<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">
    ojrad
   </journal-id>
   <journal-title-group>
    <journal-title>
     Open Journal of Radiology
    </journal-title>
   </journal-title-group>
   <issn pub-type="epub">
    2164-3024
   </issn>
   <issn publication-format="print">
    2164-3032
   </issn>
   <publisher>
    <publisher-name>
     Scientific Research Publishing
    </publisher-name>
   </publisher>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="doi">
    10.4236/ojrad.2024.144017
   </article-id>
   <article-id pub-id-type="publisher-id">
    ojrad-138148
   </article-id>
   <article-categories>
    <subj-group subj-group-type="heading">
     <subject>
      Articles
     </subject>
    </subj-group>
    <subj-group subj-group-type="Discipline-v2">
     <subject>
      Physics 
     </subject>
     <subject>
       Mathematics
     </subject>
    </subj-group>
   </article-categories>
   <title-group>
    Post-Surgical Chest and Neck Radiographs to Confirm the Successful Placement of the Inspire Implant for Obstructive Sleep Apnea: A Case Report
   </title-group>
   <contrib-group>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Alice
      </surname>
      <given-names>
       Barrington
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Gabriel
      </surname>
      <given-names>
       Rashba
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Eshwar
      </surname>
      <given-names>
       Karupakula
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Amirmasoud
      </surname>
      <given-names>
       Negarestani
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Hongmin
      </surname>
      <given-names>
       Xu
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Emad
      </surname>
      <given-names>
       Allam
      </given-names>
     </name>
    </contrib>
   </contrib-group> 
   <aff id="affnull">
    <addr-line>
     aDepartment of Radiology and Medical Imaging, Loyola University Chicago and Loyola University Medical Center, Chicago, Illinois, USA
    </addr-line> 
   </aff> 
   <pub-date pub-type="epub">
    <day>
     13
    </day> 
    <month>
     12
    </month>
    <year>
     2024
    </year>
   </pub-date> 
   <volume>
    14
   </volume> 
   <issue>
    04
   </issue>
   <fpage>
    167
   </fpage>
   <lpage>
    172
   </lpage>
   <history>
    <date date-type="received">
     <day>
      31,
     </day>
     <month>
      October
     </month>
     <year>
      2024
     </year>
    </date>
    <date date-type="published">
     <day>
      10,
     </day>
     <month>
      October
     </month>
     <year>
      2024
     </year> 
    </date> 
    <date date-type="accepted">
     <day>
      10,
     </day>
     <month>
      December
     </month>
     <year>
      2024
     </year> 
    </date>
   </history>
   <permissions>
    <copyright-statement>
     © Copyright 2014 by authors and Scientific Research Publishing Inc. 
    </copyright-statement>
    <copyright-year>
     2014
    </copyright-year>
    <license>
     <license-p>
      This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
     </license-p>
    </license>
   </permissions>
   <abstract>
    Obstructive sleep apnea (OSA) is a prevalent condition marked by repetitive pharyngeal collapse during sleep, often treated with continuous positive airway pressure (CPAP). However, CPAP compliance remains suboptimal, leading to alternative treatments like the Inspire implant, which stimulates the hypoglossal nerve to maintain airway patency. This case report discusses a 75-year-old male with OSA and CPAP intolerance, successfully treated with the Inspire implant. Postoperative imaging confirmed the proper placement of the device, and the patient reported significant improvements in symptoms. This case highlights the expected radiographic findings of the device.
   </abstract>
   <kwd-group> 
    <kwd>
     Inspire Implant
    </kwd> 
    <kwd>
      Obstructive Sleep Apnea
    </kwd> 
    <kwd>
      OSA
    </kwd> 
    <kwd>
      Continuous Positive Airway Pressure
    </kwd> 
    <kwd>
      CPAP
    </kwd> 
    <kwd>
      Radiography
    </kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <sec id="s1">
   <title>1. Introduction</title>
   <p>Obstructive sleep apnea (OSA) is an increasingly common disorder that is characterized by the pharynx closing repetitively while sleeping. The most common treatment is continuous positive airway pressure (CPAP), which prevents pharyngeal collapse <xref ref-type="bibr" rid="scirp.138148-1">
     [1]
    </xref> <xref ref-type="bibr" rid="scirp.138148-2">
     [2]
    </xref>. However, patient compliance is reported to only be about 60% - 70%, sometimes due to nasal difficulties <xref ref-type="bibr" rid="scirp.138148-2">
     [2]
    </xref>. For patients who are experiencing CPAP noncompliance, nerve stimulation is an innovative surgery that can provide OSA relief <xref ref-type="bibr" rid="scirp.138148-1">
     [1]
    </xref>. Patients can undergo implantation of the device, followed by polysomnography for titration of therapy settings. The implanted device provides electrical stimulation to the hypoglossal nerve, which results in forward displacement of the tongue and enlarges the velopharyngeal area to keep the upper airway patent <xref ref-type="bibr" rid="scirp.138148-3">
     [3]
    </xref> <xref ref-type="bibr" rid="scirp.138148-4">
     [4]
    </xref>. Typically, the implant is placed in the right anterior chest wall to account for any future cardiac implantable electronic devices and to reduce confounding signal noise from the cardiac system into the respiratory pressure sensor <xref ref-type="bibr" rid="scirp.138148-5">
     [5]
    </xref>.</p>
   <p>The Inspire implant can be radiographically evaluated post-surgically by the presence of the device in the chest wall along with the identification of the leads <xref ref-type="bibr" rid="scirp.138148-6">
     [6]
    </xref>. One lead extends towards the base of the tongue and the other is present on the chest wall to monitor respirations. There are three implantable devices available, with the Inspire Medical System being the only one currently approved the Food and Drug Administration (FDA) in the USA.</p>
  </sec><sec id="s2">
   <title>2. Clinical History</title>
   <p>A 75-year-old man with essential hypertension, type 2 diabetes, and OSA presented to otolaryngology with an inability to tolerate CPAP. His hypertension was well-controlled with amlodipine and captopril. The most recent sleep study demonstrated an apnea-hypopnea index (AHI) of 39.5 events per hour with desaturations down to 71%, which increased to 67.1 events per hour in the supine position. The patient underwent drug-induced sleep endoscopy, demonstrating 80% collapse of the velopharynx, indicating that the patient was a good candidate for Inspire device implant. The Inspire implant was placed using a two-incision approach without complication. On subsequent follow-up clinic visits, the patient reported improvement in daytime hypersomnolence, energy level, and snoring. Repeat AHI 3 months after device placement was scored at 18.7 events per hour with desaturations down to 73%, which increased to 31.8 events per hour in the supine position.</p>
  </sec><sec id="s3">
   <title>3. Imaging Findings</title>
   <fig-group id="fig1" position="float">
    <fig id="fig1" position="float">
     <label>Figure 1</label>
     <caption>
      <title>(a)--(b)--Figure 1. (a), (b): PA and lateral chest radiographs show a right anterior chest wall Inspire implant with leads superimposing the right chest and right submandibular region. Mild bibasilar atelectasis is noted.</title>
     </caption>
     <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/1780691-rId14.jpeg?20241213031932" />
    </fig>
    <fig id="fig1" position="float">
     <label>Figure 1</label>
     <caption>
      <title>(a)--(b)--Figure 1. (a), (b): PA and lateral chest radiographs show a right anterior chest wall Inspire implant with leads superimposing the right chest and right submandibular region. Mild bibasilar atelectasis is noted.</title>
     </caption>
     <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/1780691-rId15.jpeg?20241213031932" />
    </fig>
   </fig-group>
   <fig-group id="fig2" position="float">
    <fig id="fig2" position="float">
     <label>Figure 2</label>
     <caption>
      <title>(a)--(b)--Figure 2. (a), (b): AP and lateral neck radiographs confirm the stimulator in the right submandibular region. There is no focal soft tissue swelling or abnormal gas collection. Tubing from an overlying nasal cannula is present. Multilevel cervical spondylosis is noted. Several teeth are absent.</title>
     </caption>
     <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/1780691-rId16.jpeg?20241213031932" />
    </fig>
    <fig id="fig2" position="float">
     <label>Figure 2</label>
     <caption>
      <title>(a)--(b)--Figure 2. (a), (b): AP and lateral neck radiographs confirm the stimulator in the right submandibular region. There is no focal soft tissue swelling or abnormal gas collection. Tubing from an overlying nasal cannula is present. Multilevel cervical spondylosis is noted. Several teeth are absent.</title>
     </caption>
     <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/1780691-rId17.jpeg?20241213031932" />
    </fig>
   </fig-group>
   <p>Post-surgery chest radiographs revealed a right anterior chest wall Inspire implant with leads superimposing the right chest and right submandibular region. The impulse generator was similar in size and appearance to a cardiac pacemaker (<xref ref-type="fig" rid="fig1">
     Figure 1
    </xref>). Mild right hemidiaphragm elevation was chronic and similar to prior radiographs. Neck soft tissue radiographs confirmed the stimulator was in the right submandibular region. There was no focal soft tissue swelling or abnormal gas collection (<xref ref-type="fig" rid="fig2">
     Figure 2
    </xref>). The device was not flipped and the leads were not excessively stretched <xref ref-type="bibr" rid="scirp.138148-6">
     [6]
    </xref>.</p>
  </sec><sec id="s4">
   <title>4. Discussion</title>
   <p>Soft tissue neck radiographs play a pivotal role in identifying the structural factors contributing to OSA. These radiographs can reveal key findings such as retrognathia (backward positioning of the lower jaw), micrognathia (an abnormally small jaw), or a narrow posterior air space. The success of the Inspire implant is closely tied to each patient’s unique anatomy. If the genioglossus muscle is suitably positioned, the implant is more likely to yield positive outcomes <xref ref-type="bibr" rid="scirp.138148-7">
     [7]
    </xref>.</p>
   <p>Chest and neck radiographs are convenient examinations that can reveal post-surgical information about the implant, especially its position and complications. Clinical trials have revealed that adverse events associated with implants are stimulation related discomfort, device related discomfort, insomnia, and tongue abrasion <xref ref-type="bibr" rid="scirp.138148-8">
     [8]
    </xref>. Chest and neck radiographs can provide important information on correct placement of the device and leads which can reduce treatment failure and delayed surgical revisions.</p>
   <p>The integration of radiological assessments with clinical examinations enhances the precision and efficacy of the Inspire implant therapy for patients suffering from OSA, offering a novel avenue for improved quality of life and sleep health. A drawback of post-surgical radiographs is the lack of information about changes in tongue protrusion/fatiguability, which has been a reported short-term complication in Inspire implants. However, literature suggests that tongue fatiguability is not a concern in long-term treatment <xref ref-type="bibr" rid="scirp.138148-9">
     [9]
    </xref> <xref ref-type="bibr" rid="scirp.138148-10">
     [10]
    </xref>.</p>
  </sec><sec id="s5">
   <title>5. Conclusion</title>
   <p>This case demonstrates the successful use of the Inspire device in a patient with significant CPAP intolerance, resulting in improved sleep and reduced symptoms. Radiographic imaging plays an important role in confirming device placement and ensuring the absence of complications. The integration of clinical and radiological evaluations is essential for optimizing outcomes in OSA treatment as illustrated in this case report.</p>
  </sec>
 </body><back>
  <ref-list>
   <title>References</title>
   <ref id="scirp.138148-ref1">
    <label>1</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Sommer, J.U. and Hörmann, K. (2017) Innovative Surgery for Obstructive Sleep Apnea: Nerve Stimulator. In: Lin, H.-C., Ed., Advances in Oto-Rhino-Laryngology, S. Karger AG, 116-124. &gt;https://doi.org/10.1159/000470880
    </mixed-citation>
   </ref>
   <ref id="scirp.138148-ref2">
    <label>2</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Jordan, A.S., McSharry, D.G. and Malhotra, A. (2014) Adult Obstructive Sleep Apnoea. The Lancet, 383, 736-747. &gt;https://doi.org/10.1016/s0140-6736(13)60734-5
    </mixed-citation>
   </ref>
   <ref id="scirp.138148-ref3">
    <label>3</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Mashaqi, S., Patel, S.I., Combs, D., Estep, L., Helmick, S., Machamer, J., et al. (2021) The Hypoglossal Nerve Stimulation as a Novel Therapy for Treating Obstructive Sleep Apnea—A Literature Review. International Journal of Environmental Research and Public Health, 18, Article 1642. &gt;https://doi.org/10.3390/ijerph18041642
    </mixed-citation>
   </ref>
   <ref id="scirp.138148-ref4">
    <label>4</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Yamauchi, M., Satoh, M., Kitahara, T., Ota, I. and Strohl, K. (2020) Nerve Stimulation for the Treatment of Obstructive Sleep Apnea. Sleep and Biological Rhythms, 18, 77-87. &gt;https://doi.org/10.1007/s41105-020-00252-2
    </mixed-citation>
   </ref>
   <ref id="scirp.138148-ref5">
    <label>5</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Lin, C., Olson, M.D., Huyett, P. and Chio, E.G. (2022) Implantation of the Hypoglossal Nerve Stimulator via Left-Sided, 2-Incision Approach. Journal of Clinical Sleep Medicine, 18, 1219-1222. &gt;https://doi.org/10.5664/jcsm.9856
    </mixed-citation>
   </ref>
   <ref id="scirp.138148-ref6">
    <label>6</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Tabatabai, G.M., Karempelis, P. and Hsia, J.C. (2018) Hypoglossal Nerve Stimulator Generator Migration: INSPIRE Device Reimplantation with Parallels to Cardiac Implantable Electronic Devices. American Journal of Otolaryngology, 39, 639-641. &gt;https://doi.org/10.1016/j.amjoto.2018.06.011
    </mixed-citation>
   </ref>
   <ref id="scirp.138148-ref7">
    <label>7</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Wray, C.M. and Thaler, E.R. (2016) Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea: A Review of the Literature. World Journal of Otorhinolaryngology-Head and Neck Surgery, 2, 230-233. &gt;https://doi.org/10.1016/j.wjorl.2016.11.005
    </mixed-citation>
   </ref>
   <ref id="scirp.138148-ref8">
    <label>8</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Thaler, E., Schwab, R., Maurer, J., Soose, R., Larsen, C., Stevens, S., et al. (2019) Results of the ADHERE Upper Airway Stimulation Registry and Predictors of Therapy Efficacy. The Laryngoscope, 130, 1333-1338. &gt;https://doi.org/10.1002/lary.28286
    </mixed-citation>
   </ref>
   <ref id="scirp.138148-ref9">
    <label>9</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Wirth, M., Unterhuber, D., von Meyer, F., Hofauer, B., Ott, A., Edenharter, G., et al. (2020) Hypoglossal Nerve Stimulation Therapy Does Not Alter Tongue Protrusion Strength and Fatigability in Obstructive Sleep Apnea. Journal of Clinical Sleep Medicine, 16, 285-292. &gt;https://doi.org/10.5664/jcsm.8184
    </mixed-citation>
   </ref>
   <ref id="scirp.138148-ref10">
    <label>10</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Strollo, P.J., Gillespie, M.B., Soose, R.J., Maurer, J.T., de Vries, N., Cornelius, J., et al. (2015) Upper Airway Stimulation for Obstructive Sleep Apnea: Durability of the Treatment Effect at 18 Months. Sleep, 38, 1593-1598. &gt;https://doi.org/10.5665/sleep.5054
    </mixed-citation>
   </ref>
  </ref-list>
 </back>
</article>