Fibroids are the most frequent benign tumors in women. The finding of such tumor is considered extraordinary before menarche and the decrease after menopause is normal. Its pathogenesis is closely related to sex hormones, particularly estrogen, genetic predisposition and growth factors [1] . Maximum incidence is observed in women between 30 and 50 years and it is present in up to 40% of women. The prevalence of the tumor during pregnancy is 10% and it is the cause of infertility in 2% - 3% cases in which the active management is recommended to improve reproductive rate [2] . The location and size can vary, the size can range from a few millimeters to several centimeters and a giant myoma is considered when it exceeds a size of 9 cm or a weight of 800 gr [3] . Its prevalence is very difficult to define and it is estimated between 4% and 25% of cases [3] [4] .

Fibroids are often asymptomatic but 30% of the patients affected by fibroids present heavy menstrual flow or other alterations such as pelvic discomfort, menometrorrhagia, dyspareunia, urinary disorders, back pain or infertility [2] [4] . Symptomatic fibroids require treatment, being hysterectomy by laparotomy or laparoscopy of the classic option. This condition is responsible for 60% of hysterectomies performed in Western countries. Another possible treatment is surgical myomectomy by laparotomy, laparoscopy or hysteroscopy. The kind of procedure depends on the location, number and size of the fibroids. It is also possible to administer a preoperative treatment in order to reduce the volume of the myoma and the uterine bleeding with gonadotropin-releasing hormone agonist or, preferably, Ulipristal Acetate. Non-surgical options such as: embolization selective trans-arterial and therapy HIFU (High Intensity Focused Ultrasound) [2] -[4] are added to the classic surgical treatments.

In the case of giant fibroids, scientific evidence on prescribed treatment is limited or null in terms of conservative techniques. The size increase often makes it difficult to perform the usual surgical techniques and a total or even a subtotal hysterectomy is indicated. The literature is limited to the technique of excision of giant uterine fibroids and reconstruction, but there are cases in which the correct indication could be the following:

These cases are summarized in 2 options:

・ Patient with unfulfilled genesic desire.

・ Patients who do not want a hysterectomy.

It is important to remember that all reductive interventions could trigger an emotional disorder whose intensity depends not only on the factors relating to the organ or disease in question but also on the impact that the feeling of loss of personal integrity has, as well as the sexual and reproductive consequences. Among these interventions in women, hysterectomy is seen as a mutilating surgery and can exercise greater impact than any other intervention. The Health and Gender Report Ministry of Health of Spain [5] emphasizes on how surgical procedures such as hysterectomy or mastectomy appear as a source of vulnerability and require a redefinition of femininity when it has been supported and symbolized in these organs.

This case report includes a review of the literature on myomectomy and the different techniques of uterine reconstruction which allow patients to keep their uterus, the unfulfilled genesic desire and the full-body image, thus providing a better quality of life.

White 45-year-old patient. Medical history: anxiety depressive disorder with 4 years of evolution. Surgical history: saphenectomy in the right lower limb in 2010. She had no relevant family history. No toxic habits. Gyneco-Obstetric history included one gestation with a voluntary interruption when the patient was 32 years old.

Gynecological examination: a mass occupying the whole abdomen above 3 cm supra-umbilical was discovered. Abdominal ultrasound showed uterus with intramural fibroid 167 mm × 160 mm × 230 mm. Magnetic Resonance Imaging (MRI) of pelvic area displayed an intramural uterine mass 230 mm × 110 mm ×190 mm. T1 sequences were observed as a predominantly hypo-intense and homogenous solid mass and T2 sequences had heterogeneous and hyper-intense signal areas inside related to cystic necrotic areas, in keeping with giant fibroid type 4 according to the FIGO classification. The anterior myometrium had a maximum thickness of 20 mm and the posterior face had a maximum thickness 5 mm. The endometrium was located above the fibroid with a maximum fibroid interface of 3 mm. Adnexal structures were not identified. There was no dilatation of the urinary tract. Hemoglobin was 11.9 g/dL (Figure 1).

Initially, a laparotomy/laparoscopic total hysterectomy was proposed. The patient sought to preserve her uterus due to feelings of mutilation associated with hysterectomy and the loss of femininity associated with the incompleteness of her internal genitals. She also understood the few chances of pregnancy due to old age and the possibility of requiring future treatments for new uterine disorders.

Lastly, the surgery proposed was myomectomy with uterine reconstruction, intra-operative biopsy by laparotomy. The corresponding preoperative consent was signed. Surgical risks ASA II. Two units of red blood cells were reserved.

Midline laparotomy with a lengthwise opening of 12 cm of the abdominal wall was performed. The enlarged uterus is outsourced, protected by moist compresses. The upper structures of the uterine pedicle were individualized. Both round ligaments and adnexal (tubes and ovaries) were found macroscopically normal. Wet pad was placed to insulate and protect intestines.

1^st Time: MYOMECTOMY. To reduce bleeding during myomectomy, a peri-cervical Foley catheter was placed and tied to decrease uterine blood flow [6] . From that moment, the ischemia time was controlled and a limit of 30 minutes was accepted. Then, a longitudinal incision was made in the midline of the posterior face and fundic uterus at about 7 cm. This approach was decided due to the thinning of the rear wall with a maximum thickness of 5 mm, contrary to the anterior face thickness of 2 cm and the impossibility of subsequent myometrium retraction after myomectomy. Optimal dissection plane (fibroid capsule) was individualized and myomectomy was performed according to the usual traction-countertraction technique. With complete enucleation of the myoma and after ligation of the vascular pedicle, the piece (230 × 190 × 120 mm) was extracted and intra-operative biopsy was performed. The biopsy was reported as: uterine leiomioma with minimal nuclear atypia and low mitotic activity with interstitial edematous degeneration without signs of necrosis.

2^nd Time: UTERINE RECONSTRUCTION. Ischemia time was 17 minutes. The endometrial cavity was opened corresponding to the uterine fundus and 2 cm were sutured with continuous suture 2/0 vicryl. Next, a metroplasty was performed which included a rhomboid resection from the posterior uterine face, due to its extreme thinning and no retraction of uterine tissue before beginning this surgery. The rhomboid resection included two top faces of 4.5 cm and two of 2 cm from the underside. Myometrium of the upper faces, in one discontinuous layer of 0/0 vicryl sutured (due to the extreme thinness of the myometrium, which did not allow the suture in two layers as a choice) being the midline suture of uterus in inverted T. The lower sides were sutured with the over-flap technique (overlapping myometrium) with interrupted sutures with 0/0 vicryl, in order to avoid an excessive reduction of the uterine fundus, and increase the strength of the scar to an eventual pregnancy.

After that, the tourniquet was removed, peri-cervicaly serving a maximum time of 27 minutes [7] . Subsequently, a Foley catheter was introduced in the uterus and was inflated with 50 cc of a saline solution to prevent the collapse of the uterine walls and eventual adhesions. No active bleeding was found. Finally, a layer of oxidized regenerated cellulose covered the entire myomectomy scar to prevent adhesions. Drain pack in Douglas space for monitoring possible postoperative bleeding had been left and the abdominal wall was closed using continuous suture with 0/0 vicryl in fascia, then subcutaneous tissue approximation and umbilical reconstruction and intradermal suture leather with 4/0 polysorb was performed. The bleeding accounted was 230 cc of blood.

The immediate postoperative recovery had not complications. At 24 hours the patient had a hemoglobin control of 10.9 mg/dl. Drainage pack with 50 cc of debit and intrauterine Foley catheter were removed. Three days after surgery, with clinical and hemodynamic stability, a uterine ultrasound control with no bruises and oral iron treatment was indicated and the patient went home.

First postoperative control: 10 days after surgery: the patient had little genitoragia. Gynecological ultrasound: uterus AVF of 80 × 70 × 70 mm, with an undefined endometrial line and normal ovaries. Absence of free fluid in Douglas.

Second postoperative control: 30 days after surgery: minor genitorragia. Hemoglobin was 11.1 mg/dl. Gynecological trans-vaginal ultrasound: Uterus in AVF of 70 × 60 × 40 mm, lineal endometrium and normal ovaries. There was absence of free fluid in Douglas.

Third postoperative control: four months after surgery the patient was satisfied and happy by the preservation of her uterus. Regular periods had started again. Other results: control hemoglobin of 11.9 mg/dl; hormonal profile on 3^rd day of period FSH −14 mIU/ml; LH 6 mIU/ml and estradiol 40 mIU/ml. Hystero-sonography was performed yielding the following results: normal uterine morphology, inter-cornual distance of 57 mm and both fallopian tubes were permeable (Figure 2).

Seeing this favorable progress, it was decided start annual gynecological follow-ups.

Giant fibroids, defined as those larger than 9 cm, are not frequent and have a prevalence [3] of 25% in white women [4] , according to some authors; while 50% has been reported in black women [3] . However, an exact prevalence is difficult to determine. The symptoms include a wide range of possibilities such as [8] : menometrorrhagia, pelvic pressure, urinary symptoms due to compression of urethra with hydro-nephrosis [9] or bladder compression with symptoms of urgency and urge incontinence [10] , edema, or pelvic varices MMII, thrombosis or compression symptoms sacral plexus. Other symptoms described included unusual pulmonary hypertension, respiratory failure [11] , pseudo-Meigs syndrome [12] , difficulty to walk, tiredness [13] and arthrogryposis in pregnancy [14] .

The FIGO classification according to their location is [15] :

・ Submucosal fibroids:

Type 0: Submucous 100%

Type 1: Intramural < 50%

Type 2: Intramural > 50%

・ Other fibroids:

Type 3: Contacts the endometrium. 100% intramural

Type 4: Intramural

Type 5: Subserous > 50% intramural

Type 6: Subserous < 50% intramural

Type 7: Subserosal peduncled

Type 8: Other (cervical, parasitic, broad ligament)

・ Hybrid fibroids (impacts on myometrium and serosa)

There are reports of fibroids found in the retroperitoneal space [16] , having to make the differential diagnosis with other masses found in the same area, which sometimes can be malignant, for example: the mucinous cystadenoma, cystic lymphangioma, cystic mesothelioma and Mullerian cyst. In other cases, the tumors are benign such as urinomas and lymphoceles. Myomas have also been described in Retzius space [10] .

Gynecological trans-vaginal ultrasound is the technique of choice for the diagnosis because it is the most cost-effective with perfect display [6] . If the fibroid exceeds the pelvis, abdominal ultrasound is required to view the complete mass. However, MRI is considered more accurate for the diagnosis and if the fibroid is too large, an abdominal and pelvic MRI [1] will also be required for its evaluation.

In most cases, the treatment of giant myomas is surgical [8] , that is, hysterectomy by laparotomy [3] or laparoscopy vs. myomectomy by laparotomy, as in our case, or by laparoscopy [17] .

Hysterectomy is indicated in the following cases:

・ Acute bleeding unresponsive to other therapies [18] .

・ Unfulfilled genesic desire and future risk of developing: adenomyosis, endometrial hyperplasia and premalignant lesions or tumors of the cervix, endometrium or ovary.

・ Unfulfilled genesic desire with multiples fibroids or significant symptoms.

・ If the patient wishes so.

Regarded as benefit of hysterectomy:

・ To remove current symptoms and probably future symptoms which can occur in relation to other pathologies or uterine fibroids.

Disadvantages of hysterectomy:

・ Increase in morbidity that would include damage to other organs.

Myomectomy would be indicated in the following cases:

・ Unfulfilled genesic desire, if reproductive capacity can be improved.

・ If the patients wish to keep their uterus (as in the case described).

Advantage of myomectomy:

・ Improves symptoms and preserves uterus.

Disadvantages of myomectomy:

・ New fibroids may occur from new clones of abnormal myocytes.

・ Intra-operative bleeding

Before surgery, it would be appropriate to correct preoperative anemia with iron, EPO or both, depending on whether the anemia is ferropenic, chronic or mixed, respectively; thus avoiding eventual blood transfusions because they are not exempt from risks with increased morbidity and mortality [19] . Also during myomectomy, it is necessary to perform different procedures to prevent bleeding. Currently, there is moderate quality evidence that misoprostol can reduce bleeding during myomectomy, while there is lower evidence that bupivacaine plus epinephrine, tranexamic acid, the gelatin-thrombin matrix, a tourniquet peri-cervical, ascorbic acid, dinoprostone, ligation in handle and a fibrin sealant patch can reduce bleeding during myomectomy. Nevertheless, there is no evidence that oxytocin, morcellation and temporary clamping of the uterine artery can reduce blood loss.

・ Another disadvantage of myomectomy that should be taken into account is the uterine rupture in a subsequent pregnancy.

The incidence of uterine rupture is 1% according to Dubuisson et al. [20] . It is most common during the third trimester of pregnancy. However there have been reports of uterine ruptures during the second trimester [21] . In addition, laparotomy is also more commonly used in the myomectomy, especially if it is performed by an inexperienced surgeon, considering the extension of myometrial tissue destroyed if there is a frequent use of electrocoagulation and if the myometrium is sutured with a single layer [22] .

Uterine reconstruction is required in cases of:

・ Giant myoma: the myometrial tissue remains very thin after the giant myoma enucleation and does not preserve it contractile activity. The following techniques are chosen: inverted suture (a), intussusception of the myometrium (b), overlapping of the remaining myometrial tissue (c), and resection of remnant tissue (d) [23] (Figures 3(A)-(D)).

・ Multiple fundal fibroids: Riedberg technique (e) [23] (Figure 3(F)).

An excellent haemostatic suture should be made because it is the main factor to prevent adhesions after myomectomy, but there are some studies in which the use on the surgical bed of absorbable materials such as oxidized regenerated cellulose or non-absorbable materials like polytetrafluoroethylene have reduced adhesions between uterus and other pelvic or abdominal organs [24] [25] .

Considering that bleeding after a giant myomectomy is possible, a drain may be left in the Douglas space. The uterus is usually enlarged at the end of the surgery, but its size is reduced after several weeks or months [23] .

It is worth emphasizing that in our case it was decided to perform surgery (myomectomy) due to the oversize rapid growth of the fibroid. However, it seems that fibroids which grow rapidly and are asymptomatic, and the diagnostic imaging is consistent with fibroids, the best thing would be its observation because the sarcoma prevalence is very low [26] ; nevertheless, the literature does not mention whether there is a maximum size to allow the observation and not the intervention.

It was decided to perform an intra-operative biopsy to rule out a malignant diagnosis. However, the hypothesis that sarcomas develop from fibroids has not been proved [26] . Nevertheless, if the malignization of a myoma occurs, it would be an exceptional event [27] -[29] .

Our patient is trying to get pregnant, without success yet. The literature has reported cases of gestation after myomectomy of a giant fibroid [8] . The best way of delivery would be a caesarean section (before the onset of prodromal labor).

Above all, our patient is satisfied and very pleased with the results. The literature has extensive reports on this topic. One of them was written by Mackinger, Graf, Keck et al. [30] who studied a group of women who had undergone hysterectomy and revealed significantly higher levels of health complaints like depression, and diverse sexual and psychological disorders, compared to the group which had not undergone hysterectomy, considering that in the hysterectomy group, the patients showed psychological distress previous surgery. Rannestad [31] showed how hysterectomy does not cause adverse psychological results in women without psychological morbidity previous surgery, being the psychological status before surgery the best predictor of subsequent psychopathologies. Thus, women diagnosed with a major depressive disorder before surgery have higher probability of continuing with this diagnosis post-intervention or even a worsening of symptoms. Thus, preoperative psychopathology is a predictor of postoperative psychopathology [31] .

Fibroids can achieve huge sizes as indicated by some reports: Hunt in 1888 found a fibroid which weighed 63.6 kg in an autopsy; Behrend in 1930 removed a uterine fibroid of 60.7 kg; Singhabhandhu in 1973 removed the largest tumor so far (45.5 kg) from a patient who survived the intervention. Oelsner reported 2 cases in May 2003, one of 40 kg and another of 43 kg. More recently, Costa reported the removal a 9.5 kg fibroid.

Although uncommon, whenever these tumors are present they constitute a challenge for gynecologists. A hysterectomy is the most standard treatment in these cases, but we want to ensure that a myomectomy can performed, even by laparoscopy, including uterine reconstruction to preserve the woman’s uterus and ovarian functions or to prevent great moral suffering.

We recommend the following guidelines prior to myomectomy:

・ Evaluation of unfulfilled genesic desire and the meaning of the proposed surgery in patients, taking into account previous psychological disorders, which may worsen after surgery if they are not handled properly.

・ Evaluation of symptoms, considering also uncommon symptoms of fibroids.

・ MRI assessment of the location of the myoma and alterations in the anatomy of the myometrium.

・ Preoperative signing of complete informed consent.

・ Correction of preoperative anemia.

・ Reserve of blood backup.

・ Determine the need of ureteral catheterization.

・ Determine the need of bowel preparation.

・ Prepare adequate antithrombotic guidelines.

・ Define laparotomy or laparoscopic approach.

・ Perform maneuvers or techniques to reduce uterine bleeding.

・ Define the uterine incision to be performed taking into account the location of the myoma, the anatomical changes and the uterine circulation, the front face is preferred.

・ An intra-operative biopsy can be performed, though it is not indispensable.

・ Perform reconstruction if the myometrium does not retract or contract properly, although it is important to bear in mind that the uterus will be slightly larger than desired and will eventually retract.

・ Make correct hemostatic sutures. If possible the sutured must be performed in two layers.

・ Use maneuvers to prevent intrauterine and extra uterine adhesions.

・ Perform early control for potential bleeding or bruising.

・ Evaluate postoperative uterine morphology by means of gynecological trans-vaginal ultrasound and request historiography to assess tubal permeability if it is required.

The authors declare that there is no actual or potential conflict of interest in relation to this case.

M. N. Gennaro DellaRossa,B. NavarroSantana,M. RodríguezVerdejo-Arias,E. ValerCardenas,J. PlazaArranz, (2016) Uterine Reconstruction Due to a Giant Myoma. A Case Report and Literature Review. Open Journal of Obstetrics and Gynecology,06,64-72. doi: 10.4236/ojog.2016.61008