<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">IJOHNS</journal-id><journal-title-group><journal-title>International Journal of Otolaryngology and Head &amp; Neck Surgery</journal-title></journal-title-group><issn pub-type="epub">2168-5452</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/ijohns.2015.42023</article-id><article-id pub-id-type="publisher-id">IJOHNS-54737</article-id><article-categories><subj-group subj-group-type="heading"><subject>Short Report</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  Lipoma in Hard Palate—A Case Report
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>rince</surname><given-names>Peter Dhas</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ravindran</surname><given-names>Ambika</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Amirthagani</surname><given-names>Arumugam</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Jagan</surname><given-names>Somasundaram</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Department of ENT, Thanjavur Medical College, Thanjavur, India</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>drprincembbs@gmail.com(RPD)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>26</day><month>02</month><year>2015</year></pub-date><volume>04</volume><issue>02</issue><fpage>133</fpage><lpage>136</lpage><history><date date-type="received"><day>19</day>	<month>February</month>	<year>2015</year></date><date date-type="rev-recd"><day>accepted</day>	<month>12</month>	<year>March</year>	</date><date date-type="accepted"><day>17</day>	<month>March</month>	<year>2015</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  Lipoma is a benign neoplasm of the soft tissue that originates in mature adipocytes. Even though it is a very common tumor, it is relatively uncommon in oral cavity. It represents about 1% to 4% of all benign tumors in oral cavity (12). This article describes a case of a 39 years old male with an intraoral pedunculated mass in the right side of hard palate which was histopathologically proved as a simple lipoma.
 
</p></abstract><kwd-group><kwd>Hard Palate</kwd><kwd> Lipoma</kwd><kwd> Benign</kwd><kwd> Oral Cavity</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Lipomas are benign mesenchymal neoplasms composed of mature adipocytes usually surrounded by a thin fibrous capsule [<xref ref-type="bibr" rid="scirp.54737-ref1">1</xref>] . Lipomas can occur in any part of the human body, but the majority occur in trunk and neck [<xref ref-type="bibr" rid="scirp.54737-ref2">2</xref>] . They can present as a single swelling or multiple swellings. About 20% occur in the head and neck region and only 1% to 4% involve oral cavity [<xref ref-type="bibr" rid="scirp.54737-ref3">3</xref>] [<xref ref-type="bibr" rid="scirp.54737-ref4">4</xref>] . Half of oral lipomas are in the cheek and the remaining are found in the tongue, floor of the mouth, lips, palate, and gingival mucosa [<xref ref-type="bibr" rid="scirp.54737-ref5">5</xref>] . Lipomas are usually asymptomatic till they grow to a larger size and interfere with speech, mastication and swallowing [<xref ref-type="bibr" rid="scirp.54737-ref6">6</xref>] . Lipomas may occur sporadically or as one of the several inherited disorders such as familial multiple lipomatosis and benign symmetric lipomatosis [<xref ref-type="bibr" rid="scirp.54737-ref7">7</xref>] .</p><p>Based on their histopathological aspects, lipomas can be characterized as classic lipoma, fibrolipoma, intramural lipoma, spindle cell lipoma, angiolipoma, sialolipoma, pleomorphic lipoma, myxoid lipoma and atypical lipoma. The malignant counterpart of the tumor is liposarcoma which is an another common soft tissue neoplasm but rare in oral cavity [<xref ref-type="bibr" rid="scirp.54737-ref8">8</xref>] .</p></sec><sec id="s2"><title>2. Case Report</title><p>A 39 years old male patient presented with a mass in the oral cavity. A small swelling appeared in the right side of the palate before 6 years which progressively increased in size. He had problems with speech and mastication.</p><p>He is a tobacco and betel nut chewer for 20 years. Physical examination revealed a soft pedunculated mass of size 6.5 &#215; 3.5 cm arising from the right side of the hard palate at about 1 cm medial to right 2nd molar. It was covered with intact mucosa. With the aid of computed tomography, bony attachments/erosion was excluded. Also the mass failed to enhance with contrast. Complete surgical excision was done and the mass was subjected for histopathological examination. Macroscopically the resected mass was yellowish in colour. Microscopic appearance shows a well encapsulated tumor composed of muscle fat cells with vacuolated cytoplasm with intervening fibrous septae. There was no sarcomatous change. The wound healed well. The patient was followed up for 1 year without any recurrence (Figures 1-6).</p><fig id="fig1"  position="float"><label><xref ref-type="fig" rid="fig1">Figure 1</xref></label><caption><title> Showing mass in the hard palate</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/14-2460294x5.png"/></fig><fig id="fig2"  position="float"><label><xref ref-type="fig" rid="fig2">Figure 2</xref></label><caption><title> CT showing hypodense mass in hard palate</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/14-2460294x6.png"/></fig><fig id="fig3"  position="float"><label><xref ref-type="fig" rid="fig3">Figure 3</xref></label><caption><title> Preoperative picture</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/14-2460294x7.png"/></fig><fig id="fig4"  position="float"><label><xref ref-type="fig" rid="fig4">Figure 4</xref></label><caption><title> Post operative picture</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/14-2460294x8.png"/></fig><fig id="fig5"  position="float"><label><xref ref-type="fig" rid="fig5">Figure 5</xref></label><caption><title> Cut section of excised mass</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/14-2460294x9.png"/></fig><fig id="fig6"  position="float"><label><xref ref-type="fig" rid="fig6">Figure 6</xref></label><caption><title> Microscopic picture showing mature adipocytes</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/14-2460294x10.png"/></fig></sec><sec id="s3"><title>3. Discussion</title><p>The first oral lipoma was described by Roux in a review of alveolar masses in which he referred it as “Yellow Epulis” [<xref ref-type="bibr" rid="scirp.54737-ref9">9</xref>] . Lipoma is the commonest and most benign of all tumors. Intraoral region is a rare site for its development. The incidence does not differ with gender but a predilection for men has been reported [<xref ref-type="bibr" rid="scirp.54737-ref10">10</xref>] . The case we are presenting is very rare because of its site of attachment i.e. Hard palate. To the best of our knowledge only 2 cases of lipoma in hard palate mucosa has been reported (Hoceini et al., 2010; Sushruth Nayak &amp; Prachi Nayak) [<xref ref-type="bibr" rid="scirp.54737-ref11">11</xref>] . In a case series by Perez et al. on oral lipoma among 2270 cases of oral lesions in a period of 8 years, 6 cases were oral lipomas. Of the 4, 3 were reported to be in buccal mucosa, 1 in lower lip, 1 in tongue [<xref ref-type="bibr" rid="scirp.54737-ref12">12</xref>] .</p><p>Clinically oral lipomas generally present as mobile, painless submucosal nodules with a yellowish colour. In our patient it is a pedunculated mass which is a rare presentation.</p><p>The pathogenesis of lipoma still remains with lack of consensus. Various concepts such as obesity, hormonal influences, trauma and chronic irritation have been proposed [<xref ref-type="bibr" rid="scirp.54737-ref13">13</xref>] .</p><p>Histopathologically our case is a classical lipoma which has been reported to be the commonest intraoral form in various literatures. Freital et al. (2009) reviewed 26 cases of intraoral lipomas and classic lipoma was the most common among them i.e. in 15 cases [<xref ref-type="bibr" rid="scirp.54737-ref14">14</xref>] .</p><p>Surgical excision is the suggested treatment modality and if adequately resected, recurrence is rare. We followed the patient for 1 year without any recurrence.</p></sec><sec id="s4"><title>4. Conclusion</title><p>We present this case for its rare site, size and presentation. A clinician must also recognize other differential diagnoses for such a mass which are to be excluded by radiological and histopathological examination to proceed with the correct treatment.</p></sec></body><back><ref-list><title>References</title><ref id="scirp.54737-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Fregnani, E.R., Pires, F.R., Falzoni, R., Lopes, M.A. and Vargas, P.A. (2003) Lipomas of the Oral Cavity: Clinical Findings, Histological Classification and Proliferative Activity of 46 Cases. International Journal of Oral and Maxillofacial Surgery, 32, 49-53. &lt;br&gt;http://dx.doi.org/10.1054/ijom.2002.0317</mixed-citation></ref><ref id="scirp.54737-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Rosai, J. 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