<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">
    ojog
   </journal-id>
   <journal-title-group>
    <journal-title>
     Open Journal of Obstetrics and Gynecology
    </journal-title>
   </journal-title-group>
   <issn pub-type="epub">
    2160-8792
   </issn>
   <issn publication-format="print">
    2160-8806
   </issn>
   <publisher>
    <publisher-name>
     Scientific Research Publishing
    </publisher-name>
   </publisher>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="doi">
    10.4236/ojog.2024.1411142
   </article-id>
   <article-id pub-id-type="publisher-id">
    ojog-137663
   </article-id>
   <article-categories>
    <subj-group subj-group-type="heading">
     <subject>
      Articles
     </subject>
    </subj-group>
    <subj-group subj-group-type="Discipline-v2">
     <subject>
      Medicine 
     </subject>
     <subject>
       Healthcare
     </subject>
    </subj-group>
   </article-categories>
   <title-group>
    Contraception among Women Aged 35 and over at the University Hospital Center of Brazzaville
   </title-group>
   <contrib-group>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Mpia Nuelly Samantha Bialay
      </surname>
      <given-names>
       Potokoué
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Gauthier Régis Jostin
      </surname>
      <given-names>
       Buambo
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Jean Timothée
      </surname>
      <given-names>
       Ekani
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Max Lévy Emery
      </surname>
      <given-names>
       Eouani
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Jules César
      </surname>
      <given-names>
       Mokoko
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Clautaire
      </surname>
      <given-names>
       Itoua
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Léon
      </surname>
      <given-names>
       HervéIloki
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
   </contrib-group> 
   <aff id="aff1">
    <addr-line>
     aDepartment of Gynecology and Obstetrics UHC of Brazzaville, Brazzaville, Republic of the Congo
    </addr-line> 
   </aff> 
   <aff id="aff2">
    <addr-line>
     aDepartment of Gynecology and Obstetrics, Loandjili General Hospital, Pointe Noire, Republic of the Congo
    </addr-line> 
   </aff> 
   <pub-date pub-type="epub">
    <day>
     30
    </day> 
    <month>
     10
    </month>
    <year>
     2024
    </year>
   </pub-date> 
   <volume>
    14
   </volume> 
   <issue>
    11
   </issue>
   <fpage>
    1716
   </fpage>
   <lpage>
    1725
   </lpage>
   <history>
    <date date-type="received">
     <day>
      25,
     </day>
     <month>
      February
     </month>
     <year>
      2024
     </year>
    </date>
    <date date-type="published">
     <day>
      24,
     </day>
     <month>
      February
     </month>
     <year>
      2024
     </year> 
    </date> 
    <date date-type="accepted">
     <day>
      24,
     </day>
     <month>
      November
     </month>
     <year>
      2024
     </year> 
    </date>
   </history>
   <permissions>
    <copyright-statement>
     © Copyright 2014 by authors and Scientific Research Publishing Inc. 
    </copyright-statement>
    <copyright-year>
     2014
    </copyright-year>
    <license>
     <license-p>
      This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
     </license-p>
    </license>
   </permissions>
   <abstract>
    <b>Objective</b>
    <b>:</b> To study contraception among women aged 35 and over at the University Hospital of Brazzaville. 
    <b>Population and </b>
    <b>Methods</b>
    <b>:</b> This was a retrospective descriptive study, conducted from April 1st 2017 to January 31st 2022 in the Obstetrics and Gynecology Department of the University Hospital of Brazzaville, including women aged 35 years and over who had received a contraceptive method. The study variables were sociodemographic, reproductive, clinical and contraceptive method related. 
    <b>Results</b>
    <b>:</b> Two hundred and thirty customers were collected during the study period, i.e., 10.8% of the patients who received contraception. They were 38.4 ± 3 years old on average, had secondary education (46.1%), were of low socioeconomic status (54.3%), lived with a partner (98.7%) and came from an urban area (97.4%). They were multigravida (85.2%), and multiparous (63.9%) with an average of 4 living children. The indications were of two types: convenience (26.2%) and medical (73.8%). The most commonly used contraceptives were implants (72.2%) and injectable progestin (20.5%). 
    <b>Conclusion</b>
    <b>:</b> The indication for contraception for women over 35 years of age at the University Hospital Center of Brazzaville is more medical, with the use of long-acting contraceptives.
   </abstract>
   <kwd-group> 
    <kwd>
     Contraception
    </kwd> 
    <kwd>
      Women Aged 35 and over
    </kwd> 
    <kwd>
      Brazzaville
    </kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <sec id="s1">
   <title>1. Introduction</title>
   <p>Contraception is one of the planning methods that helps prevent pregnancy <xref ref-type="bibr" rid="scirp.137663-1">
     [1]
    </xref>. Thus, its use allows for the spacing of births and the reduction of unwanted pregnancies, which are sources of clandestine abortions and maternal mortality <xref ref-type="bibr" rid="scirp.137663-2">
     [2]
    </xref>.</p>
   <p>After the age of 35, the possibility of pregnancy remains and its occurrence is considered risky both for the mother, who is exposed to several chronic diseases (hypertension, diabetes, obesity, thromboembolic diseases), and for the fetus (malformation risk) <xref ref-type="bibr" rid="scirp.137663-3">
     [3]
    </xref>.</p>
   <p>Therefore, from this age onwards, contraception should be specific, taking into account the risks of degenerative pathologies.</p>
   <p>With this in mind, this study set out to study contraception among women aged 35 and over at the University Hospital Center of Brazzaville (UHC-B).</p>
  </sec><sec id="s2">
   <title>2. Population and Methods</title>
   <p>This was a retrospective descriptive study conducted from April 1st, 2017 to January 3<sup>st</sup>, 2022 at the University Hospital of Brazzaville. Customers aged 35 years and older who had received contraceptive methods were included. Customers aged 35 years and older who started the current contraceptive method before that age were not included. The database was performed using Microsoft Excel version 2010. Stata 13.1.0 software was used for statistical analysis. Our results were represented as proportions for qualitative variables, and as mean and median for quantitative variables.</p>
  </sec><sec id="s3">
   <title>3. Results</title>
   <p>During the study period, we recorded 230 women aged 35 or over among the 2119 who received contraception at the University Hospital Center of Brazzaville, i.e. 10.8%.</p>
   <p>The average age was 38 years. The 35 - 39 age group was the most represented. These women were all educated. Primary and secondary education levels represented more than 80%. As for marital status, they were in a couple in 98.7% of cases (<xref ref-type="table" rid="table1">
     Table 1
    </xref>).</p>
   <table-wrap id="table1">
    <label>
     <xref ref-type="table" rid="table1">
      Table 1
     </xref></label>
    <caption>
     <title>
      <xref ref-type="bibr" rid="scirp.137663-"></xref>Table 1. Sociodemographic characteristics of women aged 35 years and over who received contraception from April 1st, 2017 to January 31st, 2022.</title>
    </caption>
    <table class="MsoTableGrid custom-table" border="0" cellspacing="0" cellpadding="0"> 
     <tr> 
      <td class="custom-bottom-td acenter" width="43.10%"><p style="text-align:center"></p></td> 
      <td class="custom-bottom-td acenter" width="28.45%"><p style="text-align:center">N</p></td> 
      <td class="custom-bottom-td acenter" width="28.45%"><p style="text-align:center">%</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="43.10%"><p style="text-align:center">Age (years)</p></td> 
      <td class="custom-top-td acenter" width="28.45%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="28.45%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="43.10%"><p style="text-align:center">[35 - 39]</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">156</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">67.8</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="43.10%"><p style="text-align:center">[40 - 44]</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">63</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">27.4</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="43.10%"><p style="text-align:center">[45 - 49]</p></td> 
      <td class="custom-bottom-td acenter" width="28.45%"><p style="text-align:center">11</p></td> 
      <td class="custom-bottom-td acenter" width="28.45%"><p style="text-align:center">4.8</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="43.10%"><p style="text-align:center">Level of education</p></td> 
      <td class="custom-top-td acenter" width="28.45%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="28.45%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="43.10%"><p style="text-align:center">Primary</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">96</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">41.7</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="43.10%"><p style="text-align:center">Secondary</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">106</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">46.1</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="43.10%"><p style="text-align:center">Superior</p></td> 
      <td class="custom-bottom-td acenter" width="28.45%"><p style="text-align:center">28</p></td> 
      <td class="custom-bottom-td acenter" width="28.45%"><p style="text-align:center">12.2</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="43.10%"><p style="text-align:center">Socio-economic level</p></td> 
      <td class="custom-top-td acenter" width="28.45%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="28.45%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="43.10%"><p style="text-align:center">Bottom</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">125</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">54.3</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="43.10%"><p style="text-align:center">Top</p></td> 
      <td class="custom-bottom-td acenter" width="28.45%"><p style="text-align:center">105</p></td> 
      <td class="custom-bottom-td acenter" width="28.45%"><p style="text-align:center">45.7</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="43.10%"><p style="text-align:center">Marital status</p></td> 
      <td class="custom-top-td acenter" width="28.45%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="28.45%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="43.10%"><p style="text-align:center">Single</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">3</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">1.3</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="43.10%"><p style="text-align:center">In couple</p></td> 
      <td class="custom-bottom-td acenter" width="28.45%"><p style="text-align:center">227</p></td> 
      <td class="custom-bottom-td acenter" width="28.45%"><p style="text-align:center">98.7</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="43.10%"><p style="text-align:center">Provenance</p></td> 
      <td class="custom-top-td acenter" width="28.45%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="28.45%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="43.10%"><p style="text-align:center">Rural</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">6</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">2.6</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="43.10%"><p style="text-align:center">Urban</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">224</p></td> 
      <td class="acenter" width="28.45%"><p style="text-align:center">97.4</p></td> 
     </tr> 
    </table>
   </table-wrap>
   <p>Regarding the reproductive characteristics, 85% of the women were multigravida and 63.9% were multiparous. They had at least 4 children in 60% of cases. The mode of delivery was caesarean section in 46% of cases and vaginal delivery in 54% of cases (<xref ref-type="table" rid="table2">
     Table 2
    </xref>).</p>
   <table-wrap id="table2">
    <label>
     <xref ref-type="table" rid="table2">
      Table 2
     </xref></label>
    <caption>
     <title>
      <xref ref-type="bibr" rid="scirp.137663-"></xref>Table 2. Reproductive characteristics of women aged 35 years and older who received contraception from 1st April 2017 to January 31st, 2022 at Brazzaville University Hospital.</title>
    </caption>
    <table class="MsoTableGrid custom-table" border="0" cellspacing="0" cellpadding="0"> 
     <tr> 
      <td class="custom-bottom-td acenter" width="45.26%"><p style="text-align:center"></p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">N</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">%</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="45.26%"><p style="text-align:center">Gravidity</p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Paucigravida</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">34</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">14.8</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="45.26%"><p style="text-align:center">Multigravida</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">196</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">85.2</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="45.26%"><p style="text-align:center">Parity</p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Nulliparous</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">2</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">0.9</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Primiparous</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">8</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">3.5</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Pauciparous</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">73</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">31.7</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="45.26%"><p style="text-align:center">Multiparous</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">147</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">63.9</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="45.26%"><p style="text-align:center">Living child</p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">0</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">3</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">1.4</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">1 - 3</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">88</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">38.2</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="45.26%"><p style="text-align:center">≥4</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">139</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">60.4</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="45.26%"><p style="text-align:center">Age of last child</p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">0 - 1</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">144</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">63.4</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">2 - 4</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">60</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">26.5</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="45.26%"><p style="text-align:center">≥5</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">23</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">10.1</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="45.26%"><p style="text-align:center">Delivery</p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">High way</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">103</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">45.2</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Lower track</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">125</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">54.8</p></td> 
     </tr> 
    </table>
   </table-wrap>
   <p>Contraception of convenience for birth control accounted for 22% of cases. The medical indications were reported in <xref ref-type="table" rid="table3">
     Table 3
    </xref>.</p>
   <p>Levonorgestrel implant in 54% of cases, Etonogestrel subdermal implant in 18% of cases, and medroxyprogesterone acetate in 14% of cases (<xref ref-type="table" rid="table4">
     Table 4
    </xref>).</p>
   <table-wrap id="table3">
    <label>
     <xref ref-type="table" rid="table3">
      Table 3
     </xref></label>
    <caption>
     <title>
      <xref ref-type="bibr" rid="scirp.137663-"></xref>Table 3. Indications for contraception among women aged 35 and over from 1st April 2017 to 31st January 2022 at the Brazzaville University Hospital.</title>
    </caption>
    <table class="MsoTableGrid custom-table" border="0" cellspacing="0" cellpadding="0"> 
     <tr> 
      <td class="custom-bottom-td acenter" width="45.26%"><p style="text-align:center"></p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">N</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">%</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="45.26%"><p style="text-align:center">Convenience</p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Birth spacing</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">8</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">3.5</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td acenter" width="45.26%"><p style="text-align:center">Birth control</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">52</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">22.7</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td acenter" width="45.26%"><p style="text-align:center">Medical indications</p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">HTA</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">37</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">16.1</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Diabetes</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">15</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">6.5</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Heart disease</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">4</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">1.7</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Asthma</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">2</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">0.9</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Post C-section</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">103</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">44.7</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Post-EPU</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">6</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">2.6</p></td> 
     </tr> 
     <tr> 
      <td class="acenter" width="45.26%"><p style="text-align:center">Post Myomectomy</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">3</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">1.3</p></td> 
     </tr> 
    </table>
   </table-wrap>
   <table-wrap id="table4">
    <label>
     <xref ref-type="table" rid="table4">
      Table 4
     </xref></label>
    <caption>
     <title>
      <xref ref-type="bibr" rid="scirp.137663-"></xref>Table 4. Contraceptives used among women aged 35 and over from April 1st, 2017 to January 31st, 2022 at the Brazzaville University Hospital.</title>
    </caption>
    <table class="MsoTableGrid custom-table" border="0" cellspacing="0" cellpadding="0"> 
     <tr> 
      <td class="custom-bottom-td acenter" width="45.26%"><p style="text-align:center"></p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">N</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">%</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td aleft" width="45.26%"><p style="text-align:left">Long term</p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="aleft" width="45.26%"><p style="text-align:left">Etonogestrel (Implanon*)</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">42</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">18.3</p></td> 
     </tr> 
     <tr> 
      <td class="aleft" width="45.26%"><p style="text-align:left">Levonorgestrel (Norplant*)</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">124</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">53.9</p></td> 
     </tr> 
     <tr> 
      <td class="custom-bottom-td aleft" width="45.26%"><p style="text-align:left">Copper IUD</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">2</p></td> 
      <td class="custom-bottom-td acenter" width="27.37%"><p style="text-align:center">0.8</p></td> 
     </tr> 
     <tr> 
      <td class="custom-top-td aleft" width="45.26%"><p style="text-align:left">Short term</p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
      <td class="custom-top-td acenter" width="27.37%"><p style="text-align:center"></p></td> 
     </tr> 
     <tr> 
      <td class="aleft" width="45.26%"><p style="text-align:left">Medroxyprogesterone (Depo provera*)</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">32</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">14</p></td> 
     </tr> 
     <tr> 
      <td class="aleft" width="45.26%"><p style="text-align:left">Norethisterone (Noristerat*)</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">15</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">6.5</p></td> 
     </tr> 
     <tr> 
      <td class="aleft" width="45.26%"><p style="text-align:left">Microprogestatif (Microgynon*)</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">15</p></td> 
      <td class="acenter" width="27.37%"><p style="text-align:center">6.5</p></td> 
     </tr> 
    </table>
   </table-wrap>
  </sec><sec id="s4">
   <title>4. Discussion</title>
   <p>As the study was retrospective, it did not allow us to make the link between the clinical condition and the prescription. Similarly, the effectiveness and tolerance could not be assessed.</p>
   <p>Women aged 35 years and older represented 10.8% of all contraceptive users at UHC-B during the study. This low representation in our series can be explained by several factors. Indeed, from the age of 35, there is a progressive decline in fertility, which could justify the low use of contraceptive measures. In addition, the pronatalist nature of African society does not motivate women to use contraceptive measures, unlike Western or Asian societies such as China, where the one-child policy has long promoted contraception at all ages <xref ref-type="bibr" rid="scirp.137663-4">
     [4]
    </xref> <xref ref-type="bibr" rid="scirp.137663-5">
     [5]
    </xref>.</p>
   <p>The customers in our series had a mean age of 38 years and 4 months ± 3 years with extremes of 35 years and 49 years. Customers under 40 years of age accounted for more than half of the cases. However, those aged 45 to 49 years accounted for less than 5% of the cases. These results highlight the finding about the frequency of contraceptive use in our series. Indeed, this frequency decreases with age and could be explained by the decrease in fertility. Moreau in Dakar <xref ref-type="bibr" rid="scirp.137663-6">
     [6]
    </xref> reports the same finding because he worked with a population similar to ours.</p>
   <p>The customers were in couple in almost all cases. These results are similar to those of several African authors <xref ref-type="bibr" rid="scirp.137663-6">
     [6]
    </xref>-<xref ref-type="bibr" rid="scirp.137663-11">
     [11]
    </xref>. Indeed, customers living with a partner were more sexually active and thus more exposed to pregnancy. This result could be explained by the fact that our study was conducted in an urban area and that customers living in rural areas only attended urban facilities for medical reasons.</p>
   <p>In the Republic of Congo, the literacy rate has been 95% for several decades <xref ref-type="bibr" rid="scirp.137663-12">
     [12]
    </xref>, which justifies the fact that the customers in our series were all in school. On the other hand, countries with low national literacy rates also report a low frequency of contraceptive clients in their series, as is the case in Senegal with Moreau in Dakar, who reported that in their study 42.7% of the customers did not go to school. This difference is explained by the low literacy rate in their context (50%) <xref ref-type="bibr" rid="scirp.137663-6">
     [6]
    </xref> <xref ref-type="bibr" rid="scirp.137663-13">
     [13]
    </xref>.</p>
   <p>Most of our customers were multigravida (85.2%) and multiparous (63.9%) with an average of four children. These results can be explained by the advanced age of our clients and also by the need to limit births among these multiparous women. Our results are comparable to those of Maraux in France, who reported that black immigrants had more children than the French national average <xref ref-type="bibr" rid="scirp.137663-14">
     [14]
    </xref>.</p>
   <p>The indications for contraception were of two kinds: convenience and medical.</p>
   <p>Indications of convenience concerned a quarter of our customers. In most cases, these customers sought contraception in order to limit births. This could be explained by the high parity of our customers. Also, the limitation of births linked to the change in lifestyle would explain these results. Thus, the increase in the standard of living encourages older couples to limit births <xref ref-type="bibr" rid="scirp.137663-15">
     [15]
    </xref> <xref ref-type="bibr" rid="scirp.137663-16">
     [16]
    </xref>.</p>
   <p>As for medical indications, they concerned two-thirds of our customers. Post-caesarean section ranked first, followed by high blood pressure and diabetes. Post-caesarean contraception is used for several reasons: spacing and limitation of births, and pathologies related to the terrain. Cardiovascular pathologies require effective contraceptive measures, which would justify the high frequency of these pathologies in our series.</p>
   <p>Long-acting methods are preferentially prescribed in women aged 35 and over, with implants predominating in almost all cases. This is justified by the existence in this population of cardiovascular and metabolic risk factors, which would guide the prescription, taking into account the benefit/risk ratio, as recommended by the CNGOF, WHO and ANSM <xref ref-type="bibr" rid="scirp.137663-17">
     [17]
    </xref>-<xref ref-type="bibr" rid="scirp.137663-20">
     [20]
    </xref>.</p>
   <p>Among the long-acting methods used, the levonorgestrel implant ranked first with 53.9%. Our results are consistent with those of Moreau in Dakar <xref ref-type="bibr" rid="scirp.137663-6">
     [6]
    </xref>.</p>
   <p>Regarding short-acting contraceptives, injectable macro-progestins were the most widely used, notably Medroxyprogesterone and Norethisterone. The preference for injectable routes would be related to the vagaries of age to improve compliance.</p>
  </sec><sec id="s5">
   <title>5. Conclusions</title>
   <p>This study revealed a profile of customers who were mostly under 40 years of age, living with a partner, less educated and with a low socioeconomic level. They are multiparous with an average of four living children.</p>
   <p>The indications are essentially medical.</p>
   <p>Long-term methods were the most prescribed, especially implants, taking into account the customer’s clinical status.</p>
  </sec><sec id="s6">
   <title>Appendix</title>
   <p>ACT SHEET</p>
   <p>CONTRACEPTION IN WOMEN AGED 35 YEARS AND OLDER AT THE CHU-B</p>
   <p>Record number</p>
   <p>IDENTIFIER</p>
   <p>Surnames and first names:</p>
   <p>Age:</p>
   <p>Marital status: ☐ single: ☐ couple: ☐</p>
   <p>Address:</p>
   <p>Profession:</p>
   <p>Client’s Education Level: None: ☐ Primary: ☐</p>
   <p>Secondary: ☐ Upper: ☐</p>
   <p>Age of spouse:</p>
   <p>Spouse’s Occupation:</p>
   <p>Spouse’s level of education:</p>
   <p>PERSONAL HISTORY</p>
   <p>MEDICAL</p>
   <p>1. Asthma: Yes ☐ No ☐</p>
   <p>2. Heart disease: Yes ☐ No ☐</p>
   <p>3. Contraception: Yes ☐ No ☐</p>
   <p>If so, which one: ☐☐☐☐☐☐</p>
   <p>4. Diabetes: Yes ☐ No ☐</p>
   <p>5. Sickle-cell anemia: Yes ☐ No ☐</p>
   <p>6. Epilepsy: Yes ☐ No ☐</p>
   <p>7. Hepatitis: Yes ☐ No ☐</p>
   <p>8. HIV: Yes ☐ No ☐</p>
   <p>9. HTA: Yes ☐ No ☐</p>
   <p>10. Migraine: Yes ☐ No ☐</p>
   <p>11. Obesity: Yes ☐ No ☐</p>
   <p>12. Venous thrombosis: Yes ☐ No ☐</p>
   <p>13. Tuberculosis: Yes ☐ No ☐</p>
   <p>14. Processing in progress: Yes ☐ No ☐</p>
   <p>If so, which one: ☐☐☐☐☐☐</p>
   <p>CHIRURGICAUX</p>
   <p>GYNAECOLOGICAL</p>
   <p>1. Dysmenorrhea: Yes ☐ No ☐</p>
   <p>2. Non-regular menstrual cycle: ☐</p>
   <p>3. Duration of menstruation: ☐</p>
   <p>4. Date of last menstrual period: ☐</p>
   <p>5. Previous contraceptive use: Yes ☐ No ☐</p>
   <p>OBSTETRICS</p>
   <p>1. Gesture: ☐</p>
   <p>2. Parity: ☐</p>
   <p>3. Number of children alive: ☐</p>
   <p>4. Name interruption: ☐</p>
   <p>Pregnancy Volunteer</p>
   <p>1. Delivery: vaginal: ☐</p>
   <p>Caesarean section: ☐</p>
   <p>2. Last Age Child: ☐</p>
   <p>HABITS</p>
   <p>1. Alcohol: Yes ☐ No ☐</p>
   <p>2. Tobacco: Yes ☐ No ☐</p>
   <p>FAMILY HISTORY</p>
   <p>1. Heart disease: Yes ☐ No ☐</p>
   <p>2. Cancer yes which one(s)? ☐☐☐☐☐☐</p>
   <p>3. HTA: Yes ☐ No ☐</p>
   <p>4. Diabetes: Yes ☐ No ☐</p>
   <p>5. Obesity: Yes ☐ No ☐</p>
   <p>CLINICAL STATUS</p>
   <p>1. Risk Factor: Yes ☐ No ☐</p>
   <p>2. Blood pressure: ☐</p>
   <p>3. Weight (BMI): ☐</p>
   <p>4. E.g. complete gynaecological: Yes ☐ No ☐</p>
   <p>5. Uterine fibroin: Yes ☐ No ☐</p>
   <p>6. Menorrhagia: Yes ☐ No ☐</p>
   <p>7. Fasting blood glucose: ☐</p>
   <p>CLIENTS’ MOTIVATION FOR CONTRACEPTION</p>
   <p>PERSONAL DECISION: Yes ☐ No ☐</p>
   <p>1. Birth Spacing: Yes ☐ No ☐</p>
   <p>2. Birth limitation: Yes ☐ No ☐</p>
   <p>3. Other Reason: ☐☐☐☐☐☐</p>
   <p>4. NSP: ☐</p>
   <p>COUPLE DECISION: Yes ☐ No ☐</p>
   <p>1. Birth Spacing: Yes ☐ No ☐</p>
   <p>2. Birth limitation: Yes ☐ No ☐</p>
   <p>3. Other Reason: ☐☐☐☐☐☐</p>
   <p>4. NSP: ☐</p>
   <p>MEDICAL DECISION: Yes ☐ No ☐</p>
   <p>1. Birth Spacing: Yes ☐ No ☐</p>
   <p>2. Birth limitation: Yes ☐ No ☐</p>
   <p>3. Other Reason: ☐☐☐☐☐☐</p>
   <p>4. NSP: ☐</p>
   <p>DECISION AMICALE/PARENTALE: Yes ☐ No ☐</p>
   <p>1. Birth Spacing: Yes ☐ No ☐</p>
   <p>2. Birth limitation: Yes ☐ No ☐</p>
   <p>3. Other Reason: ☐☐☐☐☐☐</p>
   <p>4. NSP: ☐</p>
   <p>METHODE CONTRACEPTIVES</p>
   <p>AVAILABLE AT THE CHU-B</p>
   <p>1. Implant: Yes ☐ No ☐</p>
   <p>a-rod: Yes ☐ No ☐</p>
   <p>b-rod: Yes ☐ No ☐</p>
   <p>2. DMPA: Yes ☐ No ☐</p>
   <p>3. IUDs have with non eggs: ☐</p>
   <p>4. Pill: Yes ☐ No ☐</p>
   <p>7. Injectable: Yes ☐ No ☐</p>
   <p>CHOICE METHOD</p>
   <p>1. Implant: Yes ☐ No ☐</p>
   <p>2. DMPA: Yes ☐ No ☐</p>
   <p>3. IUDs have with non eggs</p>
   <p>4. Pill: Yes ☐ No ☐</p>
   <p>5. Injectable: Yes ☐ No ☐</p>
   <p>CURRENTLY</p>
   <p>Less of 1 the TTT: ☐</p>
   <p>1 an TTT: ☐</p>
   <p>1 to 2 years TTT: ☐</p>
   <p>2 to 3 years old TTT: ☐</p>
   <p>More than 3 years TTT: ☐</p>
   <p>CONTROL FREQUENCE</p>
   <p>once a month: ☐</p>
   <p>once a quarter: ☐</p>
   <p>once every 6 months: ☐</p>
   <p>once a year: ☐</p>
   <p>CONTROL OBSERVANCE</p>
   <p>Properly insured: ☐</p>
   <p>Poorly insured: ☐</p>
   <p>Motif: ☐☐☐☐☐☐</p>
   <p>SIDE EFFECTS METHOD</p>
   <p>Yes ☐ No ☐</p>
   <p>If so, which one(s): ☐☐☐☐☐☐</p>
  </sec>
 </body><back>
  <ref-list>
   <title>References</title>
   <ref id="scirp.137663-ref1">
    <label>1</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     WHO (2019) Geneva: Contraception.&gt;https://www.who.int/topics/contraception/fr 
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref2">
    <label>2</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Lansac, J., Lecomte, P. and Marret, H. (2014) Hormonal Contraception. In: Lansac, J., Lecomte, P. and Marret, H., Eds., Gynécologie pour le praticien (8th Edition), Masson, 411-418.
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref3">
    <label>3</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     World Health Organization (2015) Reproductive Health and Research, World Health Organization. Medical Eligibility Criteria for Contraceptive Use. 
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref4">
    <label>4</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Da Silva, P.R. (2006) The One-Child Policy in the People’s Republic of China. University of Geneva. 
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref5">
    <label>5</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Attané, I. (2000) Chinese Fertility at the Threshold of XXIE Century: Findings and Prospects. Population, 55, 233-264. &gt;https://doi.org/10.3917/popu.p2000.55n2.0264
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref6">
    <label>6</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Moreau, J.C., Ba, M.G., Faye, E.O., Dieng, T. and Faye, S. (2005) Contraception in Women Aged 35 Years and Older. Journal de la SAGO, 6, 39-42.
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref7">
    <label>7</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Mukengueshayi, A.N., Tshiala, R.N., Ilunga, T.M., et al. (2017) Use of Modern Contraceptive Methods in the Democratic Republic of Congo: Prevalence and Barriers in the Dibindi Health Zone in Mbuji-Mayi. Pan African Medical Journal, 3, Article 199.
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref8">
    <label>8</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Maiga, O.S., Poudiougou, B., Kéita, T.F.D., Ronse, I., Boundy, F., Bagayoko, D., et al. (2007) Involvement of Men in Family Planning Decision Making in Mali. Mali Medical, 22, 27-30.
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref9">
    <label>9</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Boucar, M., Hill, K., Coly, A., Djibrina, S., Saley, Z., Sangare, K., et al. (2014) Improving Postpartum Care for Mothers and Newborns in Niger and Mali: A Case Study of an Integrated Maternal and Newborn Improvement Programme. BJOG: An International Journal of Obstetrics&amp;Gynaecology, 121, 127-133. &gt;https://doi.org/10.1111/1471-0528.12818
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref10">
    <label>10</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Matungulu, C.M., Kandolo, S.I., Mukengeshayi, A.N., Nkola, A.M., Mpoyi, D.I., Mumba, S.K., et al. (2015) Determinants of Contraceptive Use in Mumbunda Health Zone in Lubumbashi, Democratic Republic of Congo. Pan African Medical Journal, 22, Article 329. &gt;https://doi.org/10.11604/pamj.2015.22.329.6262
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref11">
    <label>11</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Mamadou, M.M.L., Adama, F., Mayassine, D., et al. (2015) Determinants of Modern Contraceptive Use in the Health District of Mbacké, Senegal. Public Health, 27, 107-16.
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref12">
    <label>12</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Enquête Démographique et de Santé 2011-2012, République du Congo. &gt;https://dhsprogram.com/pubs/pdf/FR281/FR281.pdf 
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref13">
    <label>13</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Agence Nationale de la Statistique et de la Démographie (ANSD). Multiple Indicator Demographic and Health Survey in Senegal 2017.
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref14">
    <label>14</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Maraux, B. and Lert, F. (2017) Contraception among Immigrant Women from sub-Saharan Africa in Île-de-France: A Generalized Practice as in the General Population, Different Methods. In: du Loû, A.D., Ed., Parcours de vie et santé des Africains immigrés en France, La Découverte, 299-313. &gt;https://doi.org/10.3917/dec.desgr.2017.01.0299
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref15">
    <label>15</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Molloy, G.J., Sweeney, L., Byrne, M., Hughes, C.M., Ingham, R., Morgan, K., et al. (2015) Prescription Contraception Use: A Cross-Sectional Population Study of Psychosocial Determinants. BMJ Open, 5, e007794. &gt;https://doi.org/10.1136/bmjopen-2015-007794
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref16">
    <label>16</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Jost, S., Le Tohic, A., Chis, C., This, P., Grosdemouge, I. and Panel, P. (2014) Contraception among French Women Aged 15 to 45 Years. National Survey on a Representative Sample of 5963 Women. Gynécologie Obstétrique&amp;Fertilité, 42, 415-421. &gt;https://doi.org/10.1016/j.gyobfe.2014.04.008
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref17">
    <label>17</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Chabbert-Buffet, N., Marret, H., Agostini, A., Cardinale, C., Hamdaoui, N., Hassoun, D., et al. (2018) CNGOF Collège national des gynécologues et obstétriciens français. Recommendations for clinical practice Contraception. The European Journal of Obstetrics&amp;Gynecology and Reproductive Biology, 152, 5-44.
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref18">
    <label>18</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     (2015) WHO Medical Eligibility Criteria for the Adoption and Continued Use of Contraceptive Methods. 5th Edition, WHO, 13.
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref19">
    <label>19</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Rousset-Jablonski, C., Selle, F., Adda-Herzog, E., Planchamp, F., Selleret, L., Pomel, C., et al. (2018) Fertility Preservation, Contraception and Menopause Hormone Therapy in Women Treated for Rare Ovarian Tumors: Guidelines from the French National Network Dedicated to Rare Gynaecological Cancer. Bulletin du Cancer, 105, 299-314. &gt;https://doi.org/10.1016/j.bulcan.2017.10.032
    </mixed-citation>
   </ref>
   <ref id="scirp.137663-ref20">
    <label>20</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     ANSM (2018) National Directory of Medical Interactions. &gt;https://www.ansm.sante.fr/Activites/Interactions-medicamenteuses
    </mixed-citation>
   </ref>
  </ref-list>
 </back>
</article>