The retroesophageal right subclavian artery (RERSA) is a rare variation (0.5% to 1%) directly related to the esophagus with surgical implications. It is usually associated with right nonrecurrent laryngeal nerve (NRLN) and abnormal cerebral arteries and thoracic duct (TD). The embryological origin of the RERSA is related to abnormal involution of the fourth right aortic arch. Studies regarding the relationship between the right NRLN and the associated variant inferior thyroid artery (ITA) and Zuckerkandl’s tubercle (ZT) of thyroid gland in cases of RERSA are very few in spite of the surgical relevance to thyroid surgery [1] -[4] . In addition, the relationships of RERSA to left recurrent laryngeal nerve (LRLN) and TD are not well investigated, although such relationships may impact various surgeries such as correction of the aberrant vessel and various operative techniques for esophageal cancer [5] -[9] _.

During the dissection of 27 cadavers, the authors observed abnormal branching pattern of aortic arch (AA) in old man (Figure 1, lower inset); the AA branched into right common carotid artery (RCCA), left common carotid artery and left subclavian artery. The vertebral artery arose from left subclavian artery with normal morphology (grasped by forceps) (Figure 1, lower inset). Retraction of AA and RCCA revealed a RERSA crossed ventrally by LRLN at its origin from AA. Moreover, deeper dissection revealed the TD passing deep to the aberrant artery (Figure 1, upper inset). The aberrant artery gave rise to large thyrocervical trunk and from the latter artery a large tortuous ITA originated and was crossed at multiple proximal and distal levels by NRLN (Figure 1). Importantly, the intersection points between the ITA and NRLN was close to the origin of NRLN and its laryngealentry just above ZT. Moreover, the NRLN gave rise to extralaryngeal branch crossing superficial to ZT before its termination. The right vertebral artery was abnormally kinked close to the crossing point by right vagus nerve (Figure 2).

The NRLN is more prone to injury in thyroid surgery, therefore, preoperative detection and intra operative neuromonitoring of this nerve may be a must [3] [4] . The preoperative prediction of NRLN is based on ultrasonographic and tomographic detection of RERSA, in addition to other methods [3] [10] [11] . The intraoperative identification of NRLN depends on its relationship to thyroid vessels: In type 1, the nerve runs with superior thyroid artery, in type 2A, the nerve runs transversely over the trunk of ITA while in type 2B, the nerve crosses the ITA at one intersection level [3] [4] . However, in the present case, the tortuous ITA was crossed by NRLN at multiple levels of intersections; a unique pattern different from type 2B and could be of surgical importance asthis nerve could be accidentally injured during its exposure and ligation of ITA in thyroidectomy. Furthermore, the NRLN in the present case entered the larynx just above ZT before giving its rare extra laryngeal branch; the latter branch could be damaged during surgical exposure of NRLN in various neck surgeries as lymph node re-

section for esophageal cancer and thyroidectomy [6] [7] [12] . The relationship of TD and LRLN to the RERSA in the present case may be of surgical importance because the LRLN and TD could be injured during anastomosis of the divided RERSA to the ascending aorta or the RCCA on surgical correction of RERSA [5] . In addition, the duct, LRLN and NRLN should be secured during surgical treatment of esophageal cancer associated with RERSA. Moreover, the RERSA could be injured during video-assisted thoracoscopic esophagectomy. Therefore, preoperative diagnosis of RERSA in cancer esophagus patients based on symptoms as dysphagia lusoria or imaging methods may help to avoid injury of the aberrant artery [6] -[9] . The V1 segment of the right vertebral artery in the present case was kinked and therefore, it could impact the diagnosis and treatment of cerebral ischemia [13] .

To the best of our knowledge, the present case is the first showing the coexistence of RERSA with NRLN, variant ITA and kinked vertebral artery on right side, in addition to the relationships of the RERSA to TD and LRLN on left side. Moreover, the surgical anatomy of the present case was briefly discussed.