<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">
    jct
   </journal-id>
   <journal-title-group>
    <journal-title>
     Journal of Cancer Therapy
    </journal-title>
   </journal-title-group>
   <issn pub-type="epub">
    2151-1934
   </issn>
   <issn publication-format="print">
    2151-1942
   </issn>
   <publisher>
    <publisher-name>
     Scientific Research Publishing
    </publisher-name>
   </publisher>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="doi">
    10.4236/jct.2024.159030
   </article-id>
   <article-id pub-id-type="publisher-id">
    jct-135670
   </article-id>
   <article-categories>
    <subj-group subj-group-type="heading">
     <subject>
      Articles
     </subject>
    </subj-group>
    <subj-group subj-group-type="Discipline-v2">
     <subject>
      Medicine 
     </subject>
     <subject>
       Healthcare
     </subject>
    </subj-group>
   </article-categories>
   <title-group>
    Research Status of Fear of Cancer Recurrence in Breast Cancer Patients
   </title-group>
   <contrib-group>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Yun
      </surname>
      <given-names>
       Ding
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Liping
      </surname>
      <given-names>
       Zhang
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Lijuan
      </surname>
      <given-names>
       Zhang
      </given-names>
     </name>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Qiaoling
      </surname>
      <given-names>
       Zhong
      </given-names>
     </name>
    </contrib>
   </contrib-group> 
   <aff id="affnull">
    <addr-line>
     aState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China
    </addr-line> 
   </aff> 
   <pub-date pub-type="epub">
    <day>
     28
    </day> 
    <month>
     08
    </month>
    <year>
     2024
    </year>
   </pub-date> 
   <volume>
    15
   </volume> 
   <issue>
    09
   </issue>
   <fpage>
    311
   </fpage>
   <lpage>
    319
   </lpage>
   <history>
    <date date-type="received">
     <day>
      4,
     </day>
     <month>
      August
     </month>
     <year>
      2024
     </year>
    </date>
    <date date-type="published">
     <day>
      26,
     </day>
     <month>
      August
     </month>
     <year>
      2024
     </year> 
    </date> 
    <date date-type="accepted">
     <day>
      26,
     </day>
     <month>
      August
     </month>
     <year>
      2024
     </year> 
    </date>
   </history>
   <permissions>
    <copyright-statement>
     © Copyright 2014 by authors and Scientific Research Publishing Inc. 
    </copyright-statement>
    <copyright-year>
     2014
    </copyright-year>
    <license>
     <license-p>
      This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
     </license-p>
    </license>
   </permissions>
   <abstract>
    Fear of disease progression is one of the most common psychological problems in the treatment of cancer patients. Early recognition and intervention can effectively control the level of fear of disease progression and improve the quality of life of patients. The present situation and influencing factors of FoP in breast cancer patients were reviewed in this paper, in order to provide reference for clinical research of breast cancer patients.
   </abstract>
   <kwd-group> 
    <kwd>
     Fear of Cancer Recurrence
    </kwd> 
    <kwd>
      Breast Cancer
    </kwd> 
    <kwd>
      Cancer
    </kwd> 
    <kwd>
      Nursing
    </kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <sec id="s1">
   <title>1. Fear of Cancer Recurrence in Cancer Patients</title>
   <p>A systematic review showed that the incidence of fear of cancer recurrence in young cancer survivors aged 15 to 39 years ranged from 31% to 85.2% <xref ref-type="bibr" rid="scirp.135670-1">
     [1]
    </xref>. According to Lane et al. <xref ref-type="bibr" rid="scirp.135670-2">
     [2]
    </xref>, 84% of current cancer patients aged 19 years and older experienced fear of cancer recurrence, and more than 59% of them showed significant fear of cancer recurrence. The study also found that women make up the majority of this group. Cancer recurrence fear score was significantly different among survivors of different types of cancer. When the cancer recurrence fear score was ≥ 34 points, the level of cancer recurrence fear was clinically significant. According to the results of the study <xref ref-type="bibr" rid="scirp.135670-3">
     [3]
    </xref>, among all types of cancer, patients with breast and gynecological related cancers had the highest fear of recurrence, while patients with prostate cancer had the lowest score, with only 4.9% of patients scoring more than 34 points. In contrast, 14.1 percent of patients with head and neck cancer scored more than 34 points, ranking second only to prostate cancer patients. Simard <xref ref-type="bibr" rid="scirp.135670-4">
     [4]
    </xref> showed that the fear of cancer recurrence in prostate cancer patients was significantly lower than that in lung cancer, breast cancer and colorectal cancer patients. In addition, a study by Krok Schoen <xref ref-type="bibr" rid="scirp.135670-5">
     [5]
    </xref> found that in the elderly cancer patient population, approximately 16% of patients showed high levels of recurrence fear, but there was no significant difference in this fear among elderly patients with breast, ovarian, colorectal, and endometrial cancers. The fear of recurrence is often present from the moment a patient is diagnosed with cancer and may continue to affect them. A longitudinal study of patients with head and neck cancer conducted by Llewellyn <xref ref-type="bibr" rid="scirp.135670-6">
     [6]
    </xref> showed that about 30% of patients already showed fear of recurrence before treatment, and this condition did not show significant improvement in 6 to 8 months after treatment. In addition, according to a study of 1002 German cancer patients <xref ref-type="bibr" rid="scirp.135670-3">
     [3]
    </xref>, the fear of cancer recurrence may persist even years later. In the study, 17 percent of patients scored more than 34 points on the Fop-Q-SF score, compared with 19 percent and 13.4 percent five and 10 years after cancer diagnosis, data that highlight the prevalence and persistence of cancer recurrence fears among patients.</p>
  </sec><sec id="s2">
   <title>2. Research Status of Recurrence Fear in Breast Cancer Patients</title>
   <p>In the 1980s, foreign scholars began to study the fear of cancer recurrence in cancer patients. According to a survey of breast cancer patients in Korea, about 54.3% of them are experiencing a high level of fear of cancer recurrence <xref ref-type="bibr" rid="scirp.135670-7">
     [7]
    </xref>. This long-term high level of fear of relapse not only increases the psychological pressure of patients, but also leads to more serious dysfunction in their function. Kallay <xref ref-type="bibr" rid="scirp.135670-8">
     [8]
    </xref> reviewed the literature on factors related to fear of cancer recurrence in breast cancer patients during the COVID-19 pandemic, and found that high levels of fear of cancer recurrence were associated with the impact of the COVID-19 pandemic, because of the disruption or delay of treatment plans, obstruction of communication with medical personnel, and difficulty in obtaining drugs. In the study of Schapira <xref ref-type="bibr" rid="scirp.135670-9">
     [9]
    </xref>, they tracked the recurrence fear of 365 young breast cancer patients, and found that 60% of them showed a medium-high level of cancer recurrence fear, and this fear did not decrease with time, so it is of great significance to continuously monitor the level of cancer recurrence fear. Thewes <xref ref-type="bibr" rid="scirp.135670-10">
     [10]
    </xref> showed in qualitative interviews that when breast cancer patients’ fear of cancer recurrence was at a high level, they mostly adopted avoidance coping styles. The fear of cancer recurrence in breast cancer patients is also related to disease perception <xref ref-type="bibr" rid="scirp.135670-11">
     [11]
    </xref>, anxiety and depression <xref ref-type="bibr" rid="scirp.135670-12">
     [12]
    </xref>, social support <xref ref-type="bibr" rid="scirp.135670-13">
     [13]
    </xref> and other factors. Existing studies have shown that the fear of recurrence of breast cancer patients in China is at a moderate to severe level <xref ref-type="bibr" rid="scirp.135670-14">
     [14]
    </xref>-<xref ref-type="bibr" rid="scirp.135670-16">
     [16]
    </xref>. Ye Chunli <xref ref-type="bibr" rid="scirp.135670-17">
     [17]
    </xref> evaluated 180 patients with breast cancer after surgery by using the simplified fear of disease progression scale, and the results showed that 64.4% of the patients’ fear of cancer recurrence reached the clinically meaningful standard. The study also found that the fear of cancer recurrence was negatively correlated with social support and positively correlated with the feeling of disease uncertainty, indicating that the fear of cancer recurrence of patients after breast cancer surgery was high. Clinicians need to take targeted intervention measures to help patients reduce the feeling of disease uncertainty and improve the level of social support, so as to reduce the fear of cancer recurrence. In the study of Jiang Liling <xref ref-type="bibr" rid="scirp.135670-18">
     [18]
    </xref>, they used the Chinese version of the simplified Fear of disease progression scale to investigate 110 cases of breast cancer patients, and found that the recurrence fear of breast cancer patients was in a medium to low state, and found that the recurrence fear was negatively correlated with health literacy. In addition, the greater the psychological burden patients experienced, their fear of cancer recurrence increased correspondingly. At present, there are relatively few studies on the fear of cancer recurrence in China. However, according to the existing literature reports, the fear of cancer recurrence is not only at a high level in the breast cancer population, but also has become one of the most prominent psychological problems in this group. In view of this, it is particularly critical to conduct in-depth research on the current situation and influencing factors of recurrence fear in breast cancer patients, which will help to explore ways to reduce the level of recurrence fear of cancer, so as to improve their physical and mental health. This research direction can provide more effective psychological support measures for clinical practice, help breast cancer patients better cope with the psychological challenge of cancer recurrence, and promote the full recovery of their physical and mental health.</p>
  </sec><sec id="s3">
   <title>3. Factors Influencing the Fear of Cancer Recurrence in Breast Cancer Patients</title>
   <sec id="s3_1">
    <title>3.1. Demographic Factor</title>
    <p>Studies have shown that age, family income and education level are key factors that influence the fear of cancer recurrence, but these factors are expressed differently in different populations. Vachon <xref ref-type="bibr" rid="scirp.135670-19">
      [19]
     </xref> found a significant negative correlation between age and fear of cancer recurrence when studying the relationship between fear of cancer recurrence and health care behavior in breast cancer survivors. Zhang Yang <xref ref-type="bibr" rid="scirp.135670-20">
      [20]
     </xref> showed that the younger the age of cancer patients, the higher the fear of cancer recurrence. Niu <xref ref-type="bibr" rid="scirp.135670-21">
      [21]
     </xref> conducted a survey on 342 patients after breast cancer surgery and found that family income was negatively correlated with patients’ fear of cancer recurrence. According to the study of Wu Qiyun <xref ref-type="bibr" rid="scirp.135670-22">
      [22]
     </xref>, family income is one of the factors affecting the fear of cancer recurrence. Another study conducted by Hu Zewei <xref ref-type="bibr" rid="scirp.135670-23">
      [23]
     </xref>, through a survey of 124 patients after breast cancer surgery, found that patients with higher education levels experienced lower fear of cancer recurrence. In addition, the fear of cancer recurrence is influenced by other demographic factors. Pang <xref ref-type="bibr" rid="scirp.135670-24">
      [24]
     </xref> found in the meta-analysis that because women are better at expressing vulnerability and fear, the overall level of cancer recurrence fear in women is higher than that in men. Anderson <xref ref-type="bibr" rid="scirp.135670-25">
      [25]
     </xref> analyzed 19 literatures from European and American countries and found significant differences in the average level of fear of cancer recurrence between ethnic minorities and major ethnic groups. At the same time, the study of Ashing <xref ref-type="bibr" rid="scirp.135670-26">
      [26]
     </xref> surveyed Asian Americans, and the results showed that women from China reported lower levels of fear of cancer recurrence than women from other Asian countries (such as South Korea, the Philippines and Vietnam), which may be related to the cultural background of different ethnic groups.</p>
   </sec>
   <sec id="s3_2">
    <title>3.2. Disease and Therapeutic Factors</title>
    <p>Multiple studies have found that while various cancer types can cause varying levels of fear of recurrence, breast cancer patients report the most significant levels of fear <xref ref-type="bibr" rid="scirp.135670-27">
      [27]
     </xref> <xref ref-type="bibr" rid="scirp.135670-28">
      [28]
     </xref>. In a population-based cohort study in Germany, patients experienced greater fear of recurrence when their cancer recurred or metastasized <xref ref-type="bibr" rid="scirp.135670-29">
      [29]
     </xref>. A study conducted by Xing Jiwei <xref ref-type="bibr" rid="scirp.135670-30">
      [30]
     </xref> on 300 breast cancer patients also found that the severity of the disease was positively correlated with the fear of recurrence. Regarding the surgical treatment of breast cancer, studies have shown that patients with breast-conserving surgery often experience a higher level of fear of recurrence compared with patients who receive modified radical surgery <xref ref-type="bibr" rid="scirp.135670-31">
      [31]
     </xref>. In addition, studies <xref ref-type="bibr" rid="scirp.135670-32">
      [32]
     </xref> have shown that different treatments for breast cancer have an impact on the level of fear of recurrence, with patients receiving radiotherapy generally having a lower level of fear of recurrence than those receiving chemotherapy.</p>
   </sec>
   <sec id="s3_3">
    <title>3.3. Psychological Factors</title>
    <p>Depression and anxiety have a significant impact on the fear of cancer recurrence in breast cancer patients. Chirico <xref ref-type="bibr" rid="scirp.135670-12">
      [12]
     </xref> found that breast cancer patients with high anxiety and depression have higher sensitivity to stressful events, which not only increases psychological pressure, but also may lead to higher fear of recurrence. KOCH <xref ref-type="bibr" rid="scirp.135670-33">
      [33]
     </xref> also observed a positive correlation between the degree of anxiety and depression and the fear of cancer recurrence in a survey of 2671 breast cancer patients. In addition, Lebel <xref ref-type="bibr" rid="scirp.135670-34">
      [34]
     </xref> also showed that breast cancer patients with symptoms of depression and anxiety tended to experience more severe fear of recurrence. The research of Niu Yaling <xref ref-type="bibr" rid="scirp.135670-15">
      [15]
     </xref>, a domestic scholar, revealed that the recurrence fear of patients with breast cancer after surgery is negatively correlated with the level of psychosocial adaptation, indicating that psychological maladaptation may exacerbate the recurrence fear. Ye Chunli <xref ref-type="bibr" rid="scirp.135670-17">
      [17]
     </xref> also found in a survey of 180 patients after breast cancer surgery that the more uncertain patients were about the disease, the more serious their fear of cancer recurrence.</p>
   </sec>
   <sec id="s3_4">
    <title>3.4. Social Support</title>
    <p>Social support plays a crucial role in how individuals cope with stressful events. It is not only an effective external resource that can be used, but also an important reason for individual psychological adjustment in the face of stressful events. It can relieve stress and improve physical and mental condition through emotional interaction, information exchange, tool support and re-evaluation <xref ref-type="bibr" rid="scirp.135670-35">
      [35]
     </xref>. Studies <xref ref-type="bibr" rid="scirp.135670-17">
      [17]
     </xref> <xref ref-type="bibr" rid="scirp.135670-20">
      [20]
     </xref> have shown that the fear of recurrence in breast cancer patients is negatively correlated with social support. Based on the social cognitive processing model that validated breast cancer patients and their spouses, Soriano <xref ref-type="bibr" rid="scirp.135670-13">
      [13]
     </xref> analyzed the impact of social environment on the recurrence fear of breast cancer patients, and pointed out that patients with fewer social resources and their spouses may suffer greater psychological pressure, resulting in a higher recurrence fear level. On the other hand, Huang Jialian <xref ref-type="bibr" rid="scirp.135670-36">
      [36]
     </xref> randomly divided 180 breast cancer patients into intervention group and control group. The intervention group received information support, while the control group received routine nursing education. The results showed that information support significantly reduced patients’ fear of recurrence and feelings of uncertainty about their disease, while increasing their confidence and determination to cope with their cancer.</p>
    <p>Self-disclosure is a core concept in the field of psychology, originally proposed by American psychologist Jourard, who describes self-disclosure as the process of revealing information about oneself to others and sharing one’s private thoughts and emotions <xref ref-type="bibr" rid="scirp.135670-37">
      [37]
     </xref>. Self-disclosure is a positive and effective way of communication, which has a direct negative predictive effect on the fear of cancer recurrence. It not only helps individuals gain understanding and support from others through expressing bad emotions, and enhances the function of social support system, but also promotes the adjustment of cognitive structure, enhances positive perception, and improves their social relations through revealing extreme thinking. Thus reducing the fear of cancer recurrence <xref ref-type="bibr" rid="scirp.135670-38">
      [38]
     </xref>. In the study of Chen Jiao <xref ref-type="bibr" rid="scirp.135670-39">
      [39]
     </xref>, 88 postoperative breast cancer patients who received chemotherapy were randomly assigned to the control group and the intervention group. The control group received standard chemotherapy care, while the intervention group added self-disclosure intervention measures on the basis of routine care. This helps reduce the fear of cancer recurrence. In addition, Xu <xref ref-type="bibr" rid="scirp.135670-40">
      [40]
     </xref> also showed that through effective communication with others, patients can change their wrong understanding of the fear of cancer recurrence, establish a correct disease concept, and then reduce the fear of cancer recurrence.</p>
   </sec>
   <sec id="s3_5">
    <title>3.5. Coping Style</title>
    <p>Coping style is a coping strategy that involves cognitive and behavioral measures taken by individuals in response to frustration and stress. Adopting positive coping strategies can help individuals proactively deal with stressors and increase confidence in treatment <xref ref-type="bibr" rid="scirp.135670-41">
      [41]
     </xref>. Simard <xref ref-type="bibr" rid="scirp.135670-42">
      [42]
     </xref> found that patients who adopted religion as a coping strategy showed a lower level of fear of cancer recurrence, which may be because they believed that they could gain more power to fight cancer through faith. Chinese scholar Ren Jialei’s research shows <xref ref-type="bibr" rid="scirp.135670-43">
      [43]
     </xref> that when breast cancer patients adopt active coping methods, their reported fear level of cancer recurrence is lower.</p>
   </sec>
  </sec><sec id="s4">
   <title>4. Conclusion</title>
   <p>To sum up, domestic and foreign studies on the influencing factors of fear of cancer recurrence mainly focus on breast cancer patients, and the main influencing factors include demographic factors, disease and treatment factors, and cognitive psychosocial factors (disease perception, social support, anxiety and depression, etc.).</p>
  </sec><sec id="s5">
   <title>NOTES</title>
   <p>*Co-first author.</p>
   <p><sup>#</sup>Corresponding author.</p>
  </sec>
 </body><back>
  <ref-list>
   <title>References</title>
   <ref id="scirp.135670-ref1">
    <label>1</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Yang, Y., Li, W., Wen, Y., Wang, H., Sun, H., Liang, W., et al. (2019) Fear of Cancer Recurrence in Adolescent and Young Adult Cancer Survivors: A Systematic Review of the Literature. Psycho-Oncology, 28, 675-686. &gt;https://doi.org/10.1002/pon.5013
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref2">
    <label>2</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Lane, B.E., Garland, S.N., Chalifour, K., Eaton, G., Lebel, S., Galica, J., et al. (2019) Prevalence and Factors Associated with Fear of Recurrence in a Mixed Sample of Young Adults with Cancer. Journal of Cancer Survivorship, 13, 842-851. &gt;https://doi.org/10.1007/s11764-019-00802-9
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref3">
    <label>3</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Götze, H., Taubenheim, S., Dietz, A., Lordick, F. and Mehnert‐Theuerkauf, A. (2019) Fear of Cancer Recurrence across the Survivorship Trajectory: Results from a Survey of Adult Long‐Term Cancer Survivors. Psycho-Oncology, 28, 2033-2041. &gt;https://doi.org/10.1002/pon.5188
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref4">
    <label>4</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Simard, S. and Savard, J. (2008) Fear of Cancer Recurrence Inventory: Development and Initial Validation of a Multidimensional Measure of Fear of Cancer Recurrence. Supportive Care in Cancer, 17, 241-251. &gt;https://doi.org/10.1007/s00520-008-0444-y
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref5">
    <label>5</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Krok‐Schoen, J.L., Naughton, M.J., Bernardo, B.M., Young, G.S. and Paskett, E.D. (2018) Fear of Recurrence among Older Breast, Ovarian, Endometrial, and Colorectal Cancer Survivors: Findings from the WHI LILAC Study. Psycho-Oncology, 27, 1810-1815. &gt;https://doi.org/10.1002/pon.4731
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref6">
    <label>6</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Llewellyn, C.D., Weinman, J., McGurk, M. and Humphris, G. (2008) Can We Predict Which Head and Neck Cancer Survivors Develop Fears of Recurrence? Journal of Psychosomatic Research, 65, 525-532. &gt;https://doi.org/10.1016/j.jpsychores.2008.03.014
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref7">
    <label>7</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Hong, S.J. and Shin, N. (2021) Fear of Cancer Recurrence in Korean Women After Breast Cancer Treatment: A Mixed Methods Study. European Journal of Oncology Nursing, 54, Article ID: 102010. &gt;https://doi.org/10.1016/j.ejon.2021.102010
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref8">
    <label>8</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Kállay, É., Medrea, F. and Dégi, C.L. (2022) On Top of That All, Now Covid-19, Too. a Scoping Review of Specificities and Correlates of Fear of Cancer Recurrence in Breast Cancer Patients during Covid-19. The Breast, 62, 123-134. &gt;https://doi.org/10.1016/j.breast.2022.02.007
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref9">
    <label>9</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Schapira, L., Zheng, Y., Gelber, S.I., Poorvu, P., Ruddy, K.J., Tamimi, R.M., et al. (2021) Trajectories of Fear of Cancer Recurrence in Young Breast Cancer Survivors. Cancer, 128, 335-343. &gt;https://doi.org/10.1002/cncr.33921
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref10">
    <label>10</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Thewes, B., Lebel, S., Seguin Leclair, C. and Butow, P. (2015) A Qualitative Exploration of Fear of Cancer Recurrence (FCR) Amongst Australian and Canadian Breast Cancer Survivors. Supportive Care in Cancer, 24, 2269-2276. &gt;https://doi.org/10.1007/s00520-015-3025-x
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref11">
    <label>11</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Şengün İnan, F. and Üstün, B. (2018) Fear of Recurrence in Turkish Breast Cancer Survivors: A Qualitative Study. Journal of Transcultural Nursing, 30, 146-153. &gt;https://doi.org/10.1177/1043659618771142
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref12">
    <label>12</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Chirico, A., Vizza, D., Valente, M., Iacono, M.L., Campagna, M.R., Palombi, T., et al. (2021) Assessing the Fear of Recurrence Using the Cancer Worry Scale in a Sample of Italian Breast Cancer Survivors. Supportive Care in Cancer, 30, 2829-2837. &gt;https://doi.org/10.1007/s00520-021-06718-4
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref13">
    <label>13</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Soriano, E.C., Otto, A.K., LoSavio, S.T., Perndorfer, C., Siegel, S.D. and Laurenceau, J. (2020) Fear of Cancer Recurrence and Inhibited Disclosure: Testing the Social-Cognitive Processing Model in Couples Coping with Breast Cancer. Annals of Behavioral Medicine, 55, 192-202. &gt;https://doi.org/10.1093/abm/kaaa043
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref14">
    <label>14</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Jia, Y., Tang, H., Mei, H. and Zhou, Z. (2022) Research Status of Fear of Disease Pro-gression in Breast Cancer Patients. Journal of Nurses Training, 37, 1567-1571. &gt;https://doi.org/10.16821/j.cnki.hsjx.2022.17.006
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref15">
    <label>15</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Niu, Y.L. (2022) Investigation on Recurrence Fear and Psychosocial Adjustment in Patients with Breast Cancer after Surgery.&gt;https://link.cnki.net/doi/10.27162/d.cnki.gjlin.2022.003571 
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref16">
    <label>16</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Wang, H., Li, N., Li, Y., Zhang, H., Cheng, B. and Liu, W. (2022) The Effect of Social Support on Fear of Cancer Recurrence in Breast Cancer Survivors: Mediating Effects of Psychological Resilience. Military Nursing, 39, 17-20.
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref17">
    <label>17</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Ye, C., Xie, X., Luo, M., Huang, L. and Xu, X. (2019) Correlation between Fear of Cancer Recurrence and Uncertainty and Social Support in Patients with Breast Cancer after Surgery. Military Nursing, 36, 23-26.
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref18">
    <label>18</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Jiang, L., Wang, J., Li, L., Zhang, S., Gong, J., Zhu, H. and Dong, T. (2020) Correlation between Health Literacy and Fear of Cancer Recurrence in 110 Female Patients with Breast Cancer. Journal of Nursing (China), 27, 26-29. &gt;https://doi.org/10.16460/j.issn1008-9969.2020.14.026 
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref19">
    <label>19</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Vachon, E., Krueger, E., Champion, V.L., Haggstrom, D.A., Cella, D. and Cohee, A.A. (2020) The Impact of Fear of Cancer Recurrence on Healthcare Utilization among Long‐term Breast Cancer Survivors Recruited through ECOG‐ACRIN Trials. Psycho-Oncology, 30, 279-286. &gt;https://doi.org/10.1002/pon.5568
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref20">
    <label>20</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Zhang, Y., Cheng, C., Cui, P. and Chen, C. (2018) Analysis of Fear of Cancer Recurrence and Its Influencing Factors in Patients with Breast Cancer. Chinese General Practice, 21, 2479-2483. &gt;https://link.cnki.net/urlid/13.1222.R.20180413.1110.014
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref21">
    <label>21</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Niu, L., Liang, Y. and Niu, M. (2019) Factors Influencing Fear of Cancer Recurrence in Patients with Breast Cancer: Evidence from a Survey in Yancheng, China. Journal of Obstetrics and Gynaecology Research, 45, 1319-1327. &gt;https://doi.org/10.1111/jog.13978
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref22">
    <label>22</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Wu, Q., Ye, Z. and Li, L. (2015) Research Progress on the Measurement and Influencing Factors of Fear of Cancer Recurrence in Cancer Patients. Chinese Nursing Management, 15, 1020-1023.
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref23">
    <label>23</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Hu, Z., Wang, Z., Yu, D. and Qiu, X. (2019) Analysis of Fear of Cancer Recurrence in Patients after Breast Cancer Surgery and Its Influencing Factors. Journal of Nurses Training, 34, 657-660. &gt;https://doi.org/10.16821/j.cnki.hsjx.2019.07.023
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref24">
    <label>24</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Pang, C. and Humphris, G. (2021) The Relationship between Fears of Cancer Recurrence and Patient Gender: A Systematic Review and Meta-Analysis. Frontiers in Psychology, 12, Article 640866. &gt;https://doi.org/10.3389/fpsyg.2021.640866
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref25">
    <label>25</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Anderson, K., Smith, A., Diaz, A., Shaw, J., Butow, P., Sharpe, L., et al. (2021) A Systematic Review of Fear of Cancer Recurrence among Indigenous and Minority Peoples. Frontiers in Psychology, 12, Article 621850. &gt;https://doi.org/10.3389/fpsyg.2021.621850
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref26">
    <label>26</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Ashing, K.T., Cho, D., Lai, L., Yeung, S., Young, L., Yeon, C., et al. (2017) Exploring Characteristics, Predictors, and Consequences of Fear of Cancer Recurrence among Asian‐American Breast Cancer Survivors. Psycho-Oncology, 26, 2253-2260. &gt;https://doi.org/10.1002/pon.4350
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref27">
    <label>27</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Janz, N.K., Li, Y., Beesley, L.J., Wallner, L.P., Hamilton, A.S., Morrison, R.A., et al. (2016) Worry about Recurrence in a Multi-Ethnic Population of Breast Cancer Survivors and Their Partners. Supportive Care in Cancer, 24, 4669-4678. &gt;https://doi.org/10.1007/s00520-016-3314-z
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref28">
    <label>28</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Vandraas, K.F., Reinertsen, K.V., Kiserud, C.E. and Lie, H.C. (2020) Fear of Cancer Recurrence among Young Adult Cancer Survivors—Exploring Long-Term Contributing Factors in a Large, Population-Based Cohort. Journal of Cancer Survivorship, 15, 497-508. &gt;https://doi.org/10.1007/s11764-020-00943-2
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref29">
    <label>29</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Koch-Gallenkamp, L., Bertram, H., Eberle, A., Holleczek, B., Schmid-Höpfner, S., Waldmann, A., et al. (2016) Fear of Recurrence in Long-Term Cancer Survivors—Do Cancer Type, Sex, Time since Diagnosis, and Social Support Matter? Health Psychology, 35, 1329-1333. &gt;https://doi.org/10.1037/hea0000374
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref30">
    <label>30</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Xing, J., Meng, X., Xing, S., Hu, P. and Tian, L. (2018) Status and Influencing Factors of Postoperative Fear Disease Progression in Patients with Breast Cancer. Oncology Progress, 16, 254-257.
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref31">
    <label>31</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Costanzo, E.S., Lutgendorf, S.K., Mattes, M.L., Trehan, S., Robinson, C.B., Tewfik, F., et al. (2007) Adjusting to Life After Treatment: Distress and Quality of Life Following Treatment for Breast Cancer. British Journal of Cancer, 97, 1625-1631. &gt;https://doi.org/10.1038/sj.bjc.6604091
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref32">
    <label>32</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Freeman-Gibb, L.A., Janz, N.K., Katapodi, M.C., Zikmund-Fisher, B.J. and Northouse, L. (2016) The Relationship between Illness Representations, Risk Perception and Fear of Cancer Recurrence in Breast Cancer Survivors. Psycho-Oncology, 26, 1270-1277. &gt;https://doi.org/10.1002/pon.4143
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref33">
    <label>33</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Koch, L., Bertram, H., Eberle, A., Holleczek, B., Schmid-Höpfner, S., Waldmann, A., et al. (2013) Fear of Recurrence in Long-Term Breast Cancer Survivors—Still an Issue. Results on Prevalence, Determinants, and the Association with Quality of Life and Depression from the Cancer Survivorship—A Multi-Regional Population-Based Study. Psycho-Oncology, 23, 547-554. &gt;https://doi.org/10.1002/pon.3452
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref34">
    <label>34</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Lebel, S., Beattie, S., Arès, I. and Bielajew, C. (2013) Young and Worried: Age and Fear of Recurrence in Breast Cancer Survivors. Health Psychology, 32, 695-705. &gt;https://doi.org/10.1037/a0030186
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref35">
    <label>35</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     He, M. (2022) Correlation of Cancer Recurrence Fear, Social Support and Coping Style in Patients after Radical Cervical Cancer Surgery.&gt;https://link.cnki.net/doi/10.27438/d.cnki.gyadu.2022.000256 
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref36">
    <label>36</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Huang, J., Ying, Y., Ling, Y., Lu, Q. and Chen, M. (2019) The Effects of Targeted in-Formation Support on Fear of Cancer Recurrence, Disease Uncertainty and Coping Style in Patients with Breast Cancer after Surgery. Guangxi Medical Journal, 41, 272-274, 278.
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref37">
    <label>37</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Jourard, S.M. and Lasakow, P. (1958) Some Factors in Self-Disclosure. The Journal of Abnormal and Social Psychology, 56, 91-98. &gt;https://doi.org/10.1037/h0043357
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref38">
    <label>38</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Wang, J. and Zhu, B. (2022) Analysis of Influencing Factors of Fear of Cancer Recurrence in Young Female Breast Cancer Patients after Surgery. Chinese General Practice Nursing, 20, 3988-3991.
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref39">
    <label>39</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Chen, J., Cheng, H., Wei, Q., Zhong, C., Xu, Y., Xia, Y. and Zhong, Y. (2022) Self-disclosure Intervention for Postoperative Chemotherapy Patients with Breast Cancer. Journal of Nursing Science, 37, 86-89.
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref40">
    <label>40</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Xu, W., Wang, J. and Schoebi, D. (2019) The Role of Daily Couple Communication in the Relationship between Illness Representation and Fear of Cancer Recurrence in Breast Cancer Survivors and Their Spouses. Psycho-Oncology, 28, 1301-1307. &gt;https://doi.org/10.1002/pon.5082
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref41">
    <label>41</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Tan, J.H., Sharpe, L. and Russell, H. (2020) The Impact of Ovarian Cancer on Individuals and Their Caregivers: A Qualitative Analysis. Psycho-Oncology, 30, 212-220. &gt;https://doi.org/10.1002/pon.5551
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref42">
    <label>42</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Simard, S., Thewes, B., Humphris, G., Dixon, M., Hayden, C., Mireskandari, S., et al. (2013) Fear of Cancer Recurrence in Adult Cancer Survivors: A Systematic Review of Quantitative Studies. Journal of Cancer Survivorship, 7, 300-322. &gt;https://doi.org/10.1007/s11764-013-0272-z
    </mixed-citation>
   </ref>
   <ref id="scirp.135670-ref43">
    <label>43</label>
    <mixed-citation publication-type="other" xlink:type="simple">
     Roth, R.S., Lowery, J.C., Davis, J. and Wilkins, E.G. (2007) Psychological Factors Predict Patient Satisfaction with Postmastectomy Breast Reconstruction. Plastic and Reconstructive Surgery, 119, 2008-2015. &gt;https://doi.org/10.1097/01.prs.0000260584.09371.99
    </mixed-citation>
   </ref>
  </ref-list>
 </back>
</article>