A total of 157 medical records of ectopic pregnancy cases were included in this study. During the study period, 176 cases of ectopic pregnancy were recorded among 13,101 pregnancies managed in the gynecology and obstetrics department, yielding a frequency of 1.34% (95% CI: 1.16% - 1.56%). Of these, 19 records were excluded due to incompleteness or unavailability, and 157 cases with complete medical records were retained for the descriptive analyses presented below.

The 157 patients ranged in age from 17 to 47 years. The mean age was 28 ± 5.8 years, and the modal age group was [25 - 30[ years. Housewives accounted for 29.30% of patients (46/157), and 24.84% had attained university-level education (Table 1); educational level was not specified in 37.58% (59/157) of records. Marital status was not specified in 47.77% (75/157) of records, and among those with documented status, 11.46% (18/157) were single. Place of residence was documented for all 157 patients, of whom 66.24% (104/157) resided in urban areas. All percentages are calculated on the 157 analyzed cases unless otherwise stated.

The majority of patients (89.81%) reported a history of amenorrhea. Pelvic pain was noted in 90.45% of women in the study sample. Metrorrhagia, presyncope and/or syncope, and nausea were reported in 51.59%, 22.29%, and 2.55% of cases, respectively (Table 2).

Table 1. Distribution of ectopic pregnancy cases from 2017 to 2022 according to sociodemographic characteristics (CHUD-B/A, Parakou).

*Student (7); Secretary (1).

Table 2. Distribution of ectopic pregnancy cases from 2017 to 2022 according to amenorrhea, spontaneous pelvic pain, metrorrhagia, presyncope/syncope, and nausea (CHUD-B/A, Parakou).

**Simultaneous presence of amenorrhea, spontaneous pelvic pain, and metrorrhagia.

Localized pain was present in 45.86% of patients, and 6.37% had an enlarged uterus. Six of the 157 patients (3.82%) presented with a fluid thrill sign, and 49.68% had umbilical tenderness. Additionally, 36.31% of patients had Douglas pouch tenderness. These findings are summarized in Table 3.

Table 3. Distribution of ectopic pregnancy cases from 2017 to 2022 according to pain localization and uterine size (CHUD-B/A, Parakou).

Overall, 26.11% of patients underwent transparietal puncture; 15.29% underwent Douglas pouch puncture; and 7.64% had a latero-uterine mass. These data are detailed in Table 4.

Table 4. Distribution of ectopic pregnancy cases from 2017 to 2022 according to pain localization, presence of latero-uterine mass, transparietal puncture, and Douglas pouch puncture (CHUD-B/A, Parakou).

***Right flank (4), left flank (1).

Only 1.27% (2/157) of patients had a beta-human chorionic gonadotropin (beta-hCG) assay performed, and the trend of beta-hCG levels was decreasing in both cases. Ultrasound identified a latero-uterine mass in 24 patients and free peritoneal fluid (hemoperitoneum) in 30 cases.

Ectopic pregnancy was ruptured in the majority (80.25%) of cases. All patients underwent surgical treatment via laparotomy. The right side was the predominant anatomical site in 58.60% (92/157) of patients, and the ampullary region was the most common location, accounting for 64.33% (101/157) of cases. Bilateral ectopic pregnancy was identified in 1.91% of cases. These findings are presented in Table 5.

Table 5. Distribution of ectopic pregnancy cases from 2017 to 2022 according to anatomical location (CHUD-B/A, Parakou).

****Isthmo-ampullary (2), abdominal (2), interstitial (4).

All patients (100%) received surgical treatment, exclusively via laparotomy. The majority of patients (94.90%) underwent radical surgical treatment, and salpingectomy was the most frequently performed procedure (84.71%), as detailed in Table 6.

Table 6. Distribution of ectopic pregnancy cases from 2017 to 2022 according to type of treatment and surgical procedure (CHUD-B/A, Parakou).

The majority (61.78%) of patients received blood transfusion. Of these, 59.79% received autotransfusion (intraoperative blood salvage) and 40.21% received allogeneic transfusion.

Morbidity. Intraoperative complications included bowel injury (0.64%), hemorrhage (1.91%), and cardiac arrest on the operating table (1.91%). Postoperative complications included anemia in 61.15% of patients.

Mortality. One death was recorded among the 157 women included in the study (0.64%).

During the study period, 176 cases of ectopic pregnancy were recorded among 13,101 pregnancies managed in the gynecology and obstetrics department of the CHUD-B/A, yielding a frequency of 1.34%. This rate is consistent with those reported by Pamphile et al. [1] in 2022 in Gabon (1.30%), Bangambe et al. [8] in 2016 in the Democratic Republic of Congo (1.56%), and Achour et al. [9] in 2015 in Tunisia (1.02%). However, higher frequencies have been reported by Dohbit et al. [10] in Cameroon (2.3%) and Shobeiri et al. [11] in Iran (4.8%). These discrepancies may be partly explained by longer study periods in those investigations (10 years) compared with ours (6 years, 2017-2022). In the literature, the frequency of ectopic pregnancy varies substantially across different settings. Jacob et al. [12] in 2017 in Germany reported a frequency of 3%, while Andriamifidison et al. [13] in 2016 in Madagascar found a frequency of 1.67%. In Mauritania, Ijar and Abdelkader [14] recorded a frequency of 0.99% in 2019, and Kenfack et al. [15] in Cameroon reported 3.45% in 2012. These variations are likely attributable to differences in study methodologies, study populations, and geographic and cultural contexts.

All cases were managed surgically via laparotomy. No laparoscopic or medical treatment was performed.

Laparotomy remains the most widely used therapeutic approach in Africa. Laparoscopic surgery, which represents the gold standard for ectopic pregnancy management in developed countries, remains of limited use across Africa due to inadequate equipment and late patient presentation, which typically results in diagnosis at the complication stage. Recent international reviews emphasize that early diagnosis through combined β-hCG monitoring and transvaginal ultrasound is the cornerstone of fertility-preserving management, allowing medical (methotrexate) or conservative laparoscopic options to be offered to hemodynamically stable patients [16][17]. In our setting, the very low rate of β-hCG assay (1.27%) and the predominance of ruptured presentations precluded these less invasive options.

In our series, surgical treatment following laparotomy was radical in 94.90% of cases and conservative (salpingotomy) in 5.10%. Salpingectomy was the most frequently performed procedure, with a frequency of 84.71%. Pamphile et al. [1] and Andriamifidison et al. [13] reported similar rates of 83.3% and 85.4%, respectively. This procedure is the most commonly performed according to multiple authors [8][10][18][19]. The predominance of salpingectomy in this study also reflects the fact that the majority of patients presented at the complication stage, necessitating resection of the pathological tubal segment. A recent meta-analysis comparing salpingectomy and salpingotomy reported broadly similar long-term fertility outcomes when the contralateral tube is healthy, supporting salpingectomy as an acceptable option in hemodynamically unstable patients such as those typically encountered in our setting [20]. Nevertheless, broader access to early diagnosis would expand the proportion of women eligible for fertility-preserving approaches.

The anatomical location of ectopic pregnancy in our series was primarily tubal (78.98%), including 64.33% ampullary, 12.10% isthmic, and 2.55% interstitial. Bangambe et al. reported nearly similar findings: 57.7% ampullary, 22.7% isthmic, and 4.3% interstitial [8]. Koutora et al. [19] found 82.14% ampullary, 3.57% isthmic, 3.6% ovarian, 7.1% cornual, and 3.6% abdominal locations. These results are consistent with the existing literature. The predominance of ampullary implantation is attributable to the favorable nidation conditions within the ampullary portion of the fallopian tube.

In our series, 61.78% of patients required blood transfusion. These findings are comparable to those reported by Koutora et al. [19] and Bangambe et al. [8], with frequencies of 67.8% and 66.6%, respectively. However, these rates are markedly higher than those reported by Dohbit et al. [10] (2.40%), Baldé et al. [18] (11.71%), Kenfack et al. [15] (20.5%), and Nayama et al. [21] (39.9%). This difference may be explained by the fact that most women in our series presented with ruptured ectopic pregnancy complicated by hemoperitoneum.

The postoperative course of our patients was more frequently complicated (61.15%, calculated as the number of patients with at least one postoperative complication, predominantly anemia, divided by 157 analyzed cases) than that reported by certain African authors. Baldé et al. found that 31.1% of women experienced complications [18], and Dohbit et al. [10] reported a substantially lower postoperative complication rate (1.48%). These differences may be attributable to the clinical condition of patients at hospital admission. According to Bouyer et al. [22], the nature and rate of complications depend on the implantation site of the ectopic pregnancy.

The case fatality rate associated with ectopic pregnancy in our series was 0.64% (1/157). This result is consistent with that reported by Nayama et al. in Niger, who found a mortality rate of 0.7% [21]. In contrast, Baldé et al. [18] in Conakry in 2014 and Madoue et al. [23] in Chad in 2015 reported mortality rates of 1.8% and 1.9%, respectively, which are higher than our findings. No specific explanation can be offered for this discrepancy, as working conditions in our institution do not substantially differ from those in these countries. The single fatality occurred in the context of hypovolemic shock secondary to hemorrhage.