<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">AM</journal-id><journal-title-group><journal-title>Applied Mathematics</journal-title></journal-title-group><issn pub-type="epub">2152-7385</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/am.2014.54073</article-id><article-id pub-id-type="publisher-id">AM-43843</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Physics&amp;Mathematics</subject></subj-group></article-categories><title-group><article-title>
 
 
  Nelson-Aalen and Kaplan-Meier Estimators in Competing Risks
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>idier</surname><given-names>Alain Njamen-Njomen</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Joseph</surname><given-names>Ngatchou-Wandji</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Department of Mathematics and Computer Sciences, Faculty of Sciences, University of Maroua, 
Maroua, Cameroon;Department of Mathematics, Faculty of Sciences, University of Yaounde 1, Yaounde, Cameroon
;</addr-line></aff><aff id="aff2"><addr-line>University of Lorraine, Lorraine, France</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>dangaza@yahoo.fr(IAN)</email>;<email>Joseph.ngatchou-wandji@univ-lorraine.fr(JN)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>10</day><month>03</month><year>2014</year></pub-date><volume>05</volume><issue>04</issue><fpage>765</fpage><lpage>776</lpage><history><date date-type="received"><day>11</day>	<month>December</month>	<year>2013</year></date><date date-type="rev-recd"><day>11</day>	<month>January</month>	<year>2014</year>	</date><date date-type="accepted"><day>18</day>	<month>January</month>	<year>2014</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
      
   In this paper, stochastic processes developed by Aalen [1] [2] are adapted to the Nelson-Aalen and Kaplan-Meier [3] estimators in a context of competing risks. We focus only on the probability distributions of complete downtime individuals whose causes are known and which bring us to consider a partition of individuals into sub-groups for each cause. We then study the asymptotic properties of nonparametric estimators obtained.  
    
 
</p></abstract><kwd-group><kwd>Censored Data; Counting Process; Competitive Risk; Non-Parametric Estimators; The Cumulative Incidence Function; Risk Function Specific Cause; Conditional Distribution Function</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Let us consider a data model which lives time where the event of interest is a failure (or death) due to the <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c942682c-4412-4249-b6be-e66fedde527a.png" xlink:type="simple"/></inline-formula> event, <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\56624fc8-0d2a-4481-8a5b-e1e6254ca77a.png" xlink:type="simple"/></inline-formula>and the non-zero integer m, the number of possible causes. By convention, <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b15c1eaa-ccfe-4425-b094-704f5ca4cbc0.png" xlink:type="simple"/></inline-formula>corresponds to the state of functioning (or of life) of the observed individual. It is assumed that the observation is stopped when a failure (or death) occurs, but this observation may be right-censored in a non-informative way. Some examples of this situation corresponds to the case where the event of interest is due to another cause, or withdrawal of the individual from the study or at the end of the study. In the case of right censoring time, the time of failure of year for individuals and their causes are not known to the experimenter. A data model as described above is commonly called “competing risks model” (or competitors) and is studied in fields such as medical control, demography, actuarial science, economics or industrial reliability. In Andersen et al. [<xref ref-type="bibr" rid="scirp.43843-ref4">4</xref>] , an illustration and details of mathematics techniques on competing risks in biomedical applications are developed. For example in the study of AIDS, the different competitive risks can be 1) death due to AIDS, 2) death due to tuberculosis or 3) death due to other causes and in this case <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\7b11ab0b-1ba8-4a33-94e6-0691cfecd674.png" xlink:type="simple"/></inline-formula> (see <xref ref-type="fig" rid="fig1">Figure 1</xref>).</p><p>It is important to note that in most data models in competing risks, the functions that characterize the probability distribution of the variable of interest and the marginal are not always observable (see Tsiatis [<xref ref-type="bibr" rid="scirp.43843-ref5">5</xref>] , Heckman and Honor&#233; [<xref ref-type="bibr" rid="scirp.43843-ref6">6</xref>] ). Issues to be resolved include virtually the underlying functions for different causes and effects of covariates on the rate of occurrence of competing risks. One of the problems we may face is that the information on the cause of failure of the individual observation can only be known after the autopsy, while we don’t know anything about individuals censored in monitoring. In addition, the incident distributions (due to specific causes) do not allow to describe satisfactorily the probabilities of the various marginal (failures <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e625798f-9314-425c-bfff-e7ec64caada5.png" xlink:type="simple"/></inline-formula> case<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\22e98e4c-5efd-44a6-8875-1562adcf1c8d.png" xlink:type="simple"/></inline-formula>) in competing risks models. Assumptions of independence of competing risks can help ensure observability in some cases, but they are not reasonable only in such models.</p><sec id="s1_1"><title>1.1. Related Works</title><p>The estimators of Nelson-Aalen and Kaplan-Meier [<xref ref-type="bibr" rid="scirp.43843-ref3">3</xref>] are generally studied in the literature following two approaches: firstly, the method of martingale (Aalen [<xref ref-type="bibr" rid="scirp.43843-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.43843-ref2">2</xref>] ; Andersen et al. [<xref ref-type="bibr" rid="scirp.43843-ref4">4</xref>] ; Fleming and Harrington [<xref ref-type="bibr" rid="scirp.43843-ref7">7</xref>] , Prentice et al. [<xref ref-type="bibr" rid="scirp.43843-ref8">8</xref>] ) and secondly the law of the iterated logarithm (Breslow and Crowley [<xref ref-type="bibr" rid="scirp.43843-ref9">9</xref>] , F&#246;ldes and Rejt&#246; [<xref ref-type="bibr" rid="scirp.43843-ref10">10</xref>] or Major and Rejt&#246; [<xref ref-type="bibr" rid="scirp.43843-ref11">11</xref>] , F&#246;ldes and Rejt&#246; [<xref ref-type="bibr" rid="scirp.43843-ref12">12</xref>] , Gill [<xref ref-type="bibr" rid="scirp.43843-ref13">13</xref>] , Cs&#246;rg&#246; and Horv&#225;th [<xref ref-type="bibr" rid="scirp.43843-ref14">14</xref>] , Ying [<xref ref-type="bibr" rid="scirp.43843-ref15">15</xref>] and Chen and Lo [<xref ref-type="bibr" rid="scirp.43843-ref16">16</xref>] ). Recently, applications have been made in the context of competing risks (Latouche [<xref ref-type="bibr" rid="scirp.43843-ref17">17</xref>] ; Belot [<xref ref-type="bibr" rid="scirp.43843-ref18">18</xref>] ). Latouche [<xref ref-type="bibr" rid="scirp.43843-ref17">17</xref>] states that during the planification of clinical trials, the evaluation of the number of patients to be included is a critical issue because such a formulation does not exist in the Fine and Gray’s [<xref ref-type="bibr" rid="scirp.43843-ref19">19</xref>] model. For this purpose, he therefore computes the number of patients within the context of competition for an inference based function on cumulative incidence and then, he studies the properties of the model of Fine and Gray when it is wrongly specified. Belot [<xref ref-type="bibr" rid="scirp.43843-ref18">18</xref>] presents the data got from randomized clinical tests on prostate cancer patients who died for several reasons.</p></sec><sec id="s1_2"><title>1.2. Contributions</title><p>In this paper, the stochastic processes developed by Aalen [<xref ref-type="bibr" rid="scirp.43843-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.43843-ref2">2</xref>] are adapted to Nelson-Aalen and KaplanMeier estimators [<xref ref-type="bibr" rid="scirp.43843-ref3">3</xref>] in a context of competing risks (e.g. Aalen and Johansen [<xref ref-type="bibr" rid="scirp.43843-ref20">20</xref>] , Andersen et al. [<xref ref-type="bibr" rid="scirp.43843-ref4">4</xref>] ). We focus only on the complete probability distributions of downtime individuals whose causes are known and which bring us to consider a partition of individuals sub-groups for each cause. We provide a new proof of the consistency of the Nelson-Aalen estimator in the context of competing risks by using the method of martingale. Under the regularity assumptions for the sequence <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\36a60388-61ae-4eee-8ac7-e72dfc3c0a9b.png" xlink:type="simple"/></inline-formula> (<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ef2b358b-e55d-4842-9840-28702b674f69.png" xlink:type="simple"/></inline-formula>is a sequence of integers such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\61a4a435-6e97-4008-9a6c-d3bad0f81b59.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\348965ae-1c3a-43d7-a482-84abbeab19cf.png" xlink:type="simple"/></inline-formula> is the number of observable samples) we obtain an almost-safe speed estimator of Kaplan-Meier [<xref ref-type="bibr" rid="scirp.43843-ref3">3</xref>] which is the same as that obtained by Gin&#233; and Guillou [<xref ref-type="bibr" rid="scirp.43843-ref21">21</xref>] which is <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\878e6d8a-1614-4a5c-899c-c502f76d81db.png" xlink:type="simple"/></inline-formula></p><p>The rest of the paper is organized as follows: Section 2 describes preliminary results and notations used in the paper and Section 3 evaluates the conditional functions of distribution to the specific causes. Section 4 contains the main results of the paper as well as some properties of our estimators obtained. The last section concludes the paper.</p></sec></sec><sec id="s2"><title>2. Preliminary Results</title><p>Lifetime analysis (also referred to as survival analysis) is the area of statistics that focuses on analyzing the time</p><p>duration between a given starting point and a specific event. This endpoint is often called failure and the corresponding length of time is called the failure time or survival time or lifetime.</p><p>Formally, a failure time is a nonnegative random variable (r.v.) <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\0f2e043c-f4cd-404f-8970-a92b6b566daa.png" xlink:type="simple"/></inline-formula>that describes the length of time from a time origin until an event of interest occurs. We will suppose throughout that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\3344d5fd-d95e-443a-bb82-aa2c8c842da3.png" xlink:type="simple"/></inline-formula></p><p>The most basic quantities used to summarize and describe the time elapsed from a starting point until the occurrence of an event of interest are the distribution function and the hazard function. The cumulative distribution function at time <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\05a47121-d942-459d-a816-306e82a2ff7f.png" xlink:type="simple"/></inline-formula> also called lifetime distribution or the failure distribution, is the probability that the failure time of an individual is less or equal than the value <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\039ac56b-fdf2-4762-90fe-80953340e237.png" xlink:type="simple"/></inline-formula> It is given for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f037064d-7cb1-4600-8425-188f6f815a78.png" xlink:type="simple"/></inline-formula> by: <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ec9fc871-a027-4e71-bed8-dbdbc2d1bbd4.png" xlink:type="simple"/></inline-formula></p><p>The function <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c8ead241-dc3e-4224-aeae-0a3d7f05e41f.png" xlink:type="simple"/></inline-formula> is right-continuous, nondecreasing and satisfies <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5191ad2d-e33a-4ff1-88f0-dbcfb3eb9833.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\843f9db6-2bc2-4d8f-8eae-016dd09ac5cc.png" xlink:type="simple"/></inline-formula> We denote by <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9f2e3a70-b930-45af-a742-7f662fd4c418.png" xlink:type="simple"/></inline-formula> the left-continuous function obtained from <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\7449e622-221c-452a-8e4c-28ac906a6853.png" xlink:type="simple"/></inline-formula> in the following way:</p><p><img src="htmlimages\19-7402027x\56bf9556-c227-4fb1-9d9d-47c5ab7b3e11.png" /></p><p>The distribution of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\3fb229f5-4fac-429c-9ad8-18e07246ceac.png" xlink:type="simple"/></inline-formula> may equivalently be dealt with in terms of the survival function which is given, for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\bea4b943-958e-4a77-b7a0-6b0f561d94e9.png" xlink:type="simple"/></inline-formula> by:</p><p><img src="htmlimages\19-7402027x\c4210382-8414-47de-9476-4bc542451e9f.png" /></p><p>The cumulative hazard function is defined for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4f092da2-f444-4cf0-8340-d60a17400d8d.png" xlink:type="simple"/></inline-formula> by:</p><p><img src="htmlimages\19-7402027x\18c8f669-b9e1-41ce-a506-bc55c4a432ad.png" /></p><p>When <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\afcaa1d3-545b-49de-a44f-d5eba908b4d9.png" xlink:type="simple"/></inline-formula> is continuous, the relation <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e014a0e4-504a-466a-9dc0-7ccdab6301a8.png" xlink:type="simple"/></inline-formula> is valid for all <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\af81c47c-397b-4124-990a-37474e98248b.png" xlink:type="simple"/></inline-formula> We can then call <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\02e54fc6-7399-4a8d-af15-b1c841467306.png" xlink:type="simple"/></inline-formula> the log-survival function.</p><p>If <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f4340073-b399-4eb2-919e-2e17085dc6f9.png" xlink:type="simple"/></inline-formula> admits a derivative with respect to Lebesgue measure on <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\abdacbb5-b7fe-48fe-b088-377fcc910c0e.png" xlink:type="simple"/></inline-formula> the probability density function exists and is defined for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\806b8945-3d33-4587-896c-042186ffacd8.png" xlink:type="simple"/></inline-formula> by:</p><p><img src="htmlimages\19-7402027x\6cf26f43-b7ab-4a13-a79a-f66f68870dc7.png" /></p><p>Heuristically, the function <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4e2b08f9-9d00-4aea-aa4c-3669a1fb76b5.png" xlink:type="simple"/></inline-formula> may be seen as the instantaneous probability of experiencing the event.</p><p>With the same hypothesis of differentiability, the hazard function exists and is defined for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\de2512ef-0171-461e-811b-79d46d5c56ba.png" xlink:type="simple"/></inline-formula> by:</p><p><img src="htmlimages\19-7402027x\53e9fa09-bb5a-41c4-b0cb-d545515fc8b1.png" /></p><p>The quantity <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8040ce1e-7afb-4321-806b-978883be5ac6.png" xlink:type="simple"/></inline-formula> can be interpreted as the instantaneous probability that an individual dies at time <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\48cf5123-b5e7-4cf3-a49e-5974c1b0e828.png" xlink:type="simple"/></inline-formula> conditionally on he or she having survived until that time.</p><p>For an extensive introduction to lifetime analysis, the reader is referred e.g. to the books of Cox and Oakes [<xref ref-type="bibr" rid="scirp.43843-ref22">22</xref>] and Kalbfleisch and Prentice [<xref ref-type="bibr" rid="scirp.43843-ref23">23</xref>] .</p><p>The main difficulty in the analysis of lifetime data lies in the fact that the actual failure times of some individuals may not be observed. An observation is right-censored if it is known to be greater than a certain value, provided the exact time is unknown. Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\199203e3-1700-409d-8b21-6b92dd2700a4.png" xlink:type="simple"/></inline-formula> be the nonnegative r.v. with distribution function <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\da320a6f-3d68-4e68-a0d1-ae7ed3864ea4.png" xlink:type="simple"/></inline-formula> that stands for the censoring time of the individual. As before, the nonnegative r.v. <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4427f671-1822-4d8e-9b3f-01ef482ae99e.png" xlink:type="simple"/></inline-formula>with distribution function <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\80757b4c-3c98-4854-9295-fe98a1485959.png" xlink:type="simple"/></inline-formula> denotes the failure time of the individual. If <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\1e63afeb-c2db-4398-90ae-9f4adb1ab1c0.png" xlink:type="simple"/></inline-formula> is censored, instead of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\3de64250-9030-45ff-b7c1-474faf7d29f8.png" xlink:type="simple"/></inline-formula> we observe <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c97317c3-db6b-4a82-a3f4-8ea6fbe91d06.png" xlink:type="simple"/></inline-formula> which gives the information that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\dde765a5-61fd-4b7f-bdbf-15b7b9c4fea6.png" xlink:type="simple"/></inline-formula> is greater than <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8f5f9b5e-6a65-4305-86d3-bdf03b5fd739.png" xlink:type="simple"/></inline-formula> In any case, the observable r.v. consists of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\97ddd3b9-2ec8-4765-a925-15124c9b4bf9.png" xlink:type="simple"/></inline-formula>  <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\87d48081-ca18-4eed-a477-35a559e85071.png" xlink:type="simple"/></inline-formula>, where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b38f460f-6698-4171-8a5a-ff3e205d4708.png" xlink:type="simple"/></inline-formula> denotes the indicator function. The nonnegative r.v. <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\1d5481cb-499f-4066-8e7d-2d92940c28b0.png" xlink:type="simple"/></inline-formula>stands for the observed duration of time which may correspond either to the event of interest <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9599d4b0-fc37-4985-88a6-fea94f1c5c8b.png" xlink:type="simple"/></inline-formula> or to a censoring time <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\195dbdf1-3a37-491d-85c0-242fe476f5f9.png" xlink:type="simple"/></inline-formula></p><p>As a sequel to above, it is assumed that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ba1a1e50-1262-4268-a31d-6b258a773a43.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8c8e30e4-e6a3-4a2d-b7c2-fa127db91a7e.png" xlink:type="simple"/></inline-formula> are independent. Consequently, the random variable <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2f2f5c7e-5635-4d6e-b3a5-1d3739b72210.png" xlink:type="simple"/></inline-formula> has the distribution function <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8cf671d8-457b-4108-baf4-bd33786548ec.png" xlink:type="simple"/></inline-formula> given by</p><p><img src="htmlimages\19-7402027x\c16e8dc2-1332-4926-b017-c4095e2ccf85.png" /></p><p>The following subdistribution functions of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b6aa8fd1-3ab2-41c1-918f-bdd98b848320.png" xlink:type="simple"/></inline-formula> will be needed:</p><p><img src="htmlimages\19-7402027x\4c8ac523-f6d9-4df3-ac9a-8c7311c759af.png" /></p><p>and</p><p><img src="htmlimages\19-7402027x\688f4c26-6510-418d-8933-c104717b7e9a.png" /></p><p>The relation</p><p><img src="htmlimages\19-7402027x\d701d011-9057-48a9-ba58-512d391e36bd.png" /></p><p>is valid for any <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\19531a3a-b72c-42fa-9a6d-5503e1eb8e12.png" xlink:type="simple"/></inline-formula></p><p>The relations that connect the subdistribution functions <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2109d573-37b3-47ab-add0-fed5e5ded57f.png" xlink:type="simple"/></inline-formula> <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f8fa3b67-8ea0-40b0-bdba-eb0b55bf5eb6.png" xlink:type="simple"/></inline-formula> and to the distribution functions <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\208aaf03-4046-44d0-a897-ac6593b9ab5b.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\41170ee3-7db4-4c21-bc29-1f6bcf489aaf.png" xlink:type="simple"/></inline-formula> are given by:</p><p><img src="htmlimages\19-7402027x\a0fbd99c-30a7-44fe-9a2a-953991d31ea5.png" /></p><p>and</p><p><img src="htmlimages\19-7402027x\1cf5f07b-3986-4738-ad2e-54a33d42d4e5.png" /></p><p>The cumulative hazard function of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\d1ea975b-e6a9-4a70-82d4-2fdae6044501.png" xlink:type="simple"/></inline-formula> can be expressed as:</p><p><img src="htmlimages\19-7402027x\bbe7a166-c325-487b-b11b-0a63bb4fef09.png" /></p><p>Kaplan and Meier [<xref ref-type="bibr" rid="scirp.43843-ref3">3</xref>] introduced the product-limit estimator for the survival distribution function. The estimator of the cumulative hazard function is the Nelson-Aalen estimator introduced by Nelson [<xref ref-type="bibr" rid="scirp.43843-ref24">24</xref>] [<xref ref-type="bibr" rid="scirp.43843-ref25">25</xref>] and generalized by Aalen [<xref ref-type="bibr" rid="scirp.43843-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.43843-ref2">2</xref>] .</p><p>Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e7c1eab6-5d0a-49ad-ad6e-72f5fcb12dd7.png" xlink:type="simple"/></inline-formula> for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f8c6ec83-afb2-489e-8deb-15f496d38d92.png" xlink:type="simple"/></inline-formula> be <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\de3c84a8-6036-4cbf-9e14-319cdd76f980.png" xlink:type="simple"/></inline-formula> independent copies of the random vector <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\733f492c-6547-42dc-af30-d48d983e6ce0.png" xlink:type="simple"/></inline-formula> Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\1d9a8e8f-3fa7-4d18-b991-ffa99bd6b12c.png" xlink:type="simple"/></inline-formula> be the order statistics associated to the sample <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\aa4c10c5-4e47-460a-a822-df3639dd9a8d.png" xlink:type="simple"/></inline-formula> If there are ties between a failure time (or several failure times) and a censoring time, then the failure time(s) is (are) ranked ahead of the censoring time(s).</p><p>We define the empirical counterparts of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\fe48df6a-5bd5-4378-a3cb-a96475adde15.png" xlink:type="simple"/></inline-formula> <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f7edc0c3-ce71-4a26-9666-e9bcf9f265cf.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\bad6e95c-fa05-4483-9faa-03987d3d0c67.png" xlink:type="simple"/></inline-formula> by:</p><p><img src="htmlimages\19-7402027x\c7719c2c-1b2f-4220-b447-b02cf9eab2b2.png" /></p><p><img src="htmlimages\19-7402027x\c32616e4-f381-4242-b517-06b31a17c6d7.png" /></p><p><img src="htmlimages\19-7402027x\8051be61-5116-4115-b043-1b929bce1cd0.png" /></p><p>The Kaplan-Meier product-limit estimator is defined for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2631437f-fa89-4e0f-bad7-671db53bdf23.png" xlink:type="simple"/></inline-formula> by:</p><p><img src="htmlimages\19-7402027x\d25be707-d740-43bd-a4d1-f5e0a6caa541.png" /></p><p>The Nelson-Aalen estimator for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\74e3c4ce-9a41-4454-8333-ce59687e8f73.png" xlink:type="simple"/></inline-formula> is then defined for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\7eadc468-9827-445f-802a-73792a3cec93.png" xlink:type="simple"/></inline-formula> by:</p><p><img src="htmlimages\19-7402027x\56087300-f181-4fc1-960c-455efb6e5ee0.png" /></p><p>The following relations are valid for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\454eacc4-62ac-4fc3-9664-f8cca98efd7f.png" xlink:type="simple"/></inline-formula></p><p><img src="htmlimages\19-7402027x\80434d61-868c-40ce-b8e9-b883d1d584f4.png" /></p><p><img src="htmlimages\19-7402027x\0b21a5f4-373e-43c2-a4e5-eccdcaaacb66.png" /></p><p><img src="htmlimages\19-7402027x\15d4a3c6-a940-4c83-aa14-819efed15b3a.png" /></p><p>where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f3e1335f-d858-4003-bac6-03e5a4278cf1.png" xlink:type="simple"/></inline-formula> the Kaplan-Meier estimator of<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5e8ce438-7882-4e93-a226-6fbcca376f5d.png" xlink:type="simple"/></inline-formula>, is defined for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\10e73266-2883-486d-b899-8538f20f389f.png" xlink:type="simple"/></inline-formula> by:</p><p><img src="htmlimages\19-7402027x\bfa2ed65-5f3d-41b6-919b-54019dc06c43.png" /></p><p>Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\0a8da8d8-4680-476e-8924-a4cd651a20fc.png" xlink:type="simple"/></inline-formula> be a sequence of integers between <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\fdc7f15f-3f50-4b58-8905-ceb69e188829.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5ba740ac-22bb-484d-b174-186fd1fc8d4e.png" xlink:type="simple"/></inline-formula> In order to always have asymptotical results, we suppose that the sequence <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\3f3be296-e763-434e-a618-387c837ce296.png" xlink:type="simple"/></inline-formula> satisfies the following hypothesis:</p><p><inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5abfd228-1db8-4d10-b3ec-28c86da569b7.png" xlink:type="simple"/></inline-formula>for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ed3da9a2-d887-4c0c-be3b-a8e62083103a.png" xlink:type="simple"/></inline-formula> large enough, the sequence <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c5be4ff6-808f-44ef-89ca-df8faa0e5ca6.png" xlink:type="simple"/></inline-formula> is non-increasing and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\3f7b5814-7da4-490e-9bba-4154e76e0884.png" xlink:type="simple"/></inline-formula></p><p><inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\835431d8-4244-41b9-8c72-b190515c9d98.png" xlink:type="simple"/></inline-formula>for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9ef8c5c0-45f0-499d-a757-5653a2d32525.png" xlink:type="simple"/></inline-formula> large enough, the sequence <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\26b365ad-6eb5-4bf5-bf5d-4cb511f29c92.png" xlink:type="simple"/></inline-formula> is non-increasing and there exists a constant <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\71ac898a-6190-42cc-854d-13b2239f4797.png" xlink:type="simple"/></inline-formula> such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8fe5af21-4d11-4cde-8f22-876afc700c6b.png" xlink:type="simple"/></inline-formula> with <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e274b21e-6ad6-4e81-94af-c29131f33227.png" xlink:type="simple"/></inline-formula> is a non-increasing sequence such that:</p><p><img src="htmlimages\19-7402027x\7f3380a2-51e7-42c3-be7d-ed0ebf1dba8c.png" /></p><p><img src="htmlimages\19-7402027x\7da8ab7f-79ff-471f-8f34-caa4fe9f695b.png" /></p><p>Condition <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f6a121b0-24ee-4251-8114-f5fbd26cdb8a.png" xlink:type="simple"/></inline-formula> is required when applying the results of Gin? and Guillou [<xref ref-type="bibr" rid="scirp.43843-ref21">21</xref>] while Condition <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\865df8d8-6d81-4133-a9bb-b61bfa4c459e.png" xlink:type="simple"/></inline-formula> is required when applying the results of Cs<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9cfe3931-2f9f-4225-b9de-1ccb1b74a020.png" xlink:type="simple"/></inline-formula>rg&#246; [<xref ref-type="bibr" rid="scirp.43843-ref26">26</xref>] .</p><p>The following result formulates the laws of the iterated logarithm-type (LIL-type) result on the mentioned increasing intervals.</p><p>Theorem 1 (Cs&#246;rg&#246; [<xref ref-type="bibr" rid="scirp.43843-ref26">26</xref>] ; Gin&#233; and Guillou [<xref ref-type="bibr" rid="scirp.43843-ref21">21</xref>] ) Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\0d171d2f-882d-4d67-8095-3c5ac176aa53.png" xlink:type="simple"/></inline-formula> be a sequence of integers such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f3a14ca8-d2ee-43d7-9daa-bacc9c397d93.png" xlink:type="simple"/></inline-formula> and, for the almost sure results, satisfying <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\d1499da4-94e4-4c05-9439-1fc8d09de410.png" xlink:type="simple"/></inline-formula> We have<sup>1</sup>:</p><p><img src="htmlimages\19-7402027x\035a648c-a20d-499c-9c72-308491f37f8a.png" /></p><p>If, in addition, <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a983b6da-d507-47ab-a970-35a41f69f80e.png" xlink:type="simple"/></inline-formula>is assumed continuous, then we also have:</p><p><img src="htmlimages\19-7402027x\866df6eb-96fd-43ac-9cbf-02a4298040c1.png" /></p><p>Proof. See Cs&#246;rg&#246; [<xref ref-type="bibr" rid="scirp.43843-ref26">26</xref>] ; Gin&#233; and Guillou [<xref ref-type="bibr" rid="scirp.43843-ref21">21</xref>] . <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\3256c590-d216-4853-977a-608237dbd6ab.png" xlink:type="simple"/></inline-formula></p><p>The continuity of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a24a3e98-8e17-40ed-a5c9-30fb32105a14.png" xlink:type="simple"/></inline-formula> is required to linearize the Kaplan-Meier process. Indeed, if <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2fab9c38-0742-45fe-9070-19362d68a420.png" xlink:type="simple"/></inline-formula> is continuous, then <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\7c689f99-177c-4531-a786-7170e072b3fa.png" xlink:type="simple"/></inline-formula> can be approximated by <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\7ed8abc5-d7e4-4459-b03a-82dbafdb6969.png" xlink:type="simple"/></inline-formula> on the random interval <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\37ee6317-b432-4f62-aed2-a2ea56094545.png" xlink:type="simple"/></inline-formula> Precisely, we have the following result.</p><p>Proposition 1 (Gin&#233; and Guillou [<xref ref-type="bibr" rid="scirp.43843-ref21">21</xref>] ) Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4790b77b-95a6-481e-a4a1-05e9737de3ea.png" xlink:type="simple"/></inline-formula> be a sequence of integers satisfying <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a5f30ad8-77fe-464f-9d07-9d51bb7f92f9.png" xlink:type="simple"/></inline-formula> and Hypothesis<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ceb9fdad-4949-4652-b928-67e02995efee.png" xlink:type="simple"/></inline-formula>. If <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\57d19047-5e55-4489-ae83-19575f2f2289.png" xlink:type="simple"/></inline-formula> is continuous, then</p><p><img src="htmlimages\19-7402027x\7d4f831a-2c87-46b3-ac96-cf0ecfc1e0a6.png" /></p><p>Proof. See Gin&#233; and Guillou [<xref ref-type="bibr" rid="scirp.43843-ref21">21</xref>] . <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\52acdd98-4908-453f-8312-76ac1fb2aec2.png" xlink:type="simple"/></inline-formula></p></sec><sec id="s3"><title>3. Evaluation of the Conditional Functions of Distribution to the Specific Causes</title><p>Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e2b775ef-d2f0-4c25-9142-7a02d74b5b49.png" xlink:type="simple"/></inline-formula> be a continuous random variables representing respectively the lifetimes in each of the <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ec07dcc0-fffb-4c9e-8f49-a8f6b1b149ba.png" xlink:type="simple"/></inline-formula> risks competing, <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ea92a48f-f935-4ad1-b8b1-25f274b0998b.png" xlink:type="simple"/></inline-formula>be the set of index cause, where 0 corresponds to the condition of the individual observed, <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f0937de8-8e3d-47fb-962e-13cc55851123.png" xlink:type="simple"/></inline-formula>the random variable of the event of interest and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\7bcf7249-f46a-4578-b1ba-9fc6b522d458.png" xlink:type="simple"/></inline-formula> the random variable case, where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c9912fa1-bc91-4a33-a489-5a7146306ff7.png" xlink:type="simple"/></inline-formula> if <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ea4dfdb7-3313-4aa8-aa47-0218c037995f.png" xlink:type="simple"/></inline-formula> for all <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\3d871a56-43ef-4a43-ad6d-be1b1eedaa88.png" xlink:type="simple"/></inline-formula> <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ad2841bb-da32-4de2-8fce-1f36dbc3da2e.png" xlink:type="simple"/></inline-formula> is the distribution function of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\64fdb191-b771-4a27-ac69-2dfc4835fff8.png" xlink:type="simple"/></inline-formula></p><p><inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a277dec4-d700-4bb9-a731-ae85a2a66f6d.png" xlink:type="simple"/></inline-formula>the survival function such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b156205d-5b03-466f-aa4e-44c922bfe217.png" xlink:type="simple"/></inline-formula> the random variable C of the event censoring right, <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4f24bfff-bb10-4657-838c-21632ab284c2.png" xlink:type="simple"/></inline-formula> and for technical reasons, <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b5dbd215-f288-4492-9874-01f03349dbe5.png" xlink:type="simple"/></inline-formula>such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2497ffcd-1cd5-4019-b051-246567479b9c.png" xlink:type="simple"/></inline-formula> if (<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b3d3bfab-f748-4b72-a018-83c843efe518.png" xlink:type="simple"/></inline-formula>and<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9075a402-dcb2-4ebf-9740-65ce540bd83b.png" xlink:type="simple"/></inline-formula>) and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a7505e1f-0b22-4c43-87a5-e4f09f1cf9e1.png" xlink:type="simple"/></inline-formula> if<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c01d57cc-049e-46ae-aa4c-a6104daacdec.png" xlink:type="simple"/></inline-formula>.</p><p>We notice that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\af6314bd-07fd-414a-aee8-4a199668f55b.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\86ed200d-c497-4747-8631-a1baed3338ca.png" xlink:type="simple"/></inline-formula> are observable and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5a403056-c450-4f6f-af87-424c0dfe73ad.png" xlink:type="simple"/></inline-formula> is so only for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\6a48f417-4b8a-4749-8f75-dd108fdf5083.png" xlink:type="simple"/></inline-formula> uncensored.</p><p>We assume that censorship is not informative. The joint law <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\bea51d4a-6461-4094-9195-68f88b944fa9.png" xlink:type="simple"/></inline-formula> is completely specified by the specific incident distributions cause <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9043f7f1-15a4-49fd-a0c8-20f93a44e566.png" xlink:type="simple"/></inline-formula> <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5c905671-722a-4721-a971-906d184811cc.png" xlink:type="simple"/></inline-formula> defined by</p><disp-formula id="scirp.43843-formula47235"><label>(1)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\04fcb221-c5ec-4f6b-b21b-05493b23ef08.png"  xlink:type="simple"/></disp-formula><p>which are none other than the sub-distributions of the specific cause of failure <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\1f42dc2b-ab15-4917-aa96-bfd0651e28d0.png" xlink:type="simple"/></inline-formula></p><p>The cumulative hazard rate of specific-cause <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\86f7a847-ed6a-4467-b681-f3b76614e319.png" xlink:type="simple"/></inline-formula> corresponding to <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\30db5ddd-64f5-46bf-ae57-0fcefe2e63ac.png" xlink:type="simple"/></inline-formula> is given by</p><disp-formula id="scirp.43843-formula47236"><label>(2)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\06f7aa00-47d3-4d6f-a4f5-caf78f2706e8.png"  xlink:type="simple"/></disp-formula><p>Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\16e42f67-7466-49a4-a912-6a92e4d334a8.png" xlink:type="simple"/></inline-formula> be n-sample of observable triplet <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\fba37eab-9b46-456c-8cae-3aeaf6e829ba.png" xlink:type="simple"/></inline-formula> where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5953373f-92de-4966-a8e2-9c7c576323ca.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\402cb56d-b015-4b36-af9f-7659514a9706.png" xlink:type="simple"/></inline-formula>, with <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\3e790fe7-8bf8-4a37-aa77-012a416713b5.png" xlink:type="simple"/></inline-formula> and where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\0dbe2e64-ef79-444e-8faf-387f5ff8a0b4.png" xlink:type="simple"/></inline-formula> represent the time that an individual <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\913338de-e84a-434a-a90f-a5981913e9e1.png" xlink:type="simple"/></inline-formula> is subject to the cause <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\bfa65723-ebf0-4506-81df-030efc42d486.png" xlink:type="simple"/></inline-formula> If <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\70f1100f-05a4-4666-a83c-3a724b71b7d3.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\665b047c-c376-4d5c-8c8b-9f078c839a31.png" xlink:type="simple"/></inline-formula> are independent, the random variable <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\db8f4245-76c9-4f05-adb9-f80b77ba7f74.png" xlink:type="simple"/></inline-formula> admits distribution function <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\585b1552-2e22-40ae-b851-2e421d41684d.png" xlink:type="simple"/></inline-formula> defined by <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\34a41e81-604a-4cbd-97a0-cbc016466eae.png" xlink:type="simple"/></inline-formula> Then the Nelson-Aalen estimator of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\0e894f9b-3dee-45a2-aba4-51e65d56509c.png" xlink:type="simple"/></inline-formula> is given for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\064e478f-325f-484b-baf6-63192d535802.png" xlink:type="simple"/></inline-formula> by (see e.g. in Andersen et al. [<xref ref-type="bibr" rid="scirp.43843-ref4">4</xref>] )</p><disp-formula id="scirp.43843-formula47237"><label>(3)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\9ffc3a30-16b8-4416-aa32-1f66a5eb1f48.png"  xlink:type="simple"/></disp-formula><p>with</p><p><img src="htmlimages\19-7402027x\6d4ee7bf-002b-43f5-a050-d0874518cf20.png" /></p><p>and where</p><disp-formula id="scirp.43843-formula47238"><label>(4)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\d3ddd43a-4ae8-456d-a9ed-05018d458f82.png"  xlink:type="simple"/></disp-formula><p>is the counting of the number of failures observed in case of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5fba59f4-5be9-46ee-aded-e50e24e0ec81.png" xlink:type="simple"/></inline-formula> the time interval <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\d5adc236-ee03-4f11-9565-70adb434e272.png" xlink:type="simple"/></inline-formula> and</p><disp-formula id="scirp.43843-formula47239"><label>(5)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\8c270918-46df-4e21-b51e-30a22cd8cfb7.png"  xlink:type="simple"/></disp-formula><p>is the number of individuals in the sample observation that survive beyond time <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\83411a07-0584-49dd-a0c2-7d95f1b007db.png" xlink:type="simple"/></inline-formula> Thus, for any <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b340745e-27d3-4d3d-b7c6-5a7b94da2552.png" xlink:type="simple"/></inline-formula></p><disp-formula id="scirp.43843-formula47240"><label>(6)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\60fdf58d-dd3b-4224-9847-8fe9847733a4.png"  xlink:type="simple"/></disp-formula><p>represents the number of individuals who may fall down specific cause <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4d49bbeb-d4f8-42e0-9a1f-f4f674640e4c.png" xlink:type="simple"/></inline-formula> or be censored.</p><p>Estimator similar <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\40d12a15-43e6-4c77-8625-7d9c1d399432.png" xlink:type="simple"/></inline-formula> analogue to (2) and on the sub-group <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\3fac83a7-0fcb-4189-b961-eddce3b8cb2a.png" xlink:type="simple"/></inline-formula> individuals crashing case <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e75e5a33-ad2a-46cf-a91d-eb8e18e65d8e.png" xlink:type="simple"/></inline-formula> is given by</p><disp-formula id="scirp.43843-formula47241"><label>(7)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\580a869c-954c-4427-a1ae-58bb407c03d9.png"  xlink:type="simple"/></disp-formula><p>and with <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4a2bab7f-49a7-4067-86fd-1d8cf8dbf686.png" xlink:type="simple"/></inline-formula> and</p><p><img src="htmlimages\19-7402027x\75a4acf9-2a21-43dd-9009-7fbc62fddfbd.png" /></p><p>The relation between the cumulative hazard rate <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\6410ae58-634a-462e-aa1f-57c2493b06fa.png" xlink:type="simple"/></inline-formula> and survival <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c244c127-4f17-482f-989a-f9e8c1bc853d.png" xlink:type="simple"/></inline-formula> in the subgroup A<sub>j</sub> is given by<sup>2</sup></p><disp-formula id="scirp.43843-formula47242"><label>(8)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\7cdfc87a-8f2d-4895-aa94-b7281c87f45d.png"  xlink:type="simple"/></disp-formula><p>A nonparametric estimator of the distribution function <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a2a5eb0c-4f63-4361-b3e1-7668bca401e4.png" xlink:type="simple"/></inline-formula> of time life in subgroups <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\bacd37b8-e3a6-40b2-8f71-288f89f9305c.png" xlink:type="simple"/></inline-formula> is defined by</p><disp-formula id="scirp.43843-formula47243"><label>(9)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\b6c298f9-29fe-4657-8793-f8d6de1f9d97.png"  xlink:type="simple"/></disp-formula><p>is given by</p><disp-formula id="scirp.43843-formula47244"><label>(10)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\bded9e54-c2b6-4a08-8377-2a687570c656.png"  xlink:type="simple"/></disp-formula><p>The size <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ef6173bf-d0b2-40d1-bd55-3f40274aacc6.png" xlink:type="simple"/></inline-formula> of the subgroup <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4940c2c8-801c-4b04-a99b-7162ae0e4fbf.png" xlink:type="simple"/></inline-formula> individuals is not observable due to the inaccessibility of all subgroups of specific causes <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\60c17f73-829d-4f3d-bfb2-d2615ac79a77.png" xlink:type="simple"/></inline-formula> Nevertheless, we can assign a probability <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\00cc5f6b-d7d3-40b4-8121-dfba117bd5de.png" xlink:type="simple"/></inline-formula> to each of the individuals belonging to one of the <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9cca833e-e949-4240-940f-a79612ca9637.png" xlink:type="simple"/></inline-formula> subgroups. Thus, one can estimate the size <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ddb48997-fbfd-42ae-b613-ec51bfb11d51.png" xlink:type="simple"/></inline-formula> by <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2bbd6f19-95a6-48de-9b8a-3c37a842be36.png" xlink:type="simple"/></inline-formula> given by ( see e.g. in Satten and Datta [<xref ref-type="bibr" rid="scirp.43843-ref27">27</xref>] or Datta and Satten [<xref ref-type="bibr" rid="scirp.43843-ref28">28</xref>] ) <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\d26f88c9-af79-4e01-bd02-057559f8466a.png" xlink:type="simple"/></inline-formula>where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\7214c2e7-da4d-45f4-9b75-d1b6a0a53fe1.png" xlink:type="simple"/></inline-formula> is the estimator of the probability that the individual n˚<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2a8da1c9-87d2-4bb1-a302-36ccfab0e94d.png" xlink:type="simple"/></inline-formula> in the sample subgroup<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2d87cddf-2cbb-4cee-b3b5-0ebc8197606b.png" xlink:type="simple"/></inline-formula>, subset of risk of specific-cause<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b0cc79f8-b40f-40cd-9a2e-9aa4ac7fd5d0.png" xlink:type="simple"/></inline-formula>. Thus, the final estimators for the cumulative hazard rate <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\bdf1ef52-9546-42f1-8b5f-faa5d76c5f6c.png" xlink:type="simple"/></inline-formula> due to the specific cause <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5cafb2dc-5f56-43bc-a578-bb4e2af62d50.png" xlink:type="simple"/></inline-formula> and the corresponding distribution function <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\093ca4a0-3553-4e92-8a77-d91a67c0db9d.png" xlink:type="simple"/></inline-formula> have the respective expressions</p><disp-formula id="scirp.43843-formula47245"><label>(11)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\47eaf989-02d6-49be-a84e-fe2455ab3da1.png"  xlink:type="simple"/></disp-formula><p>and for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2d5d9c0d-f773-42e9-8179-a08c2e60f1b2.png" xlink:type="simple"/></inline-formula></p><disp-formula id="scirp.43843-formula47246"><label>(12)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\d48aca4c-99fd-4cf8-b0b7-9f99616b02bd.png"  xlink:type="simple"/></disp-formula></sec><sec id="s4"><title>4. Main Results</title><p>Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\226dbf3b-9ca1-47dc-a64b-d4d85dfe6d1b.png" xlink:type="simple"/></inline-formula> be a positive random variable and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\02d24a2b-db56-48a8-b595-898e64c4bcaa.png" xlink:type="simple"/></inline-formula> be a censoring variable such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\d688da5d-4bb2-4760-a2d5-9fc7ecd9bda3.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\655fd3c1-d846-45f0-ae56-f14b9e1370e3.png" xlink:type="simple"/></inline-formula> In this model of random censorship, for a sample <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c385bc38-8907-4167-89fc-588291e94495.png" xlink:type="simple"/></inline-formula> subject to a specific causes <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a41b0651-c77d-4433-8a03-04a5f8956564.png" xlink:type="simple"/></inline-formula> we can observe the couple <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a82432fd-418a-4a10-b794-7ddbd9675fe6.png" xlink:type="simple"/></inline-formula> where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e84ae110-ddd5-453c-a527-5dd75a97f28a.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f6ecb8ea-a316-45e2-b40c-6808cddaf332.png" xlink:type="simple"/></inline-formula> with <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a9c112f9-d5fb-4292-b50e-3bc9fc36eaad.png" xlink:type="simple"/></inline-formula> and where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\1777bec4-ff72-4b1c-86f2-6eb32a913df1.png" xlink:type="simple"/></inline-formula> is the time that an individual <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\6f9febfb-224f-4554-97e0-52e90deb1f6c.png" xlink:type="simple"/></inline-formula> is subject to the cause <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\da33e344-b00d-4a98-bf35-03664c375f20.png" xlink:type="simple"/></inline-formula></p><p>For a given <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8b183293-9905-416c-9656-f674dcbf1a61.png" xlink:type="simple"/></inline-formula> and an individual <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\1786bb21-2b20-4aa7-9f59-1b329e59a702.png" xlink:type="simple"/></inline-formula> with <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5fbd29bd-2044-4abb-bb23-5651b1be20cb.png" xlink:type="simple"/></inline-formula> the counting process is defined by:</p><p><img src="htmlimages\19-7402027x\cdb640c8-9c93-4731-8f82-cd9b8a752aec.png" /></p><p>Therefore, if an individual <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8028911c-f0e6-422a-bb0f-ecdb24fa119a.png" xlink:type="simple"/></inline-formula> undergoes event before time <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f7b4788e-c171-44cb-b53c-b9dfb65596c2.png" xlink:type="simple"/></inline-formula> then <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\09cce7cf-04ef-4b3f-a94b-6e97d56685a1.png" xlink:type="simple"/></inline-formula> otherwise <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\babb60a1-b856-438a-88f6-10e5ecc59296.png" xlink:type="simple"/></inline-formula> We can also define the counting process</p><p><img src="htmlimages\19-7402027x\cb3adc85-00bf-46a7-bf36-4b04339b2194.png" /></p><p>Naturally, it appears that we considered the information provided over time as a filter, which is used to describe the fact that past information is contained in the current information, hence we have the natural filtration <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\eed385b0-5575-4f7b-8009-9a7e13ed1410.png" xlink:type="simple"/></inline-formula> where</p><p><img src="htmlimages\19-7402027x\18ad0aef-df52-4511-a68f-c17aa570c228.png" /></p><p>For <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8f02049e-31ee-44c6-98ab-c8ff83d8c93a.png" xlink:type="simple"/></inline-formula> <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\0bf45917-f51d-42ee-89aa-6a500ef573c8.png" xlink:type="simple"/></inline-formula> and for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\d5ce675e-06b3-4bd2-a9a8-9fc3877580bf.png" xlink:type="simple"/></inline-formula> we have</p><p><img src="htmlimages\19-7402027x\bd41e520-edd9-43e5-9b44-7de33d550d87.png" /></p><p>If <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c5f7f829-cf5e-4570-9c76-3cc6fdbf6547.png" xlink:type="simple"/></inline-formula> denotes the left boundary at <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\86a1349c-6940-4723-b04c-02536c424ed5.png" xlink:type="simple"/></inline-formula> of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\d994f898-dc10-4ec6-84f0-a0137bb5ec58.png" xlink:type="simple"/></inline-formula> we have</p><p><img src="htmlimages\19-7402027x\90b7a6ec-c343-45cc-9784-7ca0c73237fe.png" /></p><p>since, the quantity <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\38d3515f-cb45-484c-9704-5d895612c257.png" xlink:type="simple"/></inline-formula> takes only the values 0 and 1.</p><p>For a given <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\47899445-adea-416a-a1d2-a470a822d4b0.png" xlink:type="simple"/></inline-formula> we define the function</p><p><img src="htmlimages\19-7402027x\acc87ed6-7d01-443a-966b-284e15555210.png" /></p><p>which indicates whether the individual <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f297f3d1-4842-4c00-8911-c40553f1dd6b.png" xlink:type="simple"/></inline-formula> is still at risk just before time <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8e63b0d1-3932-4c49-8914-e5335be15e20.png" xlink:type="simple"/></inline-formula> (the individual has not yet undergone the event). Therefore• if <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\69bbc28b-05f3-48c2-962a-962733ca9878.png" xlink:type="simple"/></inline-formula> then, <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f9213157-b514-467b-8e24-71babd664c6d.png" xlink:type="simple"/></inline-formula>and</p><p>• if <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\07ee3d15-7b8e-4ced-b5f3-ad59102940b4.png" xlink:type="simple"/></inline-formula> then,</p><p><img src="htmlimages\19-7402027x\f3bc842b-f3d0-4581-9c17-ed2bc7136aae.png" /></p><p>where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\7780936c-05a3-414f-aed4-215c855fb54a.png" xlink:type="simple"/></inline-formula> is the natural filtration (all information available at time<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b52091f6-1913-4fd5-ba21-2b6567e9364a.png" xlink:type="simple"/></inline-formula>), where the notation <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e3501288-b90b-4b12-b415-9472a569f42b.png" xlink:type="simple"/></inline-formula> refers to formal writing of the stochastic integral</p><p><img src="htmlimages\19-7402027x\89e669fc-9e69-40cf-a765-c0564f62ac4a.png" /></p><p>writing made possible because <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2e0f3602-8954-4460-8ed6-7848eb54a4ca.png" xlink:type="simple"/></inline-formula> is a growing process. The expression of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\6ed4fc73-40ff-40d0-85ee-6c172f2e71dd.png" xlink:type="simple"/></inline-formula> in function of the counting process <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\6028905e-6512-413d-9939-515dc863ce02.png" xlink:type="simple"/></inline-formula> is given by</p><p><img src="htmlimages\19-7402027x\4c7852d5-92e4-43e1-86a0-e1ff8eb9a93c.png" /></p><p>Thus, we have <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a324b58c-2156-4cf3-9770-34b455fedf43.png" xlink:type="simple"/></inline-formula></p><p>The stochastic process defined for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\1498065e-3bba-4a4d-8e8a-1bdeb3531d7a.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b12f1b1c-adb8-4337-91c3-584f9970679d.png" xlink:type="simple"/></inline-formula> by</p><p><img src="htmlimages\19-7402027x\77a0ee76-a65c-4f2c-9322-4abdf7096a7d.png" /></p><p>is the martingale associated with the subject at risk <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\249a708d-cc9d-4dbe-9d29-60a5861c4247.png" xlink:type="simple"/></inline-formula> Thereafter <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9ba01305-0b9b-4872-ab06-cef94e7a13eb.png" xlink:type="simple"/></inline-formula> is the compensating process <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e1245d9b-82eb-4809-b546-2880a38efea6.png" xlink:type="simple"/></inline-formula> because it is the integral of the product of two predictable processes.</p><p>Theorem 2 Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\1a97a272-bc35-49e8-b40e-46e7d525e9ec.png" xlink:type="simple"/></inline-formula> be an absolutely continuous lifetime and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\eaa85a9d-a8c4-4b87-a0c1-78b04b4459a5.png" xlink:type="simple"/></inline-formula> be a censoring variable for any arbitrary distribution <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\6bf88eb3-19ea-4242-a4f8-f08f7d1bd6d0.png" xlink:type="simple"/></inline-formula> Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\849c2aa6-7d1a-49d2-9665-6d5c19648279.png" xlink:type="simple"/></inline-formula> be the risk function associated with <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\899a6a8e-3d8b-4160-9bac-48f77246fbc5.png" xlink:type="simple"/></inline-formula> Let’s put <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\735cf21b-0465-4ca6-94a2-bb4b3f25feb3.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\176c92a3-3295-4a3f-9655-51c7e6af93a5.png" xlink:type="simple"/></inline-formula>.</p><p>For <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\d08be85f-2cca-4394-a24c-56f47a84cc70.png" xlink:type="simple"/></inline-formula> the process defined by</p><p><img src="htmlimages\19-7402027x\785bef68-2914-4fe8-ab52-ad9ac50b5a73.png" /></p><p>is a <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\680d34e5-5e74-4db9-8c3e-45f83bd43c83.png" xlink:type="simple"/></inline-formula> martingale if and only if</p><p><img src="htmlimages\19-7402027x\ae7e971d-9730-45a2-b96c-c19d4ea4905a.png" /></p><p>for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f983621c-104e-43f0-ba4f-a2fce09d8e63.png" xlink:type="simple"/></inline-formula> such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\069c3533-03bf-4b84-be6d-65c0108c2ce8.png" xlink:type="simple"/></inline-formula></p><p>Proof. See Breuils ([<xref ref-type="bibr" rid="scirp.43843-ref30">30</xref>] , p. 25) and Fleming and Harrington ([<xref ref-type="bibr" rid="scirp.43843-ref7">7</xref>] , p. 26). <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\6d4ba726-50ed-4a3c-b173-371edb63a49f.png" xlink:type="simple"/></inline-formula></p><p>For a given <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5a77f221-6478-45c9-b5ee-02296814bfa9.png" xlink:type="simple"/></inline-formula> and a given<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4e618471-cc2f-4a36-a234-f97cff2ad8d3.png" xlink:type="simple"/></inline-formula>, the expressions of<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b9fa1058-5514-4d37-bf35-ccdae0f295ad.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4db211f9-e075-43e3-a733-a69c17a061d5.png" xlink:type="simple"/></inline-formula>and <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5cd97345-7ae2-4b24-82d0-3cfd9df8eda1.png" xlink:type="simple"/></inline-formula> are those of formulas (4), (5) and (2) respectively. Using these notations, we can directly obtain the following preliminary result:</p><p>Proposition 2 For a given <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8c80ec0a-24b8-4a1a-8d25-d5d1f3ff19dd.png" xlink:type="simple"/></inline-formula> and a given<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b81544a8-dd40-4ae7-ba5e-7fc41dbd77e1.png" xlink:type="simple"/></inline-formula>, the stochastic processes defined by</p><disp-formula id="scirp.43843-formula47247"><label>(13)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\3307d91a-1bba-4711-a2d8-7a5c4f75dbcf.png"  xlink:type="simple"/></disp-formula><p>is the martingale associated with the subject specific cause <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\02d39ce4-b7a1-4461-b560-5bf4e8a48e99.png" xlink:type="simple"/></inline-formula></p><p>Proof.</p><p><img src="htmlimages\19-7402027x\f6b9b64c-b855-4985-81f8-73fc7474d852.png" />&#160; <img src="htmlimages\19-7402027x\0af74b91-318d-4466-9174-7f937d29c44f.png" /></p><p>The martingale <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\6f4a4240-d097-4f8d-bf8f-2e1a1d6c0da6.png" xlink:type="simple"/></inline-formula> represents the difference between the number of failures due to a specific cause <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\977652ad-c69f-4dc8-b039-01066b5212d1.png" xlink:type="simple"/></inline-formula> observed in the time interval<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2625986d-4206-4f59-bd3c-9705dff82db7.png" xlink:type="simple"/></inline-formula>, i.e.<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c8d6566d-b723-4747-84b4-8fda59d59b76.png" xlink:type="simple"/></inline-formula>, and the number of failures predicted by the model for the <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\587db7f5-51f1-4c42-ad69-144d0b07b7ef.png" xlink:type="simple"/></inline-formula> cause. This definition fulfills the Doob-Meyer decomposition.</p><p>The first result of this paper concerns the consistency of the Nelson-Aalen estimator for the competing risks based on martingale approach.</p><p>Theorem 3 For <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a88e1255-bfd8-4021-96b6-ab0c2b33350e.png" xlink:type="simple"/></inline-formula> such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\632b7cf7-f94d-4473-8087-d0b19dbb08ce.png" xlink:type="simple"/></inline-formula> we have</p><p><img src="htmlimages\19-7402027x\c61c3591-2339-4791-a3ff-10841bc0da05.png" /></p><p>Proof.</p><p><img src="htmlimages\19-7402027x\0ba03da8-7df4-4ecb-8088-98afd49b30a0.png" /></p><p>where the expectation of the martingale <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e0ac1e63-ebd5-4c32-85ce-8d4c53688ac9.png" xlink:type="simple"/></inline-formula> (specific for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9126bf6f-385d-4df4-b313-20787342cdcb.png" xlink:type="simple"/></inline-formula> cause) is equal to zero and where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\67774a0f-65fd-499b-9541-f639726de0fb.png" xlink:type="simple"/></inline-formula> Indeed,</p><p><img src="htmlimages\19-7402027x\9627c726-89bf-4a0f-bd4e-1c6581fd2f32.png" /></p><p>Hence, we arrive at result.</p><p>Using the fact that</p><p><img src="htmlimages\19-7402027x\d047d11c-5f83-43f7-b1ba-916df89bca2a.png" /></p><p>we have:</p><p><img src="htmlimages\19-7402027x\1809214c-d2a5-4afe-b144-735cf170b5c3.png" /></p><p>It follows that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9266ff37-5b67-45a7-9775-41e0fa075870.png" xlink:type="simple"/></inline-formula> is an asymptotically unbiased estimator of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c23897f4-afcd-43a3-844a-78671a28ee61.png" xlink:type="simple"/></inline-formula> Hence, we arrived at result. <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\84724cb1-27ab-4ee4-8f6b-ff80e413809d.png" xlink:type="simple"/></inline-formula></p><p>Our second LIL-type result provides almost sure and in probability rates of convergence of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\86d33f64-3217-4640-93da-095a27f2108a.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c70155ef-aa16-4cd3-815b-5482e08d9316.png" xlink:type="simple"/></inline-formula> for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\31bb9cd5-0642-47c9-8938-7857f23a81c0.png" xlink:type="simple"/></inline-formula> uniformly over the random increasing intervals<inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\68bad1cc-7121-44e6-a808-ae5da434371e.png" xlink:type="simple"/></inline-formula>. (See is Deheuvels and Einmahl [<xref ref-type="bibr" rid="scirp.43843-ref31">31</xref>] [<xref ref-type="bibr" rid="scirp.43843-ref32">32</xref>] for very fine results of the model law iterated logarithm functional and available in a point or on a compact strictly included in the support of H). This result is consistent with that of Stute [<xref ref-type="bibr" rid="scirp.43843-ref33">33</xref>] which constitutes a compromise between the results of Breslow and Crowley [<xref ref-type="bibr" rid="scirp.43843-ref9">9</xref>] , F&#246;ldes and Rejt&#246; [<xref ref-type="bibr" rid="scirp.43843-ref10">10</xref>] or Major and Rejt&#246; [<xref ref-type="bibr" rid="scirp.43843-ref11">11</xref>] , and those of F&#246;ldes and Rejt&#246; [<xref ref-type="bibr" rid="scirp.43843-ref12">12</xref>] , Gill [<xref ref-type="bibr" rid="scirp.43843-ref13">13</xref>] , Cs&#246;rg&#246; and Horv&#225;th [<xref ref-type="bibr" rid="scirp.43843-ref14">14</xref>] , Ying [<xref ref-type="bibr" rid="scirp.43843-ref15">15</xref>] and Chen and Lo [<xref ref-type="bibr" rid="scirp.43843-ref16">16</xref>] .</p><p>Following Gin&#233; and Guillou [<xref ref-type="bibr" rid="scirp.43843-ref34">34</xref>] , we say that a non-increasing sequence <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\7d4e7c57-6a35-4d08-b700-bc92547f2a02.png" xlink:type="simple"/></inline-formula> of numbers is regular if there exists a constant <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\6dc19aa0-fcf5-4b67-9ce2-3ac41ec367ae.png" xlink:type="simple"/></inline-formula> such that for all <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\77077e8f-585f-4c4b-b5aa-319a6e47ce83.png" xlink:type="simple"/></inline-formula> <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\07981509-a93c-436f-9a22-1b893c270fc2.png" xlink:type="simple"/></inline-formula> We denote by <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\7ba03f24-d070-4c9c-8e26-b710f9cab4ee.png" xlink:type="simple"/></inline-formula> the following hypothesis:</p><p><inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f0f6e044-b9fe-47da-b3a1-d6caae78d2de.png" xlink:type="simple"/></inline-formula>for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\46ac5fb9-b7dd-4add-abad-3299fe4f5f6f.png" xlink:type="simple"/></inline-formula> large enough, the sequence <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a98f1078-5764-4c92-8624-3464046f590c.png" xlink:type="simple"/></inline-formula> is regular non-increasing and there exists a constant <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\df647098-4303-4f2f-a2a2-6630fa82583b.png" xlink:type="simple"/></inline-formula> such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a89719a1-366a-4f6f-b0b0-a58137b033fa.png" xlink:type="simple"/></inline-formula> with <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\1c6acc6f-9858-424e-bc71-a27291fd249f.png" xlink:type="simple"/></inline-formula> is a non-increasing sequence such that</p><p><img src="htmlimages\19-7402027x\839dfb72-c943-4c6b-8f3e-f2e10c9a79dd.png" /></p><p><img src="htmlimages\19-7402027x\eb9bfa37-3f80-448f-973f-34732403868a.png" /></p><p>Theorem 4 Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\84c1fbc4-170c-444b-a688-9b863a9d339e.png" xlink:type="simple"/></inline-formula> be a sequence of integers such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\e56ed52e-fa7f-413c-89c7-633a0db7a975.png" xlink:type="simple"/></inline-formula> for all <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f6d06e87-6f30-416c-b889-0527657fdc4d.png" xlink:type="simple"/></inline-formula> and which satisfies hypothesis <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\4effe76f-d777-4ecf-aa87-4b5fa1697f76.png" xlink:type="simple"/></inline-formula> for the almost-sure part. For all <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\71fb80c5-fc7d-4a3f-a641-9c566d171de3.png" xlink:type="simple"/></inline-formula> we assume that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\9b55d7ea-f47c-4818-859f-de5f1c1a048b.png" xlink:type="simple"/></inline-formula> is alway continuous. Therefore,</p><p><img src="htmlimages\19-7402027x\37d8399c-14f4-4eca-9bb5-82a248c7ac8d.png" /></p><p>where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\623edafe-37fd-4297-b20c-ba55a9be4507.png" xlink:type="simple"/></inline-formula> is the Landau in almost sure sense, and</p><p><img src="htmlimages\19-7402027x\c3f897b6-6575-494f-8a9b-cf069905760d.png" /></p><p>where <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2c8c7e31-1d56-4d8f-b759-ae54b8988175.png" xlink:type="simple"/></inline-formula> is the Landau in probability.</p><p>Both results of Theorem above always provides a rate in probability of uniform convergence of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\40355985-09cc-497f-a547-e7bc6792f7d5.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\a7946c7d-1341-42ef-b329-3b204c362ad3.png" xlink:type="simple"/></inline-formula> for all <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5e291a0e-b5db-4f4b-adfd-03ce7e8b7598.png" xlink:type="simple"/></inline-formula> through a random growing intervals <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\2c1717fc-a149-43ea-b3ff-6d6473989a83.png" xlink:type="simple"/></inline-formula></p><p>To prove Theorem 4, we have drawn from results based on the inference of empirical processes, given that in order to linearize the Kaplan-Meier process, it is necessary to impose continuity condition on <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\eb09bf6e-9da0-4608-9aa3-85d85de331ce.png" xlink:type="simple"/></inline-formula> Firstly, under the Hypothesis <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b7090a1e-efa6-4e88-9f5b-3257d2110790.png" xlink:type="simple"/></inline-formula> we have the following result:</p><p>Lemma 1 Let <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\b2469f15-6db7-45e5-9197-ef2c58292f68.png" xlink:type="simple"/></inline-formula> be a sequence of integers such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5c66fd06-67ad-4e5c-a60c-a769e17dc774.png" xlink:type="simple"/></inline-formula> and, for the almost-sure results, such that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\ec8eda72-ff66-4721-a803-cabb83437706.png" xlink:type="simple"/></inline-formula> is satisfied. The rate of convergence of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\85d6a0ff-920a-47a8-8313-74fa0827c690.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\f7a2db88-76ec-49c7-ab77-74300955788b.png" xlink:type="simple"/></inline-formula> is given by</p><p><img src="htmlimages\19-7402027x\60fe5139-8eef-4bdc-ad15-d19086bb11b4.png" /></p><p>Proof. The proof of this result follows straightforwardly from the proof of the first part of Theorem 1 concerning the supremum of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\cf24b1ad-0bc7-4017-8a3f-2d762c953cae.png" xlink:type="simple"/></inline-formula> <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\8c6a8154-9f10-49b9-8169-4c1de370c486.png" xlink:type="simple"/></inline-formula></p><p>Proof of Theorem 4. The following decomposition is obtained for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\263c0366-f500-494e-95b9-c023b1985a79.png" xlink:type="simple"/></inline-formula> by means of integration by parts:</p><disp-formula id="scirp.43843-formula47248"><label>(14)</label><graphic position="anchor" xlink:href="htmlimages\19-7402027x\5015bec2-e713-4e36-b410-83601efda82a.png"  xlink:type="simple"/></disp-formula><p>Equality (14) entails that:</p><p><img src="htmlimages\19-7402027x\d7d45f84-4745-4e0e-8584-82974206f6ac.png" /></p><p>Notice that the assumption of continuity of <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\612544b7-6f02-4ddb-9d91-2327f6bb5ac5.png" xlink:type="simple"/></inline-formula> for <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\3a181b48-97b2-4663-a767-d19cdd2a09ae.png" xlink:type="simple"/></inline-formula> ensures that <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\c993ca43-6cb6-4900-aa74-7b3282b9473a.png" xlink:type="simple"/></inline-formula> is continuous according to proposition 1. We then conclude with Theorem 1 and Lemma 1. <inline-formula><inline-graphic xlink:href="tmlimages\19-7402027x\5e0d6617-be7b-4d95-a39f-f221de4db73e.png" xlink:type="simple"/></inline-formula></p></sec><sec id="s5"><title>5. Conclusion</title><p>In this paper, we have adapted the stochastic processes of Aalen [<xref ref-type="bibr" rid="scirp.43843-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.43843-ref2">2</xref>] to the Nelson-Aalen and Kaplan-Meier [<xref ref-type="bibr" rid="scirp.43843-ref3">3</xref>] estimators in a context of competing risks. We have focused particularly on the probability distributions of complete downtime individuals whose causes are known and which bring us to consider a partition of individuals into sub-groups for each cause. We have also provided some asymptotic properties of nonparametric estimators obtained.</p></sec><sec id="s6"><title>Acknowledgements</title><p>I would like to thank Prof. Nicolas Gabriel ANDJIGA, Prof. Celestin NEMBUA CHAMENI, Prof. Eugene Kouassi for their support and their advices. I would also like to thank specially Prof. Kossi Essona GNEYOU for his collaboration and his cooperation during the preparation of this paper.</p></sec><sec id="s7"><title>NOTES</title></sec></body><back><ref-list><title>References</title><ref id="scirp.43843-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Aalen, O.O. (1978) Nonparametric Estimation of Partial Transition Probabilities in Multiple Decrement Models. The Annals of Statistics, 6, 534-545. http://dx.doi.org/10.1214/aos/1176344198</mixed-citation></ref><ref id="scirp.43843-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Aalen, O.O. (1978) Nonparametric Inference for a Family of Counting Processes. The Annals of Statistics, 6, 701-726. http://dx.doi.org/10.1214/aos/1176344247</mixed-citation></ref><ref id="scirp.43843-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Kaplan, E.L. and Meier, P. (1958) Nonparametric Estimation from Incomplete Observations. Journal of the American Statistical Association, 53, 457-481. http://dx.doi.org/10.1080/01621459.1958.10501452</mixed-citation></ref><ref id="scirp.43843-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Andersen, P.K., Borgan, ?., Gill, R.D. and Keiding, N. (1993) Statistical Models Based on Counting Processes. Springer Series in Statistics, Spring-Verlag, New York,. http://dx.doi.org/10.1007/978-1-4612-4348-9 </mixed-citation></ref><ref id="scirp.43843-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Tsiatis, A. (1975) A Nonidentifiability Aspect of the Problem of Competing Risks. Proceeding of the National Academy of Sciences of the United States of America, 72, 20-22. http://dx.doi.org/10.1073/pnas.72.1.20</mixed-citation></ref><ref id="scirp.43843-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Heckman, J. and Honoré, B. (1989) The Identifiability of the Competing Risks Models. Biometrika, 76, 325-330. http://dx.doi.org/10.1093/biomet/76.2.325</mixed-citation></ref><ref id="scirp.43843-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Fleming, T. and Harrington, D. (1990) Counting Processes and Survival Analysis. John Wiley &amp; Sons, Inc, Hoboken.</mixed-citation></ref><ref id="scirp.43843-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Prentice, R.L., Kalbfleisch, J.D., Peterson, A.V., Flournoy, N., Farewell, V.T. and Breslow, N.E. (1978) The Analysis of Failure Times in the Presence of Competing Risks. Biometrics, 34, 541-554. http://dx.doi.org/10.2307/2530374</mixed-citation></ref><ref id="scirp.43843-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Breslow, N. and Crowley, J. (1974) A Large Sample Study of the Life Table and Product-Limit Estimates under Random Censorship. The Annals of Statistics, 2, 437-453. http://dx.doi.org/10.1214/aos/1176342705</mixed-citation></ref><ref id="scirp.43843-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">F?ldes, A. and Rejt?, L. (1981) Strong Uniform Consistency for Nonparametric Survival Curve Estimators from Randomly Censored Data. The Annals of Statistics, 9, 122-129. http://dx.doi.org/10.1214/aos/1176345337 </mixed-citation></ref><ref id="scirp.43843-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Major, P. and Rejt?, L. (1998) Strong Embedding of the Estimator of the Distribution Function under Random Censorship. The Annals of Statistics, 16, 1113-1132. http://dx.doi.org/10.1214/aos/1176350949 </mixed-citation></ref><ref id="scirp.43843-ref12"><label>12</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>F?ldes</surname><given-names> A. and Rejt?</given-names></name>,<name name-style="western"><surname> L. </surname><given-names>  </given-names></name>,<etal>et al</etal>. (<year>1981</year>)<article-title>A LIL-Type Result for the Product-Limit Estimator</article-title><source> Zeitschrift für Wahrscheinlichkeitstheorie und Verwandte Gebiete</source><volume> 56</volume>,<fpage> 75</fpage>-<lpage>86</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.43843-ref13"><label>13</label><mixed-citation publication-type="other" xlink:type="simple">Gill, R. (1983) Large Sample Behavior of the Product-Limit Estimator on the Whole Line. The Annals of Statistics, 11, 49-58. http://dx.doi.org/10.1214/aos/1176346055</mixed-citation></ref><ref id="scirp.43843-ref14"><label>14</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Cs?rg?</surname><given-names> S. and Horváth</given-names></name>,<name name-style="western"><surname> L. </surname><given-names>  </given-names></name>,<etal>et al</etal>. (<year>1981</year>)<article-title>On the Koziol-Green Model for Random Censorship</article-title><source> Biometrika</source><volume> 68</volume>,<fpage> 391</fpage>-<lpage>401</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.43843-ref15"><label>15</label><mixed-citation publication-type="other" xlink:type="simple">Ying, Z. (1989) A Note on the Asymptotic Properties of the Product-Limit Estimator on the Whole Line. Statistics &amp; Probability Letters, 7, 311-314. http://dx.doi.org/10.1016/0167-7152(89)90113-2</mixed-citation></ref><ref id="scirp.43843-ref16"><label>16</label><mixed-citation publication-type="other" xlink:type="simple">Chen, K. and Lo, S.-H. (1997) On the Rate of Uniform Convergence of the Product-Limit Estimator: Strong and Weak Laws. The Annals of Statistics, 25, 1050-1087. http://dx.doi.org/10.1214/aos/1069362738</mixed-citation></ref><ref id="scirp.43843-ref17"><label>17</label><mixed-citation publication-type="other" xlink:type="simple">Latouche, A. (2004) Modèles de Régression en Présence de Compétition. Thèse de Doctorat, Université de Paris, Paris.</mixed-citation></ref><ref id="scirp.43843-ref18"><label>18</label><mixed-citation publication-type="other" xlink:type="simple">Belot, A. (2009) Modélisation Flexible des Données de Survie en Présence de Risques Concurrents et Apports de la Méthode du Taux en Excès. Thèse de Doctorat, Université de la Méditerranée, Marseille.</mixed-citation></ref><ref id="scirp.43843-ref19"><label>19</label><mixed-citation publication-type="other" xlink:type="simple">Fine, J.P. and Gray, R.J. (1999) A Proportional Hazards Model for the Subdistribution of a Competing Risk. Journal of the American Statistical Association, 99, 496-509. http://dx.doi.org/10.1080/01621459.1999.10474144</mixed-citation></ref><ref id="scirp.43843-ref20"><label>20</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Aalen</surname><given-names> O.O. and Johansen</given-names></name>,<name name-style="western"><surname> S. </surname><given-names>  </given-names></name>,<etal>et al</etal>. (<year>1978</year>)<article-title>An Empirical Transition Matrix for Non-Homogeneous Markov Chains Based on Censored Observations</article-title><source> Scandinavian Journal of Statistics</source><volume> 5</volume>,<fpage> 141</fpage>-<lpage>150</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.43843-ref21"><label>21</label><mixed-citation publication-type="other" xlink:type="simple">Giné, E. and Guillou, E. (1999) Laws of the Iterated Logarithm for Censored Data. The Annals of Probability, 27, 2042-2067. http://dx.doi.org/10.1214/aop/1022874828</mixed-citation></ref><ref id="scirp.43843-ref22"><label>22</label><mixed-citation publication-type="other" xlink:type="simple">Cox, D. and Oakes, D. (1984) Analysis of Survival Data. Chapman and Hall, London.</mixed-citation></ref><ref id="scirp.43843-ref23"><label>23</label><mixed-citation publication-type="other" xlink:type="simple">Kalbfleisch, J. and Prentice, R. (1980) The Statistical Analysis of Failure Time Data. John Wiley, New York.</mixed-citation></ref><ref id="scirp.43843-ref24"><label>24</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Nelson</surname><given-names> W. </given-names></name>,<etal>et al</etal>. (<year>1969</year>)<article-title>Hazard Plotting for Incomplete Observations</article-title><source> Journal of Quality Technology</source><volume> 1</volume>,<fpage> 27</fpage>-<lpage>52</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.43843-ref25"><label>25</label><mixed-citation publication-type="other" xlink:type="simple">Nelson, W. (1972) A Short Life Test for Comparing a Sample with Previous Accelerated Test Results. Technometrics, 14, 175-185. http://dx.doi.org/10.1080/00401706.1972.10488894</mixed-citation></ref><ref id="scirp.43843-ref26"><label>26</label><mixed-citation publication-type="other" xlink:type="simple">Cs?rg?, S. (1996) Universal Gaussian Approximations under Random Censorship. The Annals of Statistics, 24, 27442778. http://dx.doi.org/10.1214/aos/1032181178 </mixed-citation></ref><ref id="scirp.43843-ref27"><label>27</label><mixed-citation publication-type="other" xlink:type="simple">Satten, G.A. and Datta, S. (1999) Kaplan-Meier Representation of Competing Risk Estimates. Statistics &amp; Probability Letters, 42, 299-304. http://dx.doi.org/10.1016/S0167-7152(98)00220-X</mixed-citation></ref><ref id="scirp.43843-ref28"><label>28</label><mixed-citation publication-type="other" xlink:type="simple">Datta, S. and Satten, G.A. (2000) Estimating Future Stage Entry and Occupation Probabilities in a Multistage Model Based on Randomly Right-Censored Data. Statistics &amp; Probability Letters, 50, 89-95. http://dx.doi.org/10.1016/S0167-7152(00)00086-9</mixed-citation></ref><ref id="scirp.43843-ref29"><label>29</label><mixed-citation publication-type="other" xlink:type="simple">Gill, R. and Johansen, S. (1990) A Survey of Product-Integration with a View toward Application in Survival Analysis. The Annals of Statistics, 18, 1501-1555. http://dx.doi.org/10.1214/aos/1176347865</mixed-citation></ref><ref id="scirp.43843-ref30"><label>30</label><mixed-citation publication-type="other" xlink:type="simple">Breuils, C. (2003) Analyse de Durées de Vie: Analyse Séquentielle du Modèle des Risques Proportionnels et Tests d’Homogénéité. Thèse de Doctorat, Université de Technologie de Compiègne, Compiègne.</mixed-citation></ref><ref id="scirp.43843-ref31"><label>31</label><mixed-citation publication-type="other" xlink:type="simple">Deheuvels, P. and Einmahl, J. (1996) On the Strong Limiting Behavior of Local Functionals of Empirical Processes Based upon Censored Data. The Annals of Statistics, 24, 504-525. http://dx.doi.org/10.1214/aop/1042644729</mixed-citation></ref><ref id="scirp.43843-ref32"><label>32</label><mixed-citation publication-type="other" xlink:type="simple">Deheuvels, P. and Einmahl, J. (2000) Functional Limit Laws for the Increments of Kaplan-Meier Product-Limit Processes and Applications. The Annals of Statistics, 28, 1301-1335. http://dx.doi.org/10.1214/aop/1019160336</mixed-citation></ref><ref id="scirp.43843-ref33"><label>33</label><mixed-citation publication-type="other" xlink:type="simple">Stute, W. (1994) Strong and Weak Representations of Cumulative Hazard Function and Kaplan-Meier Estimators on Increasing Sets. Journal of Statistical Planning and Inference, 42, 315-329. http://dx.doi.org/10.1016/0378-3758(94)00032-8</mixed-citation></ref><ref id="scirp.43843-ref34"><label>34</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Giné</surname><given-names> E. and Guillou</given-names></name>,<name name-style="western"><surname> A. </surname><given-names>  </given-names></name>,<etal>et al</etal>. (<year>2001</year>)<article-title>On Consistency of Kernel Density Estimators for Randomly Censored Data</article-title><source> Annales de l’Institut Henri Poincare (B) Probability and Statistics</source><volume> 37</volume>,<fpage> 503</fpage>-<lpage>522</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref></ref-list></back></article>