Venous thromboembolic disease (VTE) comprises two closely related clinical entities: deep vein thrombosis (DVT) and pulmonary embolism (PE). It results from the formation of a thrombus within the venous system, most often in the lower limbs, which may migrate to the pulmonary circulation and become life-threatening [1]-[4]. VTE is therefore a diagnostic and therapeutic emergency because of its acute mortality, haemodynamic and respiratory complications, as well as its chronic sequelae, particularly post-thrombotic syndrome and chronic thromboembolic pulmonary hypertension [5]-[8].

Long considered less frequent in Africa, VTE is now increasingly reported in African hospital settings. This apparent increase may be related to the epidemiological transition, progressive population ageing, the growing burden of cardiovascular and metabolic risk factors, and the increasing frequency of cancer, surgery, prolonged immobilisation, and high-risk gynaeco-obstetric situations [9]-[13]. It may also reflect improved availability of diagnostic tools, particularly venous Doppler ultrasound and computed tomography pulmonary angiography.

Diagnosis remains challenging because clinical manifestations are non-specific. Clinical probability scores, such as the Wells or Geneva scores, guide the diagnostic approach but do not replace imaging [14]-[16]. From a therapeutic perspective, anticoagulation is the cornerstone of management. The introduction of direct oral anticoagulants has changed treatment strategies, although their cost still limits access in many resource-constrained settings [17]-[20].

In Senegal, hospital-based data remain necessary to better understand the local profile of VTE and improve its management. The general objective of this study was to assess the management of VTE in the Cardiology Department of Idrissa Pouye General Hospital. The specific objectives were to describe the epidemiological and sociodemographic characteristics, identify aetiological factors, and analyse diagnostic, therapeutic and outcome aspects.

This was a retrospective, descriptive and analytical study conducted over a four-year period, from 1 January 2019 to 31 December 2022, in the Cardiology Department of Idrissa Pouye General Hospital in Dakar. This is a level 3 hospital with a cardiac intensive care unit. Patient records were identified from the department’s hospitalisation registers. All patients admitted during the study period with a diagnosis of venous thromboembolic disease were identified, and their medical records were then reviewed in the hospital archives using a standardised data collection form.

All patients hospitalised for VTE confirmed by imaging were included, either by venous Doppler ultrasound for venous thrombosis or by computed tomography pulmonary angiography for pulmonary embolism. Patients in whom diagnostic confirmation could not be established, those without computed tomography pulmonary angiography in cases of suspected PE, or without venous Doppler ultrasound in cases of suspected DVT, were not included.

The variables studied included sociodemographic data, namely age, sex, geographical origin, socioeconomic status, educational level and occupational sector. The VTE risk factors assessed were previous VTE, prolonged bed rest, long-distance travel, trauma, recent surgery, cancer, pregnancy, postpartum status, oestroprogestative use and other situations associated with hypercoagulability or venous stasis. Cardiovascular risk factors, clinical signs, biological, electrocardiographic, echocardiographic and radiological data were also analysed.

Therapeutic data included the type of anticoagulation, possible thrombolysis and adjunctive treatments. In-hospital outcome was assessed according to favourable evolution, occurrence of complications or death. Data were entered using Epi Info version 7.2.50 and analysed with R version 4.3.1. Qualitative variables were expressed as percentages, and quantitative variables as mean ± standard deviation or median with ranges. Statistical significance was set at p < 0.05.

During the study period, 2,996 patients were hospitalised in the Cardiology Department. Among them, 190 cases of VTE were identified, corresponding to an overall hospital prevalence of 6.34%. Isolated pulmonary embolism accounted for 93 cases, representing 48.9% of VTE cases; isolated deep vein thrombosis accounted for 78 cases, representing 41.1%; and combined DVT-PE accounted for 19 cases, representing 10.0% (Figure 1). The hospital prevalence was 3.10% for isolated PE, 2.60% for isolated DVT and 0.63% for combined DVT-PE.

The overall mean age was 48.20 ± 16.79 years. It was 47.59 ± 15.24 years among patients with PE, 47.92 ± 18.86 years among those with DVT and 52.32 ± 15.21 years in patients with combined forms. Patients aged 31 - 40 years were the most represented among PE cases, whereas patients younger than 30 years predominated among DVT cases. Patients older than 60 years accounted for 21.5% of PE cases, 29.5% of DVT cases and 31.6% of combined forms (Table 1).

Figure 1.Distribution of patients according to VTE type (n = 190).

Table 1.Main epidemiological and sociodemographic characteristics.

Female sex predominated in DVT, accounting for 73% of cases, with a sex ratio of 0.36. In PE, female predominance was more moderate, at 51.6%. Conversely, combined DVT-PE forms were slightly more frequent in men. Most patients came from the Dakar suburbs. Socioeconomic status was most often middle level, and the informal sector represented a substantial proportion of occupational activity.

VTE risk factors were dominated by medical, gynaeco-obstetric, surgical and orthopaedic factors. Prolonged bed rest was particularly frequent in DVT. Long-distance travel was more frequent in combined DVT-PE forms. Cancer was more often observed in PE and combined forms. Gynaeco-obstetric risk factors were dominated by oestroprogestative use, pregnancy, postpartum status and post-abortion status. The most frequent cardiovascular risk factors were physical inactivity and obesity or overweight (Figure 2).

Clinically, DVT mainly presented as a painful, inflammatory swollen leg, observed in 93.68% of cases, followed by local warmth, Homans’ sign, tachycardia and reduced calf ballottement. In PE, functional symptoms were dominated by dyspnoea (79.09%), chest pain (65.45%) and cough (39.09%). Tachycardia was the most frequent physical sign. Computed tomography pulmonary angiography confirmed PE, which was mostly bilateral in 77.27% of cases, with proximal involvement in 44.54%. On echocardiography, pulmonary hypertension was observed in 66.2% of explored patients and right chamber dilatation in 30.7% (Table 2).

Figure 2.Main medical risk factors for VTE according to clinical presentation.

Table 2.Clinical and paraclinical diagnostic profile.

Therapeutically, 164 patients, or 86.78%, received heparin therapy, mainly low-molecular-weight heparin. Bridging with a vitamin K antagonist, mainly acenocoumarol, was performed in 143 patients, or 75.26%. Direct oral anticoagulants, mainly rivaroxaban, were used in 79 patients, or 41.58%, either as initial therapy or as bridging therapy. Heparin therapy alone was used in some pregnant patients (Figure 3) (Table 3).

Figure 3.Therapeutic management and in-hospital outcome.

Table 3.Therapeutic and in-hospital outcome data.

PE: pulmonary embolism; DVT: deep vein thrombosis; VTE: venous thromboembolism; LMWH: low-molecular-weight heparin; UFH: unfractionated heparin; VKA: vitamin K antagonist; DOAC: direct oral anticoag

This study confirms that VTE represents a substantial cause of hospitalisation in cardiology at Idrissa Pouye General Hospital, with an overall hospital prevalence of 6.34%. This frequency reflects both the real burden of the disease and the gradual improvement in diagnostic resources. It is consistent with recent African data showing that VTE is not rare in hospital settings, contrary to earlier assumptions [21]-[24].

The predominance of isolated pulmonary embolism in our series may be related to the cardiology-based recruitment of the department, which is more likely to receive patients presenting with respiratory or haemodynamic symptoms suggestive of PE. Isolated DVT may, in some contexts, be managed in internal medicine, vascular surgery or outpatient care, which may underestimate its true burden in a study limited to a cardiology department.

The mean age, lower than that often reported in European series, probably reflects the younger demographic structure of the Senegalese population. The substantial proportion of young patients highlights the importance of specific risk factors, particularly gynaeco-obstetric conditions, oestroprogestative use, long-distance travel, immobilisation, trauma and surgery. The high representation of women among DVT cases is consistent with several African series and may be explained by exposure to hormonal and obstetric risk factors [23]-[26].

Clinical diagnosis remains challenging. In our series, DVT symptoms were dominated by a painful inflammatory swollen leg, whereas PE mainly presented with dyspnoea, chest pain and tachycardia. These signs are classical but non-specific, justifying the combined use of clinical probability assessment, laboratory testing and, above all, imaging. Venous Doppler ultrasound and computed tomography pulmonary angiography remain essential to confirm the diagnosis, characterise lesion extent and guide management [14]-[17].

Echocardiographic findings, particularly the high frequency of pulmonary hypertension and right chamber dilatation, underline the potential severity of PE and the importance of risk stratification. The use of the sPESI score helps identify patients at high risk of early complications and adapt in-hospital monitoring.

Therapeutically, anticoagulation was widely used, mainly with low-molecular-weight heparin followed by bridging to vitamin K antagonists. This strategy remains relevant in our context, particularly because of availability, clinical experience and relative cost. However, the use of direct oral anticoagulants in more than 40% of patients indicates an important shift in practice. Their ease of use is an advantage, but their cost remains a major barrier to wider use in resource-limited settings [18]-[20][27]-[30].

The limitations of this study should be acknowledged: its retrospective and single-centre design, missing data, absence of systematic long-term follow-up and lack of detailed multivariable analysis. Despite these limitations, it provides useful data on the current profile of VTE in cardiology in Senegal and highlights the need to strengthen prevention, early diagnosis and access to anticoagulant therapy.

Venous thromboembolic disease was a frequent cause of hospitalisation in the Cardiology Department of Idrissa Pouye General Hospital between 2019 and 2022, with an overall hospital prevalence of 6.34%. Isolated pulmonary embolism was the most frequent form, followed by isolated deep vein thrombosis and combined DVT-PE. Patients were relatively young, with a high representation of women among DVT cases.

Risk factors were multiple and were dominated by medical, gynaeco-obstetric, surgical, orthopaedic and cardiovascular factors. Diagnosis was based mainly on venous Doppler ultrasound and computed tomography pulmonary angiography. Treatment was dominated by heparin therapy, bridging to vitamin K antagonists and increasing use of direct oral anticoagulants.

These findings highlight the need for a structured hospital strategy focused on prevention, early diagnosis, risk stratification and improved access to anticoagulants. Prospective multicentre studies with long-term follow-up are needed to better assess prognosis and recurrence.

Conceptualisation: AAN and JSM; Formal analysis: GN; Writing - original draft: NDG and AAN; Supervision: AAN and AK; Writing - review and editing: all authors.