<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">
    oju
   </journal-id>
   <journal-title-group>
    <journal-title>
     Open Journal of Urology
    </journal-title>
   </journal-title-group>
   <issn pub-type="epub">
    2160-5440
   </issn>
   <issn publication-format="print">
    2160-5629
   </issn>
   <publisher>
    <publisher-name>
     Scientific Research Publishing
    </publisher-name>
   </publisher>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="doi">
    10.4236/oju.2024.1410055
   </article-id>
   <article-id pub-id-type="publisher-id">
    oju-137083
   </article-id>
   <article-categories>
    <subj-group subj-group-type="heading">
     <subject>
      Articles
     </subject>
    </subj-group>
    <subj-group subj-group-type="Discipline-v2">
     <subject>
      Medicine 
     </subject>
     <subject>
       Healthcare
     </subject>
    </subj-group>
   </article-categories>
   <title-group>
    Incidental Finding of Pyeloureteral Junction Syndrome during Extension Workup for Prostatic Adenocarcinoma
   </title-group>
   <contrib-group>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Jean Cedrick
      </surname>
      <given-names>
       Fouda
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Philip Fernandez
      </surname>
      <given-names>
       Owon’Abessolo
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff3"> 
      <sup>3</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Frantz Guy Epoupa
      </surname>
      <given-names>
       Ngalle
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Junior Barthélémy Mekeme
      </surname>
      <given-names>
       Mekeme
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Alkadri
      </surname>
      <given-names>
       Diarra
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff4"> 
      <sup>4</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Amadou
      </surname>
      <given-names>
       Kassogue
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff5"> 
      <sup>5</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Armel Quentin
      </surname>
      <given-names>
       Essomba
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff3"> 
      <sup>3</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Ambroise
      </surname>
      <given-names>
       Seme
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Francis
      </surname>
      <given-names>
       Nwatsock
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Ngapagna
      </surname>
      <given-names>
       Youssofa
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Herve
      </surname>
      <given-names>
       Moby
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Guy Aristide
      </surname>
      <given-names>
       Bang
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Pierre Ongolo
      </surname>
      <given-names>
       Zogo
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Pierre Joseph
      </surname>
      <given-names>
       Fouda
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Angwafo Fru
      </surname>
      <given-names>
       III
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
   </contrib-group> 
   <aff id="aff1">
    <addr-line>
     aUrpology and Andrology Department, Central Hospital of Yaounde, Yaounde, Cameroon
    </addr-line> 
   </aff> 
   <aff id="aff2">
    <addr-line>
     aFaculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
    </addr-line> 
   </aff> 
   <aff id="aff3">
    <addr-line>
     aFaculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon
    </addr-line> 
   </aff> 
   <aff id="aff4">
    <addr-line>
     aUrology Department, Luxembourg University Teaching Hospital of Bamako, Bamako, Mali
    </addr-line> 
   </aff> 
   <aff id="aff5">
    <addr-line>
     aUrology Department, Pr Bocar Sidi Sall University Teaching Hospital of Kati, Kati, Mali
    </addr-line> 
   </aff> 
   <pub-date pub-type="epub">
    <day>
     11
    </day> 
    <month>
     10
    </month>
    <year>
     2024
    </year>
   </pub-date> 
   <volume>
    14
   </volume> 
   <issue>
    10
   </issue>
   <fpage>
    532
   </fpage>
   <lpage>
    536
   </lpage>
   <history>
    <date date-type="received">
     <day>
      3,
     </day>
     <month>
      September
     </month>
     <year>
      2024
     </year>
    </date>
    <date date-type="published">
     <day>
      28,
     </day>
     <month>
      September
     </month>
     <year>
      2024
     </year> 
    </date> 
    <date date-type="accepted">
     <day>
      28,
     </day>
     <month>
      October
     </month>
     <year>
      2024
     </year> 
    </date>
   </history>
   <permissions>
    <copyright-statement>
     © Copyright 2014 by authors and Scientific Research Publishing Inc. 
    </copyright-statement>
    <copyright-year>
     2014
    </copyright-year>
    <license>
     <license-p>
      This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
     </license-p>
    </license>
   </permissions>
   <abstract>
    <b>Introduction: </b>Prostate cancer is one of the most common cancers in men. In cases of suspected locally advanced disease or lymph node or bone metastases, thoraco-abdomino-pelvic CT is still useful for detecting visceral metastases. In the course of this extension work-up, other abnormalities may be discovered by chance, which had previously remained silent, and which could be diagnosed and managed in childhood, hence the interest of presenting a case of incidental finding of pyeloureteral junction syndrome during extension workup for prostatic adenocarcinoma at Yaounde Central Hospital. 
    <b>Observation</b>
    <b>: </b>A 72-year-old patient presented to the department with acute urinary retention. The clinical examination, with an empty bladder, and in particular the digital rectal exam (DRE), was in favor of malignant prostatic hypertrophy. A workup was ordered, including a total PSA returned to 61.3 ng/ml (PSA performed one week after the episode of acute urinary retention) with cytobacteriological examination of sterile urine. Renal function was slightly impaired, with creatinemia at 14 ng/ml. Renal and vesico-prostatic ultrasound revealed a 57 g prostate with regular, clean contours and a polycystic right kidney. A prostate biopsy was indicated, which revealed a histopathological aspect in favor of a prostatic adenocarcinoma ISUP 1. An extension work-up including a thoraco-abdomino-pelvic CT scan revealed no signs of local or distant secondary localization, but a pyeloureteral junction syndrome with significant hydronephrosis, parenchymal destruction and compensatory hypertrophy of the contralateral kidney was found. 
    <b>Conclusion</b>
    <b>: </b>The prostate cancer extension work-up revealed a pathology that can be diagnosed early. It is therefore important to reinforce prenatal and natal screening, which will enable malformative uropathies to be identified early and corrected in time to preserve patients’ renal function. Furthermore, we must be careful in the ultrasound diagnosis of pyeloureteral junction syndrome.
   </abstract>
   <kwd-group> 
    <kwd>
     Prostate Cancer
    </kwd> 
    <kwd>
      Pyeloureteral Junction Syndrome
    </kwd> 
    <kwd>
      Prenatal Diagnosis
    </kwd> 
    <kwd>
      Morphological Diagnosis
    </kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <sec id="s1">
   <title>1. Introduction</title>
   <p>Prostate cancer is one of the most common cancers in men, and its incidence continues to rise in many developing countries <xref ref-type="bibr" rid="scirp.137083-1">
     [1]
    </xref>. In Cameroon, it accounts for 23.5% of cancer deaths <xref ref-type="bibr" rid="scirp.137083-2">
     [2]
    </xref> <xref ref-type="bibr" rid="scirp.137083-3">
     [3]
    </xref>. According to a study by Fouda et al., hospital prevalence of prostate cancer is 23.51%, while for pyeloureteral junction pyeloureteral junction syndrome is 0.9% <xref ref-type="bibr" rid="scirp.137083-4">
     [4]
    </xref>. Although diagnosed antenatally, pyeloureteral junction syndrome can be diagnosed at any age, with differing circumstances of discovery. However, it can also be an incidental finding during a complementary examination using ultrasound or CT scan <xref ref-type="bibr" rid="scirp.137083-5">
     [5]
    </xref>, as in the context of prostate cancer extension assessment, where TAP scan is useful for detecting metastases <xref ref-type="bibr" rid="scirp.137083-6">
     [6]
    </xref>. In the course of this extension work-up, other abnormalities may be discovered which had previously remained silent. In the following, we present a case of incidental finding of pyeloureteral junction syndrome during extension workup for prostatic adenocarcinoma at the Yaounde Central Hospital.</p>
  </sec><sec id="s2">
   <title>2. Observation</title>
   <p>The patient, aged 72, presented with acute urinary retention, for which a transurethral urinary catheter had been inserted. Clinical examination, in particular the digital examination carried out later with an empty bladder, revealed an enlarged, firm, multinodular prostate with irregular contours and a missing median sulcus, raising the suspicion of prostate cancer. A work-up was prescribed, including a total PSA returned to 61.3 ng/ml (PSA performed one week after the episode of acute urinary retention) with a cytobacteriological examination of sterile urine. Renal function was slightly impaired, with creatinemia at 14 ng/ml. Renal and vesico-prostatic ultrasound revealed a 57 g prostate with regular, clear contours and a polycystic right kidney. A prostate biopsy was indicated, and the histopathological findings were consistent with a prostatic adenocarcinoma, Gleason 6 = 3 + 3 (ISUP 1). An extension work-up including a thoraco-abdomino-pelvic CT scan was ordered and found no evidence of local or distant secondary localization. However, major dilatation of the right pyelocalic cavities with thinning of the cortex to millimetre thickness and a thin ureter were discovered, suggesting a pyeloureteral junction syndrome with significant hydronephrosis and compensatory hypertrophy of the contralateral kidney (The scintigraph is not available in our context).</p>
   <p>The patient had never experienced any symptoms associated with pyeloureteral junction syndrome. The patient refused all treatment for pyeloureteral junction syndrome and for prostate cancer, preferring surveillance despite multiple proposals made after the multidisciplinary consultation meeting. We referred the patient for nephrological consultation. At the last check-up, 06 months later, the result of the renal function was the same. We continued to monitor him for prostate cancer, but the follow-up was satisfactory.</p>
   <fig-group id="fig1" position="float">
    <fig id="fig1" position="float">
     <label>Figure 1</label>
     <caption>
      <title>Figure 1. CT scans showing pyeloureteral junction syndrome with significant hydronephrosis contrasting with a thin ureter and destruction of renal parenchyma.--Figure 1. CT scans showing pyeloureteral junction syndrome with significant hydronephrosis contrasting with a thin ureter and destruction of renal parenchyma.</title>
     </caption>
     <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/5000967-rId16.jpeg?20241031023332" />
    </fig>
    <fig id="fig1" position="float">
     <label>Figure 1</label>
     <caption>
      <title>Figure 1. CT scans showing pyeloureteral junction syndrome with significant hydronephrosis contrasting with a thin ureter and destruction of renal parenchyma.--Figure 1. CT scans showing pyeloureteral junction syndrome with significant hydronephrosis contrasting with a thin ureter and destruction of renal parenchyma.</title>
     </caption>
     <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/5000967-rId16.jpeg?20241031023332" />
    </fig>
   </fig-group>
  </sec><sec id="s3">
   <title>3. Discussion</title>
   <p>Pyeloureteral junction syndrome, also known as essential hydronephrosis or primary hydronephrosis, is defined as a urodynamic disorder of evacuation of the upper excretory tract with pyelocecal distension, upstream of a functional or organic obstacle <xref ref-type="bibr" rid="scirp.137083-7">
     [7]
    </xref>. It is the most common obstructive uropathy in newborns, affecting around 0.2% of live births, with a predominance of males <xref ref-type="bibr" rid="scirp.137083-8">
     [8]
    </xref>. SJPU is most often congenital and the diagnosis is made very early, before the age of 5 according to the literature <xref ref-type="bibr" rid="scirp.137083-9">
     [9]
    </xref> <xref ref-type="bibr" rid="scirp.137083-10">
     [10]
    </xref>, but some cases of SJPU in the elderly are found in the literature <xref ref-type="bibr" rid="scirp.137083-11">
     [11]
    </xref> <xref ref-type="bibr" rid="scirp.137083-12">
     [12]
    </xref>. So, the diagnosis can be made at any age, and the circumstances in which it is discovered vary in the literature, ranging from lumbar mass or pain to haematuria and urinary tract infections. Some authors have reported incidental findings of pyeloureteral junction syndrome. This is the case for Sayad L and Diarra A, who found frequencies of 15% and 12.9% respectively <xref ref-type="bibr" rid="scirp.137083-7">
     [7]
    </xref> <xref ref-type="bibr" rid="scirp.137083-13">
     [13]
    </xref>; on the other hand, Amadou et al. found a higher frequency of 25.7% <xref ref-type="bibr" rid="scirp.137083-14">
     [14]
    </xref>. This is no mean feat. Our study has highlighted the need to strengthen systematic antenatal screening for malformative pathologies of the kidney that may jeopardise its functional prognosis in the short, medium or long term. As the kidney is a noble organ, it is important to be able to diagnose malformative uropathy at an early stage so that appropriate treatment can be initiated to preserve the patient’s renal function. The importance and difficulty of imaging between polycystic kidney disease and hydronephrosis must be emphasised. This underlines the importance of the fact that ultrasound is operator-dependent and CT scan is more specific and sensitive than ultrasound. With this case report, we believe that ultrasound associated with uroscanner would allow the diagnosis of pyeloureteral junction syndrome, which Kpatcha also mentioned <xref ref-type="bibr" rid="scirp.137083-11">
     [11]
    </xref>.</p>
  </sec><sec id="s4">
   <title>4. Conclusion</title>
   <p>Pyeloureteral junction syndrome is a malformative disorder of the upper urinary tract that is increasingly diagnosed antenatally and managed during the first few years of life. However, frustrated forms are still discovered in adulthood because they are only mildly symptomatic, hence the need to step up antenatal screening, which will enable malformative uropathies to be identified early and corrected in time to preserve the patient's renal function. In adults, it would be useful to combine CT with ultrasound to avoid missing a pyeloureteral junction syndrome evolving at low noise.</p>
  </sec>
 </body><back>
  <ref-list>
   <title>References</title>
   <ref id="scirp.137083-ref1">
    <label>1</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Ferlay, J., Parkin, D.M. and Steliarova-Foucher, E. (2010) Estimates of Cancer Incidence and Mortality in Europe in 2008. European Journal of Cancer, 46, 765-781. &gt;https://doi.org/10.1016/j.ejca.2009.12.014 
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref2">
    <label>2</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Orock, E., E., Ndom, P. and Dah, A. (2012) Current Cancer Incidence and Trends in Yaounde, Cameroon. Oncology, Gastroenterology and Hepatology Reports, 1, 58-63. &gt;https://doi.org/10.5530/ogh.2012.1.14 
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref3">
    <label>3</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Organisation mondiale de la santé (2014) Profil des pays pour le cancer.
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref4">
    <label>4</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Fouda, J.C., Owon’Abessolo, P.F., et al. Panorama of Activities in a Urology and Andrology Department of a Tertiary Hospital in a Developing Country. Health Sciences and Diseases, 24, 131-134.
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref5">
    <label>5</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Schwartz, J., Schmidlin, F. and Iselin, C. (2004) Maladie de la jonction pyélo-urétérale: Diagnostic et traitement. Revue Médicale Suisse, 62, 2417-2422. &gt;https://doi.org/10.53738/revmed.2004.62.2507.2417 
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref6">
    <label>6</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Rozet, F., Hennequin, C., Beauval, J.-., Beuzeboc, P., Cormier, L., Fromont-Hankard, G., et al. (2018) Recommandations françaises du Comité de Cancérologie de l’AFU—Actualisation 2018-2020: Cancer de la prostate. Progrès en Urologie, 28, R81-R132. &gt;https://doi.org/10.1016/j.purol.2019.01.007 
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref7">
    <label>7</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Diarra, A.A. (2006) Syndrome de la jonction pyélo-urétérale au service d’Urologie de l’Hôpital du Point G. Thèse de Médicine, Bamako University.
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref8">
    <label>8</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Grapin-Dagorno, C. (2008) Prise en charge précoce des anomalies de la jonction pyélo urétérale. 102è Congrès de l’Association Française d’Urologie, Paris, 19-22 Novembre 2008, 15-17.
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref9">
    <label>9</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Galifer, R.B., Veyrac, C. and Faurous, P. (1983) Les anomalies congénitales de la jonction pyélo-urétérale chez l’enfant. Etude multicentrique de 985 observations chez 883 enfants. Annales d’Urologie, 21, 241-249.
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref10">
    <label>10</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Michel, A., Monod, P., Descotes, J.L., Rambeaud, J.J., Bourdat, G. and Faure, G. (1991) Surgical Treatment for Ureteropelvic Junction Syndrome in Infants and Children (Report of 73 Cases). Progrès en Urologie, 1, 987-999.
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref11">
    <label>11</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Kpatcha, T., Tengue, K., Botcho, G., Sikpa, K., Leloua, E., et al. (2014) Le syndrome de la jonction pyélo-urétérale chez l’adulte au CHU de Sylvanus Olympio: Aspects diagnostiques et thérapeutiques. Journal de la Recherche Scientifique de l’Université de Lomé, 16, 411-416.
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref12">
    <label>12</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Hossain, M.F., Shah, S.S. and Bastani, B. (2023) An Adult Case of Severe Asymptomatic Bilateral Ureteropelvic Junction Obstruction. Case Reports in Nephrology, 2023, 1-3. &gt;https://doi.org/10.1155/2023/9355564 
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref13">
    <label>13</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Sayad, L.A. (2010) Syndrome de jonction pyélo-urétérale à propos de 40 cas. Thèse, University of Marrakech.
    </mixed-citation>
   </ref>
   <ref id="scirp.137083-ref14">
    <label>14</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Amadou, I., Coulibaly, Y., Coulibaly, O.M., et al. (2018) Syndrome de la Jonction Pyélo-Urétérale: Aspects Cliniques et Thérapeutiques au CHU Gabriel Toure. Health Sciences and Diseases, 19, 69-72.
    </mixed-citation>
   </ref>
  </ref-list>
 </back>
</article>