Primary postpartum hemorrhage (PPH) is a major global public-health concern and remains a leading direct cause of maternal mortality worldwide, accounting for nearly one-fifth of maternal deaths in many settings [1]-[3]. PPH is conventionally defined as blood loss ≥ 500 ml after vaginal delivery or ≥ 1000 ml after caesarean section and is a life-threatening obstetric emergency that can rapidly progress to hemorrhagic shock, coagulopathy, and maternal death [4]-[6]. Despite global attention and tools to aid early detection such as the obstetric shock index [7][8], PPH continues to cause substantial mortality in low-resource settings, with a disproportionate impact in Sub-Saharan Africa and Zambia [9][10]. Recent literature has identified a range of clinical predictors for primary PPH, including pregnancy-induced hypertension, pre-eclampsia, diabetes, nulliparity, fetal macrosomia, prolonged labor, induction/augmentation, and failure to perform active management of the third stage of labour [11]-[18]. However, most published studies come from tertiary referral centres or from multi-country retrospective cohorts, and few provide granular, facility-level evidence from first-level (district and provincial) hospitals where most births in Zambia occur [9][10].

National and regional reports note the high burden of PPH in Zambia, but there is limited empirical evidence describing predictors of primary PPH across levels of the public health system, specifically combining firstlevel hospitals with the national referral center (WNH) [15]-[18]. Facility reports and anecdotal audits from WNH suggest a substantial referral load for PPH, but systematic, comparative analyses of risk factors at first-level versus tertiary facilities are lacking [19]-[21]. This study addressed that gap by examining predictors of primary PPH among women with vaginal deliveries across Lusaka’s public hospitals, including first-level facilities and a tertiary health facility. By sampling across these facility types, the study evaluates predictors in the environments where most women deliver and where resource constraints and transfer patterns may influence both risk and outcomes. This study provides adjusted, facility-level evidence on independent clinical predictors of primary PPH in Lusaka, clarifying which intrapartum factors remain significant after multivariable adjustment. It explicitly tests predictors previously reported in tertiary or non-Zambian cohorts and determines their relevance in first-level hospital practice. Compared with prior Zambian reports: largely descriptive, facility audits, or single-center series [15]-[18], the present case-control design and inclusion of multiple public hospital levels increase generalizability to routine maternity care settings and improve the ability to control for confounding.

Identifying independent predictors of PPH at firstlevel hospitals informs targeted interventions at the point of care where most deliveries occur, such as strengthening active management of the third stage of labor, improving early recognition and management of uterine atony and genital tract trauma, and triage/referral protocols for high-risk labors. Strengthening supply chains for uterotonics, training midwives in manual removal of retained placenta and basic surgical repair of tears, and ensuring standardized escalation pathways to higher-level care are concrete actions that follow from facility-level predictor data. Evidence from first-level hospitals can guide national policy on resource allocation, continuous professional development priorities, and monitoring indicators for PPH prevention and response, potentially reducing delays in recognition and treatment that contribute to preventable deaths [19]-[21]. Therefore, this study sought to identify independent clinical predictors of primary PPH among women with vaginal deliveries in Lusaka’s public hospitals in order to inform pragmatic, facility-level strategies to prevent and manage PPH and reduce associated morbidity and mortality.

Table 1 summarizes the sociodemographic characteristics of study participants. Cases (N = 106) and controls (N = 212) were comparable across all measured baseline variables. Median age was similar between groups (27 years [IQR: 22 - 32] for cases vs. 27 years [IQR: 22.5 - 32] for controls; p = 0.636). No statistically significant differences were observed in education level (p = 0.658), employment status (p = 0.870), residence category (p = 0.158), marital status (p = 0.683), or HIV status (p = 0.516), indicating a well-balanced study population suitable for comparative analysis.

Table 2 presents the results of univariate logistic regression assessing known predictors of primary postpartum hemorrhage (PPH). Significant associations were observed for: Uterine atony (COR = 12.7; 95% CI: 10.4 - 54.3; p < 0.0001), Retained placenta (COR = 7.4; 95% CI: 2.9 - 19.4; p < 0.0001). Genital trauma, including: Perineal tears (COR = 3.1; 95% CI: 1.8 - 5.2; p < 0.0001), Cervical tears (COR = 17.9; 95% CI: 7.8 - 29.9; p < 0.0001) and Vaginal tears (COR = 3.1; 95% CI: 1.8 - 5.2; p < 0.0001). Additionally, each additional minute in the 3rd stage of labor was associated with a 5% increase in the odds of postpartum hemorrhage (COR = 1.3; 95% CI: 1.1 - 1.7; p < 0.0001). Fetal weight also showed a modest association (COR = 1.1; 95% CI: 1.0 - 1.3; p = 0.02).

Table 3 shows bivariate comparisons of feto-maternal characteristics between cases and controls. Statistically significant differences were observed for: Fetal weight (median 3100 g vs. 3000 g; p = 0.009) and Duration of third stage of labor (median 10 vs. 7 minutes; p = 0.001). Other variables, including parity, history of caesarean section, hypertensive disorders, and diabetes, did not differ significantly between groups.

Table 1. Sociodemographic characteristics of the study participants.

IQR = Interquartile range; p-value for differences between cases and controls.

Table 2. Univariate standard logistic regression of primary PPH and known predictors of primary PPH.

COR= crude odds ratio; CI = confidence interval; Ref.; reference category.

Table 3. Feto-maternal known predictors for primary PPH between cases and controls (Bivariate).

* = Mann-Whitney test was used; ** = chi-square test was used; *** = p-value not estimated; n.e = p-value not estimated; PIH = Pregnancy Induced Hypertension.

Table 4 presents the multivariate conditional logistic regression results, adjusted for age, education level, residence, employment status, and HIV status. After adjustment, the following predictors remained significantly associated with primary PPH: Uterine atony (AOR = 7.4; 95% CI: 4.5 - 14.6; p < 0.0001), Retained placenta (AOR = 4.3; 95% CI: 3.4 - 9.7; p = 0.001), and Cervical tears (AOR = 11.3; 95% CI: 7.9 - 21.7; p < 0.0001). While the duration of third stage of labor showed a borderline association (AOR= 1.1; 95% CI: 1.05 - 1.46; p = 0.048), we interpreted this with caution due to the wide confidence interval and modest effect size. Other variables, including fetal weight (AOR = 0.99; p = 0.244), perineal tears (AOR = 1.1; p = 0.745), and vaginal tears (AOR = 1.5; p = 0.574), were not statistically significant in adjusted models.

Table 4. Multivariable logistic regression of primary PPH and the known predictors.

aOR = adjusted odds ratio.

This study provides important insights into the predictors of primary postpartum hemorrhage (PPH) among Zambian women following vaginal delivery. The well-balanced baseline characteristics between cases and controls strengthen the internal validity of the findings by minimizing confounding from sociodemographic variables.

Uterine atony emerged as the most significant predictor of primary PPH, consistent with global estimates attributing up to 70% of PPH cases to atony [22]-[24]. This aligns with findings from Tort et al. [25] and Abebe et al. [16], who identified uterine atony as a leading cause of hemorrhage-related maternal mortality across sub-Saharan Africa. Similarly, retained placenta was strongly associated with increased PPH risk, corroborating evidence from Perlman and Carusi [26] and Caviello et al. [27], that links retained placental fragments to impaired uterine contraction and excessive bleeding. Genital tract trauma, particularly cervical tears, was another significant predictor in this cohort. This finding is supported by Zafran et al. [28], Alajery et al. [29], and Mohamed et al. [30], who emphasize the importance of prompt trauma detection in vaginal deliveries. The elevated odds ratios observed for cervical injuries underscore the need for thorough post-delivery examinations, as advocated by Tartaglia et al. [31], and Nyamongo [32].

Although prolonged third stage of labor and increased fetal weight showed associations with PPH in univariate analysis, these relationships did not remain statistically significant after adjustment. Therefore, these findings should be interpreted cautiously. It is possible that confounding factors such as maternal fatigue, uterine responsiveness, or undocumented comorbidities may have influenced these associations. Nonetheless, prior studies by Nyfløt et al. [33], Frolova et al. [34], Rosenthal et al. [35], and Schneider and Kinzler [36] support the biological plausibility of these variables, particularly in relation to delayed placental expulsion and uterine fatigue. The WHO has also identified prolonged labor and macrosomia as emerging global risk patterns for PPH [14], suggesting these variables may act as contributing factors in multifactorial pathways rather than as independent predictors.

At the clinical level, first-level hospitals in Lusaka Province generally follow WHO-recommended protocols for PPH management, including active management of the third stage of labor. This typically involves administration of uterotonics (e.g., oxytocin), controlled cord traction, and uterine massage. However, implementation may vary due to staffing constraints, supply chain interruptions, and inconsistent adherence to protocols. These gaps may affect the timely recognition and treatment of PPH, particularly in high-volume or resource-limited settings.

Delays in care or referral were not formally assessed in this study but may have contributed to more severe outcomes, including ICU admission or need for blood transfusion. Previous work by Chirwa and Tembo [18] highlights how systemic barriers such as delayed transport, inadequate emergency preparedness, and limited blood availability compound the clinical burden of PPH in rural Zambian clinics. These structural challenges are critical to understanding why PPH-related outcomes remain poor despite identifiable risk factors.

From a regional perspective, UNICEF and UNFPA [13] and Abebe et al. [16] underscore how resource constraints and inconsistent protocol adherence contribute to the persistence of PPH as a major threat to maternal survival. The WHO’s 2024 Global Report calls for a redefinition of PPH thresholds and prioritizes timely intervention and uterotonic administration [14]. This aligns with recommendations from Güngördük et al. [37], Adnani et al. [38], and Ononge et al. [39], who advocate for active management of the third stage of labor as a cost-effective strategy to reduce PPH incidence in low-resource settings.

This study identified uterine atony, retained placenta, and cervical tears as independent and statistically significant predictors of primary postpartum hemorrhage (PPH) in the final multivariate model. These findings reinforce the need for vigilant monitoring and timely intervention during the third stage of labor and immediate postpartum period. Based on these results, we recommend strengthening clinical protocols at first-level hospitals to ensure consistent implementation of active management of the third stage of labor, including routine administration of uterotonics, controlled cord traction, and post-delivery genital tract examination. Improving adherence to standardized PPH protocols, enhancing emergency preparedness, and reducing delays in referral pathways are critical steps toward lowering PPH-related morbidity and mortality in resource-limited settings. These findings can inform targeted interventions and policy adjustments to improve maternal outcomes across Zambia and similar contexts.

The authors acknowledge the assistance rendered by the study participants, the midwives from the study hospitals and the doctors. The study had no funding as it was part of academic requirements.

Permission to carry out the study was sought from the management of the hospitals involved after getting ethical approval from the University of Zambia Biomedical Research Ethics Committee (UNZABREC) (REF: no 074-2019) and the National Health Research Authority (NHRA). All participants gave both verbal and written consent prior to questionnaires being administered by investigators.

This study used both questionnaire and patient’s files which are kept under the custodianship of the various health facility registries and can be made available with special request through the corresponding author.

AKYM, and CM conceptualized the study. Later KML, AK and AKYM led the data collection and analysis. CM and AKYM Drafted the manuscript and shared it with others. All authors critically reviewed the draft manuscript and approved the final version for publication.