<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">ACT</journal-id><journal-title-group><journal-title>Advances in Computed Tomography</journal-title></journal-title-group><issn pub-type="epub">2169-2475</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/act.2014.31002</article-id><article-id pub-id-type="publisher-id">ACT-44331</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Computer Science&amp;Communications</subject><subject> Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  Atypical Calcified Ganglioglioma: A Rare Case Report
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>eizo</surname><given-names>Yamashita</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Luiz</surname><given-names>Antonio Resende</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Fernanda</surname><given-names>M. P. Souza</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Marco</surname><given-names>Zanini</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Carlos</surname><given-names>Clayton</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>André</surname><given-names>P. Trindade</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Department of General Surgery, Faculty of Medicine, UNESP, Botucatu, Brazil</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>seizo_eid@uol.com.br(EY)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>28</day><month>03</month><year>2014</year></pub-date><volume>03</volume><issue>01</issue><fpage>11</fpage><lpage>13</lpage><history><date date-type="received"><day>24</day>	<month>November</month>	<year>2013</year></date><date date-type="rev-recd"><day>24</day>	<month>December</month>	<year>2013</year>	</date><date date-type="accepted"><day>1</day>	<month>January</month>	<year>2014</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
   Considered rare tumors, gangliogliomas account for 0.4% - 0.9% of intracranial neoplasms. The peak of its incidence occurs between 10 and 20 years of age. These tumors are composed of glial and ganglion cells and they are relatively low-grade neoplasms associated with good prognoses. We report a case of an atypical calcified ganglioglioma in an 18-year-old woman with history of four months of stabbing right-sided parietal headache, paroxysmal. On image studies were noted the presence of thick wall calcification in gangliogliomas. Although rare, this atypical ganglioglioma should be included in the differential diagnosis of lesions occurring in this area of the brain. 
 
</p></abstract><kwd-group><kwd>Gangliogliomas; Brain; Calcification; Atypical</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Case Report</title><p>RCGP, female, 18-year-old, with history of four months of stabbing right-sided parietal headache, paroxysmal, was admitted in our hospital. A temporal tumor was reported since her childhood. At clinical evaluation, the patient was conscious, presenting isochoric and photoreactive pupils with right-sided temporal bone consistency and right ocular proptosis. The normal muscle strength, the sensibility, the reflexes and the cranial pairs were preserved.</p><p>The patient was submitted a CT of the brain and the right temporal lobe image revealed a solid expansive process surrounded by a thick calcified capsule.</p></sec><sec id="s2"><title>2. Discussion</title><p>Gangliogliomas are rare tumors, account for 0.4% - 0.9% of intracranial neoplasms and to 1% - 4% of all pediatric neoplasm of CNS. They are relatively low-grade neoplasms associated with good prognoses. The peak of its incidence occurs between 10 and 20 years of age [<xref ref-type="bibr" rid="scirp.44331-ref1">1</xref>] . They can be manifested in newborns with or without neurological alterations and are slightly more common in males. Due its slow growing, the clinical signs and symptoms are usually of long duration such as headaches, focal seizures or, depending of its location, hypothalamic dysfunction.</p><p>The ganglioglioma is the most common tumor found in patients with chronic temporal lobe epilepsy. They predominantly affect the cerebral hemispheres, especially the temporal lobe and can also to reach the basal ganglia, cerebellum, brainstem, spinal cord, optic nerve and pineal gland [<xref ref-type="bibr" rid="scirp.44331-ref2">2</xref>] [<xref ref-type="bibr" rid="scirp.44331-ref3">3</xref>] . They can be associated with congenital anomalies such as Down’s syndrome and agenesis of the corpus callosum. Rarely hypervascularized, the presence of intratumoral bleeding is not common and, in the majority of the cases, the lesion is avascular [<xref ref-type="bibr" rid="scirp.44331-ref4">4</xref>] . According to the WHO classification, gangliogliomas are graded as Grade I or II and anaplastic gangliogliomas, as Grade III [<xref ref-type="bibr" rid="scirp.44331-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.44331-ref6">6</xref>] [<xref ref-type="bibr" rid="scirp.44331-ref7">7</xref>] . The anaplastic ganglioglioma is characterized by the presence of hypercellularity areas, vascular proliferation, necrosis and mitotic figure 1 [<xref ref-type="bibr" rid="scirp.44331-ref8">8</xref>] . On CT, can be manifested as a solid (43%), cystic (5%), or a combination of solid-cystic (52%) mass. Often, the lesions are isodense or hypodense, well-demarcated with a minimal mass effect or surrounding edema. Peripheral location and calcification are common aspects of the gangliogliomas [<xref ref-type="bibr" rid="scirp.44331-ref5">5</xref>] . The tumors can or cannot show enhancement after contrast injection. On images, the aspect is not specific and can be classified by an astrocytoma of lower grade, oligodendroglioma. On MR, they usually are isointense to hypointense in relation to the gray matter on T1, and mostly hyperintense on T2.</p><p>The malignant degeneration of gangliogliomas is rare (6%). However, the anaplasia of the glial component has been reported by some authors, and may occurs no differentiation to multiform glioblastoma, that alters significantly the case evolution.</p><p>In the current case, the only sign and symptom presented by the patient was a severe right-sided parietal headache during the past four months. Neurological and physical examinations are made and neither changes nor any kind of base pathologies such as hypertension and diabetes were observed. Blood test and biochemical analysis were all normal. The patient was submitted a CT of the brain without intravenous contrast (the patient refused the injection). The image from the right temporal lobe revealed a solid expansive process surrounded by a thick calcified capsule.</p><p>The suggested treatment for the patient was the total surgical removal of the tumor. The radiotherapy is indicated for cases of partial removal [<xref ref-type="bibr" rid="scirp.44331-ref2">2</xref>] [<xref ref-type="bibr" rid="scirp.44331-ref3">3</xref>] .</p></sec><sec id="s3"><title>3. Conclusion</title><p>Gangliogliomas is a rare tumor and clearly requires further studies about its origin. Image studies showing the presence of thick wall calcification in gangliogliomas is very rare, and except the current study, no similar case has been found in the radiological literature.</p></sec></body><back><ref-list><title>References</title><ref id="scirp.44331-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Koeller, K.K. and Henry, J.M. (2001) From the Archives of the AFIP Superficial Gliomas: Radiologic-Pathologic Correlation. RadioGraphics, 21, 1533-1556. http://dx.doi.org/10.1148/radiographics.21.6.g01nv051533</mixed-citation></ref><ref id="scirp.44331-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Haddad, S.F., Moore, S.A., Menezes, A.H. and VanGilder, J.C. (1992) Ganglioglioma: 13 Years of the Experience. Neurosurgery, 31, 171-178. http://dx.doi.org/10.1227/00006123-199208000-00001</mixed-citation></ref><ref id="scirp.44331-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Miller, D.C., Lang, F.F. and Epstein, F.J. (1993) Central Nervous System Gangliogliomas. Journal of Neurosurgery, 79, 859-866. http://dx.doi.org/10.3171/jns.1993.79.6.0859</mixed-citation></ref><ref id="scirp.44331-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Lima, P.L.B., Lima, A.M.B. and Filho, H.R.A. (2006) Ganglioglioma. Comparison with Other Low-Grade Brain Tumors. Arquivos de Neuro-Psiquiatria, 64, 613-618. http://dx.doi.org/10.1590/S0004-282X2006000400018</mixed-citation></ref><ref id="scirp.44331-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Chan, A., McAbee, G., Queenan, J. and Manning, A. (2001) Ganglioneurocytoma Mimicking a Malignant Tumor: Case Report with Literature Review of the MRI Appearance of Neurocytomas and Gangliogliomas. Journal of Neuroimaging, 11, 47-50. http://dx.doi.org/10.1111/j.1552-6569.2001.tb00009.x</mixed-citation></ref><ref id="scirp.44331-ref6"><label>6</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Kitano</surname><given-names> M.</given-names></name>,<name name-style="western"><surname> Takayama</surname><given-names> S.</given-names></name>,<name name-style="western"><surname> Nagao</surname><given-names> T. and Yoshimura</given-names></name>,<name name-style="western"><surname> O. </surname><given-names>  </given-names></name>,<etal>et al</etal>. (<year>1987</year>)<article-title>Malignant Ganglioglioma of the Spinal Cord</article-title><source> Acta Pathologica Japonica</source><volume> 37</volume>,<fpage> 1009</fpage>-<lpage>1018</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.44331-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Russel, D.S. and Rubistein, L.J. (1962) Ganglioglioma: A Case of a Long History and Malignant Evolution. Journal of Neuropathology &amp; Experimental Neurology, 21, 185-183. http://dx.doi.org/10.1097/00005072-196204000-00002</mixed-citation></ref><ref id="scirp.44331-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Wolf, H.K., Müller, M.B., Spanle, M., Zentner, J., Schramm, J. and Wiestler, O.D. (1994) Ganglioglioma: A Detailed Histopathological and Immunohistochemical Analysis of 61 Cases. Acta Neuropathologica, 88, 166-173. http://dx.doi.org/10.1007/BF00294510</mixed-citation></ref></ref-list></back></article>