<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">WJNST</journal-id><journal-title-group><journal-title>World Journal of Nuclear Science and Technology</journal-title></journal-title-group><issn pub-type="epub">2161-6795</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/wjnst.2012.24026</article-id><article-id pub-id-type="publisher-id">WJNST-23795</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Engineering</subject><subject> Physics&amp;Mathematics</subject></subj-group></article-categories><title-group><article-title>
 
 
  Reduction of the Beam Hardening Artifacts in the X-Ray Computer Tomography: Energy Discrimination with a Photon-Counting Detector
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>ukino</surname><given-names>Imura</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Takuto</surname><given-names>Yanagida</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Hisashi</surname><given-names>Morii</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Hidenori</surname><given-names>Mimura</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Toru</surname><given-names>Aoki</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group><aff id="aff1"><addr-line>Research institute of Electronics, Shizuoka University, Hamamatsu, Japan</addr-line></aff><aff id="aff2"><addr-line>Graduate School of Science and Technology, Shizuoka University, Hamamatsu, Japan</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>ryimura@ipc.shizuoka.ac.jp(UI)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>31</day><month>10</month><year>2012</year></pub-date><volume>02</volume><issue>04</issue><fpage>169</fpage><lpage>173</lpage><history><date date-type="received"><day>August</day>	<month>8,</month>	<year>2012</year></date><date date-type="rev-recd"><day>September</day>	<month>10,</month>	<year>2012</year>	</date><date date-type="accepted"><day>September</day>	<month>19,</month>	<year>2012</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  The material identification is a pressing requirement for the sensitive security applications. Dual-energy X-ray computer tomography (DXCT) has been investigated for material identification in the medical and security fields. It requires two tomographic images at sufficiently different energies. To discriminate dangerous materials of light elements such as plastic bombs in luggage, it is needed to measure accurately with several tens of kilo electron volts where such materials exhibit significant spectral differences. However, CT images in that energy region often include artifacts from beam hardening. To reduce these artifacts, a novel reconstruction method has been investigated. It is an extension of the Al-gebraic Reconstruction Technique and Total Variation (ART-TV) method that reduces the artifacts in a lower-energy CT image by referencing it to an image obtained at higher energy. The CT image of a titanium sample was recon-structed using this method in order to demonstrate the artifact reduction capability.
 
</p></abstract><kwd-group><kwd>X-Ray Computer Tomography; Artifacts; Photon Counting; Iterative Reconstruction; ART-TV; Titanium Sample; Security Applications</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Dual-energy X-ray computer tomography (DXCT) is a powerful material identification technique in the field of medical engineering [1-6]. In DXCT, the effective atomic number and electron density of a target object are derived from the attenuation coefficient or CT value at two different energies [<xref ref-type="bibr" rid="scirp.23795-ref7">7</xref>]. CT systems of this field have dual sources or the ability to rapidly switch the tube current and voltage.</p><p>DXCT is also expected to be applied to the security field. For medical use the target object is body tissue, consisting of light elements. However, these medical systems cannot be directly applied to security inspection, because the target object is composed of various elements. In addition, for space and cost reasons, medical equipment is unsuitable. The applications of DXCT technology have been applied to material discrimination in the security field [<xref ref-type="bibr" rid="scirp.23795-ref8">8</xref>]. An X-ray CT system using a conventional X-ray tube and a photon-counting line sensor has been developed and shown to be feasible for material discrimination [<xref ref-type="bibr" rid="scirp.23795-ref9">9</xref>], but one problem was the presence of artifacts due to beam hardening.</p><p>In DXCT, the effective atomic number and electron density are derived from the difference between the attenuation coefficients at different energies. Therefore, two CT images need to be obtained at a significant energy difference. In addition, the target object in the security field can include light elements such as plastic bombs. Thus, the lower X-ray energy needs to be several tens of kilo-electron volts. Depending on the thickness of the target, such low-energy X-rays may be completely absorbed and not reach the detector. In this case the attenuation is not a linear function of absorber thickness [10,11]. This nonlinear relationship induces artifacts as a beamhardening effect, evident as variations in pixel values even within the same material. An example of an image showing this artifact [<xref ref-type="bibr" rid="scirp.23795-ref12">12</xref>] is the CT image of a copper sample at 40 keV, for which a circular hole in it is blurred in comparison to its image at 90 keV. To identify the material accurately, it is necessary to reduce such artifacts and derive the correct attenuation coefficient from the low-energy CT images.</p><p>To reduce such artifacts, an iterative reconstruction method that uses CT images obtained at different energies was investigated. Higher energy images have fewer artifacts than those of lower energy [<xref ref-type="bibr" rid="scirp.23795-ref12">12</xref>]. This iterative reconstruction method uses a higher-energy CT image obtained simultaneously using polychromatic X-rays as the reference. As the basis for this method, Algebraic Reconstruction Technique and Total Variation (ART-TV) was adopted because it has been verified to be capable of overcoming data insufficiencies [13,14]. As an extension of ART-TV, we developed an improved method referred to here as ART-FG-TV, where FG stands for flatten gradient. This method utilizes a CT system that can simultaneously image an object at different X-ray energies.</p><p>Experimental projection data from a titanium sample were reconstructed with this method and evaluated in terms of artifact reduction. Although titanium is a heavier element than the atoms contained in plastics, it is selected to evaluate the effect of the ART-FG-TV because it clearly reveals artifacts from beam hardening. Also, as titanium is often included in electronic products and cameras, it is a key target material in the security field.</p></sec><sec id="s2"><title>2. Reconstruction Method and Experiment</title><sec id="s2_1"><title>2.1. Reconstruction Method</title><p>The FG step is an iterative optimization process added to the ART-TV method. It flattens the gradient of a CT image by referencing the gradient of a higher-energy CT image. Following the notation of the original algorithm [<xref ref-type="bibr" rid="scirp.23795-ref14">14</xref>], this method can be summarized by the following four steps:</p><p>1) ART reconstruction</p><disp-formula id="scirp.23795-formula148295"><label>(1)</label><graphic position="anchor" xlink:href="9-1090076\91e718ea-520c-440a-8b68-d4dacd13399c.jpg"  xlink:type="simple"/></disp-formula><p>2) FG step</p><disp-formula id="scirp.23795-formula148296"><label>(2)</label><graphic position="anchor" xlink:href="9-1090076\51ac85e4-40a7-4864-a9f6-9ae2817ac1f3.jpg"  xlink:type="simple"/></disp-formula><p>3) Positive constraint</p><disp-formula id="scirp.23795-formula148297"><label>(3)</label><graphic position="anchor" xlink:href="9-1090076\9da67b24-f45a-4172-85ae-cab8dbbca024.jpg"  xlink:type="simple"/></disp-formula><p>4) TV minimization</p><disp-formula id="scirp.23795-formula148298"><label>(4)</label><graphic position="anchor" xlink:href="9-1090076\c7b41d22-d326-4aed-a4ab-f0ed3130d401.jpg"  xlink:type="simple"/></disp-formula><p>where f and g respectively denote a reconstructed image and the projection data, where H is the projection matrix. The number of projections is P, the TV iteration number is Q, and the FG iteration number is S.</p><p>In FG procedure, argument f represents a processed image vector, whereas h is the gradient vector of the higherenergy CT image, calculated by applying a Laplacian filter to the image. θ and α are, respectively, a threshold and a constant that represents the strength of this procedure, which affect the resulting image and should be chosen appropriately. R is a set of vectors of the indices of f that the X-ray path crosses, as in <xref ref-type="fig" rid="fig1">Figure 1</xref>.</p><p>The FG procedure is described below: the image f is traced, on a pixel by pixel basis, along the X-ray path R, and focused pixel is increased as to the strength parameter α and the difference s between that pixel and its adjacent pixels, if the gradient of the reference image at the same position is less than the threshold value θ. This iterative step modifies the values of the pixels on the image f corresponding to the positions of the flat area, or the same material area, of the reference image; the decline of CT value, or the artifact mentioned in Section 1 is thereby reduced.</p></sec><sec id="s2_2"><title>2.2. Experiment</title><p>The CT images were reconstructed from the data measured using the X-ray CT system shown in <xref ref-type="fig" rid="fig2">Figure 2</xref>. It consists of a continuous X-ray tube (running at 150 kV and 10 μA) and a cadmium telluride (CdTe) X-ray/ gamma-ray detector (Amptek X-123CdTe). The sample is a titanium cylinder 15 mm in diameter. To avoid pileup at the detector, a 30-mm-thick aluminum plate is placed between the X-ray tube and the sample. The CdTe detector is wrapped with lead shielding to avoid scattered rays. Since the X-rays are collimated at the tube window and by the hole in the lead shield, they are assumed to constitute a pencil-shaped beam. Assigning the line connecting the X-ray tube and the detector to be 0 mm, data are measured by one second for each 1 mm from −16 to +16 mm. As the sample shape is cylinder, the measurement is done once and the data were repeated for 36 times to obtain a complete rotation. Examples of spectral data are shown in <xref ref-type="fig" rid="fig3">Figure 3</xref>.</p><p>The measured spectrum is divided into energy bands of 10 keV and the midpoint of each energy band is taken to define the effective energy [<xref ref-type="bibr" rid="scirp.23795-ref9">9</xref>]. Dual-source CT systems in the medical field often approximate the mean photon energy of the spectrum in terms of the total number of counts in the whole spectrum [1,2]. In contrast, our method counts the number of photons at the actual energy.</p></sec></sec><sec id="s3"><title>3. Results and Discussion</title><p>Measured CT data of the sample were reconstructed using ART-TV and ART-FG-TV at each energy band. The higher-energy image referenced in the FG procedure was also reconstructed using ART-TV. In <xref ref-type="fig" rid="fig4">Figure 4</xref>, the CT images of 50 keV and the reference image of 110 keV are shown; (a) is ART-TV, (b) is ART-FG-TV and (c) is the referenced image. Profiles along the centers of the images (dashed line in <xref ref-type="fig" rid="fig4">Figure 4</xref>) are plotted in <xref ref-type="fig" rid="fig5">Figure 5</xref>. Since the sample is a uniform titanium cylinder, the CT value should be uniform. Whereas the CT value obtained using ART-TV was non-uniform, it became more nearly uniform with ART-FG-TV. This improvement verifies that the method reduces artifacts.</p><p>In <xref ref-type="fig" rid="fig5">Figure 5</xref>, the lowest value in the ART-TV image is 0.098, and the difference between the highest and lowest values is 0.025, which is 20% of the highest value in the image. On the other hand, the lowest value in the ART-FG-TV image is 0.106, and the difference between the highest and lowest values is 0.011, which is only 9% of the largest value. Furthermore, the depression in the CT image in <xref ref-type="fig" rid="fig4">Figure 4</xref>, which is displayed in 256 shades of gray, is barely visible.</p><p>The ART-FG-TV image was also compared to one measured by conventional filtered back projection (FBP).</p><p>The image in <xref ref-type="fig" rid="fig6">Figure 6</xref>(a) is identical to that in <xref ref-type="fig" rid="fig4">Figure 4</xref>(b), whereas the image in <xref ref-type="fig" rid="fig6">Figure 6</xref>(b) is reconstructed from the same data by FBP. The image profile along the center of each image (dashed line) is shown in <xref ref-type="fig" rid="fig6">Figure 6</xref>(c). The CT value by FBP is large at the edges of the cylinder but declines sharply toward the center. Meanwhile, the CT value by ART-FG-TV is fairly flat across the cylinder, demonstrating how ART-FG-TV can flatten an artifact.</p><p>The influence of α and θ on the image was investigated. The value of α was varied from 0.01 to 0.10 in steps of 0.01 and images were reconstructed. The artifacts are reduced more by using increasingly larger values of the parameter α (<xref ref-type="fig" rid="fig7">Figure 7</xref>). However, when α is larger than 0.05, the image does not converge. Changes in the value of the threshold θ did not noticeably affect the image of this sample.</p><p>In this method, the artifact reduction is done by referencing the higher-energy CT image. Measuring the X-ray with the photon counting detector, the data are obtained as the spectrums. As previously described, the measured spectrum is split into the energy bands of 10 keV. This is enabled by measuring the energy of each photon accurately by photon counting detector. With this accuracy of measuring the energy of photon, it is possible to evaluate the reduction of artifacts numerically.</p></sec></body><back><ref-list><title>References</title><ref id="scirp.23795-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">T. R. C. Johnson, B. Krau?, M. Sedlmair, M. Grasruck, H. Bruder, D. Morhard, C. Fink, S. Weckbach, M. Lenhard, B. Schmidt, T. Flohr, M. F. Reiser and C. R. Becker, “Material Differentiation by Dual Energy CT: Initial Experience,” European Radiology, Vol. 17, No. 6, 2007, pp. 1510-1517. doi:10.1007/s00330-006-0517-6</mixed-citation></ref><ref id="scirp.23795-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">R. T. Gupta, L. M. Ho, D. Marin, D. T. Boll, H. X. Barnhart and R. C. Nelson, “Dual-Energy CT for Characterization of Adrenal Nodules: Initial Experience,” American Journal of Roentgenology, Vol. 194, No. 6, 2010, pp. 1479-1483. doi:10.2214/AJR.09.3476</mixed-citation></ref><ref id="scirp.23795-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">A. Graser, T. R. C. Johnson, H. Chandarana and M. Macari, “Dual Energy CT: Preliminary Observations and Potential Clinical Applications in the Abdomen,” European radiology, Vol. 19, No. 1, 2009, pp. 13-23. 
doi:10.2214/AJR.09.3476</mixed-citation></ref><ref id="scirp.23795-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">K. Engelke, C. Libanati, Y. Liu, H. Wang, M. Austin, T. Fuerst, B. Stampa, W. Timm and H. K. Genant, “Quantitative Computed Tomography (QCT) of the Forearm Using General Purpose Spiral Whole-Body CT Scanners: Accuracy, Precision and Comparison with Dual-Energy X-Ray Absorptiometry (DXA),” Bone, Vol. 45, No. 1, 2009, pp. 110-118. </mixed-citation></ref><ref id="scirp.23795-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">G. Hides, R. Eliahou, M. Dovdevani, P. Coulon, L. Lemaitre, O. N. Gofrit, D. Pode and J. Sosna, “Determination of Renal Stone Composition with Dual-Energy CT: In Vivo Analysis and Comparison with X-Ray Diffraction,” Radiology, Vol. 257, No. 2, 2010, pp. 394-401. 
doi:10.1148/radiol.10100249</mixed-citation></ref><ref id="scirp.23795-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">B. Ruzsics, H. Lee, P. L. Zwerner, M. Gebregziabher, P. Costello and U. J. Schoepf, “Dual-Energy CT of the Heart for Diagnosing Coronary Artery Stenosis and Myocardial Ischemia-Initial Experience,” European Radiology, Vol. 18, No. 11, 2008, pp. 2414-2424.  
doi:10.1007/s00330-008-1022-x</mixed-citation></ref><ref id="scirp.23795-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">M. Torikoshi, T. Tsunoo, M. Sasaki, M. Endo, Y. Noda, Y. Ohno, T. Kohno, K. Hyodo, K. Uesugi and N. Yagi, “Electron Density Measurement with Dual-Energy X-Ray CT Using Synchrotron Radiation,” Physics in Medicine and Biology, Vol. 48, No. 5, 2003, pp. 673-685.  
doi:10.1088/0031-9155/48/5/308</mixed-citation></ref><ref id="scirp.23795-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">G. Zentai, “X-Ray Imaging for Homeland Security,” International Journal of Signal and Imaging Systems Engineering, Vol. 3, No. 1, 2010, pp. 13-20.  
doi:10.1504/IJSISE.2010.034628</mixed-citation></ref><ref id="scirp.23795-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">W. Zou, T. Nakashima, Y. Onishi, A. Koike, B. Shinomiya, H. Morii, Y. Neo, H. Mimura and T. Aoki, “Atomic Number and Electron Density Measurement Using a Conventional X-Ray Tube and a CdTe Detector,” Japanese Journal of Applied Physics, Vol. 47, No. 9, 2008, pp. 7317-7323. doi:10.1143/JJAP.47.7317</mixed-citation></ref><ref id="scirp.23795-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">R. A. Brooks and G. D. Chiro, “Beam Hardening in X-Ray Reconstructive Tomography,” Physics in Medicine and Biology, Vol. 21, No. 3, 1976, pp. 390-398.  
doi:10.1088/0031-9155/21/3/004</mixed-citation></ref><ref id="scirp.23795-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Van de Casteele, E. E. V. Casteele, D. V. Dyck, J. Sijbers and E. Raman, “An Energy-Based Beam Hardening Model in Tomography,” Physics in Medicine and Biology, Vol. 47, No. 23, 2002, pp. 4181-4190.  
doi:10.1088/0031-9155/47/23/305</mixed-citation></ref><ref id="scirp.23795-ref12"><label>12</label><mixed-citation publication-type="other" xlink:type="simple">G. Matsumoto, Y. Imura, H. Morii, A. Miyake and T. Aoki, “Analysis of Artifact With X-Ray CT Using Energy Band by Photon Counting CdTe Detector,” Nuclear Instruments and Methods in Physics Research A, Vol. 621, No. 1-3, 2010, pp. 292-294. 
doi:10.1016/j.nima.2010.05.056</mixed-citation></ref><ref id="scirp.23795-ref13"><label>13</label><mixed-citation publication-type="other" xlink:type="simple">E. Y. Sidky, C. Kao and X. Pan, “Accurate Image Reconstruction from Few-Views and Limited-Angle Data in Divergent-Beam CT,” Journal of X-Ray Science and Technology, Vol. 14, No. 2, 2006, pp. 119-139.</mixed-citation></ref><ref id="scirp.23795-ref14"><label>14</label><mixed-citation publication-type="other" xlink:type="simple">X. Duan, J. Cheng, L. Zhang, Y. Xing, Z. Chen and Z. Zhao, “X-Ray Cargo Container Inspection System with Few-View Projection Imaging,” Nuclear Instruments and Methods in Physics Research A, Vol. 598, No. 2, 2009, pp. 439-444. doi:10.1016/j.nima.2008.08.151.</mixed-citation></ref></ref-list></back></article>