Generic medicine use is increasing both in developing and developed countries. Prescribing trends among physicians can be investigated using the drug use indicators suggested by the World Health Organization (WHO) [1] . In a previous study of this kind, we demonstrated that generic prescribing by both consultants and general practitioners in the United Arab Emirates was far from ideal [2] . However, there is evidence that not only doctors but also pharmacists hold negative views of generics and resist prescribing generic medicines [3] [4] . Patients have been shown to have poor knowledge and misconceptions about generic medicines [5] . Many studies have reported patients to have negative views about generics as they believe generics to be less effective, of lower quality and unsuitable for treatment of major illnesses, as compared to their branded equivalents [5] - [7] . It is worth noting that some patients might ask the prescriber for a particular drug by name which is usually brand and expensive drug either because of previous experience with the medicine or due to the impact of promotional activity. It has also been suggested that such an insistence on an expensive medicine may be because the patient does not pay the full cost or because they believe that those drugs are better than cheaper ones [8] . Keeping this in mind, it seems rather important to evaluate the level of knowledge, perception and attitudes of patients and if the levels are poor or misconception were of significant negative impact on generics use, interventions must be implemented to increase awareness of the public towards generic drugs as substitutes for expensive counterpart brands. It must be noted that low income patients and those without medical insurance coverage may not adhere to their prescribed drugs if they cannot afford its cost and as such drug compliance may not be achieved and this would negatively impact therapeutic outcomes. On the other hand, prescribing generic medicine by the physician or replacement of brand by generic by the pharmacist would have the opposite effect. Taken cost of medicine into consideration, it must be remembered that generics, according to estimates of Food and Drug Administration (FDA) are usually 20% - 70% less expensive than their counterpart brands [9] . In the United Arab Emirates (UAE) there is a lack of studies on generic prescribing and knowledge, perception and attitude of patients towards generic drugs. Therefore, this study was undertaken to evaluate the level of knowledge, perception and attitude of patients towards generic versus brand medicines.

Participants include more female (71, 74%) than male (25, 26%) patients. More than two thirds of participants were young (20 - 30 years) Arabs and holders of a university degree. Slightly less than 50% of the participants were with a monthly income of less than ED 10,000 (Table 1).

Views of patients on imported drugs as compared to locally produced medicines are

shown in Table 2. The majority of patients agreed to the statements that imported medicines are of higher quality (44.8%), more effective (50%), more expensive 66.7%), more advertised (65.6%) and more prescribed (42%) than locally produced drugs. Knowledge of participants of brand medicines as compared to generics is shown in Table 3. It is clear that knowledge of patients in the present study is poor as 47% - 50% of the data that is based on awareness of brand and generic medicines was not recorded by participants.

Fifty six (58.3%) of female and 14 (14.6%) of male patients did not know what is meant by generic or brand name medicines while more females (15, 15.6%) than males (11, 11.5%) knew the meaning of both drug categories (Table 4). There was no statistical significance between males and females concerning their preference of locally

Chi square test, significance at p value < 0.05.

produced or imported generics. When considering the cost, statistically significant number of females selected yes to cost being not an issue as long as their condition is treated. Although low (21, 21.9%) but statistically significant number of the youngest (20 - 30 years) age group agreed that brand medicines are more expensive than generics (Table 5). More Arab (65, 67.7%) than non-Arab patients (4, 4.2%) did not know what is meant by brand or generic. However, only less than 5% of non-Arab pharmacists did not know the meaning of both brand and generic medicines (Table 6). When asked whether more imported medicines are recommended by pharmacists, about one third of Arab patients agreed or was not sure. With regard to the statement that imported medicines produce fewer side effects than locally produced ones, statistically higher percentages of Arab patients disagreed or were not sure of such statement (Table 3). In studying the influence of the level of education on the statements that brands are more recommended by pharmacists and being more expensive than generics, statistically significant higher percentages of patients with a master degree approved both statements (Table 7). The monthly income of patients did not statistically influence their preference to locally produced or imported drugs but patients with the least monthly income (<10,000 ED) agreed or were not sure of imported medicines being of higher quality, more effective and are more prescribed by physicians than locally produced counterparts (Table 8).

In the present study, most of the participants were young Arab females with a university degree who believed that imported drugs are superior to locally manufactured counterparts. In addition, knowledge of patients of generic and brand medicines was rather poor and this was negatively reflected on their consequent responses to the questions in the survey. In general, patients have less confidence in generic drugs, because, among other reasons, the packaging of generics does not have acceptable appearance as brand drugs do. It has been reported that a significant disadvantage to the use of generics― and a factor identified as conducive to continued use of proprietary medicines―was variability in appearance of generics [10] . Also some patients insist on certain drugs, because of their previous experience or due to the impact of promotional activity in favor of these drugs. Knowledge of patients in the present study was poor as compared to

Chi square test, significance at p value < 0.05.

Chi square test, significance at p value < 0.05.

Chi square test, significance at p value < 0.05.

Chi square test, significance at p value < 0.05.

that of renal patients in Al Ain Emirate―UAE [11] . However, even in the later study, some of highly educated patients were unsure of the efficiency of generic medicines and substitution [11] . In addition, pharmacists may not promote generics as this may negatively affect their sales. Both physicians and pharmacists, who have direct contact with the patients, should be more convinced that generic drugs can have as good quality as brands. Also they themselves should be educated that brand drugs are not necessarily of higher and better quality than generics. Moreover, for the benefit of the patients, more effective communication between the treating physician and the community pharmacist should be established. We have earlier shown that 60% of physicians rarely or never discuss patient’s drug therapy with the pharmacist [12] . The present patients’ poor ability to differentiate between generic and brand drugs, could improve tremendously if both the pharmacists and the physicians focus on communicating more with their patients, educate them about the correct selection between generic and brand drugs and inform them that both categories of medicines have similar effectiveness but generics are cheaper. It is also a fact that some patients are with the wrong impression that the more expensive the medication, the better its quality and its effectiveness [13] .

Results of this survey conclude lack of knowledge of generic medicines and patients are inclined to prefer imported drugs. Efforts must be directed towards increasing public awareness of generic medicines and should also focus on educating physicians and pharmacists about generic medicines through inclusion of related topics in undergraduate curricula and continuing educational programs.

The authors are greatly indebted to all patients who participated in the study.

In the present study although we covered patients from three Emirates in UAE, coverage of patients from other Emirates would produce more informative results particularly in the light of the relatively small sample size of our study.

The authors declare that there is no conflict of interest.

Sharif, S.I., Chaar, R.J., Albadrani, Z.Z., Shahwan, J.S., Badreddin, M.N. and Charbaji, M.A.K. (2016) Eva- luation of the Knowledge and Perceptions of Patients towards Generic Medicines in UAE. Pharmacology & Pharmacy, 7, 369- 378. http://dx.doi.org/10.4236/pp.2016.79045