<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">
    oju
   </journal-id>
   <journal-title-group>
    <journal-title>
     Open Journal of Urology
    </journal-title>
   </journal-title-group>
   <issn pub-type="epub">
    2160-5440
   </issn>
   <issn publication-format="print">
    2160-5629
   </issn>
   <publisher>
    <publisher-name>
     Scientific Research Publishing
    </publisher-name>
   </publisher>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="doi">
    10.4236/oju.2024.145036
   </article-id>
   <article-id pub-id-type="publisher-id">
    oju-133252
   </article-id>
   <article-categories>
    <subj-group subj-group-type="heading">
     <subject>
      Articles
     </subject>
    </subj-group>
    <subj-group subj-group-type="Discipline-v2">
     <subject>
      Medicine 
     </subject>
     <subject>
       Healthcare
     </subject>
    </subj-group>
   </article-categories>
   <title-group>
    Klingsor Syndrome: An Observation in a Patient with Schizophrenia
   </title-group>
   <contrib-group>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Mbuya Musapudi
      </surname>
      <given-names>
       Eric
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref> 
     <xref ref-type="aff" rid="aff2"> 
      <sup>2</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Ouake
      </surname>
      <given-names>
       Hadidjatou
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Michel
      </surname>
      <given-names>
       Agounkpe
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Yevi Dodji Magloire
      </surname>
      <given-names>
       Inès
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Hodonou Fred
      </surname>
      <given-names>
       Martin
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
    <contrib contrib-type="author" xlink:type="simple">
     <name name-style="western">
      <surname>
       Avakoudjo Josué Georges
      </surname>
      <given-names>
       Dejinnin
      </given-names>
     </name> 
     <xref ref-type="aff" rid="aff1"> 
      <sup>1</sup>
     </xref>
    </contrib>
   </contrib-group> 
   <aff id="aff1">
    <addr-line>
     aDepartment of Urology and Andrology, Hubert Koutoukou Maga National Teaching Hospital, Cotonou, Benin
    </addr-line> 
   </aff> 
   <aff id="aff2">
    <addr-line>
     aDepartment of Surgery, University Clinics of Lubumbashi, Lubumbashi, Democratic Republic of the Congo
    </addr-line> 
   </aff> 
   <pub-date pub-type="epub">
    <day>
     09
    </day> 
    <month>
     05
    </month>
    <year>
     2024
    </year>
   </pub-date> 
   <volume>
    14
   </volume> 
   <issue>
    05
   </issue>
   <fpage>
    346
   </fpage>
   <lpage>
    351
   </lpage>
   <history>
    <date date-type="received">
     <day>
      25,
     </day>
     <month>
      March
     </month>
     <year>
      2024
     </year>
    </date>
    <date date-type="published">
     <day>
      19,
     </day>
     <month>
      March
     </month>
     <year>
      2024
     </year> 
    </date> 
    <date date-type="accepted">
     <day>
      19,
     </day>
     <month>
      May
     </month>
     <year>
      2024
     </year> 
    </date>
   </history>
   <permissions>
    <copyright-statement>
     © Copyright 2014 by authors and Scientific Research Publishing Inc. 
    </copyright-statement>
    <copyright-year>
     2014
    </copyright-year>
    <license>
     <license-p>
      This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
     </license-p>
    </license>
   </permissions>
   <abstract>
    <b>Background:</b> Klingsor syndrome refers to genital self-mutilation in man following delusional religious beliefs. Later, Schweitzer proposed expanding the term to include all psychotic disorders, drug and alcohol abuse. Apart from the noted hemorrhagic emergency and difficult surgical operation, there is a psychosocial impact, sexual and urinary complications (stenosis, urethral fistula) which make this pathology complex. 
    <b>Aim:</b> The Aim of this study is to describe the clinical case of Klingsor syndrome and evaluate its management in light of the literature. 
    <b>Case </b>
    <b>Presentation</b>
    <b>:</b> We report a rare case of genital self-mutilation in a 35-year-old man, non-compliant schizophrenic, received 04 days after the trauma and whose treatment consisted of remodeling of the penis stump and follow-up by psychiatrists. 
    <b>Conclusion: </b>Klingsor syndrome is a rare but serious phenomenon. Its management remains complex, but it must be early and multidisciplinary.
   </abstract>
   <kwd-group> 
    <kwd>
     Klingsor Syndrome
    </kwd> 
    <kwd>
      Génital Self-Mutilation
    </kwd> 
    <kwd>
      Schizophrenia
    </kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <sec id="s1">
   <title>1. Introduction</title>
   <p>Traumatic amputations of the external genitalia have various etiologies. It may be an animal bite, a post-circumcision accident, self-mutilation or hetero-mutilation by aggression <xref ref-type="bibr" rid="scirp.133252-1">
     [1]
    </xref> <xref ref-type="bibr" rid="scirp.133252-2">
     [2]
    </xref>. Genital self-mutilation is a rare urological emergency, most commonly seen in psychotic patients. This pathology causes urinary and sexual complications and significant psycho-social impact <xref ref-type="bibr" rid="scirp.133252-3">
     [3]
    </xref>.</p>
   <p>Advances in microsurgery have improved the results of reimplantation of the amputated penis. The repair must concern the urethra as well as the vasculonervous structures and the corpus cavenosa. However, when the surgeon does not have microsurgical equipment, vascular repair may only concern the superficial (larger) dorsal vein to avoid postoperative congestion <xref ref-type="bibr" rid="scirp.133252-4">
     [4]
    </xref>. The success of the treatment depends on the time between the occurrence of the trauma and access to care, this conventional time is set at 6 hours, but reimplantation should always be attempted within 12 hours or even 24 hours of the trauma <xref ref-type="bibr" rid="scirp.133252-5">
     [5]
    </xref>. Mohammed in South Africa had successfully re-implanted a penile autoamputation 8 hours after the trauma <xref ref-type="bibr" rid="scirp.133252-6">
     [6]
    </xref>.</p>
   <p>We report a case of genital self-mutilation in a 35-year-old man, non-compliant schizophrenic received after 04 days of the trauma.</p>
  </sec><sec id="s2">
   <title>2. Case Presentation</title>
   <p>A 35-year-old patient, a mason by profession, married and father of four children, was referred from a local hospital for self-mutilation of the external genitalia, which occurred following a psychotic attack. Before this referral, the patient had received surgical debridement, uretrovesical catheterization and transfusion. He is said to be addicted to alcohol and recently diagnosed with schizophrenia without compliance with treatment. He had a history of cranioencephalic trauma which was caused by a fall from a height of 5 meters 5 years ago.</p>
   <p>The penile amputation stump was kept in a bag (<xref ref-type="fig" rid="fig1(a)">
     Figure 1(a)
    </xref> and <xref ref-type="fig" rid="fig1(b)">
     Figure 1(b)
    </xref>).</p>
   <p>His general condition was preserved. He was hemodynamically stable. The examination noted an almost complete amputation of the penis at 3/4 of the root of the penis with absence of the testicles. The scrotal flap covered the stump of the penis with stitches allowing the uretrovesical probe to exteriorize (<xref ref-type="fig" rid="fig2">
     Figure 2
    </xref>).</p>
   <fig id="fig1" position="float">
    <label>Figure 1</label>
    <caption>
     <title>(a) (b)Figure 1. Aspect of penile amputation.</title>
    </caption>
    <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="" />
   </fig>
   <fig id="fig1" position="float">
    <label>Figure 1</label>
    <caption>
     <title>(a) (b)Figure 1. Aspect of penile amputation.</title>
    </caption>
    <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/5000929-rId13.jpeg?20250211112518" />
   </fig>
   <fig id="fig1" position="float">
    <label>Figure 1</label>
    <caption>
     <title>(a) (b)Figure 1. Aspect of penile amputation.</title>
    </caption>
    <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/5000929-rId14.jpeg?20250211112518" />
   </fig>
   <fig id="fig2" position="float">
    <label>Figure 2</label>
    <caption>
     <title>Figure 2. Remaining penis stump sutured with scrotal flap, bladder catheter in place.</title>
    </caption>
    <graphic mimetype="image" position="float" xlink:type="simple" xlink:href="https://html.scirp.org/file/5000929-rId15.jpeg?20250211112518" />
   </fig>
   <p>Given the delay, penile reimplantation was not carried out. He benefited from dressing with good local progress; psychiatric treatment began upon his admission using neuroleptics: Risperidone, Loxapine and Tegretol. The urological therapeutic plan, after the stability of his mental state was a definitive perineal urethrostomy. The patient was lost to follow-up after leaving the hospital against medical advice.</p>
  </sec><sec id="s3">
   <title>3. Discussion</title>
   <p>
    <xref ref-type="bibr" rid="scirp.133252-"></xref>Klingsor syndrome refers to genital self-mutilation in man following delusional religious beliefs. Later, Schweitzer proposed expanding the term to include all psychotic disorders, drug and alcohol abuse <xref ref-type="bibr" rid="scirp.133252-5">
     [5]
    </xref>. This is how genital self-mutilation has been classified into 3 etiological subgroups: schizophrenic patients, trans sexual people and people with religious and cultural delusions, or into two categories according to other authors: genital self-mutilation without psychosis and Klingsor syndrome with psychosis <xref ref-type="bibr" rid="scirp.133252-6">
     [6]
    </xref> <xref ref-type="bibr" rid="scirp.133252-7">
     [7]
    </xref>. Rare cases of heteromutilation, often by aggression, are also reported.</p>
   <p>Schizophrenia found in our patient is the risk factor frequently reported in the literature <xref ref-type="bibr" rid="scirp.133252-8">
     [8]
    </xref>.</p>
   <p>The incidence of these lesions is poorly known due to lack of reporting. Most often, only clinical cases are reported <xref ref-type="bibr" rid="scirp.133252-9">
     [9]
    </xref> <xref ref-type="bibr" rid="scirp.133252-10">
     [10]
    </xref>. Diabaté <xref ref-type="bibr" rid="scirp.133252-1">
     [1]
    </xref> in Senegal (2020), reported 8 cases of traumatic amputation of the external genitalia, including one case of self-mutilation. The trauma may involve the bursae, their contents and the penis. The pathological lesions vary greatly, ranging from simple skin laceration (blade, strangling hair) to removal of the testicles and penis (partial or complete) <xref ref-type="bibr" rid="scirp.133252-6">
     [6]
    </xref> <xref ref-type="bibr" rid="scirp.133252-11">
     [11]
    </xref>, as was the case we report where there was complete amputation of the testicles and penis.</p>
   <p>Our patient was 35 years old, the same age as the patient reported by Omar in Morocco <xref ref-type="bibr" rid="scirp.133252-12">
     [12]
    </xref> but it varies according to other authors; this is the case of Amal in Oman and Cardeno in the USA who reported cases whose ages were 52 and 60 years respectively <xref ref-type="bibr" rid="scirp.133252-8">
     [8]
    </xref> <xref ref-type="bibr" rid="scirp.133252-9">
     [9]
    </xref>.</p>
   <p>Klingsor syndrome is a serious situation. Apart from the noted hemorrhagic emergency and operating difficulties, there is a psychosocial impact, sexual and urinary complications (stenosis, urethral fistula) which make this pathology complex <xref ref-type="bibr" rid="scirp.133252-1">
     [1]
    </xref> <xref ref-type="bibr" rid="scirp.133252-13">
     [13]
    </xref>. Treatment must be multidisciplinary involving the urologist, psychiatrist, psychologist and emergency physician <xref ref-type="bibr" rid="scirp.133252-14">
     [14]
    </xref>.</p>
   <p>It is recommended to supervise reconstructive surgery through psychiatric care in order to prevent possible recurrence; it would be useless to carry out a reimplantation of the penis if the patient is not psychiatrically stable.</p>
   <p>On the surgical level, advances in microsurgery have made it possible to improve the results of reimplantation of the amputated penis <xref ref-type="bibr" rid="scirp.133252-11">
     [11]
    </xref>. However, when the surgeon does not have microsurgical equipment, vascular repair may only involve the superficial (larger) dorsal vein to avoid postoperative congestion.</p>
   <p>The success of this surgery depends on the good preservation of the stump and especially on the speed of the operation, the conventional time limit of which is set at 6 hours, but reimplantation must always be attempted within 12 hours or even 24 hours of the trauma. The amputated stump must be, after washing and disinfection, preserved in cold, sterile physiological serum then placed in a jar containing ice. It can also be wrapped in a sterile compress soaked in physiological saline <xref ref-type="bibr" rid="scirp.133252-1">
     [1]
    </xref> <xref ref-type="bibr" rid="scirp.133252-15">
     [15]
    </xref>. Our patient was received on the fourth day after trauma with the non-viable amputated stump making the attempt at reimplantation impossible.</p>
   <p>The result after reimplantation is generally acceptable with a satisfactory aesthetic appearance of the penis and a good erection, although loss of sensitivity of the organ is sometimes reported <xref ref-type="bibr" rid="scirp.133252-16">
     [16]
    </xref>.</p>
   <p>When the time limit for reimplantation has passed and in the event of necrosis of the amputated stump, definitive perineal urethrostomy remains the last resort.</p>
  </sec><sec id="s4">
   <title>4. Conclusion</title>
   <p>Klingsor syndrome is a rare phenomenon, most often observed in schizophrenia patients. Treatment remains complex, but it must be early and multidisciplinary.</p>
  </sec>
 </body><back>
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</article>