Obesity is defined as excessive weight and body fat due to environmental factors and individual genetic predisposition factors. According to the body mass index (BMI) categories, obesity defined as BMI more than to 30 kg/m² [1] . Obesity is not a disease of known cause, but several factors are involved in its formation. Genetic factors, internal secretions, psychological factors and environmental factors play important roles in causing obesity. Energy imbalance is the most important factor in weight gain and obesity.

Scientific studies approved weight loss surgery for patients with a BMI more than 35 kg/m². More than 90% of the obesity surgeries performed by laparoscopy which is preferred to open surgery: It leads to fewer complications, shorter hospital stay and faster recovery. Gastric bypass surgery by loop method was first done by Mason & Itoh in 1960, then Griffin and his colleagues introduced the open technique of Roux-En-Y Gastric Bypass. In 1994, first laparoscopic gastric bypass was performed in America and now America’s most common bariatric surgery is gastric bypass. The operation is usually done as Roux-en Y, stomach is approximately divided into two small areas (30 - 50 cc) and large (The remaining stomach) and food enter the small area. In mini gastric bypass the surgeon does not cut the small intestine. The smaller stomach is connected to the 150 to 200 cm of small intestine. This new bypass has fewer side effects than the old method and length of stay after surgery is less [2] .

In mini gastric bypass surgery, duration of surgery is about 30 minutes and hospital stay between 1 to 3 days while in the method of Roux-En-Y Gastric Bypass, duration of surgery was more than an hour and length of stay in hospital is between 4 and 8 days [3] [4] . In this study, candidate for bypass surgery referred to obesity clinic of Rasoul Akram Hospital during year 2013-2014, were randomly divided into two groups and one group underwent Roux-En-Y Gastric Bypass and the second group Mini Gastric Bypass and the difference between the two groups were studied.

In this study, all patients with obesity who were referred to the obesity clinic since March 2013 to March 2014 in Rasoul Akram Hospital were enrolled. Half of the group was randomized to undergo laparoscopic Roux-En-Y Gastric Bypass and the rest undergone a Laparoscopic Mini Gastric Bypass. In both groups, the duration of surgery based on the minutes and weight loss over a year after surgery were recorded in kilograms. In this study, a researcher-made questionnaire was used for data collection. All questionnaires have been completed based on direct interviews with patients or relatives of patients who had full information of the patient’s condition. Exclusion criteria included patients not wanting to participate in the study, lack of access to follow-up the patient’s health status during follow-up, any severe illness in which surgery or anesthesia was impossible for the patient, mental instability and inability to understand the procedure, drug and alcohol addiction and eating disorders. SPSS software was used for data analysis and the results of the P-Value less than 0.05 significantly was considered.

In this study, 75 patients with obesity who underwent surgery by one of the mini-gastric bypass or Roux-En-Y Gastric Bypass were studied. 62 participants were female (82.7%). Participants were between 18 and 59 years old and the average age of the participants was 36.8 ± 9.8. Before the surgery, there was no significant difference between weights in two groups (Table 1). The weight loss between the two groups based on Independent Samples Test is shown in Table 2. The weight loss after 10 days and three months did not differ significantly between groups while weight loss after one month, after six months, after 9 months and one year was significantly higher in the mini gastric bypass group than the other group (Table 2). Duration of surgery in mini gastric bypass surgery significantly was less than the other group (Figure 1).

Gastric bypass surgery was more common in the late 1990s. Effects of gastric bypass surgery are actually a combination of stomach volume reduction and mal-absorption of nutrients. This applies especially in people who consume large quantities of sweets and simple carbs and do not respond to bonding. Bypass surgery was more effective than bonding so that 60% to 70% of patients lose their excessive weight in 9 to 14 months after surgery. Studies have shown that mini gastric bypass was effective for the treatment of obesity and favorable

results in the removal of diabetes type 2 in patients with obesity [5] - [8] and lead to improve the quality of life in these patients [9] . However mini gastric bypass is easier and safer procedure compared with Roux-En-Y Gastric Bypass in two-year follow-up period, any Achilles’ heel for it has not been reported yet [10] [11] . Since the mini-gastric bypass in the stomach has not been cut and small intestine connected to 150 to 200 cm of small intestine, this method has fewer complications than the traditional Roux-En-Y Gastric Bypass [12] , but the possibility of bile reflux in this method is higher than the conventional bypass method. In a study published in 2012, 1657 patients evaluated. Under the scheme, operation time and postoperative hospital stay and the rate of postoperative complications in patients with Roux-En-Y Gastric Bypass was more and weight loss in this group was less through a 5-year follow-up [12] .

Excessive weight loss in mini gastric bypass after one year in our study was similar to other published studies [4] . In another study in 2008 on 16 patients under mini gastric bypass surgery results showed that patients had 78-minute surgery and postoperative hospital stay 1.2 days. There were no long-term complications and mortality after surgery and weight loss at two years after surgery was 72 kg [13] . Excessive weight loss in mini-gastric bypass surgery was reported as much as 70 percent in various studies over one [14] and 5 years [4] which was consistent with our results. Another study published in 2012 evaluated 1000 patients who had undergone mini gastric bypass surgery between 2005 and 2011 were studied. According to the study, mini gastric bypass was low-risk and effective method that can be performed easily and with little associated side effects. In this study, all patients had experienced reflux following surgery [15] . Previous studies have shown that mini gastric bypass surgery over the short-term, was safe and successful in excessive weight loss [16] [17] , this point was confirmed in our study.

According to recent study and adapt these results with studies in other countries, mini gastric bypass seems to be the easier way than the Roux-En-Y Gastric Bypass, which is less time consuming procedures and hospital stays are shorter. Also, due to the lack of anastomosis between the stomach and the jejunum, is a safer way and the effects and duration of surgery and hospitalization is less than Roux-En-Y Gastric Bypass, to the extent effective in weight reduction for patients with obesity. The effect of this method in the treatment of obesity complications such as low back pain, sleep apnea, high blood pressure, diabetes and depression have been proven and so could act as a substitute, among bariatric surgery considered.

The authors need to thanks to the efforts of our hardworking colleagues in Minimally Invasive Surgery Research Center, who worked on the research process.

Abdolreza Pazouki,Sima Karbalaei Esmaeili, (2016) Excessive Weight Loss Following Laparoscopic Gastric Mini Bypass or Roux-En-Y Gastric Bypass Surgery. International Journal of Clinical Medicine,07,445-449. doi: 10.4236/ijcm.2016.77047