<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">OJBIPHY</journal-id><journal-title-group><journal-title>Open Journal of Biophysics</journal-title></journal-title-group><issn pub-type="epub">2164-5388</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/ojbiphy.2012.21001</article-id><article-id pub-id-type="publisher-id">OJBIPHY-17113</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biomedical&amp;Life Sciences</subject><subject> Physics&amp;Mathematics</subject></subj-group></article-categories><title-group><article-title>
 
 
  Some No Longer Unknowns in Science
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>rieh</surname><given-names>Ben-Naim</given-names></name><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><author-notes><corresp id="cor1">* E-mail:<email>arieh@fh.huji.ac.il</email></corresp></author-notes><pub-date pub-type="epub"><day>19</day><month>01</month><year>2012</year></pub-date><volume>02</volume><issue>01</issue><fpage>1</fpage><lpage>3</lpage><history><date date-type="received"><day>October</day>	<month>26,</month>	<year>2011</year></date><date date-type="rev-recd"><day>November</day>	<month>26,</month>	<year>2011</year>	</date><date date-type="accepted"><day>December</day>	<month>5,</month>	<year>2011</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  Three out of 125 “big questions of science”, can now be claimed to have been answered. All of these questions involve water; its structure, its role in protein folding and its role in protein-protein association.
 
</p></abstract><kwd-group><kwd>Structure of Water; Protein Folding; Protein-Protein Association; Solubility of Proteins</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>Acknowledgements</title><p>The author is grateful for comments and suggestions from Robert Baldwin, David Eisenberg, Robert Mazo and Mihaly Mezei.</p></sec><sec id="s2"><title>REFERENCES</title></sec></body><back><ref-list><title>References</title><ref id="scirp.17113-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">D. Kennedy and C. Norman, “What Don’t We Know?” Science, Vol. 309, No. 5731, 2005, p. 75.  
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