Infection with the human immunodeficiency virus (HIV) remains a major global public health challenge, with a disproportionate burden borne by sub-Saharan Africa. According to the latest estimates from UNAIDS, approximately 39 million people were living with HIV in 2023, more than 65% of whom resided in sub-Saharan Africa, a region that also accounts for the majority of new infections and AIDS-related deaths [1].

The introduction and widespread adoption of combination antiretroviral therapy (ART) have profoundly transformed the prognosis of HIV infection, enabling sustained suppression of viral replication, gradual restoration of immunity, and a significant reduction in viral transmission [2]. Currently recommended first-line treatment regimens rely primarily on integrase inhibitors, particularly dolutegravir, due to their high virologic efficacy, superior genetic barrier, and favorable tolerability profile [3][4].

However, despite these advances, the immunovirological response to ART remains heterogeneous. Several studies have shown that sociodemographic, clinical, and behavioral factors such as age, sex, duration of infection, treatment adherence, risky sexual practices, and certain socioeconomic determinants significantly influence immune recovery and long-term virological control [5][6].

In resource-limited countries, particularly in Central Africa and the Republic of the Congo, recent data that comprehensively describe the clinical, biological, and behavioral profiles of people living with HIV remain relatively scarce. This lack of up-to-date local data limits the ability to accurately assess the actual effectiveness of the treatment strategies implemented and hinders the adaptation of public health policies to local realities [7][8].

Furthermore, the combined measurement of viral load and CD4 lymphocyte count remains a key indicator for evaluating the performance of HIV care programs. Sustained virological suppression, defined as an undetectable viral load, is now recognized not only as a marker of individual treatment success but also as a major driver of population-level prevention, in line with the “U = U” (Undetectable = Untransmittable) concept [9][10].

In this context, analyzing patient records from healthcare facilities is a useful approach for documenting patient characteristics and assessing laboratory test results and treatment adherence. Thus, the aim of this study was to describe the sociodemographic, biological, and therapeutic characteristics of HIV patients receiving care at the Pointe-Noire outpatient treatment center.

Sociodemographic characteristics of the patients Table 1 presents the sociodemographic characteristics of the study population. More than 72.7% (109) of the participants were female. The mean age of the patients was 36.11 ± 9.8 years, extremitie ranging from 20 to over 50 years.

Table 1. Sociodemographic characteristics of the patients.

The majority of the study population was single, had tattoos, and had a primary school education.

The purpose of this study was to describe the sociodemographic, biological, and therapeutic characteristics of HIV-positive patients receiving care at the Pointe-Noire outpatient treatment center. Women constituted the majority of the study population, at 72.7%. This finding is consistent with the results obtained by Ndziessi et al. (2025) in the Republic of the Congo, who reported a female proportion exceeding 65% in a similar cohort [11]. Similarly, Yotebieng Marcel et al. (2023), in the CA-IeDEA cohort in Central Africa, observed a majority of women among the patients followed [12]. Global data from UNAIDS also confirm that women account for nearly 63% of people living with HIV in sub-Saharan Africa. Conversely, studies conducted in the United States and France, notably by Andrew Trickey et al. (2023), show a male predominance, linked to key populations (MSM) [13]. In our context, this difference can be explained by women’s biological vulnerability, socioeconomic inequalities, and greater use of health services (PMTCT). The mean age was 36.11 ± 9.8 years, with a predominance of individuals aged 20 - 39, confirming a young population. This finding is similar to that of Yotebieng Marcel et al. (2023), who reported a mean age of approximately 35 years in cohorts from Central Africa [12]. Similarly, Kharsany et al. (2016) showed that the epidemic in sub-Saharan Africa primarily affects those aged 15 - 49 [14]. In contrast, Andrew Trickey et al. (2023) reported a higher average age (>40 years) in high-income countries [13]. This trend can be explained by high viral circulation among young people, high levels of unprotected sexual activity, and urban mobility.

The majority of patients in our study (84.0%) were single. This proportion is higher than those reported in several recent studies conducted in sub-Saharan Africa. For example, Bvochora et al. (2021) in Zimbabwe reported a proportion of single individuals of 52.4% [15]. Similarly, Yosef et al. (2022) in Ethiopia found that 41.3% of HIV-infected patients were single [16]. Our result is also higher than that of Tolmay et al. (2022), who, in a multicenter analysis, showed that the proportion of unmarried individuals in their cohorts ranged from 35% to 60% [17].

In our context, this high proportion of single individuals is the probability reflect relationship instability, a higher frequency of casual partners, and increased exposure to risky sexual behaviors. Nevertheless, marital status alone does not fully explain the risk of HIV transmission, as this risk is also influenced by sexual practices, the level of prevention, and access to testing. The majority of participants had low or intermediate levels of education, with 47.33% having a primary education and 46.01% a secondary education; this finding is similar to that reported by Yosef et al. (2022), who showed that the majority of patients being treated for HIV have an educational level at or below the secondary level, accounting for more than 73.8% of their cohort; Elenga Ike et al., (2026) also reported a more or less similar result [16][18].

This finding can be explained by the urban sociodemographic structure, as well as by the specific relational dynamics of populations affected by HIV. Drug use was reported in 14% of cases, consistent with the findings of Degenhardt et al. (2023), which showed that transmission in Africa is predominantly sexual, unlike in Europe [19].

Our study reported a virological suppression rate of 72.0%. This result is similar to that reported by Dorward et al. (2023) in a meta-analysis showing a suppression rate between 65% - 85%. Similarly, Phillips et al. (2022) reported a suppression rate of 91% for patients on dolutegravir in South Africa [20][21].

However, Kerschberger et al. (2022) reported a treatment failure rate of 60% and a high viral load in approximately 66% of cases [22]. The significant virological suppression observed in this study reflects good treatment adherence and the overall efficacy of the treatment regimen; however, virological non-suppression persisted in 27.9% of the study population.

The high proportion of patients with a CD4 count ≥ 500 cells/mm³ in our study—76.0%—is higher than that reported in several previous studies conducted among people living with HIV. Indeed, Siedner et al. (2022), in a multicenter study conducted in sub-Saharan Africa among patients initiating antiretroviral therapy, reported that approximately 32% of patients still had a CD4 count < 200 cells/mm³ at the start of treatment, reflecting late diagnosis and advanced immunodeficiency. The proportion of subjects with CD4 counts ≥ 500 cells/mm³ remained lower than that observed in our study. Similarly, Dorward et al. (2023) demonstrated, in recent African cohorts on antiretroviral therapy, a gradual improvement in immune recovery due to early initiation of treatment. The authors reported that nearly 58% - 65% of the patients followed achieved CD4 counts ≥ 500 cells/mm³ after effective treatment, although these values remained lower than the 76% found in our study [20][23].

This difference could be explained by current improvements in screening strategies, broader access to antiretroviral therapy, the introduction of dolutegravir-based treatment regimens, and earlier follow-up of patients living with HIV in our setting. Recent recommendations from the World Health Organization now favor immediate initiation of treatment upon HIV diagnosis, which contributes to better immunological recovery. Thus, the high proportion of patients with a CD4 count ≥ 500 cells/mm³ in our study may reflect a significant improvement in the immunovirological management of people living with HIV compared to older cohorts. The predominance of TDF + 3TC + DTG and ACRIPTEGA is consistent with the recommendations of the World Health Organization (2022) [2].

Dorward et al. (2023) and Venter et al. (2019) demonstrated that dolutegravir improves viral suppression, reduces treatment failure, and has a strong genetic barrier [20][24]. Kamangu et al. (2021) in the Democratic Republic of the Congo observed widespread use of efavirenz in first-line treatment regimens, which contrasts with our findings [25]. This difference can be explained by the implementation of a new treatment regimen proposed by the WHO.

This study has certain limitations, including its cross-sectional and single-center design, the relatively small sample size, and the absence of certain important clinical and therapeutic variables, such as treatment adherence or duration of follow-up. Furthermore, some behavioral data were based on patient self-reports, exposing the study to reporting bias. Despite these limitations, this study provides useful data on the sociodemographic, biological, and therapeutic profiles of HIV patients followed in Pointe-Noire.

Ultimately, this study conducted at the Pointe-Noire Outpatient Treatment Center highlights significant progress in the care of people living with HIV, particularly due to expanded access to modern dolutegravir-based antiretroviral treatments. The majority of patients demonstrate effective viral suppression and satisfactory immune recovery, reflecting the efficacy of current therapeutic strategies and improved clinical monitoring. However, the persistence of cases of viral non-suppression and incomplete immune recovery underscores the need to strengthen treatment adherence, early screening, and regular laboratory monitoring. Thus, despite the progress observed, the sustainable consolidation of epidemic control in Pointe-Noire requires continued efforts in prevention, health education, and patient support.

Mr. KAYI De Grace Yanick was assisted by exceptional colleagues and supervisors in conducting this study. Socio-demographic data, biological, and clinical data were collected by Mr. KAYI De Grace Yanick, accompanied by Azine Jeanisca Tounga and Adamou Babangida. Statistical analyses were performed by Dr. Ghislain Loubano-Voumbi and Dr. Aladin Atandi Batchy. Data collection was carried out by Mr. KAYI De Grace, assisted by Mr. Freddy Saturnin Pouki and Mr. Andrely Christ Ismaël Nsadi. Overall supervision was provided by Prof. Luc Magloire Anicet Boumba and Dr. Ghislain Loubano-Voumbi. Writing, Revision, and Editing: Prof. Luc Magloire Anicet Boumba and Dr. Ghislain Loubano-Voumbi, Coordination: Prof. Luc Magloire Anicet Boumba.