age is reported in <xref ref-type="table" rid="table1">Table 1</xref>.</p></sec><sec id="s3_2"><title>3.2. Distribution According to the Reason for Consultation (<xref ref-type="table" rid="table2">Table 2</xref>)</title><p>The reasons for consultation were summarized with the appearance of a respiratory distress in 26.6% of cases; respiratory distress associated a murmur heart in 8.2% of</p><table-wrap id="table1" ><label><xref ref-type="table" rid="table1">Table 1</xref></label><caption><title> Distribution of patients as function as age and gender</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Age bracket (days)</th><th align="center" valign="middle" >Girls (n)</th><th align="center" valign="middle" >Boys (n)</th><th align="center" valign="middle" >Total (n)</th><th align="center" valign="middle" >Frequency (%)</th></tr></thead><tr><td align="center" valign="middle" >0 - 90</td><td align="center" valign="middle" >51</td><td align="center" valign="middle" >42</td><td align="center" valign="middle" >93</td><td align="center" valign="middle" >17.7</td></tr><tr><td align="center" valign="middle" >91 - 360</td><td align="center" valign="middle" >74</td><td align="center" valign="middle" >52</td><td align="center" valign="middle" >126</td><td align="center" valign="middle" >24.0</td></tr><tr><td align="center" valign="middle" >361 - 1080</td><td align="center" valign="middle" >52</td><td align="center" valign="middle" >42</td><td align="center" valign="middle" >94</td><td align="center" valign="middle" >17.9</td></tr><tr><td align="center" valign="middle" >1081 - 2160</td><td align="center" valign="middle" >38</td><td align="center" valign="middle" >49</td><td align="center" valign="middle" >87</td><td align="center" valign="middle" >16.6</td></tr><tr><td align="center" valign="middle" >2161 - 3240</td><td align="center" valign="middle" >20</td><td align="center" valign="middle" >22</td><td align="center" valign="middle" >42</td><td align="center" valign="middle" >8.0</td></tr><tr><td align="center" valign="middle" >3241 - 4320</td><td align="center" valign="middle" >24</td><td align="center" valign="middle" >19</td><td align="center" valign="middle" >43</td><td align="center" valign="middle" >8.2</td></tr><tr><td align="center" valign="middle" >4321 - 5400</td><td align="center" valign="middle" >25</td><td align="center" valign="middle" >16</td><td align="center" valign="middle" >40</td><td align="center" valign="middle" >7.6</td></tr><tr><td align="center" valign="middle" >Total</td><td align="center" valign="middle" >284</td><td align="center" valign="middle" >242</td><td align="center" valign="middle" >526</td><td align="center" valign="middle" >100</td></tr></tbody></table></table-wrap><table-wrap id="table2" ><label><xref ref-type="table" rid="table2">Table 2</xref></label><caption><title> Reasons for consultation</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Reasons</th><th align="center" valign="middle" >Number</th><th align="center" valign="middle" >frequency %</th></tr></thead><tr><td align="center" valign="middle" >Dyspnea</td><td align="center" valign="middle" >140</td><td align="center" valign="middle" >26.6</td></tr><tr><td align="center" valign="middle" >Dyspnea with heart murmur</td><td align="center" valign="middle" >43</td><td align="center" valign="middle" >8.2</td></tr><tr><td align="center" valign="middle" >Heart murmur</td><td align="center" valign="middle" >97</td><td align="center" valign="middle" >18.4</td></tr><tr><td align="center" valign="middle" >Cyanosis</td><td align="center" valign="middle" >27</td><td align="center" valign="middle" >5.1</td></tr><tr><td align="center" valign="middle" >Chimiotherapy</td><td align="center" valign="middle" >27</td><td align="center" valign="middle" >5.1</td></tr><tr><td align="center" valign="middle" >Follow up of known cardiopathy</td><td align="center" valign="middle" >108</td><td align="center" valign="middle" >20.6</td></tr><tr><td align="center" valign="middle" >Cardiomegaly</td><td align="center" valign="middle" >11</td><td align="center" valign="middle" >2.1</td></tr><tr><td align="center" valign="middle" >Down syndrome</td><td align="center" valign="middle" >11</td><td align="center" valign="middle" >2.1</td></tr><tr><td align="center" valign="middle" >Arrhythmia</td><td align="center" valign="middle" >11</td><td align="center" valign="middle" >2.1</td></tr><tr><td align="center" valign="middle" >Poly malformatif syndrome</td><td align="center" valign="middle" >18</td><td align="center" valign="middle" >3.4</td></tr><tr><td align="center" valign="middle" >Chest pain</td><td align="center" valign="middle" >10</td><td align="center" valign="middle" >2.0</td></tr><tr><td align="center" valign="middle" >Kawasaki disease</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >1.1</td></tr><tr><td align="center" valign="middle" >Poor growth</td><td align="center" valign="middle" >11</td><td align="center" valign="middle" >2.1</td></tr><tr><td align="center" valign="middle" >Pre operative assessment</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >1.1</td></tr><tr><td align="center" valign="middle" >Total</td><td align="center" valign="middle" >526</td><td align="center" valign="middle" >100</td></tr></tbody></table></table-wrap><p>cases, perception of murmur heart in 18.4% of the cases. The assessment of cyanosis and therapeutic pre-assessment for an anti-cancer chemotherapy were the reasons for consultation in 5.1% of cases. In addition, 20.6% of patients consulted within the framework of the follow-up of a known cardiopathy from which 18.4 % had already profited from a surgical assumption of responsibility. The discovery of a cardiomegaly on radiographies of thorax, the assessment of Down syndrome, arrhythmias were found respectively in 2.1% of cases. The assessment of polymalformative syndrome justified the consultation in 3.1% of cases. The other reasons for consultation were pains of left hemi thorax, suspicion of syndrome of Kawasaki, presence of hypotrophy, or preoperative assessment at homozygous sickle cell diseases (<xref ref-type="table" rid="table2">Table 2</xref>).</p></sec><sec id="s3_3"><title>3.3. Distribution According to the Existence or Not of Cardiac Diseases</title><p>On the whole, 82 (15.6%) patients presented a normal aspect of the heart. However, 444 patients had cardiopathy with an incidence of 10.7‰. It was about congenital heart diseases at 316 (60%) patients either an incidence of 7.6‰ and acquired heart diseases at 128 (24.4%) patients with an incidence of 3.1‰.</p></sec><sec id="s3_4"><title>3.4. Distribution of the Patients with Congenital Heart Diseases According to Age and Gender (<xref ref-type="table" rid="table3">Table 3</xref>)</title><p>The population of the patients with congenital heart diseases comprised 173 girls and</p><table-wrap id="table3" ><label><xref ref-type="table" rid="table3">Table 3</xref></label><caption><title> Distribution according to age and gender for patients with congenital heart diseases</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Age bracket (days)</th><th align="center" valign="middle" >Girls (n)</th><th align="center" valign="middle" >Boys (n)</th><th align="center" valign="middle" >Total (n)</th><th align="center" valign="middle" >Frequency (%)</th></tr></thead><tr><td align="center" valign="middle" >0 - 90</td><td align="center" valign="middle" >38</td><td align="center" valign="middle" >31</td><td align="center" valign="middle" >69</td><td align="center" valign="middle" >21.9</td></tr><tr><td align="center" valign="middle" >91 - 360</td><td align="center" valign="middle" >64</td><td align="center" valign="middle" >36</td><td align="center" valign="middle" >100</td><td align="center" valign="middle" >31.7</td></tr><tr><td align="center" valign="middle" >361 - 1080</td><td align="center" valign="middle" >37</td><td align="center" valign="middle" >33</td><td align="center" valign="middle" >70</td><td align="center" valign="middle" >22.2</td></tr><tr><td align="center" valign="middle" >1081 - 2160</td><td align="center" valign="middle" >18</td><td align="center" valign="middle" >26</td><td align="center" valign="middle" >44</td><td align="center" valign="middle" >14.0</td></tr><tr><td align="center" valign="middle" >2161 - 3240</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >12</td><td align="center" valign="middle" >3.8</td></tr><tr><td align="center" valign="middle" >3241 - 4320</td><td align="center" valign="middle" >5</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >11</td><td align="center" valign="middle" >3.5</td></tr><tr><td align="center" valign="middle" >4321 - 5400</td><td align="center" valign="middle" >5</td><td align="center" valign="middle" >5</td><td align="center" valign="middle" >10</td><td align="center" valign="middle" >2.8</td></tr><tr><td align="center" valign="middle" >Total</td><td align="center" valign="middle" >173</td><td align="center" valign="middle" >143</td><td align="center" valign="middle" >316</td><td align="center" valign="middle" >100</td></tr></tbody></table></table-wrap><p>143 boys (sex-ratio to 0.83). The average age bordered 2087 days is 7 months (range: 4 - 15 years). The old patients aged to 0 - 3 years represented 75.9% of manpower; moreover, 53.6% of patients were less than one year old. The patients of more than 12 years represented 7.3% of manpower.</p></sec><sec id="s3_5"><title>3.5. Distribution According to the Type of Congenital Heart Diseases Observed (<xref ref-type="table" rid="table4">Table 4</xref> and <xref ref-type="table" rid="table5">Table 5</xref>)</title><p>The atrial septal defect (ASD) was objectified in 20.3% of the cases (<xref ref-type="fig" rid="fig1">Figure 1</xref>). It was insulated in 10.5% from cases and was associated aendocardial cushion defect (ECD) in 11.8% of cases (<xref ref-type="fig" rid="fig2">Figure 2</xref>). A ventricular septal defect (VSD) was observed in 30.1% of cases, insulated in 24.4% from cases (<xref ref-type="fig" rid="fig3">Figure 3</xref>). The Tetralogy of Fallot was found among 32 patients (10.1% of cases).</p></sec><sec id="s3_6"><title>3.6. Congenital Heart Diseases and Chromosomal Anomalies</title><p>Among the 27 patients with Down syndrome 19 girls and 8 boys were found (sex-ratio to 0.42). Ten eights of these patients were carrying endocardial cushion defect (ECD), that is to say 66.7% of patients with Down syndrome; they were 14 girls and 4 boys versus 5 carriers of ECD among patients without Down syndrome. Association the ASD ostium secondum and ECD was observed only among 8 patients with Down syndrome (44.4%). Other cardiac malformations were observed on this ground: the ASD ostium secondum insulated among two patients, the ASD ostium secondum and VSD perished membranous in two cases, VSD perished membranous and PDA at a patient, VSD insulated among three patients. A patient presented a heart without anomaly, (3.7 % from Down syndrome).</p><p>A syndrome of Noonan was observed among three carrying patients presented respectively pulmonary valvular stenosis, VSD of type III with PDA and ASD ostium secondum. In addition, two patients of same fratry were carrying a severe hypokinetic dilated cardiomyopathy of origin family (form related to X).</p><fig id="fig1"  position="float"><label><xref ref-type="fig" rid="fig1">Figure 1</xref></label><caption><title> Atrio septal defect</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/3-1910608x2.png"/></fig><fig id="fig2"  position="float"><label><xref ref-type="fig" rid="fig2">Figure 2</xref></label><caption><title> Endocardial cushion defect with atrio septal defect ostium primum</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/3-1910608x3.png"/></fig><fig id="fig3"  position="float"><label><xref ref-type="fig" rid="fig3">Figure 3</xref></label><caption><title> Ventricular septal defect</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/3-1910608x4.png"/></fig><table-wrap id="table4" ><label><xref ref-type="table" rid="table4">Table 4</xref></label><caption><title> Distribution of patients as function as type of congenital heart diseases</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Type of heart defects</th><th align="center" valign="middle" >Girls (n)</th><th align="center" valign="middle" >Boys (n)</th><th align="center" valign="middle" >Total (n)</th><th align="center" valign="middle" >Frequency (%)</th></tr></thead><tr><td align="center" valign="middle" >ASD</td><td align="center" valign="middle" >37</td><td align="center" valign="middle" >27</td><td align="center" valign="middle" >64</td><td align="center" valign="middle" >20.3</td></tr><tr><td align="center" valign="middle" >ASD insulated</td><td align="center" valign="middle" >21</td><td align="center" valign="middle" >12</td><td align="center" valign="middle" >33</td><td align="center" valign="middle" >10.5</td></tr><tr><td align="center" valign="middle" >Associated to: VSD</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >8</td><td align="center" valign="middle" >14</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >ECD</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >8</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PDA</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >DORV</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PS</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PAIVS</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >VSD</td><td align="center" valign="middle" >46</td><td align="center" valign="middle" >49</td><td align="center" valign="middle" >95</td><td align="center" valign="middle" >30.1</td></tr><tr><td align="center" valign="middle" >VSD insulated</td><td align="center" valign="middle" >40</td><td align="center" valign="middle" >37</td><td align="center" valign="middle" >77</td><td align="center" valign="middle" >24.4</td></tr><tr><td align="center" valign="middle" >Associated to: TGA</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PS</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PDA</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >5</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >AR</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >Dextrocardy</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >ECD</td><td align="center" valign="middle" >16</td><td align="center" valign="middle" >8</td><td align="center" valign="middle" >24</td><td align="center" valign="middle" >7.6</td></tr><tr><td align="center" valign="middle" >insulated</td><td align="center" valign="middle" >9</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >10</td><td align="center" valign="middle" >2.2</td></tr><tr><td align="center" valign="middle" >Associated to: ASD os</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >8</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PDA</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >DORV</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >aorto ventricular chanel</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >Pulmonary atresia</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PDA</td><td align="center" valign="middle" >21</td><td align="center" valign="middle" >16</td><td align="center" valign="middle" >37</td><td align="center" valign="middle" >11.7</td></tr><tr><td align="center" valign="middle" >Associated to: ECD</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >VSD</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >5</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >Tetralogy of Fallot</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >ASD</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >DORV</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" >2.2</td></tr><tr><td align="center" valign="middle" >Associated to: PS</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PDA</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >SV</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >0.6</td></tr><tr><td align="center" valign="middle" >Associated to: PTA (persistent truncus arteriosus)</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >Hypoplatic left heart</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >0.6</td></tr><tr><td align="center" valign="middle" >Associated to: GAT</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >GAT</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >0.9</td></tr><tr><td align="center" valign="middle" >Associated to: VSD</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >Hypoplastic left heart</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr></tbody></table></table-wrap><p>ASD: atrio septal defect; ECD: endocardial cushion defect; VSD: ventricular septal defect; GAT: great artery transposition; PS: pulmonary stenosis; AR: aortic regurgitation; DORV: double-outlet right ventricle; PAIVS: pulmonary atresia with intact ventricular septum; PAVSD: pulmonary atresia with ventricular septal defect; PDA: patent ductus arteriosus.</p><table-wrap id="table5" ><label><xref ref-type="table" rid="table5">Table 5</xref></label><caption><title> Other types of congenital heart diseases observed</title></caption><table><tbody><thead><tr><th align="center" valign="middle" ></th><th align="center" valign="middle" >Girls (n)</th><th align="center" valign="middle" >Boys (n)</th><th align="center" valign="middle" >Total (n)</th><th align="center" valign="middle" >Frequency (%)</th></tr></thead><tr><td align="center" valign="middle" >Tetralogy of Fallot</td><td align="center" valign="middle" >12</td><td align="center" valign="middle" >20</td><td align="center" valign="middle" >32</td><td align="center" valign="middle" >10.1</td></tr><tr><td align="center" valign="middle" >Associated to: PDA</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PS</td><td align="center" valign="middle" >21</td><td align="center" valign="middle" >10</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >29.8</td></tr><tr><td align="center" valign="middle" >Insulated</td><td align="center" valign="middle" >15</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" >22</td><td align="center" valign="middle" >7.0</td></tr><tr><td align="center" valign="middle" >Associated to: DORV</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >0.6</td></tr><tr><td align="center" valign="middle" >VSD</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >ASD</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >PAVSD</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >7</td><td align="center" valign="middle" >11</td><td align="center" valign="middle" >3.5</td></tr><tr><td align="center" valign="middle" >PAIVS</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0.3</td></tr><tr><td align="center" valign="middle" >Ebstein’s anomaly</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >0.6</td></tr><tr><td align="center" valign="middle" >pulmonary ectasia</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0.3</td></tr><tr><td align="center" valign="middle" >cor Triatriatum</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0.3</td></tr><tr><td align="center" valign="middle" >PTA</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >5</td><td align="center" valign="middle" >1.6</td></tr><tr><td align="center" valign="middle" >Associated to: SV</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0.3</td></tr><tr><td align="center" valign="middle" >long QT syndrome</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0.3</td></tr><tr><td align="center" valign="middle" >Rabdomyoma of tuberous sclerosis of Bourneville</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0.3</td></tr></tbody></table></table-wrap></sec><sec id="s3_7"><title>3.7. Distribution of the Patients with Acquired Heart Diseases According to Age and Gender (<xref ref-type="table" rid="table6">Table 6</xref>)</title><p>They were found among 68 girls and 60 boys (sex-ratio to 0.88). The average age of these patients was 2012 days (5 years 5 months). Among them, 82.8% of the patients were old of more than 3 years.</p></sec><sec id="s3_8"><title>3.8. Distribution According to Type of Acquired Heart Diseases (<xref ref-type="table" rid="table7">Table 7</xref>)</title><p>The severe hypokinetic dilated cardiomyopathy was noted in 24.2% of cases and they were observed in all the age brackets. The rheumatic heart diseases represented 41.4% of cases. Their incidence in the population of child received at the teaching hospital of Brazzaville for the period of study was 1.1‰. These rheumatic heart diseases were observed as of 3 years. The lesions observed were mitral regurgitation (MR) in 3.6 % of cases (43 patients), associated to aortic regurgitation among 2.3 % of patients (3 cases) and mitral stenosis (MS) in 1.6% of cases (<xref ref-type="fig" rid="fig4">Figure 4</xref>). A pericarditis was objectified at 10.1% of patients.</p><p>A suffering patient of an infection with AIDS was carrying a myocarditis.</p><table-wrap id="table6" ><label><xref ref-type="table" rid="table6">Table 6</xref></label><caption><title> Distribution according to age and gender of patients with acquired heart diseases</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Age bracket (days)</th><th align="center" valign="middle" >Girls (n)</th><th align="center" valign="middle" >Boys (n)</th><th align="center" valign="middle" >Total (n)</th><th align="center" valign="middle" >Frequency (%)</th></tr></thead><tr><td align="center" valign="middle" >0 - 90</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >6</td><td align="center" valign="middle" >4.7</td></tr><tr><td align="center" valign="middle" >91 - 360</td><td align="center" valign="middle" >5</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >8</td><td align="center" valign="middle" >6.2</td></tr><tr><td align="center" valign="middle" >361 - 1080</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >8</td><td align="center" valign="middle" >6.2</td></tr><tr><td align="center" valign="middle" >1081 - 2160</td><td align="center" valign="middle" >15</td><td align="center" valign="middle" >16</td><td align="center" valign="middle" >31</td><td align="center" valign="middle" >24.2</td></tr><tr><td align="center" valign="middle" >2161 - 3240</td><td align="center" valign="middle" >8</td><td align="center" valign="middle" >14</td><td align="center" valign="middle" >22</td><td align="center" valign="middle" >17.2</td></tr><tr><td align="center" valign="middle" >3241 - 4320</td><td align="center" valign="middle" >16</td><td align="center" valign="middle" >10</td><td align="center" valign="middle" >26</td><td align="center" valign="middle" >20.3</td></tr><tr><td align="center" valign="middle" >4320 - 5400</td><td align="center" valign="middle" >17</td><td align="center" valign="middle" >10</td><td align="center" valign="middle" >27</td><td align="center" valign="middle" >21.1</td></tr><tr><td align="center" valign="middle" >Total</td><td align="center" valign="middle" >68</td><td align="center" valign="middle" >60</td><td align="center" valign="middle" >128</td><td align="center" valign="middle" >100</td></tr></tbody></table></table-wrap><table-wrap id="table7" ><label><xref ref-type="table" rid="table7">Table 7</xref></label><caption><title> Distribution as function as type of acquired heart diseases</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Type of heart diseases</th><th align="center" valign="middle" >Total</th><th align="center" valign="middle" >Frequency</th></tr></thead><tr><td align="center" valign="middle" >Myocarditis</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >2.3</td></tr><tr><td align="center" valign="middle" >Myopericarditis</td><td align="center" valign="middle" >4</td><td align="center" valign="middle" >3.1</td></tr><tr><td align="center" valign="middle" >P&#233;ricarditis</td><td align="center" valign="middle" >13</td><td align="center" valign="middle" >10.1</td></tr><tr><td align="center" valign="middle" >Bacterian endomyopericarditis</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0.8</td></tr><tr><td align="center" valign="middle" >Rheumatismal pancarditis</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >1.6</td></tr><tr><td align="center" valign="middle" >Rheumatismal valvulopathies:</td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >MR</td><td align="center" valign="middle" >40</td><td align="center" valign="middle" >31.2</td></tr><tr><td align="center" valign="middle" >Mitral disease</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >1.6</td></tr><tr><td align="center" valign="middle" >MR+AR</td><td align="center" valign="middle" >3</td><td align="center" valign="middle" >2.3</td></tr><tr><td align="center" valign="middle" >Dilated cardiomyopathies:</td><td align="center" valign="middle" ></td><td align="center" valign="middle" ></td></tr><tr><td align="center" valign="middle" >Hypokin&#233;tique s&#233;v&#232;re</td><td align="center" valign="middle" >31</td><td align="center" valign="middle" >24.2</td></tr><tr><td align="center" valign="middle" >Cardiomyopathie whith SSD</td><td align="center" valign="middle" >11</td><td align="center" valign="middle" >8.6</td></tr><tr><td align="center" valign="middle" >Fibrosis endomyocarditis</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0.8</td></tr><tr><td align="center" valign="middle" >Hypertrophic cardiomyopathies</td><td align="center" valign="middle" >1</td><td align="center" valign="middle" >0.8</td></tr><tr><td align="center" valign="middle" >Primitive pulmonary hypertension</td><td align="center" valign="middle" >2</td><td align="center" valign="middle" >1.6</td></tr></tbody></table></table-wrap></sec><sec id="s3_9"><title>3.9. Distribution of the Patients According to the Mode of Assumption of Responsibility</title><p>On the whole, 240 patients (45.7%) had an operational indication. Among them 103 were operated (42.9% of cases) thanks to French ONG (Chain of the Hope, cardiac M&#233;c&#233;nat surgery). A total of 6 pericardial drainages had been carried out in local surgical medium. Moreover, 137 other patients were in waiting of surgical assumption of responsibility. However, 19 patients, because of existence of Down syndrome were not</p><fig id="fig4"  position="float"><label><xref ref-type="fig" rid="fig4">Figure 4</xref></label><caption><title> Rheumatismal mitral stenosis</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/3-1910608x5.png"/></fig><p>eligible for an assumption of responsibility by the ONG, like 7 patients carrying a systemic pulmonary hypertension.</p></sec><sec id="s3_10"><title>3.10. Evolution</title><p>The evolution could be specified only for 261 patients (49.7% of cases). The evolution was favorable among 113 patients (43.3%), stable at 69 patients (26.4%). An aggravation of symptoms was noted among 7 patients, (2.7% of cases). Mortality frequency was 11.9% is 31 patients: 19 girls and 12 boys. In addition, 71.9% of the deaths were observed among not operated patients carrying congenital heart diseases. Moreover, 69.6% of patients deceased (n = 16) were carrying a cyanotic congenital heart defects: PAVSD, 4 cases; PAISV, 1 case; Tetralogy of Fallot, 5 cases; TGA, 3 cases; Hypoplastic left heart, 2 cases; DOVR, 1 case. The heart defect with left to right shunt accounted for 21.7% of the deaths (5 cases); 8.69% of these deaths were observed among patients carrying a tight pulmonary stenosis. Last nine deaths were noted among patients carrying an acquired heart disease: 4 patients carrying a rheumatic valvulopathy, 3 of p&#233;ricarditis, 2 of a severe hypokinetic dilated myocardiopathy. Moreover, two patients had died respectively: of oil ingestion and a neurological malaria, their cardiopathy not being the cause of their death. The average age of the patients deceased was 758 days is 2 years 10 months for congenital heart diseases (range: 4320 - 3176 days).</p></sec></sec><sec id="s4"><title>4. Discussion</title><p>Our study, in spite of skews related to its hospital character, makes it possible to have an idea on the frequency and the types of heart diseases observed in Congolese pediatric medium. The numbers of heart diseases recruited in 4 years is more significant than those noted in studies former carried out to Congo in pediatric medium [<xref ref-type="bibr" rid="scirp.72218-ref3">3</xref>] [<xref ref-type="bibr" rid="scirp.72218-ref4">4</xref>] , because of the limitation of the means of investigation, particularly of the scarcity of the apparatuses of Doppler echography in the near total of the centers of health as observed in the majority of the countries of sub-Saharan Africa and in Madagascar [<xref ref-type="bibr" rid="scirp.72218-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.72218-ref6">6</xref>] . Indeed, the presence of an echograph portable color Doppler and medical agents trained in the pediatric department of teaching hospital of Brazzaville contributed to the improvement of the tracking of the heart diseases thus, shortening the deadlines diagnoses and of assumption of responsibility. As observed by Ba et al. [<xref ref-type="bibr" rid="scirp.72218-ref7">7</xref>] , Deloche et al. [<xref ref-type="bibr" rid="scirp.72218-ref8">8</xref>] , Bazolo et al. [<xref ref-type="bibr" rid="scirp.72218-ref9">9</xref>] the congenital heart diseases were the heart diseases most observed in our study. Compared with the former studies carried out in the same department [<xref ref-type="bibr" rid="scirp.72218-ref3">3</xref>] , the number of congenital diseases observed in four years is higher significant than that noted in 12 years (315 vs 73). The age with the diagnosis was earlier. Indeed, the least old patient had 4 days vs 9 months, and the old patients to 3 years constituted 75.86% of manpower vs 16.5% for those from 0 to 3 years [<xref ref-type="bibr" rid="scirp.72218-ref3">3</xref>] .</p><p>Contrary to the observations of Kinda et al. [<xref ref-type="bibr" rid="scirp.72218-ref6">6</xref>] , Gnansia et al. [<xref ref-type="bibr" rid="scirp.72218-ref10">10</xref>] in our series, as that of Baragou et al. [<xref ref-type="bibr" rid="scirp.72218-ref11">11</xref>] and Bazolo et al. [<xref ref-type="bibr" rid="scirp.72218-ref9">9</xref>] , the frequency of girls was higher than the boys, without significant difference: 54.2% for the girls against 45.8% for the boys (p ˃ 0.05). On the other hand, Damorou et al. [<xref ref-type="bibr" rid="scirp.72218-ref12">12</xref>] observe an equality of distribution according to gender.</p><p>With regard to the reasons for consultation, the respiratory embarrassment and the heart murmur were the principal reasons for consultation in our series, followed cyanosis. Kinda et al. [<xref ref-type="bibr" rid="scirp.72218-ref6">6</xref>] , Baragou et al. [<xref ref-type="bibr" rid="scirp.72218-ref11">11</xref>] also find presence of a heart murmur in the principal reasons for consultation. In our series as in those of Damorou et al. [<xref ref-type="bibr" rid="scirp.72218-ref12">12</xref>] , Bazolo et al. [<xref ref-type="bibr" rid="scirp.72218-ref9">9</xref>] , respiratory embarrassment was the first reason for consultation. How- ever, the heart murmur was observed in quasi similar proportions.</p><p>In Europe particularly in France, the antenatal diagnosis of congenital heart diseases has more than 25 years [<xref ref-type="bibr" rid="scirp.72218-ref13">13</xref>] . This has as a corollary a antenatal diagnosis of congenital heart diseases which reaches a little more than 50%. This detection is definitely higher for the ventricular defects plain as the hypoplastic left heart for which the rate of antenatal tracking is higher than 90% [<xref ref-type="bibr" rid="scirp.72218-ref14">14</xref>] . For any of our patients, the diagnosis of congenital heart diseases was not made before the birth. Therefore, it is necessary to underline with Sidi [<xref ref-type="bibr" rid="scirp.72218-ref15">15</xref>] early detection of heart diseases which can be effective only by one new policy of public health, organized around medical agents trained with the use an echographic Doppler portable color apparatuses.</p><p>As observed before [<xref ref-type="bibr" rid="scirp.72218-ref3">3</xref>] , the heart defects with left to right shunt proved to be higher (69.8% of cases). The VSD were malformation the most observed (30.1%), insulated or associated to other cardiac malformations, followed ASD (20.3%) and PDA (11.7%). This strong proportion of congenital heart diseases with left to right shunt with prevalence of the VSD is also brought back by Deloche et al. [<xref ref-type="bibr" rid="scirp.72218-ref8">8</xref>] , Kinda et al. [<xref ref-type="bibr" rid="scirp.72218-ref6">6</xref>] , Bazolo et al. [<xref ref-type="bibr" rid="scirp.72218-ref9">9</xref>] , with a less incidence of right to left shunt marked by a broad frequency of Tetralogy of Fallot as observed in our study. Indeed, Tetralogy of Fallot remained the most frequent cyanotic cardiopathy (10.1% of cases), though occupying the fourth position by order of frequency of the heart diseases observed. It was followed pulmonary stenosis (9.8%) and endocardial cushion defect (7.6%). Affangla et al. [<xref ref-type="bibr" rid="scirp.72218-ref16">16</xref>] in their series also note this high preponderance of Tetralogie of Fallot, but on the whole of congenital heart diseases. In a former study [<xref ref-type="bibr" rid="scirp.72218-ref3">3</xref>] , this prevalence of Tetralogie of Fallot was also observed, probably related to the diagnoses criteria. Indeed, the presence of a cyanosis more easily draws the attention of an agent of health to the possibility of a cardiac defect and the need for a specialized consultation. Baragou et al. [<xref ref-type="bibr" rid="scirp.72218-ref11">11</xref>] out of 292 cases finds it in third position after the VSD and the PDA.</p><p>In addition, the girls with ECD were higher than boys (16 cases against 8 cases), as described by Gnansia et al. [<xref ref-type="bibr" rid="scirp.72218-ref10">10</xref>] and like observed before [<xref ref-type="bibr" rid="scirp.72218-ref3">3</xref>] . Concerning ECD, 79.2% of the patients with Down syndrome were as described in the literature [<xref ref-type="bibr" rid="scirp.72218-ref10">10</xref>] ; however, associations between ASD ostium secondum and ECD in our series were observed only among at Down syndrome patients.</p><p>As for acquired heart diseases, they were observed than the congenital ones as other authors [<xref ref-type="bibr" rid="scirp.72218-ref17">17</xref>] bring it back. For Bode et al. [<xref ref-type="bibr" rid="scirp.72218-ref17">17</xref>] , in their study relating to 580 patients having cardiac examination with echocardiography, these authors noted 67.2% of congenital heart diseases and 28.8% of acquired heart diseases, frequencies comparable with those observed in our series (respectively 60% and 24.4%).</p><p>Being the rheumatic valvulopathies, they were the first motivation of cardiopathy acquired in our series (41.4% of cases), as in the studies of Affagla et al. [<xref ref-type="bibr" rid="scirp.72218-ref16">16</xref>] , Vahanian et al. [<xref ref-type="bibr" rid="scirp.72218-ref18">18</xref>] , Deloche et al. [<xref ref-type="bibr" rid="scirp.72218-ref8">8</xref>] , Bode et al. [<xref ref-type="bibr" rid="scirp.72218-ref17">17</xref>] . Their incidence represented the third (1.1‰) acquired heart diseases observed in paediatric medium at teaching hospital of Brazzaville. This incidence corroborates that reported by Moyen et al. [<xref ref-type="bibr" rid="scirp.72218-ref4">4</xref>] in the schoolboys of the suburban districts of Brazzaville (1.4‰). The rheumatic heart diseases are the acquired heart diseases most frequent in the child in sub-Saharan Africa [<xref ref-type="bibr" rid="scirp.72218-ref19">19</xref>] , whereas they are rare in Europe because of improvement of socio-economic conditions of populations and the correct assumption of responsibility of the anginas. Frequent and serious in the countries in the process of development, they at the origin of 500,000 died per year [<xref ref-type="bibr" rid="scirp.72218-ref19">19</xref>] . In our series, their appearances were early; the youngest patients were on average 3 years old 6 months at 4 years (6.9% of the rheumatic valvular heart diseases). Our data are compared to those of Affaga et al. [<xref ref-type="bibr" rid="scirp.72218-ref16">16</xref>] , Moyen et al. [<xref ref-type="bibr" rid="scirp.72218-ref4">4</xref>] , Yayehd et al. [<xref ref-type="bibr" rid="scirp.72218-ref20">20</xref>] . We noted a female prevalence (no significant difference: 27 girls against 23 boys). The valvular diseases with type of mitral regurgitation, as for them, were observed. Kimbally-Kaky et al. [<xref ref-type="bibr" rid="scirp.72218-ref21">21</xref>] in Congo, in a former study, also observed this prevalence of the mitral regurgitation in 87.5% of cases, frequency close to that observed by Kramoh et al. [<xref ref-type="bibr" rid="scirp.72218-ref22">22</xref>] in Ivory Coast (87.3% of cases). This mitral regurgitation was isolated at 86.9% from patients with associated to mitral stenosis (1.6% of reports) or aortic regurgitation (2.3% of cases).</p><p>The severe hypokinetic dilated cardiomyopathy occupy the second rank of the acquired heart diseases in our series (24.2%). Bode et al. [<xref ref-type="bibr" rid="scirp.72218-ref17">17</xref>] in Nigeria also observed them in second position after rheumatic heart diseases. However, in same country Wilson et al. [<xref ref-type="bibr" rid="scirp.72218-ref23">23</xref>] observe a retreat of rheumatic heart diseases, dilated cardiomyopathy becoming the most observed heart diseases. These observations snags lays of a real regression of rheumatic valvulars lesions which would be then related to a notable epidemiologic change in Nigeria compared to the former studies where they occupied the first place among acquired heart diseases. However, Sani et al. [<xref ref-type="bibr" rid="scirp.72218-ref24">24</xref>] in the western north of Nigeria note that rheumatic heart diseases occupy the first place among the acquired heart diseases, cardiomyopathy occupying the second position.</p><p>The hypokinetic dilated cardiomyopathy, in our series, were observed in all the age brackets. Noted as of the neonatal period, these very early cardiomyopathy could be secondary with neonatal myocarditis, myocardial ischemia post anoxic or endomyocardic fibrosis [<xref ref-type="bibr" rid="scirp.72218-ref25">25</xref>] . The hypokinetic dilated cardiomyopathy was followed bacterial and viral pericarditis (10.1%) and cardiomyopathy with sickle cell disease (8.6%). The secondary ventricular dysfunction with anemia in the child with sickle cell disease appear in our series as of the second year by the means of a cardiomegaly of adaptation with hyperkinesis and the signs of cardiac failure related to anemia. Kane et al. [<xref ref-type="bibr" rid="scirp.72218-ref26">26</xref>] in Senegal confirm the frequency of patients of sickle cell disease of the dilation of the cardiac cavities associated the hyper kinesis of the left ventricle.</p><p>One of our patients suffering from AIDS presented a myocarditis. Indeed, the cardiac diseases became a significant factor of AIDS; approximately 2.1% to 7.5% of the people reached of AIDS suffer from a significant cardiac failure [<xref ref-type="bibr" rid="scirp.72218-ref27">27</xref>] .</p><p>Our data report that half of the patients having an operational indication could profit from surgical assumption of responsibility primarily in France thanks to no governmental french organizations (ONG) (Chain of the Hope, Cardiac Mecenat Surgery). Indeed, as observed by other authors [<xref ref-type="bibr" rid="scirp.72218-ref2">2</xref>] [<xref ref-type="bibr" rid="scirp.72218-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.72218-ref6">6</xref>] [<xref ref-type="bibr" rid="scirp.72218-ref8">8</xref>] [<xref ref-type="bibr" rid="scirp.72218-ref11">11</xref>] [<xref ref-type="bibr" rid="scirp.72218-ref16">16</xref>] [<xref ref-type="bibr" rid="scirp.72218-ref20">20</xref>] , the surgical assumption of responsibility is a real problem for the countries with limited resources. Consequently, the surgical assumption of responsibility of the heart diseases is often ensured by ONG after transfers medical in Europe. Although the technical plate of the teaching hospital of Brazzaville was reinforced by the installation of artificial heart by the Chain of the Hope, thus allowing the interventions opened heart, the qualified staff shortage does not allow his use by a local team (three of the patients of our series were operated in Brazzaville by a team of the Chain of the Hope).</p><p>The evolution could be specified only for about half of the patients. Indeed, the absence of medical unit dedicated to the pediatric cardiology explains variability of patients in the four pediatrics services which account the teaching hospital of Brazzaville.</p><p>Lastly, 23 deaths were noted among patients with congenital heart diseases, primarily at not operated. The cyanotic congenital heart defects were lethal: 16 reports among 23, i.e. 69.6% of the deaths. This higher lethality was also observed by Rasamoelisoa et al. [<xref ref-type="bibr" rid="scirp.72218-ref5">5</xref>] , Bazolo et al. [<xref ref-type="bibr" rid="scirp.72218-ref9">9</xref>] . It was prevalent in our series among patients having an operational indication, but not taken charges some surgically. This snag lays of formation of specialists and installation of structures dedicated to the assumption of responsibility of these heart diseases either starting from the interventional catheterizations [<xref ref-type="bibr" rid="scirp.72218-ref28">28</xref>] or by the surgery in open heart according to indications.</p></sec><sec id="s5"><title>5. Conclusion</title><p>Although occulted in sub-Saharan Africa, heart diseases of the child are a real problem of public health because of their importance and the difficulties of assumption of responsibility related on poverty of technical plates and lack of specialists in cardiovascular surgery for the forms requiring a surgical assumption of responsibility. And the equipment staff training out of apparatus of echography Doppler color would contribute to the diagnosis and the early assumption of responsibility of its patients. It will be convenient to consider the creation of a center of surgical assumption of responsibility of these heart diseases, being able to be integrated in an existing national structure or into vocation under regional. As for the rheumatic heart diseases, first cause of acquired heart diseases, their prevention by education and treatment correct of the streptococcus anginas as well as the improvement of the conditions of hygiene could reduce the frequency like that of it was observed in the developed countries or these pathologies became rare.</p></sec><sec id="s6"><title>Cite this paper</title><p>M’pemba Loufoua- Lemay, A.B. and Massamba, A. (2016) Epidemiology of Cardiovascular Diseases in Chi- ldren at the Teaching Hospital of Brazzaville, Congo. World Journal of Cardiovascular Diseases, 6, 410-424. http://dx.doi.org/10.4236/wjcd.2016.611045</p></sec></body><back><ref-list><title>References</title><ref id="scirp.72218-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Rey, C. (2004) Traitement des cardiopathies cong&amp;eacute;nitales par cath&amp;eacute;t&amp;eacute;risme interventionnel. Archives de Pediatrie, 11, 639-641. https://doi.org/10.1016/j.arcped.2004.03.007</mixed-citation></ref><ref id="scirp.72218-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Heffernan, M. and Abramson, B. (2000) Le VIH et le c&amp;aelig;ur. Cardiol Conf Scien, 5.</mixed-citation></ref><ref id="scirp.72218-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Kane, A., Mbengue-Di&amp;egrave;ye, A., Di&amp;egrave;ye, O., Sylla, A., Sall, G., Diouf, S.M. and Kuakuvi, N. (2001) Aspects &amp;eacute;chographiques au cours de la dr&amp;eacute;panocytose en milieu p&amp;eacute;diatrique. Archives de Pediatrie, 8, 707-712. https://doi.org/10.1016/S0929-693X(00)00302-X</mixed-citation></ref><ref id="scirp.72218-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Giroux, J.D. and Finel, E. (1998) Pratique de l’&amp;eacute;chocardiographie doppler: H&amp;eacute;modynamique et cardiopathies cong&amp;eacute;nitales en n&amp;eacute;onatologie et r&amp;eacute;animation n&amp;eacute;onatale. Springer, Paris, 160 p.</mixed-citation></ref><ref id="scirp.72218-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Sani, U.M., Ahmed, H. and Jiya, N.M. (2015) Pattern of Acquired Heart Diseases among Children Seen in Sokoto, North-Western Nigeria. Nigerian Journal of Clinical Practice, 18, 718-725. https://doi.org/10.4103/1119-3077.163284</mixed-citation></ref><ref id="scirp.72218-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Wilson, S.E., Chinyere, U.C. and Queennette, D. (2014) Childhood Acquired Heart Disease in Nigeria: An Echocardiographic Study from Three Centres. African Health Sciences, 14, 609-616. https://doi.org/10.4314/ahs.v14i3.16</mixed-citation></ref><ref id="scirp.72218-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Kamoh, K.E., Ngoran, Y.N.K., Ak&amp;eacute;-Traboulsi, E., Konin, K.C., Boka, B.C., Koffi, D.B.J., Sow, T.M., Mandah, Y.C. and Kakou-Guikahue, M. (2013) Cardite rhumatismale en C&amp;ocirc;ted’Ivoire: Evolution de la pr&amp;eacute;valence hospitali&amp;egrave;re durant la d&amp;eacute;cennie 2000-2009. EMC—Cardiologie Ang&amp;eacute;iologie, 62, 34-37. https://doi.org/10.1016/j.ancard.2012.03.001</mixed-citation></ref><ref id="scirp.72218-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Kimbally-Kaky, G., Makoumbou, P. and N’zingoula, S. (2002) Le rhumatisme articulaire aigu chez l’enfant en R&amp;eacute;publique du Congo. Dakar M&amp;eacute;dical, 47, 57-59.</mixed-citation></ref><ref id="scirp.72218-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Yayehd, K., Kouleka, D., Tchamdja, T., Tcherou, T., Pessinaba, S. and Damorou, F. (2012) Valvulopathies rhumatismales &amp;agrave; Lom&amp;eacute;: Aspects &amp;eacute;pid&amp;eacute;miologiques et prise en charge. Journal de la Recherche Scientifique de l’Universite de Lome, 14, 51-58.</mixed-citation></ref><ref id="scirp.72218-ref10"><label>10</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Monsuez</surname><given-names> J.J. </given-names></name>,<etal>et al</etal>. (<year>2011</year>)<article-title>Valvulopathies rhumatismales</article-title><source> AMC Pratique</source><volume> 200</volume>,<fpage> 28</fpage>-<lpage>31</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.72218-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Vahanian, A., Garbarz, E. and Iung, B. (2011) Les cardiopathies acquises de l’enfant dans les pays en voie de d&amp;eacute;vellopement. Bulletin de l’Acad&amp;eacute;mie Nationale de M&amp;eacute;decine, 195, 315-326.</mixed-citation></ref><ref id="scirp.72218-ref12"><label>12</label><mixed-citation publication-type="other" xlink:type="simple">Bode-Thomas, F., Ige, O.O. and Yilgwan, C. (2013) Childhood Acquired Heart Diseases in Jos, Northcentral Nigeria. Nigerian Medical Journal, 54, 51-58.  
https://doi.org/10.4103/0300-1652.108897</mixed-citation></ref><ref id="scirp.72218-ref13"><label>13</label><mixed-citation publication-type="other" xlink:type="simple">Affangla, DA., Bazolo, GA., Leye, M., Fatou, AW. and Kane, A. (2014) Prise en charge des cardiopathies infantiles a propos de 43 enfants diagnostiqu&amp;eacute;s &amp;agrave; Thi&amp;egrave;s (S&amp;eacute;n&amp;eacute;gal) et op&amp;eacute;r&amp;eacute;s. M&amp;eacute;decine d’Afrique Noire, 61, 202-212.</mixed-citation></ref><ref id="scirp.72218-ref14"><label>14</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Sidi</surname><given-names> D. </given-names></name>,<etal>et al</etal>. (<year>2011</year>)<article-title>Les cardiopathies cong&amp;eacute;nitales dans les pays pauvres et la pr&amp;eacute;vention de leurs complications</article-title><source> Bulletin de l’Acad&amp;eacute;mie Nationale de M&amp;eacute;decine</source><volume> 195</volume>,<fpage> 309</fpage>-<lpage>314</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.72218-ref15"><label>15</label><mixed-citation publication-type="other" xlink:type="simple">Lelong, N., Thieulin, AC., Vodouar, V., Goffinet, F. and Khoshnood, B. (2012) Surveillance &amp;eacute;pid&amp;eacute;miologique et diagnostic pr&amp;eacute;natal des malformations cong&amp;eacute;nitales en population parisienne: &amp;eacute;volution sur 27 ans, (1981-2007). Archives de Pediatrie, 19, 1030-1038.  
https://doi.org/10.1016/j.arcped.2012.06.021</mixed-citation></ref><ref id="scirp.72218-ref16"><label>16</label><mixed-citation publication-type="other" xlink:type="simple">Bonnet, D. (2009) Le diagnostic pr&amp;eacute;natal des cardiopathies cong&amp;eacute;nitales. Archives de Pediatrie, 16, 625-627. https://doi.org/10.1016/S0929-693X(09)74091-6</mixed-citation></ref><ref id="scirp.72218-ref17"><label>17</label><mixed-citation publication-type="other" xlink:type="simple">Damorou, F., Matey, K., Douti, N., Djaato, A., Sossou, B. and Kessie, K. (2010) Les cardiopathies cong&amp;eacute;nitales au Togo, aspects &amp;eacute;pid&amp;eacute;miologiques, cliniques, diagnostiques et th&amp;eacute;rapeutiques: A propos de 141 cas collig&amp;eacute;s &amp;agrave; la Terre des Hommes (TDH). Journal de la Recherche Scientifique de l’Universite de Lome, 12, 47-52.  
https://doi.org/10.4314/jrsul.v12i1.57102</mixed-citation></ref><ref id="scirp.72218-ref18"><label>18</label><mixed-citation publication-type="other" xlink:type="simple">Baragou, S., Afassinou, M., Atta, B., Pio, M.,Goeh-akouele, E. and Damorou, F. (2013) Aspects &amp;eacute;pid&amp;eacute;miologique et diagnostiques des cardiopathies cong&amp;eacute;nitales dans une unit&amp;eacute; d’&amp;eacute;chocardiographie p&amp;eacute;diatrique a Lom&amp;eacute;(Togo): Etude prospective de Juillet 2010 &amp;agrave; D&amp;eacute;cem- bre 2012. Journal de la Recherche Scientifique de l’Universite de Lome, 15, 343-352.</mixed-citation></ref><ref id="scirp.72218-ref19"><label>19</label><mixed-citation publication-type="other" xlink:type="simple">Gnansia, E.R., Francannet, C., Bozio, A. and Bouvagnet, P. (2004) Epid&amp;eacute;miologie, &amp;eacute;tiologie et g&amp;eacute;n&amp;eacute;tique des cardiopathies cong&amp;eacute;nitales. EMC-Cardiologie Ang&amp;eacute;iologie, 1, 140-160.  
https://doi.org/10.1016/j.emcaa.2004.02.002</mixed-citation></ref><ref id="scirp.72218-ref20"><label>20</label><mixed-citation publication-type="other" xlink:type="simple">Bazoloba Ngouala, G.A., Affangla, D.A., Leye, M. and Kane, A. (2015) The Prevalence of Symptomatic Infantile Heart Disease at Louga Regional Hospital, Senegal. Cardio Vascular Journal of Africa, 26, 55-59.</mixed-citation></ref><ref id="scirp.72218-ref21"><label>21</label><mixed-citation publication-type="other" xlink:type="simple">Deloche, A., Babatasi, G., Baron, O., Roux, D., Chauvaud, S., Sidi, D. and Vouh&amp;eacute;, P. (2011) La chirurgie cardiaque p&amp;eacute;diatrique dans les pays en voie de d&amp;eacute;veloppement. Vingt ans d’exp&amp;eacute;rience de la Cha&amp;icirc;ne de l’Espoir. Bulletin de l’Acad&amp;eacute;mie Nationale de M&amp;eacute;decine, 195, 305-308.</mixed-citation></ref><ref id="scirp.72218-ref22"><label>22</label><mixed-citation publication-type="other" xlink:type="simple">Ba, M.L. and Kane, F.B. (2000) Etude pr&amp;eacute;liminaire des cardiopathies chez l’enfant mau- ritanien. M&amp;eacute;decine d’Afrique Noire, 47, 492-493.</mixed-citation></ref><ref id="scirp.72218-ref23"><label>23</label><mixed-citation publication-type="other" xlink:type="simple">Kinda, G., Millogo, G.R., Koueta, F., Dao, L., Talbousouma, S., Cisse, C., Djiguimde,A., Y&amp;eacute;, D. and Sorgho, C.L. (2015) Cardiopathies cong&amp;eacute;nitales: aspects &amp;eacute;pid&amp;eacute;miologiques et &amp;eacute;cho cardiographiques &amp;agrave; propos de 109 cas au Centre hospitalier universitaire p&amp;eacute;diatrique Charles de Gaule de Ouagadougou, Burkina Faso. Pan African Medical Journal, 81, 5624.</mixed-citation></ref><ref id="scirp.72218-ref24"><label>24</label><mixed-citation publication-type="other" xlink:type="simple">Rasamoelisoa, J., Raobijaona, H., Tovone, X.G., Rajaonarivelo, A. and Rakotoarimanana, D.R. (2000) Prise en charge des cardiopathies infantiles &amp;agrave; Madagascar. Quelles perspectives pour demain? Archives de P&amp;eacute;diatrie, 7, 573.  
https://doi.org/10.1016/S0929-693X(00)89022-3</mixed-citation></ref><ref id="scirp.72218-ref25"><label>25</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Moyen</surname><given-names> G.</given-names></name>,<name name-style="western"><surname> Okoko</surname><given-names> A.R.</given-names></name>,<name name-style="western"><surname> Mbika Cardorelle</surname><given-names> A.</given-names></name>,<name name-style="western"><surname> Obengui</surname><given-names> Gombet</given-names></name>,<name name-style="western"><surname> T.</surname><given-names> Ekoundzola</given-names></name>,<name name-style="western"><surname> J.</surname><given-names> Ma- biala</given-names></name>,<name name-style="western"><surname> R.</surname><given-names> Ibala</given-names></name>,<name name-style="western"><surname> R. and Samba</surname><given-names> C. </given-names></name>,<etal>et al</etal>. (<year>1999</year>)<article-title>Rhumatisme Articulaire aigu et cardiopathie rhumatismales de l’enfant &amp;agrave; Brazzaville</article-title><source> M&amp;eacute;decine d’Afrique Noire</source><volume> 46</volume>,<fpage> 259</fpage>-<lpage>263</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.72218-ref26"><label>26</label><mixed-citation publication-type="other" xlink:type="simple">M’pemba Loufoua Lemay, A.B., Johnson, E.A. and N’zingoula, S. (2005) Les cardiopathies cong&amp;eacute;nitales observ&amp;eacute;es dans le service de p&amp;eacute;diatrie grands enfants de CHU de Brazzaville. M&amp;eacute;decine d’Afrique Noire, 52, 173-177.</mixed-citation></ref><ref id="scirp.72218-ref27"><label>27</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Sidi</surname><given-names> D. </given-names></name>,<etal>et al</etal>. (<year>2000</year>)<article-title>Cardiologie p&amp;eacute;diatrique dans les pays en d&amp;eacute;veloppement</article-title><source> Ann Nest</source><volume> 58</volume>,<fpage> 31</fpage>-<lpage>41</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.72218-ref28"><label>28</label><mixed-citation publication-type="other" xlink:type="simple">Sidi, D.(1999) Prise en charge des cardiopathies chez l’enfant dans les pays en voie de d&amp;eacute;- veloppement. Archives de P&amp;eacute;diatrie, 6, 465-467.  
https://doi.org/10.1016/s0929-693x(99)80449-7</mixed-citation></ref></ref-list></back></article>