The pneumococcal septic arthritis is a disease of the elderly or weakened [1] -[4] . The literature shows that this organism is responsible for 3% to 10% of septic arthritis [2] .

As in any septic arthritis, outcome may be severe or by direct systemic consequences of infection either by its local and regional extension. Mortality is not less than 10% and in more than half cases, it provides joint sequelae [5] [6] .

Septic etiology in young adults appears not to be the first diagnostic hypothesis to which practitioners may think before when faced to patient with a painful wrist and fiver because rheumatic causes are far more frequent [7] . According to Dubost et al., staphylococci and streptococci Group B above are the main germs responsible of septic arthritis in the past three decades [8] .

The poverty of the literature on the topic justified that we reported this case to highlight the unusual anatomical location and particularity of the affected patient.

A woman of 46 years, a nursing assistant, consulted in February 2009 to the emergency ward of the hospital of Beauvais with pain, lameness and swelling on his right wrist started three days before (Figure 1). She had no particular medical history. A fever of 38˚C, and a pain in the overall mobilization of the wrist, was signs of clinical examination. There was no lymphadenopathy. Laboratory tests showed C Reactive Protein (CRP) at 304.5 mg/l, white blood cells (WBC) at 23,500 cells/ml and procalcitonin (PCT) at 2.94 μg/l. Arthritis of the wrist hypothesis was raised and reinforced by the scanner which identified a joint effusion and the sheath of the extensors.

Surgical drainage by dorsal approach associated with a washing were made (Figure 2). The patient was put under probabilistic parenteral antibiotic therapy with amoxicillin-clavulanic acid. The wrist was immobilized in a splint plaster. Examination of wrist sample and blood cultures has identified a sensible pneumococcus. Antibiotic therapy combining 1 g of levofloxacin and 1.2 g of rifampin per day was instituted. The third postoperative day, the patient was afebrile (Figure 3 shows the appearance of the wrist at the third postoperative day). CRP, PCT and WBC were significantly regressed. In the second week, inflammation biomarkers were normalized and wrist gradually regained mobility with the gentle rehabilitation.

Meanwhile, the door of entry of the infection was investigated by X-rays of the lungs, sinuses, and cardiac ultrasound that have found anything. Serologies of human immunodeficiency virus (HIV), hepatitis B and C were negative.

Face scan had shown signs of left sphenoid sinusitis blowing the floor that did not require special treatment beyond that which had been established for joint infection. A protein profile that revealed a sharp decrease in immunoglobulin type G4. Antibiotic treatment was continued for six weeks and the patient vaccinated against pneumococcus. In the fourth month, the patient was asymptomatic, the biological balance and mobility of normal wrist.

Streptococcus pneumoniae is responsible for septic arthritis in 3% to 10% and particularly affects peripheral joints of the child such as hip [2] .

In healthy adults, bone and bone joint infections due to this organism are rare [3] . In most cases, these infections occur in subjects with risk factors; then it is subjects weakened by age and declining immune defenses. The infection of joints by pneumococcus is favored by the presence of factor inducing immunosuppression [9] . Most of these patients have at least one joint disease or underlying extra articular [4] .

Among these co-morbidities, studies report the airway infections, heart disease, liver diseases, autoimmune diseases, hypertension, diabetes mellitus, chronic renal failure, malignancies, smoking regular, alcohol consumption, body mass index higher, the presence of prosthetic material, trauma [9] - [11] . Splenectomy, HIV infection, especially combined or humoral immunodeficiencies are also important risk factors [4] [9] . The most frequently affected joints are the knee, followed by the shoulder, elbow and hip occasionally [4] [12] -[15] .

To our knowledge, the literature reports no cases of arthritis of the wrist due to this germ in adults without apparent risk factor.

In our patient, we believe that this bacterium is located encapsulated wrist hematogenously in favor of bacteremia caused by sinusitis. Opsonization is the phenomenon by which the encapsulated bacteria are phagocytosed and removed could not be effective because of the immunoglobulin deficiency of the patient; immunoglobulins G are the most effective class of antibodies in the ospsonization [9] . It is a selective Immunodeficiency subclass (IgG4) immunoglobulin. In general, a selective deficit is congenital. In this context congenital, infectious order events related to that type of deficiency should occur at a younger age. This also supports the hypothesis that we issued earlier on professional risk factor for the caregiver.

Note that despite whether an adult, you have in the absence of a secondary immunodeficiency, primary immune deficiency look as is the case in our patient. The authors reported in 2013 the case of a woman of 59 years with a selective IgM deficiency who presented a septic arthritis due to pneumococcus [16] .

In terms diagnosis, because of the frequency of rheumatic and causes reaction, septic origin is not necessarily the first case in front of a medical history without any particular patient with febrile wrist pain [11] . Even if the assertion of joint infection, pneumococcus is not the germ that can evoke in first intention.

As soon as septic arthritis is suspected, the puncture of the joint is imperative and urgent optionally by aid of a radiographic or sonographic identification [4] . However, the wrist joint cannot be easily punctured without local anesthesia, the risk of contact of lidocaine which is antibacterial with synovial can sterilize the sample [17] . Thus, in situations where the optimal conditions for joint aspiration are not met, the scan stills a very useful to the affirmation of positive diagnosis tool.

Our observation in a patient with no apparent risk factors demonstrates that pneumococcal infection in a more distant articulation of the ENT is still possible. Scan has been a very significant contribution in confirming the positive diagnosis that leads to surgical drainage.

The approach of the systematic search for the gateway must be done. In the study of the patient’s immune status, the realization of the protein profile could be interesting and then guide the practitioner in the decision to vaccinate the patient against Streptococcus pneumoniae if he was not. We recommend looking always for a cause of immunodeficiency including primary Ig defiencies even among adult.

It would be valuable that future studies elucidate the exact role of immunoglobulin G type 4 in pneumococcal infections.

None.

AtchiWalla,AnaniAbalo,MalewéKolou, (2015) Wrist Septic Arthritis Due to Streptococcus pneumoniae Revealing a Selective Immunoglobulin G4 Subclass Deficiciency: A Case Report. Open Journal of Orthopedics,05,350-354. doi: 10.4236/ojo.2015.511047