<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">OJMI</journal-id><journal-title-group><journal-title>Open Journal of Medical Imaging</journal-title></journal-title-group><issn pub-type="epub">2164-2788</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/ojmi.2014.41001</article-id><article-id pub-id-type="publisher-id">OJMI-43538</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  Ectopic Spleen Mimicking Kidney Activity Post-Nephrectomy
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>ong</surname><given-names>Yun Ma</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Raphaella</surname><given-names>Da Silva</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Muhammad</surname><given-names>Shah</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Leonard</surname><given-names>M. Freeman</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center and the Albert Einstein College of Medicine, New York, USA</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>lfreeman@montefiore.org(LMF)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>07</day><month>03</month><year>2014</year></pub-date><volume>04</volume><issue>01</issue><fpage>1</fpage><lpage>3</lpage><history><date date-type="received"><day>3</day>	<month>December</month>	<year>2013</year></date><date date-type="rev-recd"><day>3</day>	<month>January</month>	<year>2014</year>	</date><date date-type="accepted"><day>10</day>	<month>January</month>	<year>2014</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  Ectopic spleen may simulate kidney activity on renal scintigraphic imaging. Accurate diagnosis requires correlation with the patient’s history and anatomic imaging studies. We report a case where the spleen migrated to the left renal fossa and mimicked the left kidney after a left nephrectomy.
 
</p></abstract><kwd-group><kwd>Ectopic Spleen; Stimulate; Kidney Activity; Nephrectomy</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Ectopic spleen occurs when the spleen migrates from its fixed location in the left upper quadrant to an abnormal position. Developmental failures of the splenic ligaments, especially the gastrosplenic and splenorenal ligaments, which secure the spleen in its normal position, can result in a long splenic mesentery and an abnormally mobile spleen. In most of these situations, the ectopic spleen does not have clinical significance. However, when the ectopic spleen mimics variant and unexpected situations, e.g., in the scrotum [<xref ref-type="bibr" rid="scirp.43538-ref1">1</xref>] or pancreatic tail [<xref ref-type="bibr" rid="scirp.43538-ref2">2</xref>] , it may significantly compromise clinical diagnosis. Here, we report a case where ectopic spleen simulates kidney activity on a renal scintigraphic study.</p></sec><sec id="s2"><title>2. Case Report</title><p>A 46-year-old man presented with recurrent urinary tract infection [<xref ref-type="bibr" rid="scirp.43538-ref3">3</xref>] [<xref ref-type="bibr" rid="scirp.43538-ref4">4</xref>] . Patient had a left radiacal nephrectomy several years earlier for a renal cell carcinoma. Renal dynamic flow images (<xref ref-type="fig" rid="fig1">Figure 1</xref>) showed prompt aortic activity, good right kiney blood flow and radiotracer activity in the left renal fossa; appearing to be the left kidney [<xref ref-type="bibr" rid="scirp.43538-ref5">5</xref>] -[<xref ref-type="bibr" rid="scirp.43538-ref8">8</xref>] . Subsequent follow through functional images demonstrated (<xref ref-type="fig" rid="fig2">Figure 2</xref>) normal right kidney uptake and fair transit of radiotracer into the collecting system. After 24 minutes, there were significant amount of radiotracer retention in the right kidney, consistent with significant right urinary tract obstruction. The factitious left kidney demonstrated fair uptake, but no evidence of transit or excretion. After the first 6 - 8 minutes, activity disappears from the left renal fossa without the progressive excretion expected from a normal kidney. After 24 minutes, there was only faint radiotracer activity noted in the left renal fossa [<xref ref-type="bibr" rid="scirp.43538-ref9">9</xref>] [<xref ref-type="bibr" rid="scirp.43538-ref10">10</xref>] . Axial CT images (<xref ref-type="fig" rid="fig3">Figure 3</xref>) demonstrated the left renal fossa was occupied by the migrated spleen (arrow). Patient was treated with right ureteral stent placement and repeated renal scan demonstrated the resolved right renal obstruction.</p></sec><sec id="s3"><title>3. Discussion</title><p>In this case, the spleen mimics not only the location and configuration of the left kidney, but also the perfusion. It is essential for Radiologists and Nuclear Medicine physicians to recognize numerous congenital variants of the spleen in order to avoid pitfalls and give correct interpretations. An ectopic spleen may be incidentally detected as an abdominal or pelvic mass, for example, Lask [<xref ref-type="bibr" rid="scirp.43538-ref7">7</xref>] et al. reported splenic tissue simulating a renal mass and Servadio [<xref ref-type="bibr" rid="scirp.43538-ref8">8</xref>] et al. reported splenic tissue mimic renal and adrenal tumor. The absence of the spleen in its normal position on CT images allows one to suspect an ectopic spleen and avoid incorrect diagnoses. However, the ectopic splenic tissue can be easily confirmed with Technitium 99<sup>m</sup> labeled sulfur colloid or Technitium 99<sup>m</sup> labeled heated denature red blood cell scans.</p></sec><sec id="s4"><title>4. Conclusion</title><p>Ectopic spleen is an uncommon phenomenon occurring in about 0.5% of the population. It is important for the physician interpreting imaging studies to recognize its possible existence. A careful history and correlation with other imaging studies will help one to avoid this pitfall.</p></sec><sec id="s5"><title>NOTES</title></sec></body><back><ref-list><title>References</title><ref id="scirp.43538-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Emmett, J.M. and Dreyfuss, M.L. (1943) Accessory Spleen in the Scrotum. Annals of Surgery, 117, 754-759. http://dx.doi.org/10.1097/00000658-194305000-00013</mixed-citation></ref><ref id="scirp.43538-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Kawamoto, S., Johnson, P.T., Hall, H., Cameron, J.L., Hruban, R.H. and Fishman, E.K. (2012) Intrapancreatic Accessory Spleen: CT Appearance and Differential Diagnosis. Abdominal Imaging, 37, 812-827. http://dx.doi.org/10.1007/s00261-011-9830-x</mixed-citation></ref><ref id="scirp.43538-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Kobayashi, Y., Usui, Y., Shima, M., et al. (2006) Evaluation of Renal Function after Laparoscopic Partial Nephrectomy with Renal Scintigraphy Using 99mtechnetium-Mercaptoacetyltriglycine. International Journal of Urology, 13, 1371-1374. http://dx.doi.org/10.1111/j.1442-2042.2006.01579.x</mixed-citation></ref><ref id="scirp.43538-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Inoue, Y., Kurimoto, S., Kameyama, S., et al. (2004) Prolonged Renal Parenchymal Retention of 99mTc Mercaptoacetyltriglycine after Nephron-Sparing Surgery. Nuclear Medicine Communications, 25, 509-513. http://dx.doi.org/10.1097/00006231-200405000-00013</mixed-citation></ref><ref id="scirp.43538-ref5"><label>5</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Onuki</surname><given-names> T.</given-names></name>,<name name-style="western"><surname> Terao</surname><given-names> H.</given-names></name>,<name name-style="western"><surname> Muraoka</surname><given-names> K.</given-names></name>,<name name-style="western"><surname> et al. </surname><given-names>  </given-names></name>,<etal>et al</etal>. (<year>2008</year>)<article-title>Splenosis Mimicking Local Recurrence after Radical Nephrectomy: A Report of Two Cases</article-title><source> Hinyokika Kiyo</source><volume> 54</volume>,<fpage> 353</fpage>-<lpage>356</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.43538-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Froehner, M., Leike, S., Manseck, A., et al. (1998) Splenunculus Mimicking Late Local Recurrence of Renal Cell Carcinoma. Scandinavian Journal of Urology and Nephrology, 32, 418-419. http://dx.doi.org/10.1080/003655998750015232</mixed-citation></ref><ref id="scirp.43538-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Lask, D., Abarbanel, J., Rechnic, Y., et al. (1995) Ectopic Splenic Tissue Simulating a Renal Mass. Journal of Urology, 153, 1610-1611. http://dx.doi.org/10.1016/S0022-5347(01)67475-5</mixed-citation></ref><ref id="scirp.43538-ref8"><label>8</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Servadio</surname><given-names> Y.</given-names></name>,<name name-style="western"><surname> Leibovitch</surname><given-names> I.</given-names></name>,<name name-style="western"><surname> Apter</surname><given-names> S.</given-names></name>,<name name-style="western"><surname> et al. </surname><given-names>  </given-names></name>,<etal>et al</etal>. (<year>1994</year>)<article-title>Symptomatic Heterotopic Splenic Tissue in the Left Renal Fossa</article-title><source> European Urology</source><volume> 25</volume>,<fpage> 174</fpage>-<lpage>176</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.43538-ref9"><label>9</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Liu</surname><given-names> P. and Daneman</given-names></name>,<name name-style="western"><surname> A. </surname><given-names>  </given-names></name>,<etal>et al</etal>. (<year>1985</year>)<article-title>Unusual Position of the Spleen—A Report of Two Patients</article-title><source> Journal of the Canadian Association Radiologists</source><volume> 36</volume>,<fpage> 163</fpage>-<lpage>165</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.43538-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">Forino, M., Davis, G.L. and Zins, J.H. (1993) Renal Splenic Heterotopia, a Rare Mimic of Renal Neoplasia: Case Report of Imaging and Fine-Needle Aspiration Biopsy. Diagnostic Cytopathology, 9, 565-569. http://dx.doi.org/10.1002/dc.2840090520</mixed-citation></ref></ref-list></back></article>