<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">
    oju
   </journal-id>
   <journal-title-group>
    <journal-title>
     Open Journal of Urology
    </journal-title>
   </journal-title-group>
   <issn pub-type="epub">
    2160-5440
   </issn>
   <issn publication-format="print">
    2160-5629
   </issn>
   <publisher>
    <publisher-name>
     Scientific Research Publishing
    </publisher-name>
   </publisher>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="doi">
    10.4236/oju.2025.154012
   </article-id>
   <article-id pub-id-type="publisher-id">
    oju-142177
   </article-id>
   <article-categories>
    <subj-group subj-group-type="heading">
     <subject>
      Articles
     </subject>
    </subj-group>
    <subj-group subj-group-type="Discipline-v2">
     <subject>
      Medicine 
     </subject>
     <subject>
       Healthcare
     </subject>
    </subj-group>
   </article-categories>
   <title-group>
    Antenatal Diagnosis of Sacrococcygeal Teratoma: A Case Report
   </title-group>
   <contrib-group>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Oumar
      </surname>
      <given-names>
       Bah
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Mohameden
      </surname>
      <given-names>
       Moctar
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Mohamed
      </surname>
      <given-names>
       Rajel
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Mouhamedou
      </surname>
      <given-names>
       Diagana
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
   </contrib-group> 
   <aff id="aff1">
    <addr-line>
     aGynecology Department, Cheikh Zayed Hospital, Nouakchott, Mauritania
    </addr-line> 
   </aff> 
   <aff id="aff2">
    <addr-line>
     aUrology Department, Cheikh Zayed Hospital, Nouakchott, Mauritania
    </addr-line> 
   </aff> 
   <pub-date pub-type="epub">
    <day>
     24
    </day> 
    <month>
     04
    </month>
    <year>
     2025
    </year>
   </pub-date> 
   <volume>
    15
   </volume> 
   <issue>
    04
   </issue>
   <fpage>
    115
   </fpage>
   <lpage>
    119
   </lpage>
   <history>
    <date date-type="received">
     <day>
      25,
     </day>
     <month>
      February
     </month>
     <year>
      2025
     </year>
    </date>
    <date date-type="published">
     <day>
      21,
     </day>
     <month>
      February
     </month>
     <year>
      2025
     </year> 
    </date> 
    <date date-type="accepted">
     <day>
      21,
     </day>
     <month>
      April
     </month>
     <year>
      2025
     </year> 
    </date>
   </history>
   <permissions>
    <copyright-statement>
     © Copyright 2014 by authors and Scientific Research Publishing Inc. 
    </copyright-statement>
    <copyright-year>
     2014
    </copyright-year>
    <license>
     <license-p>
      This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
     </license-p>
    </license>
   </permissions>
   <abstract>
    Sacrococcygeal teratoma represents the most prevalent type of neonatal tumor, with an occurrence rate of approximately 1 in 35,000 to 40,000 live births. The prenatal diagnosis is predominantly conducted through morphological ultrasound and Doppler studies, facilitating early detection and the monitoring of potential complications. In this report, we present a case of sacrococcygeal teratoma diagnosed at 22 weeks of gestation, with no Doppler evidence of fetal hydrops or anemia. Due to a significant risk of premature labor, delivery was conducted via cesarean section at 34 weeks of gestation. Neonatal surgical intervention was carried out on the second-day post-birth. This case allows for an analysis of diagnostic and therapeutic strategies, compared against existing literature.
   </abstract>
   <kwd-group> 
    <kwd>
     Sacrococcygeal Teratoma
    </kwd> 
    <kwd>
      Prenatal Diagnosis
    </kwd> 
    <kwd>
      Ultrasound
    </kwd> 
    <kwd>
      Neonatal Surgery
    </kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <sec id="s1">
   <title>1. Introduction</title>
   <p>Sacrococcygeal teratoma (SCT) represents the most prevalent form of congenital tumor, exhibiting a notable female predominance with a ratio of 3 to 4 girls for every boy affected <xref ref-type="bibr" rid="scirp.142177-1">
     [1]
    </xref> <xref ref-type="bibr" rid="scirp.142177-2">
     [2]
    </xref>. This tumor originates from pluripotent germ cells within the embryonic primitive streak during the 3rd to 4th week of gestation <xref ref-type="bibr" rid="scirp.142177-3">
     [3]
    </xref>. Altman’s classification system categorizes four types of teratomas according to the extent of their intra-pelvic and intra-abdominal involvement <xref ref-type="bibr" rid="scirp.142177-4">
     [4]
    </xref>.</p>
   <p>Prenatal diagnosis is primarily based on morphological ultrasound imaging, which facilitates the detection of a mass attached to the coccyx that may have tissue and/or cystic components. Doppler ultrasound is employed to evaluate the vascularization of the tumor and to identify potential complications, such as fetal-placental hydrops <xref ref-type="bibr" rid="scirp.142177-5">
     [5]
    </xref>. Magnetic Resonance Imaging (MRI) may be utilized to provide a more detailed assessment of intra-pelvic extension <xref ref-type="bibr" rid="scirp.142177-6">
     [6]
    </xref>. However, controversies exist regarding the most reliable ultrasound criteria for predicting neonatal prognosis. Furthermore, the impact of maternal and genetic factors on the occurrence of TSC remains a subject of debate in the literature.</p>
   <p>In this paper, we present a case of sacrococcygeal teratoma that was diagnosed in utero and subsequently managed postnatally.</p>
  </sec><sec id="s2">
   <title>2. Clinical Observation</title>
   <sec id="s2_1">
    <title>2.1. Maternal History and Case Identification</title>
    <p>This is a 34-year-old patient, gravida 3 para 2, with no known family history of teratoma or germ cell tumors, with a history of two cesarean sections, admitted at 22 weeks of amenorrhea for the investigation of pelvic pain. A morphological ultrasound was conducted, revealing a sacrococcygeal mass that raised the possibility of a sacrococcygeal teratoma, myelomeningocele, or meningocele.</p>
   </sec>
   <sec id="s2_2">
    <title>2.2. Ultrasound Findings</title>
    <p>The morphological ultrasound examination identified a mass attached to the coccyx, characterized by a lobulated appearance and a mixed echostructure. The mass predominantly consisted of a liquid component alongside a tissue component with vascularization seen on Doppler imaging and was associated with a 10 cm cystic formation. There was no evidence of fetal hydrops or cardiac insufficiency. The Doppler ultrasound revealed moderate vascularization, which contributed to the assessment of hemodynamic risk and the monitoring of tumor progression. (<xref ref-type="fig" rid="fig1">
      Figure 1
     </xref>; <xref ref-type="fig" rid="fig2">
      Figure 2
     </xref>)</p>
    <fig id="fig1" position="float">
     <label>Figure 1</label>
     <caption>
      <title>Figure 1. Sagittal ultrasound section showing a heterogeneous sacrococcygeal mass with vascularization detected by color Doppler.</title>
     </caption>
     <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/5001018-rId14.jpeg?20250424021902" />
    </fig>
    <fig id="fig2" position="float">
     <label>Figure 2</label>
     <caption>
      <title>Figure 2. Vascularization of the teratoma on Doppler ultrasound.</title>
     </caption>
     <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/5001018-rId15.jpeg?20250424021902" />
    </fig>
   </sec>
   <sec id="s2_3">
    <title>2.3. Obstetric and Neonatal Management</title>
    <p>A cesarean section was conducted at 34 weeks of gestation due to a significant risk of premature labor. A female newborn weighing 2200 grams, with an Apgar score of 7/10, was delivered. The neonatal examination confirmed the presence of a large sacrococcygeal mass. Surgical intervention performed on the second day of life involved a complete excision of the teratoma along with the removal of the coccyx to reduce the risk of recurrence. The procedure lasted two hours and required close postoperative monitoring due to the risk of hemorrhage and infection. Histological analysis confirmed the mature nature of the teratoma, with no signs of malignancy. (<xref ref-type="fig" rid="figFigures 3">
      Figures 3
     </xref>)</p>
    <fig id="fig3" position="float">
     <label>Figure 3</label>
     <caption>
      <title>Figure 3. Sacrococcygeal mass after cesarean section.</title>
     </caption>
     <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/5001018-rId16.jpeg?20250424021902" />
    </fig>
   </sec>
  </sec><sec id="s3">
   <title>3. Discussion</title>
   <sec id="s3_1">
    <title>3.1. Comparison with Literature Data</title>
    <p>This case aligns with existing literature that indicates a higher incidence of sacrococcygeal teratoma in females <xref ref-type="bibr" rid="scirp.142177-1">
      [1]
     </xref> <xref ref-type="bibr" rid="scirp.142177-2">
      [2]
     </xref>. Although maternal age was not specified, some studies have noted a higher prevalence in mothers over the age of 30 <xref ref-type="bibr" rid="scirp.142177-7">
      [7]
     </xref>.</p>
    <p>The diagnosis was established at 22 weeks of amenorrhea, which aligns with the standard detection period of 18 to 24 weeks of amenorrhea <xref ref-type="bibr" rid="scirp.142177-8">
      [8]
     </xref>. The mass was 10 cm in size, though there have been reports of masses reaching up to 25 cm <xref ref-type="bibr" rid="scirp.142177-9">
      [9]
     </xref>. The absence of fetal complications, particularly hydrops fetalis, serves as a positive prognostic indicator. However, the ultrasound criteria for distinguishing benign forms from potentially aggressive ones remain a topic of debate in the literature.</p>
   </sec>
   <sec id="s3_2">
    <title>3.2. Management and Outcome</title>
    <p>Performing a cesarean section at 34 weeks of amenorrhea complies with the guidelines for managing large teratomas (&gt;5 cm), which helps to minimize obstetric complications. The newborn’s weight of 2200 g is within the typical range of 2000 to 3500 g <xref ref-type="bibr" rid="scirp.142177-5">
      [5]
     </xref>.</p>
    <p>Performing surgery on the second day of life aligns with guidelines designed to mitigate the risks of hemorrhage and malignant degeneration. Our case highlights the importance of a multidisciplinary approach involving obstetricians, neonatologists, and pediatric surgeons in order to optimize the prognosis. Neonatal survival rates have improved due to advancements in imaging and surgery, with current postnatal mortality around 15%, compared to 35% - 60% during the antenatal period <xref ref-type="bibr" rid="scirp.142177-7">
      [7]
     </xref>.</p>
   </sec>
  </sec><sec id="s4">
   <title>4. Conclusion</title>
   <p>Sacrococcygeal teratoma is a rare tumor, typically benign, but it can lead to severe complications if it is large and hypervascular. Prenatal diagnosis is based on ultrasound and Doppler imaging, while MRI can provide detailed information regarding tumor extension. Rigorous prenatal monitoring facilitates the anticipation of potential complications and allows for the adjustment of delivery methods. Neonatal surgical intervention is crucial for preventing complications and enhancing prognosis.</p>
  </sec>
 </body><back>
  <ref-list>
   <title>References</title>
   <ref id="scirp.142177-ref1">
    <label>1</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Peter Altman, R., Randolph, J.G. and Lilly, J.R. (1974) Sacrococcygeal Teratoma: American Academy of Pediatrics Surgical Section Survey 1973. Journal of Pediatric Surgery, 9, 389-398. &gt;https://doi.org/10.1016/s0022-3468(74)80297-6
    </mixed-citation>
   </ref>
   <ref id="scirp.142177-ref2">
    <label>2</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Derikx, J.P., de Backer, A., van de Schoot, L., et al. (2006) Sacrococcygeal Teratoma: A Meta-Analysis. Journal of Pediatric Surgery, 41, 388-393.
    </mixed-citation>
   </ref>
   <ref id="scirp.142177-ref3">
    <label>3</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Gross, S.J., Benzie, R.J., Sermer, M., Skidmore, M.B. and Wilson, S.R. (1987) Sacrococcygeal Teratoma: Prenatal Diagnosis and Management. American Journal of Obstetrics and Gynecology, 156, 393-396. &gt;https://doi.org/10.1016/0002-9378(87)90290-0
    </mixed-citation>
   </ref>
   <ref id="scirp.142177-ref4">
    <label>4</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Yoon, H.M., Hwang, J., Kim, K.W., et al. (2021) Sacrococcygeal Teratoma in Neonates, Infants and Children: A Comprehensive Update for 2021. Pediatric Radiology, 51, 750-766.
    </mixed-citation>
   </ref>
   <ref id="scirp.142177-ref5">
    <label>5</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Hedrick, H.L., Flake, A.W., Crombleholme, T.M., Howell, L.J., Johnson, M.P., Wilson, R.D., et al. (2004) Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome. Journal of Pediatric Surgery, 39, 430-438. &gt;https://doi.org/10.1016/j.jpedsurg.2003.11.005
    </mixed-citation>
   </ref>
   <ref id="scirp.142177-ref6">
    <label>6</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Holterman, A.X., Filiatrault, D., Lallier, M., et al. (2002) Imaging Findings in Fetal Sacrococcygeal Teratoma: Comparison of Ultrasonography and MRI. Pediatric Radiology, 32, 748-753.
    </mixed-citation>
   </ref>
   <ref id="scirp.142177-ref7">
    <label>7</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Bond, S.J., Harrison, M.R., Schmidt, K.G., Silverman, N.H., Flake, A.W., Slotnick, R.N., et al. (1990) Death Due to High-Output Cardiac Failure in Fetal Sacrococcygeal Teratoma. Journal of Pediatric Surgery, 25, 1287-1291. &gt;https://doi.org/10.1016/0022-3468(90)90535-h
    </mixed-citation>
   </ref>
   <ref id="scirp.142177-ref8">
    <label>8</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Flake, A.W., Crombleholme, T.M., Johnson, M.P., et al. (1999) Fetoscopic Treatment of Sacrococcygeal Teratoma. Journal of Pediatric Surgery, 34, 129-132.
    </mixed-citation>
   </ref>
   <ref id="scirp.142177-ref9">
    <label>9</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Derikx, J.P., de Backer, A., van de Schoot, L., et al. (2006) Prognostic Factors for Recurrence and Metastasis in Sacrococcygeal Teratoma. Journal of Pediatric Surgery, 41, 62-67.
    </mixed-citation>
   </ref>
  </ref-list>
 </back>
</article>