<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">
    ojog
   </journal-id>
   <journal-title-group>
    <journal-title>
     Open Journal of Obstetrics and Gynecology
    </journal-title>
   </journal-title-group>
   <issn pub-type="epub">
    2160-8792
   </issn>
   <issn publication-format="print">
    2160-8806
   </issn>
   <publisher>
    <publisher-name>
     Scientific Research Publishing
    </publisher-name>
   </publisher>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="doi">
    10.4236/ojog.2025.1510140
   </article-id>
   <article-id pub-id-type="publisher-id">
    ojog-146384
   </article-id>
   <article-categories>
    <subj-group subj-group-type="heading">
     <subject>
      Articles
     </subject>
    </subj-group>
    <subj-group subj-group-type="Discipline-v2">
     <subject>
      Medicine 
     </subject>
     <subject>
       Healthcare
     </subject>
    </subj-group>
   </article-categories>
   <title-group>
    Childbirth after 40 Years: A Case-Control Study at the University Hospital Center of Libreville from January 1, 2023 to January 1, 2025
   </title-group>
   <contrib-group>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Jean Pierre Ngou Mve
      </surname>
      <given-names>
       Ngou
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Kévin Ngou Mve
      </surname>
      <given-names>
       Ngou
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Marcel
      </surname>
      <given-names>
       Methogo
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Jean Daniel
      </surname>
      <given-names>
       Zouakeu
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Pélagie
      </surname>
      <given-names>
       Bikie
      </given-names>
     </name>
    </contrib>
   </contrib-group> 
   <aff id="affnull">
    <addr-line>
     aGynecology-Obstetrics Department, University Hospital Center of Libreville, Libreville, Gabon
    </addr-line> 
   </aff> 
   <pub-date pub-type="epub">
    <day>
     26
    </day> 
    <month>
     09
    </month>
    <year>
     2025
    </year>
   </pub-date> 
   <volume>
    15
   </volume> 
   <issue>
    10
   </issue>
   <fpage>
    1670
   </fpage>
   <lpage>
    1677
   </lpage>
   <history>
    <date date-type="received">
     <day>
      11,
     </day>
     <month>
      September
     </month>
     <year>
      2025
     </year>
    </date>
    <date date-type="published">
     <day>
      12,
     </day>
     <month>
      September
     </month>
     <year>
      2025
     </year> 
    </date> 
    <date date-type="accepted">
     <day>
      12,
     </day>
     <month>
      October
     </month>
     <year>
      2025
     </year> 
    </date>
   </history>
   <permissions>
    <copyright-statement>
     © Copyright 2014 by authors and Scientific Research Publishing Inc. 
    </copyright-statement>
    <copyright-year>
     2014
    </copyright-year>
    <license>
     <license-p>
      This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
     </license-p>
    </license>
   </permissions>
   <abstract>
    <b>Objective:</b> To evaluate the frequency, clinical characteristics, and maternal and perinatal outcomes of childbirth among women aged 40 and above at the University Hospital Center of Libreville. 
    <b>Patients</b> 
    <b>and</b> 
    <b>Method</b>
    <b>:</b> We conducted a two-year retrospective case-control study including 377 deliveries among women aged ≥40 and over compared with 530 randomly selected deliveries among women aged 20 to 34 years at the same institution. Associations were assessed using chi-square tests with a significance threshold of p &lt; 0.05. 
    <b>R</b>
    <b>esult</b>
    <b>:</b> Of 11,771 deliveries, 377 involved women aged ≥40 (3.2%). Most were multiparous (49.1% vs. 40.9% in controls, p &lt; 0.02). Dysfunctional labor occurred more often in older women (13.0% vs. 11.5%, p &lt; 0.05). Instrumental extractions (11.1% vs. 6.4%, p &lt; 0.01) and cesarean delivery (16.2% vs. 12.1%, p = 0.07) were more frequent. Neonatal outcomes showed higher rates of low Apgar scores &lt; 7 at 5 min (10.3% vs. 8.9%, p = 00.4), congenital anomalies (2.1% vs. 0.5%) and perinatal mortality (3.44% vs. 1.51%). 
    <b>Conclusion</b>
    <b>:</b> Childbirth after 40 years remains a high-risk obstetric event, associated with increased dysfunctional labor, operative deliveries, and neonatal morbidity. Strengthened early prenatal care, with close obstetric-pediatric collaboration, is essential to improve outcomes.
   </abstract>
   <kwd-group> 
    <kwd>
     Age ≥ 40 Years
    </kwd> 
    <kwd>
      Late Pregnancy
    </kwd> 
    <kwd>
      Dystocia
    </kwd> 
    <kwd>
      Maternal-Fetal Prognosis
    </kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <sec id="s1">
   <title>1. Introduction</title>
   <p>Over recent decades, the number of pregnancies at advanced maternal age has increased worldwide, driven by sociocultural changes delaying motherhood and advances in assisted reproductive technologies <xref ref-type="bibr" rid="scirp.146384-1">
     [1]
    </xref> <xref ref-type="bibr" rid="scirp.146384-2">
     [2]
    </xref>. A multicenter study in Israel reported that birth rates among women aged 35 - 39 years and 40 - 44 years increased by 272% and 318% respectively over four decades, with advanced maternal age linked to higher risks of preeclampsia, prematurity, and cesarean delivery <xref ref-type="bibr" rid="scirp.146384-3">
     [3]
    </xref>. Although such pregnancies are considered high risk, some authors emphasize that age alone does not account for adverse outcomes <xref ref-type="bibr" rid="scirp.146384-4">
     [4]
    </xref>.</p>
   <p>In Sub-Saharan Africa and particularly in Gabon, the frequency and outcomes of childbirth at age ≥ 40 remain poorly documented <xref ref-type="bibr" rid="scirp.146384-5">
     [5]
    </xref>. African series report variable frequencies ranging between 1.02% and 1.87%, values that are markedly lower than those observed in industrialized countries <xref ref-type="bibr" rid="scirp.146384-6">
     [6]
    </xref>. The objective of this study was to evaluate the frequency, clinical characteristics and maternal-fetal prognosis of these deliveries considered high-risk, especially in our context.</p>
  </sec><sec id="s2">
   <title>2. Patients and Methods</title>
   <sec id="s2_1">
    <title>2.1. Study Design and Setting</title>
    <p>We conducted a retrospective, descriptive, and comparative case-control study over two years (January 1, 2023 to January 1, 2025) at the maternity unit of the University Hospital Center of Libreville, a referral hospital performing about 6000 deliveries annually and equipped with adult and neonatal intensive care units.</p>
   </sec>
   <sec id="s2_2">
    <title>2.2. Population</title>
    <p>Cases included all parturients aged ≥40 years with complete medical records who delivered at the hospital during the study period. Controls comprised 530 deliveries among women aged 20 - 34 years, randomly selected from the same period and institution. Inclusion and exclusion criteria were identical across groups except for maternal age.</p>
   </sec>
   <sec id="s2_3">
    <title>2.3. Data Collection</title>
    <p>Data were extracted from delivery registers and patient records. Variables included sociodemographic, parity, medical and obstetric history (hypertension, diabetes), prenatal consultations, fetal presentation, dysfunctional labor, mode of delivery, postpartum hemorrhage, maternal mortality, Apgar score, congenital anomalies, stillbirth, and early neonatal death.</p>
   </sec>
   <sec id="s2_4">
    <title>2.4. Definitions</title>
    <p>To remove any terminological ambiguity, the following terms were defined in the protocol:</p>
   </sec>
   <sec id="s2_5">
    <title>2.5. Seized Collection and Statistical Analysis</title>
    <p>Data were analyzed using Epi Info 2010. Associations between maternal age and outcomes were tested with chi-square tests, with p &lt; 0.05 considered significant. Multivariable logistic regression was not feasible due to missing individual-level data.</p>
   </sec>
   <sec id="s2_6">
    <title>2.6. Ethical Considerations</title>
    <p>Approval was obtained from the Gabon National Ethics Committee and the hospital administration. Patient confidentiality and anonymity were strictly maintained in line with ethical guidelines. Decree 00732/PR/MRSDT of September 15, 2008, fixing the composition and functioning of the National Ethics Committee on Scientific Research.</p>
   </sec>
  </sec><sec id="s3">
   <title>3. Results</title>
   <p>Among 11,771 deliveries involved women aged ≥40 years (3.2%). Most were 40 - 42 years (80.6%). Multiparity was more frequent in cases (49.1% vs. 40.9%, p &lt; 0.02, <xref ref-type="table" rid="table1">
     Table 1
    </xref>).</p>
   <table-wrap id="table1">
    <label>
     <xref ref-type="table" rid="table1">
      Table 1
     </xref></label>
    <caption>
     <title>
      <xref ref-type="bibr" rid="scirp.146384-"></xref>Table 1. Distribution of parturient according to parity.</title>
    </caption>
    <table class="MsoTableGrid custom-table" border="0" cellspacing="0" cellpadding="0"> 
     <tr> 
      <td rowspan="2" class="custom-top-td acenter" width="32.27%"><p style="text-align:center">Parity</p></td> 
      <td class="custom-bottom-td custom-top-td acenter" width="26.58%" colspan="2"><p style="text-align:center">Case</p></td> 
      <td class="custom-bottom-td custom-top-td acenter" width="26.58%" colspan="2"><p style="text-align:center">Control</p></td> 
      <td rowspan="2" class="custom-top-td acenter" width="14.58%"><p style="text-align:center">p</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td custom-top-td acenter" width="13.16%"><p style="text-align:center">n</p></td> 
      <td class="custom-bottom-td custom-top-td acenter" width="13.42%"><p style="text-align:center">%</p></td> 
      <td class="custom-bottom-td custom-top-td acenter" width="13.16%"><p style="text-align:center">n</p></td> 
      <td class="custom-bottom-td custom-top-td acenter" width="13.42%"><p style="text-align:center">%</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="32.27%"><p style="text-align:center">Primiparous (P1)</p></td> 
      <td class="custom-top-td acenter" width="13.16%"><p style="text-align:center">4</p></td> 
      <td class="custom-top-td acenter" width="13.42%"><p style="text-align:center">1.1</p></td> 
      <td class="custom-top-td acenter" width="13.16%"><p style="text-align:center">34</p></td> 
      <td class="custom-top-td acenter" width="13.42%"><p style="text-align:center">6.4</p></td> 
      <td class="custom-top-td acenter" width="14.58%"><p style="text-align:center">&lt;0.001</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="32.27%"><p style="text-align:center">Pauciparous (P2 - P3)</p></td> 
      <td class="acenter" width="13.16%"><p style="text-align:center">39</p></td> 
      <td class="acenter" width="13.42%"><p style="text-align:center">10.3</p></td> 
      <td class="acenter" width="13.16%"><p style="text-align:center">98</p></td> 
      <td class="acenter" width="13.42%"><p style="text-align:center">18.5</p></td> 
      <td class="acenter" width="14.58%"><p style="text-align:center">&lt;0.001</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="32.27%"><p style="text-align:center">Multiparous (P4 - P6)</p></td> 
      <td class="acenter" width="13.16%"><p style="text-align:center">185</p></td> 
      <td class="acenter" width="13.42%"><p style="text-align:center">49.1</p></td> 
      <td class="acenter" width="13.16%"><p style="text-align:center">217</p></td> 
      <td class="acenter" width="13.42%"><p style="text-align:center">40.9</p></td> 
      <td class="acenter" width="14.58%"><p style="text-align:center">0.01</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="32.27%"><p style="text-align:center">Large multiparous (&gt;P7)</p></td> 
      <td class="acenter" width="13.16%"><p style="text-align:center">149</p></td> 
      <td class="acenter" width="13.42%"><p style="text-align:center">39.5</p></td> 
      <td class="acenter" width="13.16%"><p style="text-align:center">181</p></td> 
      <td class="acenter" width="13.42%"><p style="text-align:center">34.2</p></td> 
      <td class="acenter" width="14.58%"><p style="text-align:center">0.09</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="32.27%"><p style="text-align:center">Total</p></td> 
      <td class="custom-bottom-td acenter" width="13.16%"><p style="text-align:center">377</p></td> 
      <td class="custom-bottom-td acenter" width="13.42%"><p style="text-align:center">100</p></td> 
      <td class="custom-bottom-td acenter" width="13.16%"><p style="text-align:center">530</p></td> 
      <td class="custom-bottom-td acenter" width="13.42%"><p style="text-align:center">100</p></td> 
      <td class="custom-bottom-td acenter" width="14.58%"><p style="text-align:center"></p></td> 
     </tr> 
    </table>
   </table-wrap>
   <table-wrap id="table2">
    <label>
     <xref ref-type="table" rid="table2">
      Table 2
     </xref></label>
    <caption>
     <title>
      <xref ref-type="bibr" rid="scirp.146384-"></xref>Table 2. Distribution of parturient according to the number of CPNs.</title>
    </caption>
    <table class="MsoTableGrid custom-table" border="0" cellspacing="0" cellpadding="0"> 
     <tr> 
      <td rowspan="2" class="custom-top-td acenter" width="19.46%"><p style="text-align:center">Parity</p></td> 
      <td class="custom-bottom-td custom-top-td acenter" width="33.40%" colspan="2"><p style="text-align:center">Case</p></td> 
      <td class="custom-bottom-td custom-top-td acenter" width="33.40%" colspan="2"><p style="text-align:center">Control</p></td> 
      <td rowspan="2" class="custom-top-td acenter" width="13.73%"><p style="text-align:center">p</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td custom-top-td acenter" width="16.17%"><p style="text-align:center">n</p></td> 
      <td class="custom-bottom-td custom-top-td acenter" width="17.23%"><p style="text-align:center">%</p></td> 
      <td class="custom-bottom-td custom-top-td acenter" width="16.17%"><p style="text-align:center">n</p></td> 
      <td class="custom-bottom-td custom-top-td acenter" width="17.23%"><p style="text-align:center">%</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="19.46%"><p style="text-align:center">0 - 1 ANC</p></td> 
      <td class="custom-top-td acenter" width="16.17%"><p style="text-align:center">11</p></td> 
      <td class="custom-top-td acenter" width="17.23%"><p style="text-align:center">2.9%</p></td> 
      <td class="custom-top-td acenter" width="16.17%"><p style="text-align:center">11</p></td> 
      <td class="custom-top-td acenter" width="17.23%"><p style="text-align:center">2.1%</p></td> 
      <td class="custom-top-td acenter" width="13.73%"><p style="text-align:center">0.41</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="19.46%"><p style="text-align:center">2 ANC</p></td> 
      <td class="acenter" width="16.17%"><p style="text-align:center">19</p></td> 
      <td class="acenter" width="17.23%"><p style="text-align:center">5.0%</p></td> 
      <td class="acenter" width="16.17%"><p style="text-align:center">42</p></td> 
      <td class="acenter" width="17.23%"><p style="text-align:center">7.9%</p></td> 
      <td class="acenter" width="13.73%"><p style="text-align:center">0.08</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="19.46%"><p style="text-align:center">≥3 ANC</p></td> 
      <td class="acenter" width="16.17%"><p style="text-align:center">347</p></td> 
      <td class="acenter" width="17.23%"><p style="text-align:center">92.1%</p></td> 
      <td class="acenter" width="16.17%"><p style="text-align:center">477</p></td> 
      <td class="acenter" width="17.23%"><p style="text-align:center">90.0%</p></td> 
      <td class="acenter" width="13.73%"><p style="text-align:center">0.29</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="19.46%"><p style="text-align:center">Total</p></td> 
      <td class="custom-bottom-td acenter" width="16.17%"><p style="text-align:center">377</p></td> 
      <td class="custom-bottom-td acenter" width="17.23%"><p style="text-align:center">100%</p></td> 
      <td class="custom-bottom-td acenter" width="16.17%"><p style="text-align:center">530</p></td> 
      <td class="custom-bottom-td acenter" width="17.23%"><p style="text-align:center">100%</p></td> 
      <td class="custom-bottom-td acenter" width="13.73%"><p style="text-align:center"></p></td> 
     </tr> 
    </table>
   </table-wrap>
   <p>The number of antenatal consultations (ANCs) differed little between the groups; most women had attended at least three consultations (p &gt;0.008, <xref ref-type="table" rid="table2">
     Table 2
    </xref>).</p>
   <sec id="s3_1">
    <title>3.1. Social, Occupational and Marital Status</title>
    <p>Across both groups, most of the women were covered by health insurance. The majority were in paid employment and married; only 38.66% were single or in a consensual union (<xref ref-type="table" rid="table3">
      Table 3
     </xref>).</p>
    <table-wrap id="table3">
     <label>
      <xref ref-type="table" rid="table3">
       Table 3
      </xref></label>
     <caption>
      <title>
       <xref ref-type="bibr" rid="scirp.146384-"></xref>Table 3. Distribution of parturient according to the mode of delivery.</title>
     </caption>
     <table class="MsoTableGrid custom-table" border="0" cellspacing="0" cellpadding="0"> 
      <tr> 
       <td rowspan="2" class="custom-top-td acenter" width="36.18%"><p style="text-align:center">Mode of delivery</p></td> 
       <td class="custom-bottom-td custom-top-td acenter" width="25.54%" colspan="2"><p style="text-align:center">Case</p></td> 
       <td class="custom-bottom-td custom-top-td acenter" width="25.54%" colspan="2"><p style="text-align:center">Controls</p></td> 
       <td rowspan="2" class="custom-bottom-td custom-top-td acenter" width="12.76%"><p style="text-align:center">p</p></td> 
      </tr> 
      <tr> 
       <td class="custom-bottom-td custom-top-td acenter" width="12.76%"><p style="text-align:center">n</p></td> 
       <td class="custom-bottom-td custom-top-td acenter" width="12.78%"><p style="text-align:center">%</p></td> 
       <td class="custom-bottom-td custom-top-td acenter" width="12.76%"><p style="text-align:center">n</p></td> 
       <td class="custom-bottom-td custom-top-td acenter" width="12.78%"><p style="text-align:center">%</p></td> 
      </tr> 
      <tr> 
       <td class="custom-top-td acenter" width="36.18%"><p style="text-align:center">Spontaneous vaginal birth</p></td> 
       <td class="custom-top-td acenter" width="12.76%"><p style="text-align:center">274</p></td> 
       <td class="custom-top-td acenter" width="12.78%"><p style="text-align:center">72.7</p></td> 
       <td class="custom-top-td acenter" width="12.76%"><p style="text-align:center">432</p></td> 
       <td class="custom-top-td acenter" width="12.78%"><p style="text-align:center">81.5</p></td> 
       <td class="custom-top-td acenter" width="12.76%"><p style="text-align:center">&lt;0.001</p></td> 
      </tr> 
      <tr> 
       <td class="acenter" width="36.18%"><p style="text-align:center">Instrumental extractions</p></td> 
       <td class="acenter" width="12.76%"><p style="text-align:center">42</p></td> 
       <td class="acenter" width="12.78%"><p style="text-align:center">11.1</p></td> 
       <td class="acenter" width="12.76%"><p style="text-align:center">34</p></td> 
       <td class="acenter" width="12.78%"><p style="text-align:center">6.4</p></td> 
       <td class="acenter" width="12.76%"><p style="text-align:center">0.01</p></td> 
      </tr> 
      <tr> 
       <td class="acenter" width="36.18%"><p style="text-align:center">Upper way</p></td> 
       <td class="acenter" width="12.76%"><p style="text-align:center">61</p></td> 
       <td class="acenter" width="12.78%"><p style="text-align:center">16.2</p></td> 
       <td class="acenter" width="12.76%"><p style="text-align:center">64</p></td> 
       <td class="acenter" width="12.78%"><p style="text-align:center">12.1</p></td> 
       <td class="acenter" width="12.76%"><p style="text-align:center">0.07</p></td> 
      </tr> 
      <tr> 
       <td class="custom-bottom-td acenter" width="36.18%"><p style="text-align:center">Total</p></td> 
       <td class="custom-bottom-td acenter" width="12.76%"><p style="text-align:center">377</p></td> 
       <td class="custom-bottom-td acenter" width="12.78%"><p style="text-align:center">100</p></td> 
       <td class="custom-bottom-td acenter" width="12.76%"><p style="text-align:center">530</p></td> 
       <td class="custom-bottom-td acenter" width="12.78%"><p style="text-align:center">100</p></td> 
       <td class="custom-bottom-td acenter" width="12.76%"><p style="text-align:center"></p></td> 
      </tr> 
     </table>
    </table-wrap>
   </sec>
   <sec id="s3_2">
    <title>3.2. Gynecological and Obstetric History</title>
    <p>Women aged ≥40 years more often had a history of abortions (30.2%) or pelvic surgery (9.6%), including caesarean sections (6.4%) and other procedures (3.2% for cysts, fibroids or laparoscopic surgery). High blood pressure was slightly more common among women aged 20 - 34 (2.0% vs. 1.3%), whereas diabetes was more frequent after 40 (3.7% vs. 2.3%); neither difference reached statistical significance. Older women had more spontaneous abortions (65.8% vs. 48.4%) and fewer induced abortions (24.2% vs. 51.4%), a significant difference.</p>
   </sec>
   <sec id="s3_3">
    <title>3.3. Presentation at the Maternity Unit and Clinical Examination</title>
    <p>Only 59.7% of women aged 40 and over arrived at the maternity unit early, compared with 73.4% of younger women. They were more likely to present in advanced labor with full cervical dilatation (17.0% vs. 7.0%) or to deliver outside the facility (2.9% vs. 0.9%). There was no major difference in the pathologies detected at clinical examination.</p>
   </sec>
   <sec id="s3_4">
    <title>3.4. Pregnancy Term and Fetal Presentation</title>
    <p>Preterm births accounted for 9% of pregnancies in the older group and 16.8% in the younger group. Cephalic presentation was predominant (87.6% in women aged 40 - 52 and 86.4% in those aged 20 - 34). Breech presentations were slightly less common in the older group (11.1% vs. 12.9%). Malpresentations were comparable between groups (12.4% vs. 13.6%).</p>
   </sec>
   <sec id="s3_5">
    <title>3.5. Labor and Delivery</title>
    <p>Spontaneous vaginal delivery occurred more frequently in the 20 - 34 group (81.5%) than in women over 40 (72.7%), whereas instrumental deliveries were more common after 40 (11.6% vs. 6.4%). The rate of caesarean delivery was similar in both groups.</p>
   </sec>
   <sec id="s3_6">
    <title>3.6. Postpartum Hemorrhage and Maternal Mortality</title>
    <p>Postpartum hemorrhage occurred in 7.7% of the older women and 7.0% of the younger women, without significant difference. There was one maternal death (0.26%) in the group aged 40 and above, due to postpartum hemorrhage, and three deaths (0.56%) among younger women, due to vascular-renal syndromes (two eclampsia and one retroplacental hematoma).</p>
   </sec>
   <sec id="s3_7">
    <title>3.7. Neonatal Status and Intensive Care Transfer</title>
    <p>An Apgar score ≥ 7 was recorded in 90.0% of cases in both groups, indicating generally good neonatal outcomes. Among 368 live births to women aged ≥40, 17 newborns (4.6%) were transferred to intensive care for suspected maternal-fetal infection or acute fetal distress, compared with 3.2% of neonates born to younger women.</p>
   </sec>
   <sec id="s3_8">
    <title>3.8. Malformation and Fetal Mortality</title>
    <p>Eight cases of congenital malformations (2.1%) were identified in mothers aged ≥40 (including hydrocephalus, omphalocele, achondroplasia, anencephaly, cervical cystic hygroma, club foot and Potter’s syndrome) compared with three cases (0.5%) in younger women. Early neonatal death or stillbirth was reported in 13 cases (3.44%) among the older mothers vs. eight cases (1.51%) in the 20 - 34 age group, and there were nine intra-uterine fetal demises (2.38%) in the older cohort.</p>
   </sec>
  </sec><sec id="s4">
   <title>4. Discussion</title>
   <p>This study has the limits of a retrospective study based on data collection: urgently completed files with summary and poorly archived information.</p>
   <p>During this study, we identified two main biases:</p>
   <p>During this study period, we observed a frequency of 3.20% of deliveries in parturients aged 40 years and over. Our figure remains slightly high compared to those of the literature, which varies globally between 1.02% and 1.87% in African series. Foumsou et al. <xref ref-type="bibr" rid="scirp.146384-7">
     [7]
    </xref> in Tchad and Maleya et al. in Congo <xref ref-type="bibr" rid="scirp.146384-8">
     [8]
    </xref> found frequencies of 2.8% and 2.4% respectively. This difference is to be due to the recruitment of parturients admitted to our service who often have a high socio-economic level compared to the general population.</p>
   <p>African series also report elderly parturients: 52 years for Samake et al. <xref ref-type="bibr" rid="scirp.146384-9">
     [9]
    </xref> in Côte d’Ivoire and 53 years for Ouattara et al. <xref ref-type="bibr" rid="scirp.146384-10">
     [10]
    </xref> in Burkina Faso.</p>
   <p>We observed a large multiparous population (88.6% vs. 75.1%, p &lt; 0.01) as shown by the study by Spellacy et al. <xref ref-type="bibr" rid="scirp.146384-11">
     [11]
    </xref>.</p>
   <p>Pregnancies after the age of 40 often occur in multiparous. 49.1% of our parturients have a parity between 4 and 6. If we consider the large multiparous (parity &gt; 7), they represent 39.5% in our study. Tebeu et al. <xref ref-type="bibr" rid="scirp.146384-12">
     [12]
    </xref>, in Cameroon, found 94.46% of multiparous in parturients aged 40 years or older.</p>
   <p>Western studies have found a decrease in old primiparous, as in the Bellaisch-Allar <xref ref-type="bibr" rid="scirp.146384-13">
     [13]
    </xref> series. It must be understood that in these countries, success requires professional achievement, women freed from the fear of an unwanted pregnancy prefer to postpone the procreation project.</p>
   <p>Our study found 9% of premature babies (term less than 37 weeks) in parturients aged 40 years and over. This rate is higher than that found by Denax et al. <xref ref-type="bibr" rid="scirp.146384-14">
     [14]
    </xref>, 3.4%. Foix et al. <xref ref-type="bibr" rid="scirp.146384-15">
     [15]
    </xref> found 6.8% with a high risk of prematurity at the age of 35. On the other hand, for Andriamady et al. <xref ref-type="bibr" rid="scirp.146384-16">
     [16]
    </xref>, the risk of prematurity is significantly increased by 23.1% among parturients aged 40 years and over.</p>
   <p>Childbirth took place spontaneously in 72.7% of cases in parturients aged 40 and over vs. 81.5% in those under 40. The difference is statistically significant. Parturients aged 40 and over have a higher risk of giving birth by caesarean section or instrumental extraction than parturients in the group aged 20 to 34, p &lt; 0.05.</p>
   <p>Cesarean delivery is much more common in parturients aged 40 years or older (16.2%) compared to 12.08% in parturients aged 20 to 34 years, but the difference is not statistically significant (p &gt; 0.05). The rate of caesarean delivery is particularly high in this population since it varies according to the authors between 15 and 40% with even higher values in the elderly primiparous, where it reaches 50 or even 70% in the study of Kinenkinda et al. <xref ref-type="bibr" rid="scirp.146384-17">
     [17]
    </xref>.</p>
   <p>No difference was observed in the occurrence of postpartum hemorrhages in both groups of parturients (7.7% vs. 7.0%). Some authors describe a frequency of delivery hemorrhages after 40 years due to the poor quality of the uterine muscle. The study by Tebeu et al. <xref ref-type="bibr" rid="scirp.146384-18">
     [18]
    </xref> reports a high frequency of hospitalization following childbirth (48.61%) of deliveries.</p>
   <p>The thromboembolic risk is increased in the literature, especially if there is a predisposition to the type of superficial or deep thrombophlebitis as in the study of Essiben et al. <xref ref-type="bibr" rid="scirp.146384-19">
     [19]
    </xref>. Lehmann et al. <xref ref-type="bibr" rid="scirp.146384-20">
     [20]
    </xref> found a twice as high risk of postpartum hemorrhage and an infectious risk (endometriosis, pyelonephritis) seven times greater than in the control group. Our study did not find thromboembolic diseases and postpartum infections. We systematically use a postpartum antibiotic cover.</p>
   <p>The maternal death rate of parturients aged 40 years or older in our study is low, 0.26%. Owono Etoundi et al. <xref ref-type="bibr" rid="scirp.146384-21">
     [21]
    </xref> report a rate of 1.1%.</p>
  </sec><sec id="s5">
   <title>5. Conclusion</title>
   <p>The delivery of a woman aged 40 and over is at high risk. Pregnancy follow-up must be rigorous and early and require obstetric-pediatric collaboration to limit the complications associated with this delivery.</p>
  </sec>
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