Convulsive seizures are a frequent reason for consultation in pediatrics. Often associated with fever, then called febrile convulsions, convulsive seizures can be the initial manifestation of a serious cerebral pathology [1] [4] . Five percent (5%) of all children will have one or more seizures, of varying severity; always posing as a priority the problem of their cause and their immediate therapeutic management [1] . The immediate management, within 24 hours, of children admitted for seizures in the context of fever remains a matter of concern. Recognition of the different characteristics of seizures in infants and young children in the acute phase seems to be essential to establishing adequate care for these children [2] . A review of the Cochrane Database in 2008 recalled that the lack of data on the treatment of convulsive seizures in children prevented the provision of an indisputable therapeutic approach [3] . This latest position was reiterated by French experts in 2009 [4] . In 2018, the same Cochrane Database review compared the effectiveness of Lorazepam and Midazolam to that of Diazepam in convulsive illnesses in children, again without concluding a clear superiority of one or the other molecule. [5] . If the management of convulsive seizures is a therapeutic emergency, the etiological treatment is just as important.

Our study aimed to describe the clinical, etiological and therapeutic characteristics of convulsive seizures in infants and children (newborns excluded) at the Hôpital Spécialisé Mère-Enfant Blanche GOMES in Brazzaville

This was a descriptive study with prospective data collection. The study population consists of all patients aged 1 month to 17 years, admitted to the pediatric department of the Hôpital Spécialisé Mère-Enfant Blanche GOMES in Brazzaville (Congo) between October 1, 2021 and October 31, 2022, for a seizure. Children who died on arrival were excluded, as were those who had not undergone any paraclinical assessment. In addition to socio-demographic parameters, the following were taken into account: the circumstances of the birth, personal and family history of convulsive seizures, temperature, duration of the seizure, topography of the seizure, results of the thick drop in the search for plasmodium falciparum hematozoa, analysis of cerebrospinal fluid, electroencephalogram, and possibly computed tomography and magnetic resonance imaging of the brain, therapeutic modalities and immediate evolution. Data processing and analysis were carried out using Epi-info version 7.2.5.0 software.

The hospital frequency in this series of 11.43% is fairly consistent with data from both sub-Saharan and Western literature. Diawara et al. in Mali found a hospital frequency of 16.58% [6] . In Japan, Nishiyama Masahiro et al. found a frequency of 12.1% [7] . In the USA and Europe, the prevalence of seizures varies from 2% to 5% [8] - [11] . The frequency of seizures varies depending on geographic areas, but several studies have also cited genetic and environmental factors [9] [10] [12] - [20] . The sex ratio (G = 58/F = 62) was 0.93, almost balanced.

The average age of our series is 4.62 years. The age group from 1 month to 5 years was the most represented (72.5%). Sahin et al. [21] reported a mean age of 5.4 years and a sex ratio of 0.8. The series by Mwipopo et al. [22] reported 91% of children aged 1 month to 5 years. Convulsive seizures remain common in pediatrics, with a clear predominance in children under 6 years old.

A history of convulsive seizure was found in 24.17% of patients. Kaputu Kalala et al. in Kinshasa, in a group of children with generalized convulsive seizures, found 32% of previous convulsions, and the existence of a previous convulsive seizure would be statistically correlated with an unfavorable outcome [2] .

Fever was found in 77.5% of patients on admission. In the series by Mwipopo et al. [22] , fever was present in 91% of children. The strong tendency to self-medicate with paracetamol before consulting a pediatrician in our context of practice and the methodological differences would explain the difference in these results. Convulsions in the context of fever, often severe and recurrent, are common in Sub-Saharan Africa. Their frequency varies between 3 and 38% in different studies [23] [24] .

The seizure was tonic-clonic in 71 (59.17%) patients and generalized in 82.5% of cases. Most studies report the predominance of tonic-clonic and generalized characteristics of convulsive seizures in infants and young children [22] [25] [26] .

Cerebral malaria was the most common etiology (48.33%). Infectious causes in general, malaria in particular, remain the primary etiology of convulsive seizures in children in Sub-Saharan Africa [25] [25] - [32] . Febrile seizures came in second place (30.83%) and were mainly linked to nasopharyngeal or upper respiratory infection. Febrile seizure is a major challenge in pediatric practice due to its high incidence in young children and its tendency to recur [33] . The cause of febrile seizures is multifactorial. Febrile seizures are generally thought to result from a vulnerability of the developing central nervous system to the effects of fever, associated with underlying genetic predisposition and environmental factors [34] . Febrile seizure is an age-dependent response of the immature brain to fever. During the maturation process, there is enhanced neuronal excitability that predisposes the child to febrile seizures [35] . As such, febrile seizures mainly occur in children before the age of three when the epileptogenic threshold is low [35] .

The use of anticonvulsants was necessary in 79% of cases. Diazepam intrarectally was the first-line anticonvulsant (60% of cases). It was associated with Phenobarbital with an electric syringe pump in 30% of cases. In the series by Sahin et al. [21] , intravenous Midazolam was the first-line treatment in 48.9% of cases, and their study took place in an intensive care unit. Midazolam is a water-soluble benzodiazepine that can be administered in several routes, including intravenous, intramuscular, and oral to stop seizures. A study carried out in Kenya published in 2008 showed that administration of midazolam at the currently recommended dose (0.3 mg/kg) made it possible to quickly reach median maximum plasma concentrations of Midazolam between 64 and 616 ng/ml, with few clinically significant cardio-respiratory effects [36] . In this study, the authors report that a single dose of Midazolam terminated (within 10 minutes) seizures in all children (100%), 75% and 63% after IV, IM and buccal administration respectively. The Cochrane Database review in 2018 reported that the intravenous effectiveness of Midazolam was correlated with the time to obtain the venous line [5] . A formulation of oral Midazolam (BUCCOLAM^©) has obtained European Marketing Authorization. This molecule has proven equivalent or greater effectiveness than rectal diazepam without there being a greater risk [37] . This formulation will surely change our practices. In our series, midazolam was only used in three patients, and no patient received phenytoin, despite the fact that convulsive status epilepticus was observed in 25% of cases. The rarity of Phenytoin and the lack of possibility of intubating children in our context should push us towards the frequent use of Midazolam both in the periphery and in our reference health establishments. As for the etiological treatment, IV artesunate was the most used molecule in our series (95.33%), followed by antibiotic therapy based on Betalactamine (Ceftriaxone in particular). In 15% of cases, patients received an anti-malarial agent and a parenteral antibiotic concomitantly. This reflects the predominance of infectious causes in Sub-Saharan Africa and the insufficiency of the technical platform in our context, which does not allow certain examinations with etiological purposes to be carried out urgently.

Genetic and metabolic factors were not reported in this study due to insufficient technical resources and low purchasing power. The low socioeconomic level explains this low purchasing power. The implementation of universal health coverage could overcome this problem.

Convulsive seizures remain frequent in current pediatric practice in Congo. They can take various clinical forms, even if generalized seizures remain the most common. Most children presenting with a convulsive seizure had no particular pathological history. The etiologies are still dominated in our context by malaria, but febrile convulsions make up a large part of it. Symptomatic treatment is subject to discussion. However, benzodiazepines remain the first choice with the type and route of administration varying from one country to another. The management of convulsive seizures could be improved in our practice by the adequate use of anticonvulsants pre- and intra-hospital. Etiological treatment depends on the promptness and precision of paraclinical examinations.