<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">Health</journal-id><journal-title-group><journal-title>Health</journal-title></journal-title-group><issn pub-type="epub">1949-4998</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/health.2024.166038</article-id><article-id pub-id-type="publisher-id">Health-134030</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biomedical&amp;Life Sciences</subject><subject> Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  Cheyne-Stokes Respiration in Heart Failure Is Not a Therapeutic Target: A Lesson from 
  CANPAP, 
  SERVE-HF and 
  ADVENT-HF Trials (Letter to the Editor)
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Fumihiko</surname><given-names>Yasuma</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Junichiro</surname><given-names>Hayano</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group><aff id="aff2"><addr-line>Heart Beat Science Lab. Co., Nagoya, Japan</addr-line></aff><aff id="aff1"><addr-line>Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan</addr-line></aff><pub-date pub-type="epub"><day>07</day><month>06</month><year>2024</year></pub-date><volume>16</volume><issue>06</issue><fpage>561</fpage><lpage>564</lpage><history><date date-type="received"><day>10,</day>	<month>May</month>	<year>2024</year></date><date date-type="rev-recd"><day>23,</day>	<month>June</month>	<year>2024</year>	</date><date date-type="accepted"><day>25,</day>	<month>June</month>	<year>2024</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  Letter to the Editor
 
</p></abstract><kwd-group><kwd>Letter to the Editor</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>Conflicts of Interest</title><p>The authors declare no conflict of interest regarding the publication of this paper.</p></sec><sec id="s2"><title>Cite this paper</title><p>Yasuma, F. and Hayano, J. (2024) Cheyne-Stokes Respiration in Heart Failure Is Not a Therapeutic Target: A Lesson from CANPAP, SERVE-HF and ADVENT-HF Trials (Letter to the Editor). Health, 16, 561-564. https://doi.org/10.4236/health.2024.166038</p></sec></body><back><ref-list><title>References</title><ref id="scirp.134030-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Bradley, T.D., Logan, A.G., Lorenzi Filho, G., Kimoff, R.J., Durán Cantolla, J., Arzt, M., et al. (2024) Adaptive Servo-Ventilation for Sleep-Disordered Breathing in Patients with Heart Failure with Reduced Ejection Fraction (ADVENT-HF): A Multicentre, Multinational, Parallel-Group, Open-Label, Phase 3 Randomised Controlled Trial. The Lancet Respiratory Medicine, 12, 153-166.  
https://doi.org/10.1016/s2213-2600(23)00374-0</mixed-citation></ref><ref id="scirp.134030-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Bradley, T.D., Logan, A.G., Kimoff, R.J., Sériès, F., Morrison, D., Ferguson, K., et al. (2005) Continuous Positive Airway Pressure for Central Sleep Apnea and Heart Failure. New England Journal of Medicine, 353, 2025-2033.  
https://doi.org/10.1056/nejmoa051001</mixed-citation></ref><ref id="scirp.134030-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Cowie, M.R., Woehrle, H., Wegscheider, K., Angermann, C., d’Ortho, M., Erdmann, E., et al. (2015) Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. New England Journal of Medicine, 373, 1095-1105.  
https://doi.org/10.1056/nejmoa1506459</mixed-citation></ref><ref id="scirp.134030-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Arzt, M., Floras, J.S., Logan, A.G., Kimoff, R.J., Series, F., Morrison, D., et al. (2007) Suppression of Central Sleep Apnea by Continuous Positive Airway Pressure and Transplant-Free Survival in Heart Failure: A Post Hoc Analysis of the Canadian Continuous Positive Airway Pressure for Patients With Central Sleep Apnea and Heart Failure Trial (CANPAP). Circulation, 115, 3173-3180.  
https://doi.org/10.1161/circulationaha.106.683482</mixed-citation></ref><ref id="scirp.134030-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Hayano, J., Yasuma, F., Okada, A., Mukai, S. and Fujinami, T. (1996) Respiratory Sinus Arrhythmia. Circulation, 94, 842-847. https://doi.org/10.1161/01.cir.94.4.842</mixed-citation></ref><ref id="scirp.134030-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Yasuma, F., Nomura, H., Hayashi, H., Okada, T. and Tsuzuki, M. (1989) Breathing Abnormalities during Sleep in Patients with Chronic Heart Failure. Japanese Circulation Journal, 53, 1506-1510. https://doi.org/10.1253/jcj.53.1506</mixed-citation></ref><ref id="scirp.134030-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Lieber, C. and Mohsenin, V. (1992) Cheyne-Stokes Respiration in Congestive Heart Failure. Yale Journal of Biology and Medicine, 65, 39-50.</mixed-citation></ref><ref id="scirp.134030-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Hanly, P.J. and Zuberi-Khokhar, N.S. (1996) Increased Mortality Associated with Cheyne-Stokes Respiration in Patients with Congestive Heart Failure. American Journal of Respiratory and Critical Care Medicine, 153, 272-276.  
https://doi.org/10.1164/ajrccm.153.1.8542128</mixed-citation></ref><ref id="scirp.134030-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Naughton, M.T. (2012) Cheyne-Stokes Respiration: Friend or Foe? Thorax, 67, 357-360. https://doi.org/10.1136/thoraxjnl-2011-200927</mixed-citation></ref><ref id="scirp.134030-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">Yasuma, F. (2013) Is Cheyne-Stokes Respiration Friend or Foe of Heart Failure? Thorax, 68, 106-107. https://doi.org/10.1136/thoraxjnl-2012-202725</mixed-citation></ref><ref id="scirp.134030-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Yasuma, F., Hayashi, H., Noda, S., Tsuzuki, M., Tanaka, M. and Okada, T. (1995) A Case of Mitral Regurgitation Whose Nocturnal Periodic Breathing Was Improved After Mitral Valve Replacement. Japanese Heart Journal, 36, 267-272.  
https://doi.org/10.1536/ihj.36.267</mixed-citation></ref><ref id="scirp.134030-ref12"><label>12</label><mixed-citation publication-type="other" xlink:type="simple">Yasuma, F. (2005) Cheyne-Stokes Respiration in Congestive Heart Failure: Continuous Positive Airway Pressure of 5 - 8 cm H2O for 1 Year in Five Cases. Respiration, 72, 198-201. https://doi.org/10.1159/000084053</mixed-citation></ref><ref id="scirp.134030-ref13"><label>13</label><mixed-citation publication-type="other" xlink:type="simple">Yasuma, F., Tanahashi, T., Mori, T., Shimizu, Y. and Murohara, T. (2013) Preoperative Management of Deteriorating Mitral Regurgitation and Heart Failure with Continuous Positive Airway Pressure. Internal Medicine, 52, 1709-1713.  
https://doi.org/10.2169/internalmedicine.52.9387</mixed-citation></ref><ref id="scirp.134030-ref14"><label>14</label><mixed-citation publication-type="other" xlink:type="simple">Yasuma, F. and Hayano, J. (2004) Respiratory Sinus Arrhythmia: Why Does the Heartbeat Synchronize With Respiratory Rhythm? Chest, 125, 683-690.  
https://doi.org/10.1378/chest.125.2.683</mixed-citation></ref></ref-list></back></article>