<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">
    ijohns
   </journal-id>
   <journal-title-group>
    <journal-title>
     International Journal of Otolaryngology and Head &amp; Neck Surgery
    </journal-title>
   </journal-title-group>
   <issn pub-type="epub">
    2168-5452
   </issn>
   <issn publication-format="print">
    2168-5460
   </issn>
   <publisher>
    <publisher-name>
     Scientific Research Publishing
    </publisher-name>
   </publisher>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="doi">
    10.4236/ijohns.2025.142010
   </article-id>
   <article-id pub-id-type="publisher-id">
    ijohns-141207
   </article-id>
   <article-categories>
    <subj-group subj-group-type="heading">
     <subject>
      Articles
     </subject>
    </subj-group>
    <subj-group subj-group-type="Discipline-v2">
     <subject>
      Medicine 
     </subject>
     <subject>
       Healthcare
     </subject>
    </subj-group>
   </article-categories>
   <title-group>
    Management of Choanal Atresia: A Quarter-Century of Experience
   </title-group>
   <contrib-group>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Ciré
      </surname>
      <given-names>
       Ndiaye
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Barry Mamadou
      </surname>
      <given-names>
       Woury
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Pilor
      </surname>
      <given-names>
       Ndongo
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Mbaye
      </surname>
      <given-names>
       Aminata
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Ahmed
      </surname>
      <given-names>
       Houra
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Thiam Ndeye
      </surname>
      <given-names>
       Fatou
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Arame
      </surname>
      <given-names>
       Thiam
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Tall
      </surname>
      <given-names>
       Abdourahmane
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Ndiaye
      </surname>
      <given-names>
       Malick
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Diom Evelyne
      </surname>
      <given-names>
       Siga
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff3"> 
      <sup>3</sup>
     </xref>
    </contrib>
   </contrib-group> 
   <aff id="aff1">
    <addr-line>
     aDepartment of Otolaryngology-Head and Neck Surgery, National University Hospital of Fann, Dakar, Senegal
    </addr-line> 
   </aff> 
   <aff id="aff2">
    <addr-line>
     aDepartment of Otolaryngology-Head and Neck Surgery, Idrissa Pouye General Hospital, Dakar, Senegal
    </addr-line> 
   </aff> 
   <aff id="aff3">
    <addr-line>
     aDepartment of Otolaryngology-Head and Neck Surgery, La Paix Hospital, Ziguinchor, Senegal
    </addr-line> 
   </aff> 
   <pub-date pub-type="epub">
    <day>
     14
    </day> 
    <month>
     03
    </month>
    <year>
     2025
    </year>
   </pub-date> 
   <volume>
    14
   </volume> 
   <issue>
    02
   </issue>
   <fpage>
    89
   </fpage>
   <lpage>
    95
   </lpage>
   <history>
    <date date-type="received">
     <day>
      18,
     </day>
     <month>
      January
     </month>
     <year>
      2025
     </year>
    </date>
    <date date-type="published">
     <day>
      11,
     </day>
     <month>
      January
     </month>
     <year>
      2025
     </year> 
    </date> 
    <date date-type="accepted">
     <day>
      11,
     </day>
     <month>
      March
     </month>
     <year>
      2025
     </year> 
    </date>
   </history>
   <permissions>
    <copyright-statement>
     © Copyright 2014 by authors and Scientific Research Publishing Inc. 
    </copyright-statement>
    <copyright-year>
     2014
    </copyright-year>
    <license>
     <license-p>
      This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
     </license-p>
    </license>
   </permissions>
   <abstract>
    <b>Introduction</b>
    <b>: </b>Choanal atresia is characterized by the abnormal presence of obstructive tissue preventing communication between the nasal cavity and the nasopharynx. The aim of this study was to determine the epidemiological profile of patients and to evaluate the results of treatment. 
    <b>Materials and methods</b>: We conducted a retrospective descriptive study from January 1, 2000 to December 31, 2023. All patients treated for choanal atresia in the ENT department of the Fann University Hospital were included. All patients admitted to the department for respiratory distress related to choanal atresia were included in the study. Diagnosis was made on CT scan and endoscopic examination. Sociodemographic, clinical, radiological and therapeutic parameters were studied. 
    <b>Results</b>
    <b>: </b>During the study period, 37 cases were identified. The mean age was 1 year, with extremes ranging from 1 day to 14 years, and 91% of patients were less than 6 months old. The sex ratio was 1. Moderate respiratory distress was the most frequent circumstance of discovery. Bone atresia was found in 45.94% of cases. The success rate varied according to the surgical technique used. 
    <b>Conclusion</b>
    <b>:</b> Endoscopic treatment gives better results than blind divulsion. 
   </abstract>
   <kwd-group> 
    <kwd>
     Choanal Imperforation
    </kwd> 
    <kwd>
      Nasal Obstruction
    </kwd> 
    <kwd>
      Neonate
    </kwd> 
    <kwd>
      Endoscopy
    </kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <sec id="s1">
   <title>1. Introduction</title>
   <p>Choanal atresia is a rare birth defect of the nasal cavity characterized by the complete or partial obstruction of the choana <xref ref-type="bibr" rid="scirp.141207-1">
     [1]
    </xref>.</p>
   <p>Choanal atresia has been extensively studied in both pediatric and adult populations, with an incidence ranging between 1/5000 and 1/10,000 live births <xref ref-type="bibr" rid="scirp.141207-2">
     [2]
    </xref> <xref ref-type="bibr" rid="scirp.141207-3">
     [3]
    </xref>. It can be unilateral or bilateral. Previous studies reported that 90% of atresias were purely bony and 10% were purely membranous <xref ref-type="bibr" rid="scirp.141207-3">
     [3]
    </xref>. In more recent studies, some authors have reported that choanal atresia is mixed in 70% of cases and purely bony in 30% of cases <xref ref-type="bibr" rid="scirp.141207-4">
     [4]
    </xref>. Regardless of the feature, the treatment of atresia involves surgical resection of the stenosis. Our surgical approach has evolved over the years. For 12 years, we performed blind dilations followed by calibration. Since 2011, with the acquisition of endoscopic equipment, patients have been treated by endonasal endoscopic approach. This study aimed at investigating the clinical characteristics and the types of atresia, as well as to compare the anatomical outcomes between dilation and the endoscopic approach.</p>
  </sec><sec id="s2">
   <title>2. Materials and Methods</title>
   <p>We conducted a retrospective and descriptive study ranging from 1<sup>st</sup> January 2000 to 31<sup>st</sup> December 2023 at the Oto-Rhino-Laryngology Department of FANN Teaching Hospital in Dakar, Senegal. In this study, we included all patients who underwent a treatment for unilateral or bilateral choanal atresia.</p>
   <sec id="s2_1">
    <title>2.1. Diagnostic Criteria</title>
    <p>The diagnosis of atresia was suspected in the presence of congenital high airway obstruction.</p>
    <p>Given this clinical presentation, we performed either the mist test with a metal tongue depressor or the probe test, which involves inserting a small-caliber probe into the nasal cavities to detect an obstruction. CT scans were only performed in cases of suspected unilateral choanal atresia, which were less urgent than bilateral patterns. Since 2011, the endoscopy has been implemented in our practice. Therefore, we used endoscopes as diagnostic tools to visualize the atretic choana.</p>
   </sec>
   <sec id="s2_2">
    <title>2.2. Type of Surgery</title>
    <p>Before 2011, puncture-dilation of the atresia was the surgical technique used. Then, with endoscopy, we use endonasal endoscopic to perform the surgical approach. The surgery involved puncturing the atresia followed by dilation. We systematically performed resection of the posterior septum below the plane of the tail of the middle turbinates. After the surgery, we left an intubation tube size 3 in place as a calibration device. This device was removed 2 months later.</p>
   </sec>
   <sec id="s2_3">
    <title>2.3. Criteria for Surgery Assessment</title>
    <p>The success of the intervention was assessed:</p>
    <p>Sociodemographic, clinical, CT scan, and therapeutic data were collected. Data processing was performed using Microsoft Excel.</p>
   </sec>
  </sec><sec id="s3">
   <title>3. Results</title>
   <p>During our study period, 37 patients were consulted for choanal atresia. The mean age at the moment of diagnosis was 1 year, with extremes of 1 day and 14 years; 91% of the patients were less than 6 months. The sex ratio was 1.</p>
   <sec id="s3_1">
    <title>3.1. Circumstances of Discovery</title>
    <p>Respiratory distress was the only revealing sign. It was distributed as presented in <xref ref-type="fig" rid="fig1">
      Figure 1
     </xref>.</p>
    <fig id="fig1" position="float">
     <label>Figure 1</label>
     <caption>
      <title>Figure 1. Circumstances of discovery of choanal atresia.</title>
     </caption>
     <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/2461030-rId14.jpeg?20250314103338" />
    </fig>
   </sec>
   <sec id="s3_2">
    <title>3.2. Clinical Data</title>
    <table-wrap id="table1">
     <label>
      <xref ref-type="table" rid="table1">
       Table 1
      </xref></label>
     <caption>
      <title>
       <xref ref-type="bibr" rid="scirp.141207-"></xref>Table 1. Pathologies associated with choanal atresia.</title>
     </caption>
     <table class="MsoTableGrid custom-table" border="0" cellspacing="0" cellpadding="0"> 
      <tr> 
       <td class="custom-bottom-td custom-top-td acenter" width="54.76%"><p style="text-align:center">Pathologies associated</p></td> 
       <td class="custom-bottom-td custom-top-td acenter" width="45.24%"><p style="text-align:center">n</p></td> 
      </tr> 
      <tr> 
       <td class="custom-top-td aleft" width="54.76%"><p style="text-align:left">ankyloglossia</p></td> 
       <td class="custom-top-td acenter" width="45.24%"><p style="text-align:center">1</p></td> 
      </tr> 
      <tr> 
       <td class="aleft" width="54.76%"><p style="text-align:left">CHARGE syndrom</p></td> 
       <td class="acenter" width="45.24%"><p style="text-align:center">5</p></td> 
      </tr> 
      <tr> 
       <td class="aleft" width="54.76%"><p style="text-align:left">Crouzon syndrome</p></td> 
       <td class="acenter" width="45.24%"><p style="text-align:center">1</p></td> 
      </tr> 
      <tr> 
       <td class="aleft" width="54.76%"><p style="text-align:left">cranio-facial dysmorphy</p></td> 
       <td class="acenter" width="45.24%"><p style="text-align:center">1</p></td> 
      </tr> 
      <tr> 
       <td class="aleft" width="54.76%"><p style="text-align:left">Omphalocele</p></td> 
       <td class="acenter" width="45.24%"><p style="text-align:center">1</p></td> 
      </tr> 
      <tr> 
       <td class="custom-bottom-td aleft" width="54.76%"><p style="text-align:left">Heart defect</p></td> 
       <td class="custom-bottom-td acenter" width="45.24%"><p style="text-align:center">1</p></td> 
      </tr> 
     </table>
    </table-wrap>
    <p>Regarding the family history, 30.30% of patients had first-degree consanguinity. One case of familial atresia was found. This involved a family where the father had unilateral choanal atresia, as well as his two sons, while the daughter did not have choanal atresia. In 9 patients (24%), the atresia was associated with another pathology (<xref ref-type="table" rid="table1">
      Table 1
     </xref>).</p>
   </sec>
   <sec id="s3_3">
    <title>3.3. CT Scan Data</title>
    <p>CT scans of the facial bones were performed in 27% of patients. The atresia had the following characteristics: bony in 45.94%, mixed in 15%, and membranous in 39.06%. It was unilateral in 39% and bilateral in 61% of patients.</p>
   </sec>
   <sec id="s3_4">
    <title>3.4. Therapeutic Data</title>
    <p>Blind puncture alone or dilation of the stenosed choana was performed in 23 patients. Twelve (12) patients underwent endonasal endoscopic surgery and 2 patients had dilation followed by endoscopic surgery in two operative stages. All surgeries were followed by calibration for an average of 8 weeks. The immediate outcome was unremarkable in 97.29% of cases. Death occurred in one patient on day 1 postoperative. <xref ref-type="table" rid="table2">
      Table 2
     </xref> reports the results of each surgical technique after an average follow-up of one year.</p>
    <table-wrap id="table2">
     <label>
      <xref ref-type="table" rid="table2">
       Table 2
      </xref></label>
     <caption>
      <title>
       <xref ref-type="bibr" rid="scirp.141207-"></xref>Table 2. Results one year after treatment.</title>
     </caption>
     <table class="MsoTableGrid custom-table" border="0" cellspacing="0" cellpadding="0"> 
      <tr> 
       <td class="custom-bottom-td custom-top-td acenter" width="25.22%"><p style="text-align:center">Surgical technique</p></td> 
       <td class="custom-bottom-td custom-top-td acenter" width="15.74%"><p style="text-align:center">n</p></td> 
       <td class="custom-bottom-td custom-top-td acenter" width="29.09%"><p style="text-align:center">Success rate after 1 year (%)</p></td> 
       <td class="custom-bottom-td custom-top-td acenter" width="29.95%"><p style="text-align:center">Stenosis rate after 1 year (%)</p></td> 
      </tr> 
      <tr> 
       <td class="custom-top-td aleft" width="25.22%"><p style="text-align:left">Puncture-dilation</p></td> 
       <td class="custom-top-td acenter" width="15.74%"><p style="text-align:center">23</p></td> 
       <td class="custom-top-td acenter" width="29.09%"><p style="text-align:center">50</p></td> 
       <td class="custom-top-td acenter" width="29.95%"><p style="text-align:center">50</p></td> 
      </tr> 
      <tr> 
       <td class="aleft" width="25.22%"><p style="text-align:left">Endoscopic surgery</p></td> 
       <td class="acenter" width="15.74%"><p style="text-align:center">12</p></td> 
       <td class="acenter" width="29.09%"><p style="text-align:center">73</p></td> 
       <td class="acenter" width="29.95%"><p style="text-align:center">27</p></td> 
      </tr> 
      <tr> 
       <td class="custom-bottom-td aleft" width="25.22%"><p style="text-align:left">puncture-dilation + endoscopic surgery</p></td> 
       <td class="custom-bottom-td acenter" width="15.74%"><p style="text-align:center">2</p></td> 
       <td class="custom-bottom-td acenter" width="29.09%"><p style="text-align:center">100</p></td> 
       <td class="custom-bottom-td acenter" width="29.95%"><p style="text-align:center">0</p></td> 
      </tr> 
     </table>
    </table-wrap>
   </sec>
  </sec><sec id="s4">
   <title>4. Discussion</title>
   <p>The incidence of choanal atresia is estimated at 1 case per 5000 to 8000 live births <xref ref-type="bibr" rid="scirp.141207-5">
     [5]
    </xref>. However, the actual incidence might be slightly higher if we consider that some neonatal deaths due to asphyxia could be attributed to the unrecognized presence of this anomaly. This is especially true in our countries where the death of a newborn does not systematically lead to an autopsy. The 37 cases collected over 22 years probably do not reflect the reality. The average age of patients at the time of diagnosis varies from one series to another, ranging from 11 weeks to 10 years <xref ref-type="bibr" rid="scirp.141207-6">
     [6]
    </xref>-<xref ref-type="bibr" rid="scirp.141207-9">
     [9]
    </xref>. This wide variability is related to the inclusion criteria of study populations in different series. Indeed, the average age at diagnosis in predominantly pediatric series is earlier than in mixed series consisting of adults and children. Most authors report a predominance of atresia in females <xref ref-type="bibr" rid="scirp.141207-5">
     [5]
    </xref> <xref ref-type="bibr" rid="scirp.141207-7">
     [7]
    </xref> <xref ref-type="bibr" rid="scirp.141207-9">
     [9]
    </xref>-<xref ref-type="bibr" rid="scirp.141207-11">
     [11]
    </xref>. However, in our series, the sex ratio was 1, without any explanatory argument for this finding.</p>
   <p>Regarding laterality, the unilateral pattern is more common than the bilateral pattern in almost all studies <xref ref-type="bibr" rid="scirp.141207-6">
     [6]
    </xref>-<xref ref-type="bibr" rid="scirp.141207-11">
     [11]
    </xref>. However, in our series, bilateral atresia was more significantly found, representing 63.63% of cases. These results do not align with the literature, which can be explained by the fact that unilateral atresias are well tolerated and rarely motivate a consultation. Therefore, the diagnosis is often unrecognized, especially in our limited setting context and a lack of ORL specialists. It is often only considered in cases of neonatal respiratory distress, which constituted 78.79% of our circumstances of discovery. Concerning the diagnosis, CT scan plays a key role. It confirms choanal atresia, assesses its characteristics, nature, whether it is unilateral or bilateral, the extent of bony obstruction, its thickness, and the bony anomalies that constitute it (inclination of the pterygoid processes, thickening of the vomer). In 71% of cases, CT scan reveal mixed atresia, and it is purely bony in 29% <xref ref-type="bibr" rid="scirp.141207-12">
     [12]
    </xref> <xref ref-type="bibr" rid="scirp.141207-13">
     [13]
    </xref>. Knowing whether the atresia is bony or mixed helps plan the surgery and anticipate potential difficulties <xref ref-type="bibr" rid="scirp.141207-14">
     [14]
    </xref>. CT scan was performed in only 27% of cases due to its high cost, the urgency of the situation, and the difficulty of anesthesia in newborns during the procedure. This imaging approach helps rule out a cephalocele or congenital hypertrophy of the inferior turbinates and identify other associated bony anomalies.</p>
   <p>Congenital anomalies are associated with choanal atresia in 50% of cases, with CHARGE syndrome being the most common anomaly <xref ref-type="bibr" rid="scirp.141207-15">
     [15]
    </xref>-<xref ref-type="bibr" rid="scirp.141207-17">
     [17]
    </xref>. In our series, congenital anomalies were found in 24% of patients. As in the literature, CHARGE syndrome accounted for nearly half of the cases.</p>
   <p>The reference treatment for choanal atresia is endonasal endoscopic surgery <xref ref-type="bibr" rid="scirp.141207-18">
     [18]
    </xref>-<xref ref-type="bibr" rid="scirp.141207-20">
     [20]
    </xref>. The endoscopic approach offers the advantage of good visualization and allows for extensive resection. It is a short-duration and low-morbidity intervention that can be proposed at birth for bilateral choanal atresias, whether mixed or bony. This surgical technique was introduced into our practice in 2011. Before this date, our patients underwent blind dilation of the stenosed choana. With this blind dilation technique, the postoperative stenosis rate was 50%. Compared to the literature, the endoscopic technique gave better results with good choanal patency in 73% of cases. Dumaz et al. reported a success rate of 85.3% in a total of 238 operated patients <xref ref-type="bibr" rid="scirp.141207-20">
     [20]
    </xref>. I Achour et al. found a rate of 76.2% after the first surgery and 95% after surgical revision <xref ref-type="bibr" rid="scirp.141207-21">
     [21]
    </xref>. Despite these good results, endonasal endoscopic surgery is difficult in newborns. This difficulty is related to the narrowness of the nasal cavities, which makes it difficult to pass the endoscope and instruments. Sometimes, we use otological instruments in the absence of pediatric endonasal instrumentation. Besides instrumental and anatomical constraints, there are difficulties with anesthesia in newborns in this emergency context.</p>
  </sec><sec id="s5">
   <title>5. Conclusion</title>
   <p>Endonasal endoscopic surgery has revolutionized the surgical management of choanal atresia. It represents the treatment of choice and yields better results than blind dilation. There is no consensus on the use of calibration devices or the application of topical agents at the site of the reopened choana. However, extensive resection of the stenosis reduces the risk of recurrence.</p>
  </sec><sec id="s6">
   <title>Informed Consent</title>
   <p>Informed consent was obtained from the patient to report this case.</p>
  </sec>
 </body><back>
  <ref-list>
   <title>References</title>
   <ref id="scirp.141207-ref1">
    <label>1</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Anajar, S., Hassnaoui, J., Rouadi, S. and Abada, R. (2017) A Rare Case Report of Bilateral Choanal Atresia in an Adult. International Journal of Surgery Case Reports, 37, 127-129. &gt;https://doi.org/10.1016/j.ijscr.2017.05.002 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref2">
    <label>2</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Moreddu, E., Rizzib, M., Adilc, E., Balakrishnand, K., Chane, K. and Chengf, A. (2019) International Pediatric Otolaryngology Group (IPOG) Consensus Recommendations: Diagnosis, Pre-Operative, Operative and Post-Operative Pediatric Choanal Atresia Care. International Journal of Pediatric Otorhinolaryngology, 123, 151-155. &gt;https://doi.org/10.1016/j.ijporl.2019.05.010 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref3">
    <label>3</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Holtmann, L., Stähr, K., Kirchner, J., Lang, S. and Mattheis, S. (2018) Endonasal Endoscopic Surgery of Choanal Atresia-Long Term Results. Laryngorhinootologie, 97, 264-268. 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref4">
    <label>4</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Lesciotto, K.M., Heuzé, Y., Jabs, E.W., Bernstein, J.M. and Richtsmeier, J.T. (2018) Choanal Atresia and Craniosynostosis: Development and Disease. Plastic and Reconstructive Surgery, 141, 156-168. &gt;https://doi.org/10.1097/PRS.0000000000003928 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref5">
    <label>5</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Andaloro, C. and La Mantia, I. (2024) Choanal Atresia. StatPearls Publishing.
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref6">
    <label>6</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Khamassi, K., Selmi, Z., Stambouli, I., Lahiani, R., Harzallah, M., Nejah, D., Ben Salah, M., Kaffel, N. and Ferjaoui, M. (2011) Prise en Charge de l’atrésie Choanale. Journal Tunisien d’ORL et de Chirurgie Cervico-Faciale, 26, 24-27.
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref7">
    <label>7</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Hajri, H., Mannoubi, S., Mathlouthi, N., Kaffel, N., Marrakchi, M., Kooli, H., and Ferjaoui, M. (2006) Imperforation Choanale Aspects Cliniques, Approache Therapeutique. Journal Tunisien d’ORL et de Chirurgie Cervico-Faciale, 17, 30-34. &gt;https://doi.org/10.4314/jtdorl.v17i1.42072 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref8">
    <label>8</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Bohimbo, J.E., Ngaba Mballa, O.N., Atanga, L., Fokouo, V. and Ndjolo, A. (2018) L’atrésie choanale congénitale à l’hopital central de yaoundé: A Propos de six cas. Health Sciences and Diseases, 19, 123-125.
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref9">
    <label>9</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     El Korbi, A., Dgani, I., Ferjaoui, M., Cebil, E., Kolsi, N., Bouattay, R., Harrathi, K. and Koubaa, J. (2022) Résultats de la chirurgie endonasale de l’atrésie choanale: Facteurs influençant le resténose. Société Tunisienne d’ORL et de Chirurgie Cervico-Faciale, 48, 74-78.
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref10">
    <label>10</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Moreddu, E., Nicollas, R., Le Treut-Gay, C., Farinetti, A. and Triglia, J. (2014) Prise en charge chirurgicale des Atrésies choanales: 30 ans d’expérience. Annales Françaises d’oto-Rhino-Laryngologie et de Pathologie Cervico-Faciale, 131, A64. &gt;https://doi.org/10.1016/j.aforl.2014.07.174 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref11">
    <label>11</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Bajin, M.D., et al. (2021) Endonasal Choanal Atresia Repair; Evaluating the Surgical Results of 58 Cases. The Turkish Journal of Pediatrics, 63, 136-140.&gt;https://doi.org/10.24953/turkjped.2021.01.016 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref12">
    <label>12</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Brown, O.E., Pownell, P. and Manning, S.C. (1996) Choanal Atresia: A New Anatomic Classification and Clinical Management Applications. The Laryngoscope, 106, 97-101. &gt;https://doi.org/10.1097/00005537-199601000-00019 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref13">
    <label>13</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Brown, O.E., Smith, T., Armstrong, E. and Grundfast, K. (1986) The Evaluation of Choanal Atresia by Computed Tomography. International Journal of Pediatric Otorhinolaryngology, 12, 85-98. &gt;https://doi.org/10.1016/S0165-5876(86)80061-1 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref14">
    <label>14</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Messineo, D., Chernikava, M., Pasquali, V., Bertin, S., Ciotti, M., de Soccio, G., Savastano, V. and Catalano, C. (2021) Radiological Parameters Review for Choanal Atresia. Pediatric Reports, 13, 302-311. &gt;https://doi.org/10.3390/pediatric13020038 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref15">
    <label>15</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Hengerer, A.S., Brickman, T.M. and Jeyakumar, A. (2008) Choanal Atresia: Embryologic Analysis and Evolution of Treatment, a 30-Year Experience. The Laryngoscope, 118, 862-866. &gt;https://doi.org/10.1097/MLG.0b013e3181639b91 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref16">
    <label>16</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Keller, J.L. and Kacker, A. (2000) Choanal Atresia, Charge Association, and Congenital Nasal Stenosis. Otolaryngologic Clinics of North America, 33, 1343-1351. &gt;https://doi.org/10.1016/S0030-6665(05)70285-1 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref17">
    <label>17</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Zainine, R., Sahtout, S., El Aoud, C., Sellami, M., Trabelsi, S., Tabebi, S., Beltaief, N. and Besbes, G. (2013) Atrésie choanale: A propos de 29 cas. Société Tunisienne d’ORL et de Chirurgie Cervico-Faciale, 26, 19-23.
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref18">
    <label>18</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Kwong, K.M. (2015) Current Updates on Choanal Atresia. Frontiers in Pediatrics, 3, Article 52. &gt;https://doi.org/10.3389/fped.2015.00052 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref19">
    <label>19</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Moreddu, E., Rossi, M.E., Nicollas, R. and Triglia, J.M. (2019) Prognostic Factors and Management of Patients with Choanal Atresia. The Journal of Pediatrics, 204, 234-239. &gt;https://doi.org/10.1016/j.jpeds.2018.08.074 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref20">
    <label>20</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Durmaz, A., Tosun, F., Yildirim, N., Sahan, M., Kivrakdal, C. and Gerek, M. (2008) Transnasal Endoscopic Repair of Choanal Atresia: Results of 13 Cases and Meta-Analysis. Journal of Craniofacial Surgery, 19, 1270-1274. &gt;https://doi.org/10.1097/SCS.0b013e3181843564 
    </mixed-citation>
   </ref>
   <ref id="scirp.141207-ref21">
    <label>21</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Achour, I., Kharrat, M., Ben Ayed, W. and Thabet, W. (2023) Atrésie des choanes: Diagnostic et prise en charge thérapeutique. Société Tunisienne d’ORL et de Chirurgie Cervico-Faciale, 49, 33-38.
    </mixed-citation>
   </ref>
  </ref-list>
 </back>
</article>