Accurate diagnosis of lesions of the oral cavity is a major challenge, given the complexity of the oral environment and the potentially misleading evolution of these lesions [1] . Clinical assessment alone, which is often subjective, is insufficient for optimal management [2] . Close collaboration between clinicians and pathologists, assessed by histoclinical concordance, is essential to ensure quality care [3] . International studies have revealed variable rates of histoclinical concordance. For example, research carried out in Iran and Italy reported rates ranging from 68.5% to 72.2%, underlining the inherent difficulty in interpreting oral lesions [4] [5] . In Africa, the subject is understudied, but available data, notably from Nigeria, suggest lower concordance (54.6% to 59.7%), potentially indicating specific challenges linked to local contexts [6] . A recent study by Smith et al. (2023) also highlighted the impact of regional variations on the accuracy of histopathological diagnosis of oral lesions [7] .

Yaounde, the political capital and major urban center of Cameroon, presents a specific epidemiological context for oral pathologies, potentially influenced by socio-economic, cultural and healthcare access factors distinct from other African regions. The prevalence and type of oral lesions observed in Yaounde could differ significantly from Nigerian data or from studies carried out in East or Southern Africa, thus limiting the direct generalization of the results of the latter to the Cameroonian context [8] . In addition, clinical practices, available diagnostic resources and the training of healthcare professionals in Yaounde may also influence histoclinical concordance. Understanding the concordance rate in this specific setting is crucial for identifying local challenges and adapting strategies to improve diagnostic quality. The aim of this research is to establish a profile of oral pathologies and identify the factors contributing to discordance in Yaounde, in order to improve diagnostic accuracy and patient management, and consequently quality of care.

A total of 472 patient records were included in the study.

1) Socio-demographic characteristics

The mean age of the patients was 38.06 ± 20 years, with extremes of 1 and 89 years. The most represented age group was 15 to 30 years. These data are similar to those reported by Olujide and al. in Nigeria, where the mean age was 36.1 years [9] . The female/male sex ratio was 1.06, with no significant difference between the sexes. This result is comparable with data from Golgoush and al. in Iran [10] . This observation could be explained by a positive attitude and more frequent use of oral health services by women. Indeed, men tend to take less good care of their health [11] .

2) Clinical features

Of the 472 files analyzed, 80.93% did not include a clinical diagnosis and/or clinical information. This lack of information is probably due to incomplete completion of clinical information sheets by prescribers. Ear, nose and throat (ENT) specialists were the most common prescribers (38.77%).

This may be linked to the fact that 48.48% of lesions were tumors. Prior to 2007, when the training of oral health physicians began in Cameroon, ENT specialists were considered to be the most important prescribers. Exophytic soft tissue lesions were the most frequent (43.37%), in line with the findings of Golgoush and al. in Iran [10] . Simple biopsy was the most commonly used sampling method (58.69%), a technique favoured by ENT specialists. This percentage is lower than that reported by Benyabya et al. in Morocco [11] . This difference could be explained by a higher proportion of biopsy-exereses (40.04%) in our study, due to the predominance of tumoral lesions. The salivary glands were the organs most affected (22.67%), in particular the parotid gland, followed by the buccal mucosa (16.1%). These results differ from those reported by Ku and al. in New Zealand, where lesions of the oral mucosa were more frequent [12] .

In this study, the location of oral lesions showed variations from other studies carried out in Africa. While Tchounga and al. [13] reported a predominance of lesions in the mandible (13.94%), other studies found different results. Olujide et al. [9] and Flero-Gerbay and al. [14] all reported a higher prevalence of lesions in the mandible. This discrepancy could be attributed to the clinical diversity of oral lesions and geographical variations in their distribution. Indeed, factors such as lifestyle habits, exposure to carcinogens and access to healthcare can influence the distribution of oral lesions in different regions.

In terms of clinical diagnosis, exophytic soft-tissue lesions were the most frequently mentioned (65.56%), with tonsillitis predominating (2.22%). This result is comparable to that of Golgoush and al. [10] , who found 44.18% exophytic lesions. However, Luqman and al. [15] in Saudi Arabia reported a predominance of bony lesions (41.37%), particularly periapical granulomas (23.9%). These differences may be due to a variety of factors, including differences in study populations, prescribing practices and clinical diagnostic accuracy. In addition, differences in prescriber training and clinical experience may also influence the accuracy of clinical diagnoses [16] .

3) Assessment of concordance, Histopathological features

No immunohistochemical findings were derived in our 10-year study, although some histological findings were still imprecise.

This could be explained by the fact that some of these laboratories lack immunohistochemistry equipment or, more plausibly, by the high cost of analysis.

The most common histological diagnoses were exophytic soft tissue lesions (56.99%), mainly pleomorphic salivary gland adenoma, followed by bone lesions (36.65%), mainly odontogenic cysts (3.18%).

This result is comparable to that found by Golgoush and al. [10] with a higher predominance for exophytic soft tissue lesions (44.18%), mainly inflammatory fibroids (12.02%), followed by bone lesions (34%), mainly radiculodental cysts (13%). This agreement could be linked to the ever-increasing incidence of tumoral and dental lesions in a context of depravity of morals, degradation of lifestyle associated with poor oral hygiene in full flagrance in Cameroon. This agreement could also be linked to the irradiation of the mouth that patients undergo, which affects the functioning of the salivary glands [13] .

4) Concordance assessment

The overall concordance rate observed in our Yaoundé study (57.83%) is within the range of results reported in Africa, notably the Nigerian study by Olujide et al. in 2019, which revealed a rate of 54.6% on 502 cases of oral lesions [9] . However, this rate is significantly lower than that found by Golgoush et al. in 2022 in Iran (72.2% on 3001 oral lesion samples over 12 years) [10] . This disparity could be explained by the difference in study period and sample size, but also by the availability of more advanced diagnostic means in Middle Eastern countries. These comparisons highlight the potential influence of socio-economic contexts and available resources on the accuracy of histoclinical diagnosis.

Analysis by age group revealed a maximum overall concordance rate in the 15 - 30 age group (64.52%). This observation could be attributed to the higher prevalence of odontogenic lesions in this younger population, characterized by a complete dentition [14] [15] . Interestingly, previous studies by Essabbah et al. [14] and Forman et al. [15] reported better concordance in older patients (70 - 83 years), where malignant lesions were predominant. This discrepancy suggests that the nature of the prevalent lesions in a given age population could influence the ease of their clinical diagnosis and, consequently, the histoclinical concordance. Regarding gender, our study showed a higher overall concordance rate in women (60%), which is consistent with the results of Forman et al. [17] who also observed better concordance in women. This could be related to greater health awareness and earlier consultation in case of symptoms in women [13] . Nevertheless, a study by Talaf et al. [18] reported higher concordance in men, highlighting the complexity of sociocultural and behavioral factors in access to care and their potential impact on diagnostic concordance.

Implications for clinical practice and improvement strategies: The 57.83% concordance rate in Yaoundé highlights a need for improved diagnostic protocols. Strengthened multidisciplinary collaboration between clinicians and pathologists, including regular consultation meetings and discussions of complex cases, could reduce discrepancies. The integration of more standardized clinical criteria and the increased use of complementary imaging tools could also improve the accuracy of the initial clinical diagnosis. Targeted continuing education on the recognition of common and atypical oral lesions, as well as the interpretation of histopathological findings, are essential to harmonize diagnostic practices.

Limitations and potential biases: Several limitations must be considered when interpreting these results. The retrospective nature of the study relies on the quality and completeness of medical records, which may have gaps or inconsistencies. In addition, the inherent subjectivity of the clinical assessment of oral lesions constitutes a potential bias. Although the study covers a 10-year period, the evolution of diagnostic practices and available resources within Yaoundé health centers during this period was not systematically evaluated. The sample size, although sufficient according to the initial calculation, may not be representative of all regional variations within Cameroon. Finally, the selection bias, inherent in the inclusion of only cases that underwent a biopsy, may not reflect concordance for all oral lesions managed clinically. A prospective analysis with a standardized data collection protocol would be necessary to overcome some of these limitations.

The moderate concordance observed in this study highlights a major challenge for the quality of oral pathology care in Yaounde. Improving the diagnosis and management of oral lesions is crucial to ensuring optimal patient care.

Persistent challenges related to the diagnostic accuracy and management of oral lesions have a direct impact on the quality of care. This research has highlighted the need to optimize diagnostic and therapeutic protocols in order to improve the quality of care offered to patients.