The purpose of this study is to investigate the disease distribution of tuberculosis in national regional project. 960 patients were selected from national tuberculosis control program who took treatments in the Fourth People’s Hospital Clinical Laboratory in Nanning Guangxi from January to November in 2013. Then we observed all those patients’ disease distribution and analyzed all the lab test indexes. We analyzed the results according to gender and age distribution. From the age distribution, we found that the incidence was lower at the age of 40 or younger, while higher incidence occurred to patients over 40 years old. There is statistical significance comparing these two age groups. P is less than 0.001. Disease distribution: 731 patients were infected with TB; 21 patients were co-infected with tuberculosis (TB) and HIV. 196 patients were co-infected with TB and fungal. 12 patients were co-infected with TB, HIV and fungal. From the laboratory testing, we know there were 87 patients whose liver function indexes were abnormal. There were 192 patients whose blood RT indexes were abnormal. The liver function and blood RT indexes of patients with co-infection were higher than those infected purely. There is statistical significance in comparison P < 0.05. The study indicates that patients with older age are more likely infected with tuberculosis. In addition, there are a high proportion of patients with co-infection among these patients in this study. Meanwhile, the liver functions and blood RT indexes of patients combining with infection are higher than those infected TB purely. Prompt clinical prevention and treatment should be under reasonable inspections. General analysis can enable us to investigate more effective treatment plan. Then the best treatment result will be obtained.
In recent years, the incidence of tuberculosis (TB) has been on a rising trend year by year. Furthermore, because resistance of body is becoming lower, TB is susceptible to be invaded and attacked by a variety of bacteria and viruses, which lead to co-infection disease. As a consequence, the whole body organs are badly influenced and it does much harm to our health. At the same time, TB seriously affects people’s life and causes serious damage to people’s life. To prevent and control TB is becoming more and more significant, and leads to great pressure as well. Therefore, there is much point in investigating the distributions and laboratory diagnosis of disease, which can treat TB patients effectively [
To understand the disease distribution of tuberculosis in national regional project, this research was carried out from January 2013 to November 2013 in our hospital. All the lab test indexes are analyzed and the results will show as follows.
We selected 960 patients of national tuberculosis control program who took treatments in tuberculosis clinic of our hospital and at the inpatient department from January to November in 2013. Among those objectives, there were 739 cases of males and 221 cases of females accounting for 76.98% and 23.02% separately. Tuberculosis pathology of all objectives represents as low fever, malaise and night sweats, accompanying cough, expectoration, hemopstysis, chest tightness, chest pain, etc. The imaging, sputum, blood, body fluids, n/med tuberculosis bacterium were used to confirm TB. And the standard of choosing the objects in this study is that there is mycobacterium tuberculosis on the culture or smear.
Instrumentation: Olympus BX51 microscope was used to test sputum smears and other body fluids. Acid dye was provided by Zhuhai Mr Cable biological technology co., Ltd. Sysmex 2000i blood instrument and related reagents were used to finish blood routine examination. Automatic biochemical analyzer, Germany Roche PPE800 and related reagents were used to examine liver function. All reagents were used before their production validity.
Select 960 patients of national tuberculosis control program who took treatments in tuberculosis clinic of our hospital and at the inpatient department from January to November in 2013. Then we observed all those patients’ disease distribution. Artificially, it could be divided into TB group, TB co-infected with HIV group, TB co- infected with fungi and TB co-infected with HIV and FV, etc. And then all the lab test indexes analyzed according to state specified standards, such as the imaging test, specimen culturing, and blood testing and main indexes of liver function, like WBC (white blood) cell, NE (neutrophilicgranulocyte), LYMlymphocyte), EO (basophile granulocyte), EA (eosinophile granulocyte), RBC (red blood cell), HBG (hemoglobin), PLT (blood platelet), TBIL (total bilirubin), DBIL (bilirubin direct; conjugated bilirubin) and so on.
This study obtained support and approval from Guangxi Association of STD (sexually transmitted disease) and AIDS (acquired immune deficiency syndrome) prevention (No. 49852135-5). During this research, we protected patients’ privacy. If not, the related research studies were approved by Guangxi Association of STD and AIDS prevention and those patients’ approval.
Statistic process software GraphPad Prism 19.0 was used to analyze statistically. Patient’s age, blood routine and liver function indicators are for measuring data, which are under normal distribution. The comparison of technical data was tested by chi-square. Data are analyzed by t inspection and x2 inspection and results showed with the average X ± S. Take P < 0.05 as the statistically significant difference.
Among those 960 TB patients, there are 739 cases of male accounting for 76.98% and female of 221 cases, accounting for 23.02%. Comparison of prevalence rate between male and female showed chi-square = 559.01, P = 0.00012. The differences of prevalence rate between male and female make a statistical significance. While the age of distribution of disease is as follows: 28 cases from 0 to 20 years old, 132 cases from 21 to 30 years old, 141 cases from 31 to 40 years old, 168 cases from 41 to 50, 191 cases from 51 to 60, 189 cases from 61 to 70 and 139 cases above 71 years old. According to this age distribution, we can know that under the age of 40, the incidence of TB infection is relatively low, reported for 273 cases, accounting for 28.44%. While higher incidence occurring over age of 40, there were 687 cases, accounting for 71.56%. Comparing this two age distribution, chi-square = 357.08, P = 0.000187 showed that the difference is statistically significant. In terms of distribution of disease, this research mainly focused on statistical significant complications, general bacterial infections are not included in this study. According to different TB infections, we divided those patients into four groups. They were 731 cases of pure TB infection group, accounting for 76.14%, 21 cases of tuberculosis complicated by HIV infection group, accounting for 2.19%, 196 cases of merger of fungal infection group accounting for 0.42%, and 12 cases with HIV and TB fungal infection group, accounting for 1.25%. In the laboratory tests, there were 87 cases of abnormal liver function index and 192 cases of abnormal blood routine index, accounting for 9.06% and 20.00% respectively. Most of them merged in co-infection groups. Compared with pure infections, the liver function and blood routine index of co-infected patients is higher. And the comparison results make statistical significance; P is less than 0.05 at least. At the same time, most of the comparisons between the co-infection groups made a statistical significance; P is less than 0.05 on average. Disease distribution and laboratory test results show as follows.