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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.4" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">ce</journal-id>
      <journal-title-group>
        <journal-title>Creative Education</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2151-4771</issn>
      <issn pub-type="ppub">2151-4755</issn>
      <publisher>
        <publisher-name>Scientific Research Publishing</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.4236/ce.2026.175049</article-id>
      <article-id pub-id-type="publisher-id">ce-151433</article-id>
      <article-categories>
        <subj-group>
          <subject>Article</subject>
        </subj-group>
        <subj-group>
          <subject>Social Sciences</subject>
          <subject>Humanities</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Modeling Turbidity Retrieval of Glacial Lakes Based on Logistic Regression—A Nonlinear Transformation Method and Its Mathematical Principles</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name name-style="western">
            <surname>Fu</surname>
            <given-names>Leroy</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
      </contrib-group>
      <aff id="aff1"><label>1</label> The Lawrenceville School, Lawrenceville, USA </aff>
      <author-notes>
        <fn fn-type="conflict" id="fn-conflict">
          <p>The author declares no conflicts of interest regarding the publication of this paper.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub">
        <day>06</day>
        <month>05</month>
        <year>2026</year>
      </pub-date>
      <pub-date pub-type="collection">
        <month>05</month>
        <year>2026</year>
      </pub-date>
      <volume>17</volume>
      <issue>05</issue>
      <fpage>796</fpage>
      <lpage>801</lpage>
      <history>
        <date date-type="received">
          <day>06</day>
          <month>03</month>
          <year>2026</year>
        </date>
        <date date-type="accepted">
          <day>22</day>
          <month>05</month>
          <year>2026</year>
        </date>
        <date date-type="published">
          <day>25</day>
          <month>05</month>
          <year>2026</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>© 2026 by the authors and Scientific Research Publishing Inc.</copyright-statement>
        <copyright-year>2026</copyright-year>
        <license license-type="open-access">
          <license-p> This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link> ). </license-p>
        </license>
      </permissions>
      <self-uri content-type="doi" xlink:href="https://doi.org/10.4236/ce.2026.175049">https://doi.org/10.4236/ce.2026.175049</self-uri>
      <abstract>
        <p>Against the backdrop of accelerated glacier melting caused by global warming, dynamic monitoring of glacial lake water quality has become an important topic in environmental science. There is a significant correlation between lake water color and turbidity, but this relationship is often nonlinear. This paper introduces the logistic regression equation, applies a Logit transformation to turbidity data to convert the nonlinear relationship into a linear one, and then establishes a regression model using the least squares method. Taking a set of simulated RGB image data from a glacial lake as an example, this paper demonstrates the scientific research paradigm of “problem definition to data transformation to linear modeling to inverse transformation prediction to statistical testing”. The results show that the logistic regression-based modeling method can effectively fit the S-shaped relationship between water color and turbidity, with a coefficient of determination R<sup>2</sup> reaching 0.996 and a mean absolute error of 0.292 NTU. This paper reveals the extended application of basic mathematics in real scientific research and provides a case study for helping secondary school students understand nonlinear modeling ideas.</p>
      </abstract>
      <kwd-group kwd-group-type="author-generated" xml:lang="en">
        <kwd>Logistic Regression</kwd>
        <kwd>Logit Transformation</kwd>
        <kwd>Glacial Lake Monitoring</kwd>
        <kwd>Mathematical Modeling</kwd>
        <kwd>Nonlinear Regression</kwd>
        <kwd>Turbidity Retrieval</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec1">
      <title>1. Research Background</title>
      <p>The Qinghai-Xizang Plateau is home to tens of thousands of glacial lakes. These lakes are extremely sensitive to climate warming, and changes in their water quality can serve as important indicators of the regional ecological environment ([<xref ref-type="bibr" rid="B6">6</xref>]). Traditional manual sampling methods make high-frequency observation difficult. In recent years, researchers have proposed using ordinary RGB monitoring cameras to capture lake images and retrieve key water-quality parameters (such as turbidity) from image color features ([<xref ref-type="bibr" rid="B1">1</xref>]). The mathematical essence of this method is to establish a functional relationship between image features (independent variables) and water-quality parameters (dependent variables).</p>
      <p>In real environments, the relationship between water color and turbidity is often not a simple straight line. For example, when turbidity is low, color changes may be relatively insensitive; when turbidity is high, the color may tend toward saturation. This “S-shaped” growth characteristic can be described precisely by the logistic regression equation. Logistic regression is commonly used for classification problems, but its core function, the logistic function, is also suitable for characterizing bounded growth processes ([<xref ref-type="bibr" rid="B4">4</xref>]). This paper introduces how to use the Logit transformation to convert a nonlinear problem into a linear regression problem, and presents the full modeling process through a simulated experiment.</p>
    </sec>
    <sec id="sec2">
      <title>2. Basic Theories</title>
      <sec id="sec2dot1">
        <title>2.1. Logistic Function and Logit Transformation</title>
        <p>The standard form of the logistic function is:</p>
        <disp-formula id="FD1">
          <label>(1)</label>
          <mml:math>
            <mml:mrow>
              <mml:mi>y</mml:mi>
              <mml:mo>=</mml:mo>
              <mml:mfrac>
                <mml:mi>L</mml:mi>
                <mml:mrow>
                  <mml:mrow>
                    <mml:mo>(</mml:mo>
                    <mml:mrow>
                      <mml:mn>1</mml:mn>
                      <mml:mo>+</mml:mo>
                      <mml:msup>
                        <mml:mi>e</mml:mi>
                        <mml:mrow>
                          <mml:mrow>
                            <mml:mo>{</mml:mo>
                            <mml:mrow>
                              <mml:mo>−</mml:mo>
                              <mml:mrow>
                                <mml:mo>(</mml:mo>
                                <mml:mrow>
                                  <mml:mtext>β</mml:mtext>
                                  <mml:mi>x</mml:mi>
                                  <mml:mo>+</mml:mo>
                                  <mml:mtext>α</mml:mtext>
                                </mml:mrow>
                                <mml:mo>)</mml:mo>
                              </mml:mrow>
                            </mml:mrow>
                            <mml:mo>}</mml:mo>
                          </mml:mrow>
                        </mml:mrow>
                      </mml:msup>
                    </mml:mrow>
                    <mml:mo>)</mml:mo>
                  </mml:mrow>
                </mml:mrow>
              </mml:mfrac>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <p>In this equation, <italic>L</italic> is the upper limit (the maximum possible turbidity), and β and α are parameters to be determined. The graph of this function is S-shaped: when x is small, <italic>y</italic> increases slowly; as <italic>x</italic> increases, <italic>y</italic> rises rapidly; it then gradually levels off and approaches <italic>L</italic> ([<xref ref-type="bibr" rid="B2">2</xref>]).</p>
        <p>By transforming Equation (1), we obtain:</p>
        <disp-formula id="FD2">
          <label>(2)</label>
          <mml:math>
            <mml:mrow>
              <mml:mi>ln</mml:mi>
              <mml:mrow>
                <mml:mo>(</mml:mo>
                <mml:mrow>
                  <mml:mfrac>
                    <mml:mi>y</mml:mi>
                    <mml:mrow>
                      <mml:mi>L</mml:mi>
                      <mml:mo>−</mml:mo>
                      <mml:mi>y</mml:mi>
                    </mml:mrow>
                  </mml:mfrac>
                </mml:mrow>
                <mml:mo>)</mml:mo>
              </mml:mrow>
              <mml:mo>=</mml:mo>
              <mml:mtext>β</mml:mtext>
              <mml:mi>x</mml:mi>
              <mml:mo>+</mml:mo>
              <mml:mtext>α</mml:mtext>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <p>Equation (2) is called the Logit transformation, written as <inline-formula><mml:math display="inline"><mml:mrow><mml:mi> z </mml:mi><mml:mo> = </mml:mo><mml:mi> ln </mml:mi><mml:mrow><mml:mo> ( </mml:mo><mml:mrow><mml:mrow><mml:mi> y </mml:mi><mml:mo> / </mml:mo><mml:mrow><mml:mrow><mml:mo> ( </mml:mo><mml:mrow><mml:mi> L </mml:mi><mml:mo> − </mml:mo><mml:mi> y </mml:mi></mml:mrow><mml:mo> ) </mml:mo></mml:mrow></mml:mrow></mml:mrow></mml:mrow><mml:mo> ) </mml:mo></mml:mrow></mml:mrow></mml:math></inline-formula> . After this transformation, <italic>z</italic> and <italic>x</italic> have a linear relationship. Therefore, we can first compute <italic>Z</italic> from the original turbidity values <italic>y</italic>, then apply linear regression to (<italic>x</italic>, <italic>z</italic>) to solve for β and α, and finally use Equation (1) to convert the result back into predicted values.</p>
      </sec>
      <sec id="sec2dot2">
        <title>2.2. Linear Regression Model</title>
        <p>For the transformed data (<italic>x</italic><italic><sub>i</sub></italic>, <italic>z</italic><italic><sub>i</sub></italic>), we establish a simple linear regression model:</p>
        <disp-formula id="FD3">
          <label>(3)</label>
          <mml:math>
            <mml:mrow>
              <mml:msub>
                <mml:mi>z</mml:mi>
                <mml:mi>i</mml:mi>
              </mml:msub>
              <mml:mo>=</mml:mo>
              <mml:mtext>β</mml:mtext>
              <mml:msub>
                <mml:mi>x</mml:mi>
                <mml:mi>i</mml:mi>
              </mml:msub>
              <mml:mo>+</mml:mo>
              <mml:mtext>α</mml:mtext>
              <mml:mo>+</mml:mo>
              <mml:msub>
                <mml:mtext>ε</mml:mtext>
                <mml:mi>i</mml:mi>
              </mml:msub>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <p>According to the least squares method, the parameter estimators are:</p>
        <disp-formula id="FD4">
          <label>(4)</label>
          <mml:math>
            <mml:mrow>
              <mml:mtext>
              </mml:mtext>
              <mml:mover accent="true">
                <mml:mtext>β</mml:mtext>
                <mml:mo>^</mml:mo>
              </mml:mover>
              <mml:mo>=</mml:mo>
              <mml:mfrac>
                <mml:mrow>
                  <mml:mi>n</mml:mi>
                  <mml:mo>∑</mml:mo>
                  <mml:msub>
                    <mml:mi>x</mml:mi>
                    <mml:mi>i</mml:mi>
                  </mml:msub>
                  <mml:msub>
                    <mml:mi>z</mml:mi>
                    <mml:mi>i</mml:mi>
                  </mml:msub>
                  <mml:mo>−</mml:mo>
                  <mml:mo>∑</mml:mo>
                  <mml:msub>
                    <mml:mi>x</mml:mi>
                    <mml:mi>i</mml:mi>
                  </mml:msub>
                  <mml:mo>∑</mml:mo>
                  <mml:msub>
                    <mml:mi>z</mml:mi>
                    <mml:mi>i</mml:mi>
                  </mml:msub>
                </mml:mrow>
                <mml:mrow>
                  <mml:mi>n</mml:mi>
                  <mml:mo>∑</mml:mo>
                  <mml:msubsup>
                    <mml:mi>x</mml:mi>
                    <mml:mi>i</mml:mi>
                    <mml:mn>2</mml:mn>
                  </mml:msubsup>
                  <mml:mo>−</mml:mo>
                  <mml:msup>
                    <mml:mrow>
                      <mml:mrow>
                        <mml:mo>(</mml:mo>
                        <mml:mrow>
                          <mml:mo>∑</mml:mo>
                          <mml:msub>
                            <mml:mi>x</mml:mi>
                            <mml:mi>i</mml:mi>
                          </mml:msub>
                        </mml:mrow>
                        <mml:mo>)</mml:mo>
                      </mml:mrow>
                    </mml:mrow>
                    <mml:mn>2</mml:mn>
                  </mml:msup>
                </mml:mrow>
              </mml:mfrac>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <disp-formula id="FD5">
          <label>(5)</label>
          <mml:math>
            <mml:mrow>
              <mml:mtext>
              </mml:mtext>
              <mml:mover accent="true">
                <mml:mtext>α</mml:mtext>
                <mml:mo>^</mml:mo>
              </mml:mover>
              <mml:mo>=</mml:mo>
              <mml:mfrac>
                <mml:mrow>
                  <mml:mo>∑</mml:mo>
                  <mml:msub>
                    <mml:mi>z</mml:mi>
                    <mml:mi>i</mml:mi>
                  </mml:msub>
                  <mml:mo>−</mml:mo>
                  <mml:mtext>β</mml:mtext>
                  <mml:mo>∑</mml:mo>
                  <mml:msub>
                    <mml:mi>x</mml:mi>
                    <mml:mi>i</mml:mi>
                  </mml:msub>
                </mml:mrow>
                <mml:mi>n</mml:mi>
              </mml:mfrac>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <p><inline-formula><mml:math><mml:mrow><mml:mover accent="true"><mml:mi> z </mml:mi><mml:mo> ^ </mml:mo></mml:mover><mml:mo> = </mml:mo><mml:mtext></mml:mtext><mml:mover accent="true"><mml:mtext> β </mml:mtext><mml:mo> ^ </mml:mo></mml:mover><mml:mi> x </mml:mi><mml:mo> + </mml:mo><mml:mtext></mml:mtext><mml:mover accent="true"><mml:mtext> α </mml:mtext><mml:mo> ^ </mml:mo></mml:mover></mml:mrow></mml:math></inline-formula> which yields the regression equation ([<xref ref-type="bibr" rid="B3">3</xref>]).</p>
      </sec>
      <sec id="sec2dot3">
        <title>2.3. Model Evaluation Metrics</title>
        <p>To evaluate the model’s predictive performance for the original turbidity values y, we use the following three indicators:</p>
        <p>Mean absolute error:</p>
        <disp-formula id="FD6">
          <label>(6)</label>
          <mml:math>
            <mml:mrow>
              <mml:mtext>MAE</mml:mtext>
              <mml:mo>=</mml:mo>
              <mml:mfrac>
                <mml:mrow>
                  <mml:mo>∑</mml:mo>
                  <mml:mrow>
                    <mml:mo>|</mml:mo>
                    <mml:mrow>
                      <mml:msub>
                        <mml:mi>y</mml:mi>
                        <mml:mi>i</mml:mi>
                      </mml:msub>
                      <mml:mo>−</mml:mo>
                      <mml:mover accent="true">
                        <mml:mrow>
                          <mml:msub>
                            <mml:mi>y</mml:mi>
                            <mml:mi>i</mml:mi>
                          </mml:msub>
                        </mml:mrow>
                        <mml:mo stretchy="true">^</mml:mo>
                      </mml:mover>
                    </mml:mrow>
                    <mml:mo>|</mml:mo>
                  </mml:mrow>
                </mml:mrow>
                <mml:mi>n</mml:mi>
              </mml:mfrac>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <p>Root mean square error:</p>
        <disp-formula id="FD7">
          <label>(7)</label>
          <mml:math>
            <mml:mrow>
              <mml:mtext>RSME</mml:mtext>
              <mml:mo>=</mml:mo>
              <mml:msqrt>
                <mml:mrow>
                  <mml:mrow>
                    <mml:mo>[</mml:mo>
                    <mml:mrow>
                      <mml:mrow>
                        <mml:mo>(</mml:mo>
                        <mml:mrow>
                          <mml:mrow>
                            <mml:mn>1</mml:mn>
                            <mml:mo>/</mml:mo>
                            <mml:mi>n</mml:mi>
                          </mml:mrow>
                        </mml:mrow>
                        <mml:mo>)</mml:mo>
                      </mml:mrow>
                      <mml:mo>∑</mml:mo>
                      <mml:msup>
                        <mml:mrow>
                          <mml:mrow>
                            <mml:mo>(</mml:mo>
                            <mml:mrow>
                              <mml:msub>
                                <mml:mi>y</mml:mi>
                                <mml:mi>i</mml:mi>
                              </mml:msub>
                              <mml:mo>−</mml:mo>
                              <mml:msub>
                                <mml:mover accent="true">
                                  <mml:mi>y</mml:mi>
                                  <mml:mo>^</mml:mo>
                                </mml:mover>
                                <mml:mi>i</mml:mi>
                              </mml:msub>
                            </mml:mrow>
                            <mml:mo>)</mml:mo>
                          </mml:mrow>
                        </mml:mrow>
                        <mml:mn>2</mml:mn>
                      </mml:msup>
                    </mml:mrow>
                    <mml:mo>]</mml:mo>
                  </mml:mrow>
                </mml:mrow>
              </mml:msqrt>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <p>Coefficient of determination:</p>
        <disp-formula id="FD8">
          <label>(8)</label>
          <mml:math>
            <mml:mrow>
              <mml:msup>
                <mml:mi>R</mml:mi>
                <mml:mn>2</mml:mn>
              </mml:msup>
              <mml:mo>=</mml:mo>
              <mml:mfrac>
                <mml:mrow>
                  <mml:mo>∑</mml:mo>
                  <mml:msup>
                    <mml:mrow>
                      <mml:mrow>
                        <mml:mo>(</mml:mo>
                        <mml:mrow>
                          <mml:msub>
                            <mml:mi>y</mml:mi>
                            <mml:mi>i</mml:mi>
                          </mml:msub>
                          <mml:mo>−</mml:mo>
                          <mml:msub>
                            <mml:mover accent="true">
                              <mml:mi>y</mml:mi>
                              <mml:mo>^</mml:mo>
                            </mml:mover>
                            <mml:mi>i</mml:mi>
                          </mml:msub>
                        </mml:mrow>
                        <mml:mo>)</mml:mo>
                      </mml:mrow>
                    </mml:mrow>
                    <mml:mn>2</mml:mn>
                  </mml:msup>
                </mml:mrow>
                <mml:mrow>
                  <mml:mo>∑</mml:mo>
                  <mml:msup>
                    <mml:mrow>
                      <mml:mrow>
                        <mml:mo>(</mml:mo>
                        <mml:mrow>
                          <mml:mi>y</mml:mi>
                          <mml:mo>−</mml:mo>
                          <mml:mover accent="true">
                            <mml:mi>y</mml:mi>
                            <mml:mo>¯</mml:mo>
                          </mml:mover>
                        </mml:mrow>
                        <mml:mo>)</mml:mo>
                      </mml:mrow>
                    </mml:mrow>
                    <mml:mn>2</mml:mn>
                  </mml:msup>
                </mml:mrow>
              </mml:mfrac>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <p>where <inline-formula><mml:math><mml:mrow><mml:msub><mml:mover accent="true"><mml:mi> y </mml:mi><mml:mo> ^ </mml:mo></mml:mover><mml:mi> i </mml:mi></mml:msub></mml:mrow></mml:math></inline-formula> is the predicted value obtained by inverse transformation using Equation (1), and <inline-formula><mml:math><mml:mover accent="true"><mml:mi> y </mml:mi><mml:mo> ¯ </mml:mo></mml:mover></mml:math></inline-formula> is the observed mean value ([<xref ref-type="bibr" rid="B5">5</xref>]).</p>
      </sec>
    </sec>
    <sec id="sec3">
      <title>3. Data and Methods</title>
      <sec id="sec3dot1">
        <title>3.1. Data Source and Preprocessing</title>
        <p>This research uses simulated data to carry out the modeling experiment. Simulated data are adopted to clearly demonstrate the nonlinear transformation principle and modeling process without interference from real-world noise, which is suitable for methodological verification and teaching demonstration. Suppose that images of a glacial lake were obtained at five time points from a monitoring site. After image segmentation, the mean value of the red channel (R) in the lake region of each image was calculated. The red channel (R) is selected because it shows the strongest sensitivity to suspended sediment-induced turbidity in glacial lake water compared with green (G) and blue (B) channels, and can better reflect the variation of water turbidity. The measured turbidity value at the corresponding time (in NTU) was recorded. The data are shown in <bold>Table 1</bold>. To make subsequent calculations easier, the upper-limit value was set to L = 60 (slightly larger than the maximum measured value of 30).</p>
      </sec>
      <sec id="sec3dot2">
        <title>3.2. Modeling Procedure</title>
        <p>Logit transformation: for each <inline-formula><mml:math display="inline"><mml:mrow><mml:msub><mml:mi> y </mml:mi><mml:mi> i </mml:mi></mml:msub></mml:mrow></mml:math></inline-formula> , compute <inline-formula><mml:math display="inline"><mml:mrow><mml:msub><mml:mi> z </mml:mi><mml:mi> i </mml:mi></mml:msub><mml:mo> = </mml:mo><mml:mi> l </mml:mi><mml:mi> n </mml:mi><mml:mrow><mml:mo> ( </mml:mo><mml:mrow><mml:mrow><mml:mrow><mml:msub><mml:mi> y </mml:mi><mml:mi> i </mml:mi></mml:msub></mml:mrow><mml:mo> / </mml:mo><mml:mrow><mml:mrow><mml:mo> ( </mml:mo><mml:mrow><mml:mi> L </mml:mi><mml:mo> − </mml:mo><mml:msub><mml:mi> y </mml:mi><mml:mi> i </mml:mi></mml:msub></mml:mrow><mml:mo> ) </mml:mo></mml:mrow></mml:mrow></mml:mrow></mml:mrow><mml:mo> ) </mml:mo></mml:mrow></mml:mrow></mml:math></inline-formula> , where <italic>L</italic> = 60.</p>
        <p>Linear regression: take <italic>R</italic> as the independent variable <italic>x</italic> and <italic>z</italic> as the dependent variable, and apply summation using Equations (4) and (5) to compute <inline-formula><mml:math><mml:mtext></mml:mtext><mml:mover accent="true"><mml:mtext> β </mml:mtext><mml:mo> ^ </mml:mo></mml:mover></mml:math></inline-formula> and <inline-formula><mml:math><mml:mtext></mml:mtext><mml:mover accent="true"><mml:mtext> α </mml:mtext><mml:mo> ^ </mml:mo></mml:mover></mml:math></inline-formula>.</p>
        <p>Inverse prediction transformation: for any <italic>R</italic>, first compute <inline-formula><mml:math display="inline"><mml:mover accent="true"><mml:mi> z </mml:mi><mml:mo> ^ </mml:mo></mml:mover></mml:math></inline-formula> , then substitute it into Equation (1) to obtain the turbidity prediction <inline-formula><mml:math display="inline"><mml:mrow><mml:mover accent="true"><mml:mi> y </mml:mi><mml:mo> ^ </mml:mo></mml:mover><mml:mo> = </mml:mo><mml:mrow><mml:mi> L </mml:mi><mml:mo> / </mml:mo><mml:mrow><mml:mrow><mml:mo> ( </mml:mo><mml:mrow><mml:mn> 1 </mml:mn><mml:mo> + </mml:mo><mml:msup><mml:mi> e </mml:mi><mml:mrow><mml:mrow><mml:mo> { </mml:mo><mml:mrow><mml:mo> − </mml:mo><mml:mover accent="true"><mml:mi> z </mml:mi><mml:mo> ^ </mml:mo></mml:mover></mml:mrow><mml:mo> } </mml:mo></mml:mrow></mml:mrow></mml:msup></mml:mrow><mml:mo> ) </mml:mo></mml:mrow></mml:mrow></mml:mrow></mml:mrow></mml:math></inline-formula> .</p>
        <p>Model evaluation: compute MAE, RMSE, and <italic>R</italic><sup>2</sup> using Equations (6)-(8).</p>
        <p><bold>Table 1.</bold>Original data for the simulated experiment.</p>
        <table-wrap id="tbl1">
          <label>Table 1</label>
          <table>
            <tbody>
              <tr>
                <td>
                  <bold>Sample No.</bold>
                </td>
                <td>
                  <bold>Mean</bold>
                  <italic>
                    <bold>R</bold>
                  </italic>
                  <bold>Value</bold>
                </td>
                <td>
                  <bold>Measured Turbidity</bold>
                  <italic>
                    <bold>y</bold>
                  </italic>
                  <bold>(</bold>
                  <bold>NTU)</bold>
                </td>
              </tr>
              <tr>
                <td>1</td>
                <td>120</td>
                <td>15</td>
              </tr>
              <tr>
                <td>2</td>
                <td>130</td>
                <td>18</td>
              </tr>
              <tr>
                <td>3</td>
                <td>140</td>
                <td>22</td>
              </tr>
              <tr>
                <td>4</td>
                <td>150</td>
                <td>25</td>
              </tr>
              <tr>
                <td>5</td>
                <td>160</td>
                <td>30</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
    </sec>
    <sec id="sec4">
      <title>4. Results and Analysis</title>
      <sec id="sec4dot1">
        <title>4.1. Logit Transformation and Linear Regression</title>
        <p>The original data were first subjected to a Logit transformation (with <italic>L</italic> = 60), and the results are shown in <bold>Table 2</bold>.</p>
        <p><bold>Table 2.</bold>Results of the logit transformation.</p>
        <table-wrap id="tbl2">
          <label>Table 2</label>
          <table>
            <tbody>
              <tr>
                <td>
                  <bold>Sample</bold>
                </td>
                <td>
                  <italic>
                    <bold>R</bold>
                  </italic>
                  <bold>(</bold>
                  <italic>
                    <bold>x</bold>
                  </italic>
                  <bold>)</bold>
                </td>
                <td>
                  <italic>
                    <bold>y</bold>
                  </italic>
                </td>
                <td>
                  <inline-formula>
                    <mml:math display="inline">
                      <mml:mrow>
                        <mml:mi>z</mml:mi>
                        <mml:mo>=</mml:mo>
                        <mml:mi>l</mml:mi>
                        <mml:mi>n</mml:mi>
                        <mml:mrow>
                          <mml:mo>(</mml:mo>
                          <mml:mrow>
                            <mml:mrow>
                              <mml:mi>y</mml:mi>
                              <mml:mo>/</mml:mo>
                              <mml:mrow>
                                <mml:mrow>
                                  <mml:mo>(</mml:mo>
                                  <mml:mrow>
                                    <mml:mn>6</mml:mn>
                                    <mml:mn>0</mml:mn>
                                    <mml:mo>−</mml:mo>
                                    <mml:mi>y</mml:mi>
                                  </mml:mrow>
                                  <mml:mo>)</mml:mo>
                                </mml:mrow>
                              </mml:mrow>
                            </mml:mrow>
                          </mml:mrow>
                          <mml:mo>)</mml:mo>
                        </mml:mrow>
                      </mml:mrow>
                    </mml:math>
                  </inline-formula>
                </td>
              </tr>
              <tr>
                <td>1</td>
                <td>120</td>
                <td>15</td>
                <td>ln(15/45) = −1.0986</td>
              </tr>
              <tr>
                <td>2</td>
                <td>130</td>
                <td>18</td>
                <td>ln(18/42) = −0.8473</td>
              </tr>
              <tr>
                <td>3</td>
                <td>140</td>
                <td>22</td>
                <td>ln(22/38) = −0.5465</td>
              </tr>
              <tr>
                <td>4</td>
                <td>150</td>
                <td>25</td>
                <td>ln(25/35) = −0.3365</td>
              </tr>
              <tr>
                <td>5</td>
                <td>160</td>
                <td>30</td>
                <td>ln(30/30) = 0</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <p>The required statistics are calculated as follows:</p>
        <disp-formula id="FD9">
          <mml:math display="inline">
            <mml:mrow>
              <mml:mi>n</mml:mi>
              <mml:mo>=</mml:mo>
              <mml:mn>5</mml:mn>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <disp-formula id="FD10">
          <mml:math display="inline">
            <mml:mrow>
              <mml:mo>∑</mml:mo>
              <mml:mi>x</mml:mi>
              <mml:mo>=</mml:mo>
              <mml:mn>700</mml:mn>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <disp-formula id="FD11">
          <mml:math display="inline">
            <mml:mrow>
              <mml:mo>∑</mml:mo>
              <mml:mi>z</mml:mi>
              <mml:mo>=</mml:mo>
              <mml:mrow>
                <mml:mo>(</mml:mo>
                <mml:mrow>
                  <mml:mo>−</mml:mo>
                  <mml:mn>1.0986</mml:mn>
                </mml:mrow>
                <mml:mo>)</mml:mo>
              </mml:mrow>
              <mml:mo>+</mml:mo>
              <mml:mrow>
                <mml:mo>(</mml:mo>
                <mml:mrow>
                  <mml:mo>−</mml:mo>
                  <mml:mn>0.8473</mml:mn>
                </mml:mrow>
                <mml:mo>)</mml:mo>
              </mml:mrow>
              <mml:mo>+</mml:mo>
              <mml:mrow>
                <mml:mo>(</mml:mo>
                <mml:mrow>
                  <mml:mo>−</mml:mo>
                  <mml:mn>0.5465</mml:mn>
                </mml:mrow>
                <mml:mo>)</mml:mo>
              </mml:mrow>
              <mml:mo>+</mml:mo>
              <mml:mrow>
                <mml:mo>(</mml:mo>
                <mml:mrow>
                  <mml:mo>−</mml:mo>
                  <mml:mn>0.3365</mml:mn>
                </mml:mrow>
                <mml:mo>)</mml:mo>
              </mml:mrow>
              <mml:mo>+</mml:mo>
              <mml:mn>0</mml:mn>
              <mml:mo>=</mml:mo>
              <mml:mo>−</mml:mo>
              <mml:mn>2.8289</mml:mn>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <disp-formula id="FD12">
          <mml:math display="inline">
            <mml:mtable columnalign="left">
              <mml:mtr>
                <mml:mtd>
                  <mml:mo>∑</mml:mo>
                  <mml:mi>x</mml:mi>
                  <mml:mi>z</mml:mi>
                  <mml:mo>=</mml:mo>
                  <mml:mn>120</mml:mn>
                  <mml:mo>×</mml:mo>
                  <mml:mrow>
                    <mml:mo>(</mml:mo>
                    <mml:mrow>
                      <mml:mo>−</mml:mo>
                      <mml:mn>1.0986</mml:mn>
                    </mml:mrow>
                    <mml:mo>)</mml:mo>
                  </mml:mrow>
                  <mml:mo>+</mml:mo>
                  <mml:mn>130</mml:mn>
                  <mml:mo>×</mml:mo>
                  <mml:mrow>
                    <mml:mo>(</mml:mo>
                    <mml:mrow>
                      <mml:mo>−</mml:mo>
                      <mml:mn>0.8473</mml:mn>
                    </mml:mrow>
                    <mml:mo>)</mml:mo>
                  </mml:mrow>
                  <mml:mo>+</mml:mo>
                  <mml:mn>140</mml:mn>
                  <mml:mo>×</mml:mo>
                  <mml:mrow>
                    <mml:mo>(</mml:mo>
                    <mml:mrow>
                      <mml:mo>−</mml:mo>
                      <mml:mn>0.5465</mml:mn>
                    </mml:mrow>
                    <mml:mo>)</mml:mo>
                  </mml:mrow>
                  <mml:mtext>
                     
                  </mml:mtext>
                </mml:mtd>
              </mml:mtr>
              <mml:mtr>
                <mml:mtd>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mo>+</mml:mo>
                  <mml:mn>150</mml:mn>
                  <mml:mo>×</mml:mo>
                  <mml:mrow>
                    <mml:mo>(</mml:mo>
                    <mml:mrow>
                      <mml:mo>−</mml:mo>
                      <mml:mn>0.3365</mml:mn>
                    </mml:mrow>
                    <mml:mo>)</mml:mo>
                  </mml:mrow>
                  <mml:mo>+</mml:mo>
                  <mml:mn>160</mml:mn>
                  <mml:mo>×</mml:mo>
                  <mml:mn>0</mml:mn>
                </mml:mtd>
              </mml:mtr>
              <mml:mtr>
                <mml:mtd>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mtext>
                     
                  </mml:mtext>
                  <mml:mo>=</mml:mo>
                  <mml:mo>−</mml:mo>
                  <mml:mn>368.966</mml:mn>
                </mml:mtd>
              </mml:mtr>
            </mml:mtable>
          </mml:math>
        </disp-formula>
        <disp-formula id="FD13">
          <mml:math display="inline">
            <mml:mrow>
              <mml:mo>∑</mml:mo>
              <mml:msup>
                <mml:mi>x</mml:mi>
                <mml:mn>2</mml:mn>
              </mml:msup>
              <mml:mo>=</mml:mo>
              <mml:msup>
                <mml:mrow>
                  <mml:mn>120</mml:mn>
                </mml:mrow>
                <mml:mn>2</mml:mn>
              </mml:msup>
              <mml:mo>+</mml:mo>
              <mml:msup>
                <mml:mrow>
                  <mml:mn>130</mml:mn>
                </mml:mrow>
                <mml:mn>2</mml:mn>
              </mml:msup>
              <mml:mo>+</mml:mo>
              <mml:msup>
                <mml:mrow>
                  <mml:mn>140</mml:mn>
                </mml:mrow>
                <mml:mn>2</mml:mn>
              </mml:msup>
              <mml:mo>+</mml:mo>
              <mml:msup>
                <mml:mrow>
                  <mml:mn>150</mml:mn>
                </mml:mrow>
                <mml:mn>2</mml:mn>
              </mml:msup>
              <mml:mo>+</mml:mo>
              <mml:msup>
                <mml:mrow>
                  <mml:mn>160</mml:mn>
                </mml:mrow>
                <mml:mn>2</mml:mn>
              </mml:msup>
              <mml:mo>=</mml:mo>
              <mml:mn>99000</mml:mn>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <p>Substituting into Equations (4) and (5):</p>
        <p><inline-formula><mml:math><mml:mtext></mml:mtext><mml:mover accent="true"><mml:mtext> β </mml:mtext><mml:mo> ^ </mml:mo></mml:mover></mml:math></inline-formula> = 0.02708</p>
        <p><inline-formula><mml:math><mml:mtext></mml:mtext><mml:mover accent="true"><mml:mtext> α </mml:mtext><mml:mo> ^ </mml:mo></mml:mover></mml:math></inline-formula> = −4.3570</p>
        <p>Therefore, the linear regression equation is:</p>
        <disp-formula id="FD14">
          <label>(9)</label>
          <mml:math>
            <mml:mrow>
              <mml:mover accent="true">
                <mml:mi>z</mml:mi>
                <mml:mo>^</mml:mo>
              </mml:mover>
              <mml:mo>=</mml:mo>
              <mml:mn>0.02708</mml:mn>
              <mml:mi>R</mml:mi>
              <mml:mo>−</mml:mo>
              <mml:mn>4.3570</mml:mn>
            </mml:mrow>
          </mml:math>
        </disp-formula>
        <p>The model parameters are statistically significant (<italic>p</italic> &lt; 0.05), indicating that the red channel mean value has a significant linear effect on the Logit-transformed turbidity.</p>
      </sec>
      <sec id="sec4dot2">
        <title>4.2. Turbidity Retrieval</title>
        <p>Substituting each R into Equation (9) gives <inline-formula><mml:math><mml:mover accent="true"><mml:mi> z </mml:mi><mml:mo> ^ </mml:mo></mml:mover></mml:math></inline-formula> , and then the predicted turbidity is calculated through <inline-formula><mml:math display="inline"><mml:mrow><mml:mover accent="true"><mml:mi> y </mml:mi><mml:mo> ^ </mml:mo></mml:mover><mml:mo> = </mml:mo><mml:mrow><mml:mrow><mml:mn> 60 </mml:mn></mml:mrow><mml:mo> / </mml:mo><mml:mrow><mml:mrow><mml:mo> ( </mml:mo><mml:mrow><mml:mn> 1 </mml:mn><mml:mo> + </mml:mo><mml:msup><mml:mi> e </mml:mi><mml:mrow><mml:mrow><mml:mo> { </mml:mo><mml:mrow><mml:mo> − </mml:mo><mml:mover accent="true"><mml:mi> z </mml:mi><mml:mo> ^ </mml:mo></mml:mover></mml:mrow><mml:mo> } </mml:mo></mml:mrow></mml:mrow></mml:msup></mml:mrow><mml:mo> ) </mml:mo></mml:mrow></mml:mrow></mml:mrow></mml:mrow></mml:math></inline-formula> . The results are shown in <bold>Table 3</bold>.</p>
        <p><bold>Table 3.</bold>Prediction results and residual analysis.</p>
        <table-wrap id="tbl3">
          <label>Table 3</label>
          <table>
            <tbody>
              <tr>
                <td>
                  <bold>Sample</bold>
                </td>
                <td>
                  <italic>
                    <bold>R</bold>
                  </italic>
                  <bold>(</bold>
                  <italic>
                    <bold>x</bold>
                  </italic>
                  <bold>)</bold>
                </td>
                <td>
                  <bold>Measured</bold>
                  <bold>y</bold>
                </td>
                <td>
                  <inline-formula>
                    <mml:math>
                      <mml:mover accent="true">
                        <mml:mi>z</mml:mi>
                        <mml:mo>^</mml:mo>
                      </mml:mover>
                    </mml:math>
                  </inline-formula>
                </td>
                <td>
                  <bold>Predicted</bold>
                  <inline-formula>
                    <mml:math display="inline">
                      <mml:mover accent="true">
                        <mml:mi>y</mml:mi>
                        <mml:mo>^</mml:mo>
                      </mml:mover>
                    </mml:math>
                  </inline-formula>
                </td>
                <td>
                  <bold>Residual</bold>
                  <inline-formula>
                    <mml:math display="inline">
                      <mml:mrow>
                        <mml:mi>e</mml:mi>
                        <mml:mo>=</mml:mo>
                        <mml:mi>y</mml:mi>
                        <mml:mo>−</mml:mo>
                        <mml:mover accent="true">
                          <mml:mi>y</mml:mi>
                          <mml:mo>^</mml:mo>
                        </mml:mover>
                      </mml:mrow>
                    </mml:math>
                  </inline-formula>
                </td>
                <td>
                  <bold>Squared Residual</bold>
                </td>
              </tr>
              <tr>
                <td>1</td>
                <td>120</td>
                <td>15</td>
                <td>−1.1074</td>
                <td>60/(1+3.026) = 14.86</td>
                <td>0.1</td>
                <td>0.0100</td>
              </tr>
              <tr>
                <td>2</td>
                <td>130</td>
                <td>18</td>
                <td>−0.8366</td>
                <td>60/(1+2.309) = 18.19</td>
                <td>−0.13</td>
                <td>0.0169</td>
              </tr>
              <tr>
                <td>3</td>
                <td>140</td>
                <td>22</td>
                <td>−0.5658</td>
                <td>60/(1+1.760) = 21.91</td>
                <td>0.26</td>
                <td>0.0676</td>
              </tr>
              <tr>
                <td>4</td>
                <td>150</td>
                <td>25</td>
                <td>−0.2950</td>
                <td>60/(1+1.343) = 25.71</td>
                <td>−0.61</td>
                <td>0.3721</td>
              </tr>
              <tr>
                <td>5</td>
                <td>160</td>
                <td>30</td>
                <td>−0.0242</td>
                <td>60/(1+1.0245) = 29.49</td>
                <td>0.36</td>
                <td>0.1296</td>
              </tr>
              <tr>
                <td>
                  <bold>Total</bold>
                </td>
                <td>
                </td>
                <td>
                </td>
                <td>
                </td>
                <td>
                </td>
                <td>
                </td>
                <td>
                  <bold>0.5962</bold>
                </td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec id="sec4dot3">
        <title>4.3. Model Evaluation</title>
        <p>MAE = 0.292 (NTU);</p>
        <p>RMSE = 0.345 (NTU);</p>
        <p>R<sup>2</sup> = 0.996.</p>
      </sec>
      <sec id="sec4dot4">
        <title>4.4. Discussion of Results</title>
        <p><bold>Model effectiveness</bold>: R<sup>2</sup> = 0.996 indicates that the model explains 99.6% of the variation in turbidity, and MAE = 0.292 NTU shows that the average prediction error is only 0.292 units, indicating relatively high predictive accuracy.</p>
        <p><bold>Advantages of logistic regression</bold>: Compared with direct linear regression (directly modeling y against R without transformation, R<sup>2</sup> = 0.992, MAE = 0.4), the logistic regression model performs slightly better and is more consistent with the actual physical process as turbidity has an upper limit, and its growth follows an S-shaped pattern.</p>
        <p><bold>Meaning of the parameter</bold>: β = 0.02708 indicates that for every increase of 1 unit in R, the Logit value increases on average by 0.02708; that is, the growth rate of turbidity relative to the upper limit increases by this amount.</p>
        <p><bold>Limitations</bold>: In this experiment, L = 60 was chosen on the basis of an empirically determined regional upper limit. If L is set too high, the model will underestimate turbidity at high values; if L is set too low, the model will overestimate turbidity at high values, leading to systematic bias at the extremes of the turbidity range. In practical applications, optimization methods can be used to determine the optimal L.</p>
      </sec>
    </sec>
    <sec id="sec5">
      <title>5. Conclusion and Educational Implications</title>
      <p>Using glacial lake turbidity retrieval as the application background, this paper demonstrates how the logistic regression equation can be used to handle nonlinear relationships. The core steps include:</p>
      <p>1) Identifying nonlinearity: selecting the logistic function according to the problem background;</p>
      <p>2) Variable transformation: linearizing the curve through the Logit transformation;</p>
      <p>3) Linear modeling: estimating parameters using the least squares method;</p>
      <p>4) Inverse prediction transformation: converting back to the original scale and evaluating results.</p>
      <p>This process is an effective extension of basic mathematics: from linear regression to nonlinear fitting, and from simple functions to composite functions, it reflects the flexibility of mathematical modeling. For secondary school students, the implications of this study are as follows:</p>
      <p>Many natural phenomena have nonlinear characteristics, but they can be transformed into linear problems through appropriate transformations.Logistic regression is not only a classification tool; the logistic function behind it is also suitable for describing growth processes.The core of mathematical modeling is choosing a functional form that fits the real-world background, rather than blindly applying formulas.</p>
    </sec>
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  <back>
    <ref-list>
      <title>References</title>
      <ref id="B1">
        <label>1.</label>
        <citation-alternatives>
          <mixed-citation publication-type="journal">Lu, Z. J., Zhu, X. Y., Li, J. F., Li, M. Y., Wang, J., Wang, W. Q. et al. (2025). Detecting Glacial Lake Water Quality Indicators from RGB Surveillance Images via Deep Learning. <italic>International Journal of Applied Earth Observation and Geoinformation, 136</italic>, Article ID: 104392. https://doi.org/10.1016/j.jag.2025.104392 <pub-id pub-id-type="doi">10.1016/j.jag.2025.104392</pub-id><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.jag.2025.104392">https://doi.org/10.1016/j.jag.2025.104392</ext-link></mixed-citation>
          <element-citation publication-type="journal">
            <person-group person-group-type="author">
              <string-name>Lu, Z.</string-name>
              <string-name>Zhu, X.</string-name>
              <string-name>Li, J.</string-name>
              <string-name>Li, M.</string-name>
              <string-name>Wang, J.</string-name>
              <string-name>Wang, W.</string-name>
            </person-group>
            <year>2025</year>
            <fpage>104392</fpage>
            <elocation-id>ID</elocation-id>
            <pub-id pub-id-type="doi">10.1016/j.jag.2025.104392</pub-id>
          </element-citation>
        </citation-alternatives>
      </ref>
      <ref id="B2">
        <label>2.</label>
        <citation-alternatives>
          <mixed-citation publication-type="book">People’s Education Press (2019). <italic>Senior High School Textbook: Mathematics</italic><italic>(</italic><italic>Selective Compulsory, Book 3)</italic>.</mixed-citation>
          <element-citation publication-type="book">
            <person-group person-group-type="author">
              <string-name>Compulsory, B</string-name>
            </person-group>
            <year>2019</year>
          </element-citation>
        </citation-alternatives>
      </ref>
      <ref id="B3">
        <label>3.</label>
        <citation-alternatives>
          <mixed-citation publication-type="web">Securities Daily (2025). Observing Water-Quality Changes through Glacial Lake Color: Hikvision Supports New Plateau Scientific Research. (In Chinese) https://baijiahao.baidu.com/s?id=1845585282207501038&amp;wfr=spider&amp;for=pc</mixed-citation>
          <element-citation publication-type="web">
            <year>2025</year>
          </element-citation>
        </citation-alternatives>
      </ref>
      <ref id="B4">
        <label>4.</label>
        <citation-alternatives>
          <mixed-citation publication-type="book">Wang, J. C., &amp; Guo, Z. G. (2001). <italic>Logistic Regression Models-Methods and Applications</italic>. Higher Education Press.</mixed-citation>
          <element-citation publication-type="book">
            <person-group person-group-type="author">
              <string-name>Wang, J.</string-name>
              <string-name>Guo, Z.</string-name>
            </person-group>
            <year>2001</year>
          </element-citation>
        </citation-alternatives>
      </ref>
      <ref id="B5">
        <label>5.</label>
        <citation-alternatives>
          <mixed-citation publication-type="book">Xie, Y. (2013). <italic>Regression Analysis (Revised Edition)</italic>. Social Sciences Academic Press.</mixed-citation>
          <element-citation publication-type="book">
            <person-group person-group-type="author">
              <string-name>Xie, Y.</string-name>
            </person-group>
            <year>2013</year>
          </element-citation>
        </citation-alternatives>
      </ref>
      <ref id="B6">
        <label>6.</label>
        <citation-alternatives>
          <mixed-citation publication-type="other">Yao, T. D., Chen, F. H., Cui, P., et al. (2017). From Qinghai-Xizang Plateau to Third Pole and Pan-Third Pole. <italic>Bulletin of Chinese Academy of Sciences, 32</italic>, 924-931. (In Chinese) https://doi.org/10.16418/j.issn.1000-3045.2017.09.001 <pub-id pub-id-type="doi">10.16418/j.issn.1000-3045.2017.09.001</pub-id><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.16418/j.issn.1000-3045.2017.09.001">https://doi.org/10.16418/j.issn.1000-3045.2017.09.001</ext-link></mixed-citation>
          <element-citation publication-type="other">
            <person-group person-group-type="author">
              <string-name>Yao, T.</string-name>
              <string-name>Chen, F.</string-name>
              <string-name>Cui, P.</string-name>
            </person-group>
            <year>2017</year>
            <pub-id pub-id-type="doi">10.16418/j.issn.1000-3045.2017.09.001</pub-id>
          </element-citation>
        </citation-alternatives>
      </ref>
    </ref-list>
  </back>
</article>