Oalib Open Access Library Journal 2333-9721 2333-9705 Scientific Research Publishing 10.4236/oalib.1115984 Oalib-154423 Article Biomedical Life Sciences Business Economics Chemistry Materials Science Computer Science Communications Earth Environmental Sciences Engineering Medicine Healthcare Physics Mathematics Social Sciences Humanities Contribution of Laser in Periodontal Treatment: Systematic Review 0009-0003-6223-4187 Moqri Imane El Idrissi 1 0000-0002-1927-5288 Amine Khadija 2 0000-0002-1497-387X Kissa Jamila 2 Faculty of Dentistry, University Hassan II of Casablanca, Casablanca, Morocco Department of Periodontics, Faculty of Dentistry, University Hassan II of Casablanca, Casablanca, Morocco

The authors declare no conflicts of interest.

 08 10 2026 10 2026 13 10 1 14 03 09 2026 07 10 2026 10 10 2026 © 2026 by the authors and Scientific Research Publishing Inc. 2026 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/ ). https://doi.org/10.4236/oalib.1115984

Objectives: The aim of this systematic review is to evaluate, through scientific evidence, the contribution of laser treatment as an adjunct to periodontal therapy to short-term clinical outcomes, with follow-up periods of up to six months. Materials and methods: A systematic review of the literature was conducted, including all publications from January 2020 to September 2024 across three databases (PubMed, ScienceDirect, and Google Scholar). The articles that did not meet the inclusion criteria or that met any exclusion criteria were excluded. Results: Three studies showed a significant difference in periodontal pocket depth and clinical attachment loss (CAL) between the test group (treated with the diode laser) and the control group (P < 0.005). However, four studies showed that patients treated with a combination of initial periodontal treatment and photodynamic therapy had a reduction in bacterial recolonization of the periodontal pockets within the same group before periodontal treatment and at the end of treatment after the addition of the diode laser therapy. These studies did not prove any significant difference between the test and control groups. Conclusions: The evaluation of the contribution of the laser diode adjonction to periodontal treatment in this systematic review presented certain limitations. These limitations were related to the use of different therapeutic protocols, the parameters assessed after treatment differ between studies, and the short follow-up periods of patients after treatment. Therefore, the available evidence allows conclusions to be drawn only regarding short-term outcomes and does not permit assessment of long-term stability. Further studies with longer follow-up periods are needed to evaluate the durability of the observed treatment outcomes.

 Chronic Periodontitis Microbiology Laser Therapy Photochemotherapy Periodontal Debridement 1. Introduction

For decades, periodontal disease has been a major challenge to oral health and quality of life [1]. Periodontitis is defined as the progressive destruction of dental supporting tissues. Its main feature is the loss of periodontal tissue support, manifested by clinical attachment loss, bone loss measured on radiography, periodontal pocket formation, and gingival bleeding [2].

The management of periodontitis is based on controlling the bacterial load through non-surgical and surgical treatments aimed at eliminating these pathogenic factors, restoring function, and regenerating or repairing the supporting tissues lost as a result of inflammation [2]. However, it is well known that debridement alone is generally incomplete due to limited access to certain areas of the periodontium [3].

In this situation, various complementary techniques have been recommended, such as laser radiation [4].

To reinforce the effects of conventional periodontal treatment, lasers have been used as an adjunctive therapy for their disinfection potential (photochemical effect) and anti-inflammatory effects [1]. Although some studies have reported the clinical efficacy of different types of lasers in periodontal treatment, controversy persists [4].

The aim of this systematic review is to evaluate, through scientific evidence, the contribution of laser treatment to periodontal therapy in stabilizing long-term outcomes.

 2. Materials and Methods

The protocol of this systematic review was designed according to the Preferred Reporting Items for Systematic review and Meta-Analyses (PRISMA statement) [5]. An electronic literature search was conducted from the following databases: PubMed, Google Schoolar and Science direct. The search focused on studies published from January 2020 to September 2024.The search strategy used Mesh keywords and search equations using “Boolean” operators «AND» and «OR». The keywords used and the corresponding search equations were as follows: Chronic periodontitis, microbiology, laser therapy, photochemotherapy, periodontal debridement, (“Chronic Periodontitis/microbiology” [Mesh]) AND “Lasers, Semiconductor/therapeutic use” [Mesh], OR (“Periodontal Debridement” [Mesh]) AND “Laser Therapy” [Mesh], OR (“Chronic Periodontitis/microbiology” [Mesh]) AND “Photochemotherapy/methods” [Mesh], OR (“Chronic Periodontitis” [Mesh]) AND “Laser Therapy” [Mesh].

The study selection process was based on predefined inclusion and exclusion criteria. Eligible studies included clinical studies evaluating adjunctive diode laser treatment in patients aged ≥ 18 years diagnosed with periodontitis, published in English or French, and providing sufficient information regarding the study design, sample size, treatment protocol, materials, equipment, and relevant clinical and/or microbiological outcomes. Randomized clinical trials and other eligible clinical studies were considered, whereas (single case reports/case series) were excluded. Studies involving animals, patients with systemic pathologies, incomplete data, book chapters, narrative reviews, systematic reviews, and meta-analyses were excluded.

Titles and abstracts were independently screened by two reviewers, followed by independent full-text assessment of potentially eligible studies. Data extraction was also performed independently by the two reviewers using a predefined data extraction form. The extracted variables included author, year of publication, participants’ age, study design, sample size, type of periodontal treatment, type of laser used, laser parameters, duration of follow-up, and clinical and microbiological periodontal outcomes. No disagreements occurred between the two reviewers during the screening, eligibility assessment, or data extraction processes. The extracted data were organized in a summary table for qualitative synthesis. The unit of analysis was recorded for each study, and outcomes reported at the patient, tooth, or periodontal pocket level were extracted according to the methodology of the original study. Split-mouth studies were included when they met the predefined eligibility criteria, and within-patient comparisons between test and control sites were retained as reported by the original authors. Clinical parameters included periodontal probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP), while microbiological parameters included changes in the bacterial load of periodontal pathogens, particularly bacteria belonging to the red and orange complexes, such as Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Treponema denticola (Td).

 3. Results

The articles selection followed several steps which are presented in the flow diagram below, suggested by “the PRISMA Statement” [5] [Figure 1Figure 1]. The electronic search in PubMed, Science direct, and Google scholar provided 1504 articles published between January 2020 and September 2024. After reading all the abstracts and eliminating duplicates, 41 articles were selected for full-text review. Following full-test assessment, 18 studies were selected that met the inclusion criteria for this Systematic Review, while 23 studies were excluded for the following reasons: single case report, animal studies involving rats, dogs or other animal models, and in vitro studies.

3.1. Study Characteristics

The search yielded 18 studies, of which 13 were randomized. All studies were

Figure 1.Prisma Flow diagram of article screening and selection process.

prospective except one, which was retrospective.

The included studies evaluated the effect of diode laser therapy following non-surgical periodontal treatment. This assessment was based on the improvements of clinical parameters in all the included studies, except for the study conducted by El Mobadder et al. in 2022, which focused on the evaluation of microbiological parameters only [6]. Only 5 studies obtained evaluated microbiological parameters associated with clinical parameters in periodontitis. 12 studies subdivided their study populations into 2 groups: a control group that received initial periodontal treatment only, and a test group receiving the diode laser therapy combined with initial periodontal treatment [Table 1]. On the other hand, 6studies divided their study populations into 3 or 4 groups: a control group that received initial periodontal treatment only, a test group receiving the diode laser therapy combined with initial periodontal treatment, and another group evaluating the combination of a biochemical adjuvant with laser diode therapy or the biochemical adjunct with initial treatment only [Table 1].

All included studies had short-term follow-up periods ranging from 2 weeks to 6 months.

 3.2. Risk of Bias in Included Studies

The quality assessment showed that 11 studies were rated with low risk of bias [8][10]-[12][14][16][18]-[20][22][23]. The assessment of risk of bias is summarized in Table 2.

Table 1. Characteristics of the included studies.

Reference Study design Intervention
Type of study Population Age(y) Follow-up Before l’intervention Intervention
C. Yang et al . 2022 [ 7 ] Prospective 92 patients-GRP test1-GRP test 2-GRP control 47.3 3 months6 months Grp test1: SRPGrp test 2: SRPGrp control: SRP Cross-section-Grp test1: minocycline hydrochloride-Grp test 2: PDT-Grp control
S. K. Anwar et al . 2024 [ 8 ] Prospective 50 patients-Grp test-Grp control 17 - 35 6 months -Grp test: SRP-Grp control: SRP Cross-section-Grp test: PDT-Grp control: ATB
N. Derikvand et al .2020 [ 9 ] Prospective 50 patients-Grp test-Grp control 35 - 50 -1.5 months-3 months -Grp test: SRP-Grp control: SRP Cross section-Grp test: PDT + methylene blue-Grp control
J. W. Lu et al . 2023 [ 10 ] Prospective 154 pockets-Grp test-Grp control _ -3 months-6 months -Grp test: SRP-Grp control: SRP -Grp test: SRP + PDT-Grp control: SRP
F. H. Niazi et al . 2020 [ 11 ] Prospective 73 patients-Grp test 1-Grp control-Grp test 2 _ -3 months-6 months -Grp test 1: SRP-Grp control: SRP- Grp test 2: SRP -Grp test 1: Laser diode-Grp control:- Grp test 2: SP gel
S. Gottumukkala et al . 2024 [ 12 ] Prospective 20 patients-Grp test1-Grp test2 42.20 -3 months-6 months -Grp test: SRP-Grp test: SRP Cross-section-Grp test: PDT-Grp test: LANAP
A. El Sharaki et al . 2024 [ 13 ] Prospective 60 patients-Grp control-Grp test 20 - 40 -3 months-6 months -Grp control: SRP-Grp test: SRP -Grp control: ATB-Grp test: laser
B. Poormoradi et al .2024 [ 14 ] Prospective 32 patients-Grp control-Grp test 38.24 -1 month-2 months -Grp control: SRP-Grp test: SRP Cross section-Grp control-Grp test: laser
T. Kamble et al .2024 [ 15 ] Prospective 33 patients-Grp control-Grp test 1-Grp test 2 -3 months -Grp control: SRP-Grp test1: SRP-Grp test2: SRP -Grp control-Grp: PDT-Grp: doxycycline
A. Singh et al .2024 [ 16 ] Prospective 45 patients-Grp test 1-Grp control-Grp test 2 -3 months-6 months -Grp control: SRP+ OFD-Grp test 2: SRP+ OFD -Grp test 1: PDT-Grp control-Grp test 2: PDT
M. Alghafri et al .2024 [ 17 ] Prospective 22 patients-Grp control-Grp test -3 months-6 months -Grp control: SRP-Grp test: SRP -Grp: control-Grp: SRP + PDT
S. Elmeligy et al . 2024 [ 18 ] Prospective 24 patients-Grp control-Grp test 1-Grp test 2 40.12 -2 weeks-4 weeks-6 weeks -Grp control: SRP-Grp test 1: SRP-Grp test 2: SRP -Grp control-Grp test 1: PDT-Grp test 2: Erythritol air polishing
A. Sayed-Monir et al . 2023 [ 19 ] Prospective 12 patients-Grp control-Grp test 20 - 56 2 months -Grp control: SRP-Grp test: SRP -Grp control-Grp test: laser
M. El Mobadder et al . 2023 [ 20 ] Prospective 32 patients- Grp control-Grp test 43 3 months -Grp control: SRP-Grp test: SRP -Grp control-Grp test: PDT
M. El Mobadder et al . 2022 [ 21 ] 30 patients-Grp control-Grp test -3 months-6 months -Grp control: SRP-Grp test: SRP -Grp control-Grp test: laser +NaCl
M. El Mobadder et al . 2022 [ 6 ] Retrospective 120 patients-Grp control-Grp test 1-Grp test 2-Grp test 3 6 months -Grp control: SRP-Grp test 1: SRP-Grp test 2: SRP-Grp test 3: SRP -GRP control-Grp test 1: laser-Grp test 2: H 2 O 2 -Grp test 3: H 2 O 2 + laser
M. R Mokhtari et al . 2021 [ 22 ] Prospective 36 patients-Grp control-Grp test ≥18 6 weeks18 weeks -Grp control: SRP-Grp test: SRP Cross section-Grp control-Grp test: laser
S. M. Staden et al . 2020 [ 23 ] Prospective 25 patients-Grp control-Grp test 45 ± 6 6 weeks -Grp control: SPR-GRP test: SPR Cross study-Grp control-Grp test: laser

Grp: group, y: year, SRP scaling root planning, PDT: photo-dynamic therapy, SP gel: Salvadora Persica gel, LANAP: laser assisted new attachment procedure, OFD: open flap debridement, ATB: antibiotics.

Table 2. Risk of bias assessment.

Randomization Allocation concealment Examiner blinding Completion of follow-up Risk of bias
C. Yang et al . 2022 [ 7 ] Yes No No No (2 patients were lost) High
S. K. Anwar et al . 2024 [ 8 ] Yes Yes Yes Yes Low
N. Derikvand et al . 2020 [ 9 ] No No Yes Yes High
J. Wei Lu et al . 2023 [ 10 ] Yes No Yes Yes Low
F. H. Niazi et al . 2020 [ 11 ] Yes No Yes Yes Low
S. Gottumukkala et al . 2024 [ 12 ] Yes Yes Yes No (2 patients were lost) Low
A. El Sharaki et al . 2024 [ 13 ] No No No yes High
B. Poormoradi et al . 2024 [ 14 ] Yes Yes Yes Yes Low
T. Kamble et al . 2024 [ 15 ] No No No Yes High
A. Singh et al . 2024 [ 16 ] Yes Yes No Yes Low
M. Alghafri et al . 2024 [ 17 ] Yes Yes No No (2 patients were lost) High
S. Elmeligy et al . 2024 [ 18 ] Yes Yes Yes Yes Low
A. Sayed-Monir et al . 2023 [ 19 ] Yes No Yes Yes Low
M. El Mobadder et al . 2023 [ 20 ] Yes Yes No Yes Low
M. El Mobadder et al . 2022 [ 21 ] No No No Yes High
M. El Mobadder et al . 2022 [ 6 ] No No Yes Yes High
M. R Mokhtari et al . 2021 [ 22 ] Yes Yes Yes Yes Low
S. M. Staden et al . 2020 [ 23 ] Yes Yes Yes Yes Low

Regarding treatment outcomes, 5 included studies reported statistically significant improvements in one or more periodontal parameters following treatment with adjunctive diode laser therapy. However, these findings represent within-group changes and should be distinguished from between-group comparisons. In the majority of the included studies, no statistically significant difference was demonstrated between the diode laser groups and the control groups receiving conventional periodontal treatment alone [Table 3]. Overall, 13 studies did not demonstrate a statistically significant additional benefit of diode laser therapy compared with the respective control treatment [Table 3].

Among these studies, four compared diode laser therapy with or in combination with biochemical adjuncts used alongside periodontal treatment, including hydrogen peroxide (H2O2), erythritol, doxycycline, and Salvadora persica (SP) gel [Table 3]. These comparisons further reflected differences in treatment protocols and adjunctive interventions across the included studies.

Table 3. Treatment outcomes.

Comparison Pocket depth Clinical attachment loss Bleeding on probing Microbiological tests
Outcomes P Value Outcomes P Value Outcomes P Value Outcomes P Value
C. Yang et al . 2022 [ 7 ] 6 months
Grp test1Grp test 2: PDTGrp contrôle 3.82 ± 0.953.52 ± 0.974.79 ± 1.24 0.042 6.46 ± 0.795.99 ± 0.946.10 ± 0.94 0.028
S. K . Anwar et al . 2024 [ 8 ] 3 months
Grp testGrp control 4.52 ± 1.963.88 ± 2.05 0.082 4.84 ± 3.053.48 ± 3.04 0.078 Pg: 54.49 ± 93.63 (10 3 )Aa: 2.05 ± 3.95 (10 3 )Pg: 23.96 ± 39.15 (10 3 )Aa: 4.08 ± 4.76 (10 3 ) Pg: 0.701Aa: 0.181
N. Derikvand et al . 2020 [ 9 ] 6 months
Grp testGrp control 2.64 ± 0.753.20 ± 0.87 0.019
J. Wei Lu et al . 2023 [ 10 ] 24 weeks
Grp testGrp control 3.06 ± 0.864.46 ± 1.57 2.58 ± 0.943.03 ± 1.25 15.49%64.29%
F. H . Niazi et al . 2020 [ 11 ] 6 months
GRP test 1: laserGRP test 2: SP gelGRP contrôle 4.02 ± 0.484.93 ± 0.855.00 ± 0.75 0.002 3.00 ± 0.943.65 ± 1.074.03 ± 0.77
S. Gottumukkala et al . 2024 [ 12 ] 6 months
GRP test 1: PDTGRP test 2: LANAP 3.21 ± 0.463.52 ± 0.50 0.641 2.03 ± 0.543.22 ± 0.62 0.2
A. El Sharak i 2024 [ 13 ] 6 months
GRP test: laserGRP controle: ATB 3.1 ± 0.53.6 ± 0.6 3.9 ± 0.7 24.8 ± 8.730.5 ± 9.6
B. Poormoradi et al . 2024 [ 14 ] 8 weeks
GRP test: laserGRP controle 1.92 ± 0.652.21 ± 0.82 0.326 0.17 ± 0.070.26 ± 1.15 0.552 0.06 ± 0.070.12 ± 0.13
T. Kamble et al . 2024 [ 15 ] 3 months 4.5 ± 0.8
GRP A: PDTGRP B: doxycyclineGRP C: controle 2.18 ± 0.4054.36 ± 0.505.27 ± 0.64 0.49 0.64 ± 0.52.18 ± 0.43.09 ± 0.3 0.54 20 ± 6.11130 ± 82.14193 ± 8.063
A. Singh et al . 2024 [ 16 ] 6 months
GRP A: PDTGRP B: open flapGRP C: PDT + open flap 3.33 ± 0.813.47 ± 0.513.20 ± 0.56 3.60 ± 0.733.67 ± 0.613.53 ± 0.51
M. Alghafri et al . 2024 [ 17 ] 6 months
GRP test: PDTGRP controle 2.91 ± 0.563.21 ± 0.92 0.26 3.53 ± 0.932.95 ± 0.45 0.09
S. Elmeligy et al . 2024 [ 18 ] 6 weeks
GPR test 1: PDTGRP test 2: ErythritolGRP controle 0.86 ± 0.381.07 ± 0.371.58 ± 035 0.004 0.83 ± 0.361.05 ± 0.571.68 ± 0.35 0.004 Aa: 00 - 200 (min-max)Pg: 50 - 1000 (min-max)Aa: 00 - 300 (min-max)Pg: 5 - 1000 (min-max)Aa: 00 - 100 (min-max)Pg: 14 - 150 (min-max) Aa: 0.816Pg: 0.735
A. Sayed- Monir et al . 2023 [ 19 ] 2 months
GRP controleGRP test: laser 1.12 ± 0.381.21 ± 0.27 0.06 0.88 ± 0.311.14 ± 0.21 0.07 3.03 ± 2.495.16 ± 2.44 0.06
M. El Mobad d er 2023 [ 20 ] 3 months
GRP controleGRP test 4.85 ± 0.423.79 ± 0.35 5.99 ± 1.085.01 ± 0.81
M. El Mobad d er 2022 [ 21 ] 6 months
GRP controleGRP test: laser + NaCl 5.28 ± 0.674.03 ± 0.49 6.32 ± 1.075.76 ± 1.03 20.70 ± 9.4414.32 ± 9.07 6.2 × 10 9 5.6 × 10 8
M. El Mobad d er 2022 [ 6 ] 6 months
GRP controleGRP test1: laserGRP test2: H 2 O 2 GRP test3: laser + H 2 O 2 ---- 7.26 × 10 7 4.01 × 10 7 4.32 × 10 7 3.21 × 10 7 0.0001
M. R Mokhtari et a l . 2021 [ 22 ] 18 weeks
GRP contrôleGRP test: laser 4.23 ± 0.843.94 ± 0.85 0.2 4.42 ± 1.414.13 ± 1.42 1.0 18.41 ± 12.1112.11 ± 9.05 0.02
S. M. Staden et a l . 2020 [ 23 ] 6 weeks
GRP contrôleGRP test: laser 0.46440.4984 0.763 0.46480.5288 0.586 41.6450.144 0.005 Aa: 0.28 × 10 5 Pg: 0.468 × 10 5 Td: 0.4 × 10 4 Aa: 0.29 × 10 5 Pg: 0.440 × 10 5 Td: 0.424 × 10 5 Aa: 0.733Pg: 0.672Td: 0.852

Grp: group, PDT: photo-dynamic therapy, SP gel: Salvadora Persica gel, LANAP: laser assisted new attachment procedure, ATB: antibiotics, Aa: Aggregatibacter actinomycetemcomitans, Pg: Porphyromonas gingivalis, Td: Treponema denticola, NaCl: Sodium chloride.

 4. Discussion

Periodontal inflammation is initiated by the formation of a bacterial biofilm; therefore, the main aim of periodontal therapy is to eliminate these pathogens through non-surgical and surgical techniques [7][8]. The addition of diode laser therapy to non-surgical treatment has been proposed as an adjunctive approach to target pathogenic bacteria. The laser transmits energy to the bacteria cells, causing denaturation of bacterial proteins [16]. The aim of this Review is to assess the contribution of laser therapy to periodontal treatment to clinical and microbiological outcomes:

4.1. Effect on Clinical Parameters:

In this review, three studies reported statistically significant differences between the test group, which received diode laser therapy as an adjunct to periodontal treatment, and the control group for probing pocket depth and clinical attachment level (CAL) (P < 0.005) [11][13][18]. These findings suggest a potential additional short-term clinical benefit of diode laser therapy in the specific studies concerned. The observed effects have been attributed to the laser’s broad antimicrobial spectrum, which targets both Gram-negative and Gram-positive bacteria (it’s a non-specific destruction mechanism reducing the risk of developing bacterial resistance), as well as its ability to penetrate and disrupt the biofilm structure, potentially facilitating the elimination of residual bacteria.

However, the majority of the included studies did not demonstrate statistically significant differences between the test and control groups [7][8][9][12][14][17][19][22][23]. In several studies, improvements in periodontal parameters were observed within both treatment groups following therapy, without a statistically significant additional benefit attributable to diode laser therapy. The absence of significant between-group differences may be related to several factors, including the laser parameters applied, such as wavelength (940 nm), power (0.7 to 1 w), pulsed mode, and exposure time (10 to 15 seconds), which may not have been optimal, as well as the relatively small sample sizes, which may have limited the statistical power to detect differences between groups. In addition, the relatively short follow-up periods may not have been sufficient to assess the persistence of clinical effects.

 4.2. Effect on Microbiological Parameters:

Among the studies investigating microbiological outcomes, four reported reductions in the recolonization of periodontal pockets by A. actinomycetemcomitans (Aa), P. intermedia (Pi), and P. gingivalis (Pg) following treatment combining initial periodontal therapy with photodynamic therapy [6][8][18][23]. However, these studies did not demonstrate statistically significant differences in bacterial levels between the test and control groups. Rather, some studies reported statistically significant reductions in the levels of specific bacteria, particularly Aa and Pg, within the laser-treated groups when comparing bacterial levels before treatment with those measured after treatment. These within-group changes indicate an improvement following treatment but do not, in isolation, establish an additional effect of diode laser therapy compared with conventional periodontal treatment.

The lack of statistically significant between-group differences may be related to several study limitations, including relatively small sample sizes and the inclusion of predominantly patients with stage I and II periodontitis, which may limit the generalizability of the findings to more advanced forms of periodontal disease. Furthermore, the short follow-up periods may have limited the ability to detect sustained microbiological effects [18].

 4.3. Comparison between the Effect of Diode Laser and the Effect of a Biochemical Adjuvant in Association with Periodontal Treatment

Two studies investigated the combination of laser therapy with biochemical agents, including hydrogen peroxide (H2O2) and sodium hypochlorite (NaOCl), and reported reductions in bacterial load following the combined interventions [6][21]. In the study involving H2O2, hydroxyl radicals were proposed to exert antibacterial effects through oxidative damage to bacterial cells. Elmobader et al. reported a reduction in bacterial load following treatment; however, the interpretation of this finding should be based on the comparison between the test and control groups rather than on within-group changes alone [6].

Another study compared adjunctive photodynamic therapy with an SP gel (Salvadora persica). The photodynamic therapy group showed greater improvements in probing pocket depth reduction and clinical attachment loss compared with the SP gel group, whereas the SP gel group demonstrated a greater improvement in bleeding on probing index (BOP) [9]. The reduction in gingival bleeding observed with the SP gel may be related to its organic and inorganic constituents, including silica, calcium, sodium bicarbonate, vitamin C, and tannic acid [11].

The addition of doxycycline to periodontal treatment was also compared with adjunctive diode laser therapy in one study [15]. Although the diode laser groups showed improvements in some clinical and microbiological parameters, these findings should be interpreted according to whether the differences were statistically significant between groups or represented changes occurring within the laser-treated groups. Therefore, the available evidence does not consistently demonstrate a significant additional benefit of diode laser therapy over conventional periodontal treatment or systemic doxycycline.

 5. Conclusion

The results of this review indicate that adjunctive laser therapy during periodontal treatment may provide short-term improvements in some clinical periodontal parameters compared with conventional periodontal treatment alone. The diode laser may contribute to periodontal pocket decontamination and reduction of gingival inflammation. However, these findings are based exclusively on follow-up periods of six months or less and therefore provide evidence only of short-term clinical outcomes. The long-term stability of the observed benefits cannot be determined from the available evidence. Further well-designed clinical trials with longer follow-up periods are needed to assess the persistence of these effects and to establish optimal treatment protocols for the adjunctive use of diode laser therapy in periodontal practice. Based on the short-term evidence currently available, the systematic use of diode laser therapy as an adjunct to non-surgical periodontal treatment cannot be strongly recommended.

 Limitations of the Study

The studies examined in this review used different therapeutic protocolsThe parameters assessed after treatment differed between studies (some evaluated clinical parameters, others assessed biological parameters and some assessed both at the same time)The duration of follow-up of patients after treatment was short, and varied between studies

Therefore, it is difficult to make a precise comparison between the included studies, and to determine the contribution of diode laser therapy to the treatment of periodontal pockets as an adjuvant to conventional treatment.

 Acknowledgements

I would like to thank all the people who contributed to this work, for their close guidance during the writing of the review.

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