Postoperative delirium is a significant yet often overlooked complication following coronary artery bypass grafting (CABG), and it is correlated with prolonged intensive care unit (ICU) stays and increased hospitalization duration [1] .

The American Psychiatric Association’s fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines delirium by five key features, including disturbance in attention and awareness, a rapid development of disturbance with fluctuating severity, additional disturbances in cognition, absence of better explanations by pre-existing neurocognitive disorders, and evidence linking the disturbance to another medical condition [2] .

The incidence of post-cardiac surgery delirium ranges from 26% to 52%, with some studies reporting percentages as high as 70% [3] [4] . Particularly common in elderly patients undergoing major surgical procedures, postoperative delirium occurs in 21% to 50% of cases [5] . Among patients older than 60 years, the reported incidence is consistent, ranging from 30% to 52% [6] [7] . This condition has been associated with severe consequences, including postoperative cognitive dysfunction, prolonged mechanical ventilation, extended hospital and ICU stays, heightened healthcare costs, and increased long-term cardiovascular events after CABG [8] .

Coronary artery disease, a leading cause of death globally, necessitates life-saving treatments such as coronary artery bypass grafting (CABG). However, CABG is accompanied by neuropsychiatric complications, notably delirium, which significantly impacts postoperative recovery and prognosis [9] [10] . Comorbidities such as atrial fibrillation, prior stroke, anemia, peripheral vascular disease, and psychiatric conditions like cognitive impairment contribute to postoperative delirium [11] [12] .

The emerging understanding of the pathophysiology of delirium includes the association of increased serum cortisol levels with its development. Prolonged and excessive secretion of glucocorticoids due to physiological and emotional stress from major surgery may contribute to delirium [13] . Despite numerous studies, the precise pathophysiology of delirium remains poorly understood [14] . Cortisol, a crucial stress hormone, is secreted in response to surgical stimuli severity, with a reciprocal control mechanism, the hypothalamic-pituitary-adrenal axis, existing between the brain and glucocorticoid hormones. Elevated cortisol levels could impact cognition by affecting hippocampal or prefrontal cortical function, thus directly or indirectly manipulating cognition [15] .

For these reasons, high serum cortisol has been proposed as an important factor in predicting delirium after CABG. While not universally supported, several studies have demonstrated an association between high serum cortisol levels and the development of delirium. This study seeks to evaluate the association of high serum cortisol in the development of delirium in patients after off-pump coronary artery bypass grafting, aiming to contribute to early patient management for improved postoperative outcomes.

The age distribution of patients across the study groups is depicted in Table 2. A notable proportion of patients, 36.36% in Group A and 45.45% in Group B, were within the 55 - 64 years age range. Statistical analysis indicated that the mean age difference between the two groups was not statistically significant (p > 0.05). Specifically, the mean age was 54.50 ± 17.97 in Group A and 55.22 ± 15.45 in Group B, suggesting a similar distribution of age across both cohorts.

Table 3 illustrates the distribution of patients by gender in both study groups. In Group A, 81.81% of patients were male and 18.18% were female, while in Group B, 86.36% were male and 13.64% were female. Statistical analysis revealed no significant difference in gender distribution between the two groups.

Table 4 presents the distribution of patients categorized by their preoperative cortisol levels. In both Group A and Group B, the mean ± SD serum cortisol levels (in nmol/l) were 323.93 ± 94.51 and 330.21 ± 38.64, respectively. Notably, there was no statistically significant difference observed between the two groups in terms of preoperative cortisol levels.

N = Total number of respondents. n₁ = Respondents in group A, and n₂ = Respondents in group B. ns = Not significant. SD = Standard Deviation. Data were presented as frequency (f) and mean ± SD. Figures in the parentheses denote the corresponding %. Statistical analysis was done by ^A Chi-square test and ^B independent t-test. p-value ≤ 0.05 was considered significant.

N = Total number of respondents. n₁ = Respondents in group A, and n₂ = Respondents in group B. ns = Not significant. Data were presented as frequency (f), Figures in the parentheses denote the corresponding %. Statistical analysis was done by Chi-square test. p-value ≤ 0.05 was considered significant.

N = Total number of respondents. n₁ = Respondents in group A, and n₂ = Respondents in group B. ns = Not significant. Data were presented as mean ± SD. Statistical analysis was done by independent t-test. p-value ≤ 0.05 was considered significant.

Preoperative clinical history, such as smoking, ischemic heart disease/myocardial infarction (IHD/MI), hypertension, and diabetes mellitus (DM), was compared between patients in Group A and Group B, showing no statistically significant differences (p > 0.05), as depicted in Table 5. Similarly, analysis of drug history did not reveal any significant findings.

Table 6 presents data concerning per-operative attributes. The duration of anesthesia, crucial in postoperative delirium management, was observed to be 4.48 ± 1.12 hours in Group A and 4.82 ± 1.41 hours in Group B, with a non-significant p-value of 0.398. Similarly, the mean ± SD duration of surgery was 163.83 ± 43.168 minutes in Group A and 188.05 ± 52.675 minutes in Group B. Atrial fibrillation (AF) was detected in 3 patients (13.60%) in Group A and 2 patients (9.10%) in Group B, while ventricular tachycardia (VT) occurred in 2 patients (9.10%) in Group A and 1 patient (4.50%) in Group B. Notably, statistical analysis revealed no significant differences in terms of the duration of surgery or perioperative complications (p > 0.05).

Table 7 displays post-operative cortisol levels and the incidence of delirium. The mean ± SD post-operative serum cortisol level (nmol/l) was 389.98 ± 68.77 in Group A and 829.71 ± 79.80 in Group B, with a statistically significant difference (p-value = 0.001). Delirium was assessed from the 1st to the 5th postoperative day (POD). Notably, delirium occurred in 1 patient (4.5%) in Group A and 6 patients (27.3%) in Group B, with a statistically significant difference (p-value = 0.039).

n₁ = Respondents in group A, and n₂ = Respondents in group B. ns = Not significant. Data were presented as frequency (f), Figures in the parentheses denote the corresponding %. Statistical analysis was done by Chi-square test. p-value ≤ 0.05 was considered significant.

N = Total number of respondents. n₁ = Respondents in group A, and n₂ = Respondents in group B. ns = Not significant. SD = Standard Deviation. Data were presented as frequency (f) and mean ± SD. Figures in the parentheses denote the corresponding %. Statistical analysis was done by ^A Chi-square test and ^B independent t-test. p-value ≤0.05 was considered significant.

Table 8 presents the sodium (Na⁺) and potassium (K⁺) levels of patients up to the 5th postoperative day (POD). Statistical analysis revealed that there was no significant difference in these levels (p-value > 0.05).

Table 9 illustrates the comparison of postoperative outcomes between Group A and Group B. The mean ± SD duration of ICU stay was 63.89 ± 10.36 hours

N = Total number of respondents. n₁ = Respondents in group A, and n₂ = Respondents in group B. ns = Not significant and s = significant. SD = Standard Deviation. Data were presented as frequency (f) and mean ± SD. Figures in the parentheses denote the corresponding %. Statistical analysis was done by ^A Independent t-test and ^B Chi-square test. p-value ≤ 0.05 was considered significant.

N = Total number of respondents. n₁ = Respondents in group A, and n₂ = Respondents in group B. ns = Not significant. SD = Standard Deviation. Data were presented as mean ± SD. Statistical analysis was done by independent t-test. p-value ≤ 0.05 was considered significant.

N = Total number of respondents. n₁ = Respondents in group A, and n₂ = Respondents in group B. ns = Not significant. SD = Standard Deviation. Data were presented as frequency (f) and mean ± SD. Figures in the parentheses denote the corresponding %. Statistical analysis was done by ^A Chi-square test and ^B independent t-test. p-value ≤ 0.05 was considered significant.

for Group A and 79.29 ± 12.27 hours for Group B, indicating a statistically significant difference (p-value 0.001). There was no statistically significant difference in the mean ± SD duration of ventilator use between the groups, with Group A at 6.88 ± 0.31 hours and Group B at 7.01 ± 0.45 hours (p-value 0.276). However, there was a significant difference in hospital stay duration, with Group A at 8.38 ± 2.10 days and Group B at 11.44 ± 2.85 days (p-value 0.001). Additionally, one mortality was reported in Group B, representing 4.5% of patients in this group (p-value 0.312).

High serum cortisol is recognized as a significant contributor to cognitive impairment and the development of delirium following OPCABG. For this study, a total of 44 patients were selected based on inclusion and exclusion criteria, with each group consisting of 22 patients categorized by serum cortisol levels assessed on the first postoperative day. Group A comprised patients with normal postoperative serum cortisol levels, while Group B included those with elevated levels. Sedation levels were evaluated using the Richmond Agitation Sedation Scale (RASS), and delirium was diagnosed using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU), assessed twice daily for five consecutive days following OPCABG, with onset and occurrence of delirium recorded. Analysis of demographic variables revealed a mean age of 54.50 ± 17.97 for Group A and 55.22 ± 15.45 for Group B, with no statistically significant difference observed (p > 0.05). Similar findings were reported by Mu et al. [17] who identified advanced age as an independent predictor of postoperative delirium alongside high serum cortisol levels. Gender distribution analysis showed that out of 44 study subjects, 84.10% were male and 15.90% were female, with no significant difference between groups (p = 0.680), consistent with previous studies by Burkhart et al. [6] and Cox et al. [21] (2010, 2015). The pre-operative mean cortisol level was comparable between the two groups (p = 0.802), consistent with findings by Eshmaway et al. [22] , but inconsistent with those of Kazmierski et al. [23] . No significant differences were observed in the distribution of risk factors such as smoking, IHD/MI, HTN, and Diabetes, nor in the type of drugs used by patients between the groups (p > 0.05), consistent with Mu et al.’s findings [16] . In terms of surgical factors, anesthesia and surgery duration, as well as perioperative arrhythmia, showed no significant differences between groups (p > 0.05), consistent with Mu et al.’s findings [17] . Postoperatively, 27.3% of patients in Group B experienced delirium, significantly higher than the 4.5% in Group A (p = 0.039). Mu et al. also found a positive association between high postoperative serum cortisol and delirium onset. Duration of ICU and hospital stay was significantly longer in Group B (p = 0.001), consistent with Mu et al. [16] and Hudetz et al.’s [24] findings. One patient died during the study from sepsis, although statistically not significant. Overall, the study supports the association between elevated postoperative serum cortisol levels and increased delirium incidence, highlighting its potential for early detection and improved patient management.

While the current study did not employ specific statistical tests for controlling confounding variables, we implemented several methodological strategies to mitigate their influence. These included the establishment of strict inclusion and exclusion criteria to minimize heterogeneity among study groups, transparent reporting of patient characteristics and comorbidities, and the involvement of experienced multidisciplinary teams in patient care. These measures were undertaken to address potential confounders such as atrial fibrillation, prior stroke, anemia, peripheral vascular disease, and psychiatric conditions. While statistical tests for controlling confounding variables are commonly utilized, our study design and methodology were carefully crafted to reduce confounding effects without the need for additional statistical tests. We believe that the inclusion of this explanation enhances the transparency and validity of our findings.

This study demonstrates a clear association between elevated serum cortisol levels following coronary bypass grafting and the onset of postoperative delirium. Significantly higher rates of delirium were observed among patients with elevated cortisol levels compared to those with normal levels. These findings suggest that monitoring serum cortisol levels may serve as a valuable predictive tool for identifying individuals at risk of postoperative delirium. Implementing such monitoring protocols could potentially lead to more effective management strategies for delirium following off-pump coronary artery bypass grafting, ultimately resulting in improved postoperative outcomes.

A notable limitation of the study is the insufficient preoperative baseline psychiatric and cognitive screening tests, attributed to the challenges posed by the COVID-19 pandemic, which restricted detailed psychiatric examination procedures. Consequently, evaluation by a specialist psychiatrist upon admission was necessary. Despite our efforts to ensure at least a single consultation from a neurologist or psychiatric specialist for each patient, the absence of comprehensive baseline assessments may have impacted the thoroughness of our evaluation. This limitation is particularly pertinent as preoperative mental disorders, including depression, cognitive impairment, and dementia, are widely acknowledged as significant predictors of postoperative delirium. Additionally, immediate post-operative baseline serum cortisol concentrations were not measured, which could have provided insights into patients’ baseline cortisol levels and their potential impact on postoperative delirium. Furthermore, while hypercortisolemia may directly influence delirious symptoms, it remains unclear whether it is a cause or a consequence of delirium-related stress. Thus, further research is warranted to elucidate the mechanisms underlying the relationship between circulating cortisol levels and delirium.

1) It is recommended to incorporate routine postoperative serum cortisol level estimation during the initial postoperative period following off-pump coronary artery bypass grafting. This practice can aid in predicting the occurrence of delirium, thereby facilitating better patient stratification in this regard.

2) Further validation of the study’s findings is warranted through larger prospective studies conducted across multiple centers. These studies should encompass a broader spectrum of cases, including high-risk patients and those undergoing on-pump CABG procedures, to ensure comprehensive validation and generalizability of the results.

The authors express their gratitude to all the patients who participated in this study for their valuable time and cooperation. Additionally, appreciation is extended to the teaching staff, colleagues, and medical personnel involved in this research for their support and assistance.

The first author conceptualized and designed the study, collected data from the hospital, conducted data analysis, and drafted the manuscript. The second author contributed to the manuscript preparation and provided critical analysis of the study. All authors were involved in the interpretation of the findings and have approved the final version of the manuscript.

The authors have no conflicts of interest to disclose regarding the publication of this paper.

Jha, V.K., Chowdhury, M.A.T., Magdum, M., Tiwari, M., Maruf, M.A.B., Khan, M.S.I. Sinha, P., Kapar, R.N. and Hoque, M.R. (2024) Implications of Elevated Serum Cortisol in the Onset of Postoperative Delirium Following Off-Pump Coronary Artery Bypass Grafting: Insights from a Bangladesh-Based Single Center Experience. World Journal of Cardiovascular Diseases, 14, 252-267. https://doi.org/10.4236/wjcd.2024.144020