<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">
    ojmi
   </journal-id>
   <journal-title-group>
    <journal-title>
     Open Journal of Medical Imaging
    </journal-title>
   </journal-title-group>
   <issn pub-type="epub">
    2164-2788
   </issn>
   <issn publication-format="print">
    2164-2796
   </issn>
   <publisher>
    <publisher-name>
     Scientific Research Publishing
    </publisher-name>
   </publisher>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="doi">
    10.4236/ojmi.2024.143013
   </article-id>
   <article-id pub-id-type="publisher-id">
    ojmi-136375
   </article-id>
   <article-categories>
    <subj-group subj-group-type="heading">
     <subject>
      Articles
     </subject>
    </subj-group>
    <subj-group subj-group-type="Discipline-v2">
     <subject>
      Medicine 
     </subject>
     <subject>
       Healthcare
     </subject>
    </subj-group>
   </article-categories>
   <title-group>
    Hemangioblastoma Incidentally Discovered at CT Scan in Bamako: About a Case
   </title-group>
   <contrib-group>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Traore
      </surname>
      <given-names>
       Ousmane
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref> 
     <xref ref-type="aff" rid="aff3"> 
      <sup>3</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       N’Diaye
      </surname>
      <given-names>
       Mamadou
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Dembélé
      </surname>
      <given-names>
       Mamadou
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Dembélé
      </surname>
      <given-names>
       Adama
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Diakité
      </surname>
      <given-names>
       Siaka
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff3"> 
      <sup>3</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Sidibé Mansa
      </surname>
      <given-names>
       Drissa
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Camara
      </surname>
      <given-names>
       Nagnoumague
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Keita Adama
      </surname>
      <given-names>
       Diaman
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref> 
     <xref ref-type="aff" rid="aff3"> 
      <sup>3</sup>
     </xref>
    </contrib>
   </contrib-group> 
   <aff id="aff1">
    <addr-line>
     aDepartment of Radiology and Medical Imaging, The Marie Curie Medical Clinic, Bamako, Mali
    </addr-line> 
   </aff> 
   <aff id="aff2">
    <addr-line>
     aFaculty of Medicine and Odontostomatology, The University of Science, Techniques and Technologies, Bamako, Mali
    </addr-line> 
   </aff> 
   <aff id="aff3">
    <addr-line>
     aDepartment of Radiology and Medical Imaging, The University Hospital Center of Point “G”, Bamako, Mali
    </addr-line> 
   </aff> 
   <pub-date pub-type="epub">
    <day>
     01
    </day> 
    <month>
     08
    </month>
    <year>
     2024
    </year>
   </pub-date> 
   <volume>
    14
   </volume> 
   <issue>
    03
   </issue>
   <fpage>
    123
   </fpage>
   <lpage>
    127
   </lpage>
   <history>
    <date date-type="received">
     <day>
      19,
     </day>
     <month>
      August
     </month>
     <year>
      2024
     </year>
    </date>
    <date date-type="published">
     <day>
      24,
     </day>
     <month>
      August
     </month>
     <year>
      2024
     </year> 
    </date> 
    <date date-type="accepted">
     <day>
      24,
     </day>
     <month>
      September
     </month>
     <year>
      2024
     </year> 
    </date>
   </history>
   <permissions>
    <copyright-statement>
     © Copyright 2014 by authors and Scientific Research Publishing Inc. 
    </copyright-statement>
    <copyright-year>
     2014
    </copyright-year>
    <license>
     <license-p>
      This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
     </license-p>
    </license>
   </permissions>
   <abstract>
    Hemangioblastomas are benign vascular tumors of the brain. These are rare tumors, usually located in the cerebellum and most often affecting young adults. The aim was to study the value of CT in the management of hemangioblastoma through observation. We report the case of a 38-year-old patient referred to the radiology and Medical Imaging Department of the Marie Curie Medical Clinic in Bamako, Mali, for an orbito-cerebral CT scan in a context of bilateral eyelid edema. The examination was performed using multi-slice computed tomography (16 slices) with reconstruction in the 3 planes of space without and with the injection of an iodinated contrast agent. The CT scan was crucial in making the diagnosis of hemangioblastoma incidentally, which allowed for adequate management. The patient was operated on, and the radiological outcome was favorable, without significant cystic formation, after postoperative control and clinical signs were resolved. CT can be an interesting alternative in countries like ours despite MRI being the examination of choice in hemangioblastomas.
   </abstract>
   <kwd-group> 
    <kwd>
     Hemangioblastoma
    </kwd> 
    <kwd>
      CT Scan
    </kwd> 
    <kwd>
      Incidental Discovery and Bamako
    </kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <sec id="s1">
   <title>1. Introduction</title>
   <p>Hemangioblastomas are relatively rare tumors of the central nervous system, representing 1.5% to 2.5% of all intracranial tumors and 7% to 8% of all posterior cranial fossa (PCF) tumors <xref ref-type="bibr" rid="scirp.136375-1">
     [1]
    </xref>. They occur mainly in the cerebellar hemispheres in 76% of cases, making them the most common primary cerebellar tumor in adults <xref ref-type="bibr" rid="scirp.136375-2">
     [2]
    </xref>. Approximately 70% of cases are reported to be sporadic, and the remaining 30% are reported to be familial cases associated with LHL. It is estimated that 60% - 80% of patients with von Hippel-Lindau disease develop CNS hemangioblastoma during their lifetime <xref ref-type="bibr" rid="scirp.136375-3">
     [3]
    </xref>. Hemangioblastoma has an excellent prognosis with complete excision <xref ref-type="bibr" rid="scirp.136375-3">
     [3]
    </xref>. In imaging, CT is usually the first examination performed, it can provide important information; but MRI remains the examination of choice for the examination of the posterior cerebral fossa and its tumors, better specifying their cystic and solid components <xref ref-type="bibr" rid="scirp.136375-4">
     [4]
    </xref>. We report the case of a hemangioblastoma discovered incidentally on CT scan in order to study the value of CT scan in the management of this pathology.</p>
  </sec><sec id="s2">
   <title>2. Observation</title>
   <p>This was a 38-year-old patient with no known medical or surgical history, consulted at the University Hospital Center of the Institute of Tropical Ophthalmology of Africa (CHU-IOTA) for visual loss, occipital intense headache and bilateral eyelid swelling, non-painful progressively developing over a period of 4 weeks following a wasp sting since September 2023. There were swellings and redness in the skin following this wasp sting, which left skin spots after local treatment with hydrocortisone ointment. He had no vomiting. Given the persistence of ophthalmological clinical signs, the patient was specified for an orbito-cerebral computed tomography (CT) scan in the radiology and medical imaging department of the Marie Curie Medical Clinic in Bamako, Mali. Given these clinical signs, the patient was referred for an orbito-cerebral computed tomography (CT) scan. This CT scan was performed using a 16-slice GE Optima multi-slice device from 2007. An acquisition without injection of contrast product (CSP) and an acquisition with CSP injection was performed. The CT scan revealed a thin-walled cystic formation not enhanced by injection of contrast product measuring 61 × 36 mm on an axial section at the level of the posterior cerebral fossa in the right cerebellar region, it contained a spontaneously dense 08 × 05 mm mural nodule that enhanced intensely after injection of CSP (<xref ref-type="fig" rid="fig1">
     Figure 1
    </xref>).</p>
   <p>This cystic mass exerted a mass effect on the fourth ventricle V4 responsible for a moderate dilatation of the supratentorial upstream ventricular system involving the lateral ventricles and the 3<sup>rd</sup> ventricle with sign of transependymal resorption including spontaneous periventricular hypodensity (<xref ref-type="fig" rid="fig2">
     Figure 2
    </xref>).</p>
   <p>The patient was operated with good clinical and radiological evolution. Our patient had no more visual disturbance with headache resolution after one week postoperatively.</p>
  </sec><sec id="s3">
   <title>3. Discussion</title>
   <p>Hemangioblastoma is a benign tumor of the central nervous system that occurs most commonly in the cerebellum. The diagnosis of hemangioblastoma is based</p>
   <fig id="fig1" position="float">
    <label>Figure 1</label>
    <caption>
     <title>Figure 1. Orbito-cerebral CT scan in axial reconstruction without injection of PDC (A) and with injection of PDC (B): Cystic mass at the right cerebellar level with mural nodule (black arrow) intensely enhanced after injection of PDC suggestive of a hemangioblastoma.</title>
    </caption>
    <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/2060467-rId15.jpeg?20240927060501" />
   </fig>
   <fig id="fig2" position="float">
    <label>Figure 2</label>
    <caption>
     <title>Figure 2. Orbito-cerebral CT scan with PDC injection in sagittal (A) and axial (B) reconstruction. (A) Cystic mass of the posterior cerebral fossa with enhanced mural nodule after intense PDC injection; (B) Moderate active biventricular supratentorial hydrocephalus (a).</title>
    </caption>
    <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/2060467-rId16.jpeg?20240927060501" />
   </fig>
   <p>mainly on histological and immunophenotypic features, with clinical, radiological and molecular information providing additional support <xref ref-type="bibr" rid="scirp.136375-3">
     [3]
    </xref>. Our patient was radiologically suggested and histologically confirmed. Immunophenotyping and molecular analysis were not performed in our case due to financial difficulty and the unavailability of these tests. In the various observations published in the literature the average age of the patients was 42.7 years, with a slight predominance for the male sex <xref ref-type="bibr" rid="scirp.136375-1">
     [1]
    </xref>. In our case, the subject was male and 38 years old. In our study, the symptomatology presented by our patient was considered secondary to the mass effect conditioning the symptoms of increased intracranial pressure (ICP) (headache, eyelid edema, visual disturbance). This result was comparable to that of the literature <xref ref-type="bibr" rid="scirp.136375-1">
     [1]
    </xref>. The most frequent location of these tumors in the literature was the posterior cranial fossa <xref ref-type="bibr" rid="scirp.136375-3">
     [3]
    </xref>. In our case, the tumor was in the posterior cerebral fossa more precisely at the right cerebellar level. CT scan allowed to evoke the diagnosis of hemangioblastoma in our case. The literature favors magnetic resonance imaging (MRI) as the examination of choice <xref ref-type="bibr" rid="scirp.136375-1">
     [1]
    </xref>. Our patient did not have MRI. CT scan was sufficient for the diagnosis of hemangioblastoma in our case. In the literature, this tumor presents as a cystic formation with a hypervascular intramural nodule whose CT imaging demonstrates isodensity with respect to the brain within the solid component. Calcification is generally absent. On magnetic resonance imaging, hemangioblastomas tend to appear as a hypoenti-T1 to isointense, a hyperintense T2 nodule with serpentine flow voids in the nodular part <xref ref-type="bibr" rid="scirp.136375-3">
     [3]
    </xref> <xref ref-type="bibr" rid="scirp.136375-5">
     [5]
    </xref>-<xref ref-type="bibr" rid="scirp.136375-7">
     [7]
    </xref>. Our patient had the intramural intracystic iso-dense hypervascular nodule after iodine injection. He had no calcification in our observation. CT has the advantage of being available and accessible in our country compared to MRI which is much more expensive and not available everywhere. The radiological differential diagnosis of hemangioblastoma in our daily practice is uncommon but can be done with glial tumors, particularly pilocytic astrocytoma which does not have a hypervascular mural nodule and is found in children. Brain metastases are less common in the posterior cerebral fossa and are enhanced in the periphery. On the other hand, histologically there were many differential diagnoses cited in the literature, such as Meningioma; Solitary fibrous tumor; Glalic neoplasms; Paraganglioma and Hemangioma, which have similar but different histological characteristics depending on the aspects <xref ref-type="bibr" rid="scirp.136375-3">
     [3]
    </xref>. Our case was confirmed histologically.</p>
  </sec><sec id="s4">
   <title>4. Conclusion</title>
   <p>Hemangioblastoma is a benign neoplasm that can occur throughout the central nervous system, but the most common location is the posterior cranial fossa. It may be discovered incidentally. CT is usually the first test performed to suggest the diagnosis, but MRI remains the test of choice.</p>
  </sec><sec id="s5">
   <title>Ethical Aspect</title>
   <p>The patient had given informed consent and anonymity was maintained.</p>
  </sec>
 </body><back>
  <ref-list>
   <title>References</title>
   <ref id="scirp.136375-ref1">
    <label>1</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Kuharic, M., Jankovic, D., Splavski, B., Boop, F.A. and Arnautovic, K.I. (2018) Hemangioblastomas of the Posterior Cranial Fossa in Adults: Demographics, Clinical, Morphologic, Pathologic, Surgical Features, and Outcomes. A Systematic Review. World Neurosurgery, 110, e1049-e1062.&gt;https://doi.org/10.1016/j.wneu.2017.11.173
    </mixed-citation>
   </ref>
   <ref id="scirp.136375-ref2">
    <label>2</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Slater, A., Moore, N.R. and Huson, S.M. (2003) The Natural History of Cerebellar Hemangioblastomas in Von Hippel-Lindau Disease. American Journal of Neuroradiology, 24, 1570‑1574.
    </mixed-citation>
   </ref>
   <ref id="scirp.136375-ref3">
    <label>3</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Yoda, R.A. and Cimino, P.J. (2022) Neuropathologic Features of Central Nervous System Hemangioblastoma. Journal of Pathology and Translational Medicine, 56, 115-125. &gt;https://doi.org/10.4132/jptm.2022.04.13
    </mixed-citation>
   </ref>
   <ref id="scirp.136375-ref4">
    <label>4</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Ech-Cherif El Kettani, N., Benchaaboun, H., El Hassani, M.R., Chakir, N. and Jiddane, M. (2010) Hémangioblastomes de la fosse cérébrale postérieure. Feuillets de Radiologie, 50, 23-26. &gt;https://doi.org/10.1016/j.frad.2010.02.011
    </mixed-citation>
   </ref>
   <ref id="scirp.136375-ref5">
    <label>5</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Ho, V.B., Smirniotopoulos, J.G., Murphy, F.M. and Rushing, E.J. (1992) Corrélation radiologique pathologique: Hémagioblastome. American Journal of Neuroradiology, 13, 1343-1352.
    </mixed-citation>
   </ref>
   <ref id="scirp.136375-ref6">
    <label>6</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Parizel, P.M., Baleriaux, D., Rodesch, G., et al. (1989) Imagerie RM RM améliorée par le Gd-DTPA des tumeurs rachidiennes. American Journal of Roentgenology, 152, 1087-1096. &gt;https://doi.org/10.2214/ajr.152.5.1087 
    </mixed-citation>
   </ref>
   <ref id="scirp.136375-ref7">
    <label>7</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Ganti, S.R., Silver, A.J., Hilal, S.K., Mawad, M.E. and Sane, P. (1982) Computed Tomography of Cerebellar Hemangioblastomas. Journal of Computer Assisted Tomography, 6, 912-919. &gt;https://doi.org/10.1097/00004728-198210000-00008
    </mixed-citation>
   </ref>
  </ref-list>
 </back>
</article>