<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">OJRad</journal-id><journal-title-group><journal-title>Open Journal of Radiology</journal-title></journal-title-group><issn pub-type="epub">2164-3024</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/ojrad.2015.52017</article-id><article-id pub-id-type="publisher-id">OJRad-57328</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Physics&amp;Mathematics</subject></subj-group></article-categories><title-group><article-title>
 
 
  Anterior sacral Meningocele Associated with Tethered Cord Syndrome Presenting with Constipation: US, CT, MRI and X-Ray Findings
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>okhan</surname><given-names>Soker</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Eda</surname><given-names>Soker</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Bozkurt</surname><given-names>Gulek</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Tugba</surname><given-names>Tumer</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Omer</surname><given-names>Kaya</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Muhammet</surname><given-names>Arslan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ayse</surname><given-names>Yildirim Celikdemir</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Cengiz</surname><given-names>Yılmaz</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Department of Radiology, Numune Teaching and Research Hospital, Adana, Turkey</addr-line></aff><aff id="aff3"><addr-line>Department of Radiology, Mersin University Faculty of Medicine, Mersin, Turkey</addr-line></aff><aff id="aff2"><addr-line>Department of Physical Therapy and Rehabilitation, Numune Teaching and Research Hospital, Adana, Turkey</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>gsoker@hotmail.com(OS)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>26</day><month>05</month><year>2015</year></pub-date><volume>05</volume><issue>02</issue><fpage>111</fpage><lpage>116</lpage><history><date date-type="received"><day>14</day>	<month>May</month>	<year>2015</year></date><date date-type="rev-recd"><day>accepted</day>	<month>20</month>	<year>June</year>	</date><date date-type="accepted"><day>23</day>	<month>June</month>	<year>2015</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  Anterior sacral meningocele is characterized by the herniation of the thecal sac into the retroperitoneal space. A 33-year-old man was referred to our hospital with the complaints of a longlasting constipation and nonspecific lower abdominal pain. At ultrasound, a cystic mass was detected at the presacral space. Computed Tomography revealed a defect at the anterior aspect of the sacrum, together with a presacral cystic mass which showed a connection with the dural sac. At Magnetic Resonance Imaging, it was demonstrated that the cystic mass made an impression on the rectum, and did not possess any solid components. An anteroposterior pelvis radiogram demonstrated a sacral deformity and the scimitar sign. Upon these imaging findings, the patient got the diagnosis of an anterior sacral meningocele. The possibility of an anterior sacral meningocele must always be kept in mind in the differential diagnosis of a pelvic cystic mass.
 
</p></abstract><kwd-group><kwd>Anterior sacral Meningocele</kwd><kwd> Pelvic Cyst</kwd><kwd> Tethered Cord</kwd><kwd> MRI</kwd><kwd> Ultrasonography</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Anterior sacral meningocele (ASM) is characterized by the herniation of the thecal sac into the presacral retroperitoneal space [<xref ref-type="bibr" rid="scirp.57328-ref1">1</xref>] -[<xref ref-type="bibr" rid="scirp.57328-ref3">3</xref>] . It is a rare entity and constitutes a very small portion of the cystic masses of the pelvis. It makes up only 5% of all retrorectal masses [<xref ref-type="bibr" rid="scirp.57328-ref4">4</xref>] -[<xref ref-type="bibr" rid="scirp.57328-ref6">6</xref>] . The prevalence of ASM is 1 in 1000 live births [<xref ref-type="bibr" rid="scirp.57328-ref7">7</xref>] . The disease is usually asymptomatic, but may turn symptomatic when the size of the mass starts to increase. In such occasions, urinary problems, dysmenorrhea, constipation, and even an ileus may develop [<xref ref-type="bibr" rid="scirp.57328-ref8">8</xref>] -[<xref ref-type="bibr" rid="scirp.57328-ref10">10</xref>] . It may be mistaken for other causes of a pelvic cystic mass, especially when the neck connecting the cyst with the thecal sac is narrow. Due to the high complication risk of needle aspiration, pelvic cystic mass cases must be thoroughly examined and the possibility of an ASM must always be kept in mind as a vital differential diagnosis.</p></sec><sec id="s2"><title>2. Case Report</title><p>A 33-year-old man applied to our hospital with the complaints of a long-lasting constipation and a nonspecific lower abdominal pain. His physicals did not reveal any abnormalities, and his routine laboratory work-up was within normal limits. The patient was examined by ultrasonography (US) (DC-7, Mindray Ltd., China). US examination disclosed a cystic mass of a size of 6.0 &#215; 7.5 &#215; 7.5 cm, at the posterior aspect of the bladder. The lesion was extending to the presacral space posteriorly, and had a bilobulated appearance at this site (<xref ref-type="fig" rid="fig1">Figure 1</xref>). No solid components could be visualized in the cyst. Although an ASM was among the differential list, a Computed Tomography (CT) examination was planned because other differential diagnostic possibilities could not yet be ruled out at this level of the evaluation. CT examination was performed with a 16-row multidetector scanner (Somatom Sensation 16, Siemens AG, Germany). CT revealed a bony defect at the anterior part of the sacral bone, together with a presacral cystic mass which demonstrated a connection with the dural sac (<xref ref-type="fig" rid="fig2">Figure 2</xref>). Magnetic Resonance Imaging (MRI) examination was done in a 1.5 Tesla (T) MRI system (Magnetom, Siemens AG, Germany). At MRI, a cystic mass which was hypointense on T1-weighted (T1W), and hyperintense on T2-weighted (T2W) sequences at the presacral space was demonstrated. Sagittal images clearly demonstrated that the cyst was in connection with the dural sac through the bony defect at the sacrum (<xref ref-type="fig" rid="fig3">Figure 3</xref>). It was also noted that the spinal cord was low-lying and ending at the level of the lower plate of the L5 vertebral body (Fig- ure 4). After intravenous contrast injection, no solid or neural components could be visualized in the mass. The axial T1W images showed that the mass was exerting pressure on the rectum (<xref ref-type="fig" rid="fig5">Figure 5</xref>). An anteroposterior (AP) pelvis radiogram demonstrated a sacral deformity and the scimitar sign (<xref ref-type="fig" rid="fig6">Figure 6</xref>). Upon these imaging findings, the patient got the diagnosis of an anterior sacral meningocele. The neurologic examination of the patient revealed no deficits. The patient was provided satisfying information concerning the necessity of surgery and follow-up. But, rejecting the idea of surgery, the patient, who demonstrated no clinical symptoms other than constipation, was put into a follow-up program. The patient was followed by US for a year, and no progression in the lesion size was detected during this time period.</p><fig id="fig1"  position="float"><label><xref ref-type="fig" rid="fig1">Figure 1</xref></label><caption><title> A bilobulated anechoic cystic mass is present at the posterior aspect of the bladder (arrows)</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/8-1780216x5.png"/></fig><fig id="fig2"  position="float"><label><xref ref-type="fig" rid="fig2">Figure 2</xref></label><caption><title> At axial CT, hypodense pelvic mass lesion is seen extending to the retroperitoneal space through a bony defect at the anterior wall of the sacrum (arrow)</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/8-1780216x6.png"/></fig><fig id="fig3"  position="float"><label><xref ref-type="fig" rid="fig3">Figure 3</xref></label><caption><title> At sagittal T2 weighted MRI sequence the continuation of the cystic mass with the thecal sac is clearly visible</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/8-1780216x7.png"/></fig><fig id="fig4"  position="float"><label><xref ref-type="fig" rid="fig4">Figure 4</xref></label><caption><title> Sagittal T1W sequence demonstrates the low- ending spinal cord at the sacral level (arrow)</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/8-1780216x8.png"/></fig><fig id="fig5"  position="float"><label><xref ref-type="fig" rid="fig5">Figure 5</xref></label><caption><title> These sagittal and axial MRI views demonstrate the pelvic cystic mass with no enhancing solid components in the mass. Pay attention the impression exerted on the rectum by the cystic mass (arrow)</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/8-1780216x9.png"/></fig><fig id="fig6"  position="float"><label><xref ref-type="fig" rid="fig6">Figure 6</xref></label><caption><title> AP-pelvis radiogram demonstrating sacral bone at the left lateral aspect of the sacrum (scimitar sign)</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/8-1780216x10.png"/></fig></sec><sec id="s3"><title>3. Discussion</title><p>ASM is characterized by the herniation of the thecal sac into the presacral retroperitoneal space through the sacral foramen or a defect at the sacral bone [<xref ref-type="bibr" rid="scirp.57328-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref2">2</xref>] . The disease is usually asymptomatic, but may turn symptomatic when the size of the mass starts to increase. In such occasions, urinary problems, dysmenorrhea, constipation as in our case, and even an ileus, may develop. Patients may demonstrate nonspecific symptoms [<xref ref-type="bibr" rid="scirp.57328-ref8">8</xref>] -[<xref ref-type="bibr" rid="scirp.57328-ref10">10</xref>] . In advanced stages of the disease when the size of the cystic mass reaches critical levels and the mass starts exerting serious pressure on the neighboring tissues, symptoms arise such as sciatalgia, decreased rectum and detrussor tonus, sensory loss at the lower sacral dermatomes, and paresthesia [<xref ref-type="bibr" rid="scirp.57328-ref3">3</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref8">8</xref>] .</p><p>Conventional radiography, US, CT and MRI all play important roles in the diagnosis of ASM. Radiologic imaging findings include a bony defect at the anterior wall of the sacrum, enlarged foramens, and a cystic mass localized at the pelvis. The relation and continuation of the pelvic cyst and the dural sac must be demonstrated in order to reach a definitive diagnosis.</p><p>The AP pelvis radiogram may demonstrate the sacral bony defect clearly. This defect may present in various forms in a wide spectrum of appearances, from an enlarged sacral foramen to a complete sacral agenesis. The unilateral sacral agenesis, which is a unilateral concave defect, is known as the scimitar sign [<xref ref-type="bibr" rid="scirp.57328-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref11">11</xref>] . The scimitar sign is seen in 50% of the patients and is known to be a pathognomonic finding of ASM [<xref ref-type="bibr" rid="scirp.57328-ref12">12</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref13">13</xref>] . Our patient, too, demonstrated the scimitar sign.</p><p>The pelvic cystic mass is easily demonstrated at US. But in order to make a definitive diagnosis, the relation of the mass with the dural sac must be disclosed well. Especially those cysts with narrow necks may be mistaken for an ovarian cyst or a full bladder [<xref ref-type="bibr" rid="scirp.57328-ref2">2</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref4">4</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref14">14</xref>] . It is very important to make a definitive differential diagnosis of an ASM in pelvic cystic masses. This is because in patients who suffer from this disease and who lack this differential evaluation, a surgical or an interventional approach may lead to very serious complications such as a meningitis or a sudden fall in intracranial pressure [<xref ref-type="bibr" rid="scirp.57328-ref6">6</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref9">9</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref15">15</xref>] . US is also very valuable in the follow-up of patients who are not scheduled for surgery [<xref ref-type="bibr" rid="scirp.57328-ref4">4</xref>] . CT may demonstrate the bony abnormalities at the anterior sacral wall in a much better fashion than any other imaging modality. Administration of intrathecal contrast media may disclose the relation of the dural sac and the presacral cyst perfectly. It may also help detect any solid components of the cystic mass [<xref ref-type="bibr" rid="scirp.57328-ref4">4</xref>] . But since CT myelography is an invasive procedure and utilizes ionizing radiation, it must be saved for those cases with cysts with a narrow neck which present difficulties in the detection of the relation of the cyst and the thecal sac [<xref ref-type="bibr" rid="scirp.57328-ref12">12</xref>] .</p><p>MRI is superior to other imaging modalities in the diagnosis of ASM, due its multiplanar imaging capability. Uncomplicated cysts which possess no solid components appear hypointens on T1W, and hyperintense on T2W, sequences. Utilization of contrast media also helps in the demonstration of associating pathological conditions such as a lipoma or a dermoid tumor [<xref ref-type="bibr" rid="scirp.57328-ref11">11</xref>] . MRI may detect the neural components which may be present in the cyst [<xref ref-type="bibr" rid="scirp.57328-ref16">16</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref17">17</xref>] . It has been reported that the spinal cord and the caudaequina are normal in ASM in most cases. But in rare cases as ours, a tethered cord may be present. The level of the conusmedullaris may be clearly depicted on the sagittal MRI views [<xref ref-type="bibr" rid="scirp.57328-ref14">14</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref18">18</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref19">19</xref>] . MRI also makes possible the demonstration of the cyst in three planes, its relations with the neighboring structures, and the continuation of the cyst with the thecal sac without the administration of contrast media [<xref ref-type="bibr" rid="scirp.57328-ref4">4</xref>] .</p><p>Since ASM does not regress, the symptomatic ASM patient must be treated surgically in order to provide comfort and safety [<xref ref-type="bibr" rid="scirp.57328-ref4">4</xref>] . The purpose of surgery is to terminate the connection between the dural sac and ASM [<xref ref-type="bibr" rid="scirp.57328-ref12">12</xref>] . Asymptomatic patients may be followed up by US. The surgical option must be kept in mind for those patients whose cysts demonstrate an increase in size [<xref ref-type="bibr" rid="scirp.57328-ref4">4</xref>] .</p><p>ASM may be mistaken for a tail gut duplication cyst, a presacralneurenteric cyst, a sacrococcygealteratoma, a hydatid cyst, or an ovarian cyst [<xref ref-type="bibr" rid="scirp.57328-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref20">20</xref>] [<xref ref-type="bibr" rid="scirp.57328-ref21">21</xref>] . The demonstration of the continuation of the presacral cyst with the thecal sac provides this differentiation.</p><p>Before you begin to format your paper, first write and save the content as a separate text file. Keep your text and graphic files separate until after the text has been formatted and styled. Do not use hard tabs, and limit use of hard returns to only one return at the end of a paragraph. Do not add any kind of pagination anywhere in the paper. Do not number text heads―the template will do that for you.</p><p>Finally, complete content and organizational editing before formatting. Please take note of the following items when proofreading spelling and grammar:</p></sec><sec id="s4"><title>4. Conclusion</title><p>ASM is a rare cause of the cystic lesions of the pelvis. It may be mistaken for other causes of a pelvic cystic mass, especially when the neck connecting the cyst with the thecal sac is narrow. Due to the high complication risk of needle aspiration, pelvic cystic mass cases must be thoroughly examined and the possibility of an ASM must always be kept in mind as a vital differential diagnosis. MRI is a very effective and safe modality in the demonstration of all of the findings of ASM. 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