More than half of our included women (52.2%) were already in confirmed menopause compared to 47.8% of perimenopausal women.

The mean age was 50.5 years with the extremes ranging from 41 years to 62 years (Table 1).

Genital-urinary syndromes (42.5%), were dominated by decreased libido (41.7%), urination disorder (23%) and vaginal dryness (14.6%). All these signs appeared mainly during the confirmed menopausal period with: respectively: 77% for joint pain; 64.8% for hot flash; 68.7% for night sweat; and 75% for genital-urinary syndromes (Table 2).

Of all the climacteric syndromes studied, there was only a statistically significant relationship between urinary genital syndromes and marital disagreement; Pearson’s Chi-square = 33.63; ddl = 1; P = 0.001. However, there was no statistically significant relationship between climacteric syndrome and family life (Tables 3-5).

Almost a quarter of the women surveyed (24.8%) reported the change in the work relationship. The main reasons for these changes were: more absenteeism at work (47.1%), more absenteeism and less availability (31.4%), and less attendance at

work (21.5%). Compared to the change in relationship with co-workers, only 3.5% of women noticed a change in relationship with co-workers compared to 96.5% who saw absolutely nothing. The types of change in professional relationship noted by the women surveyed concerned respectively: dispute (50%), disagreement (25%) and disobedience of their superiors (25%). However, there was no statistically significant relationship between climacteric syndrome and working life.

Among the elements related to self-esteem, 91.1% of women said they were able to play the role of wife, while 39.8% confirmed that they were appreciated by other colleagues and 22.1% already had an idea of mental decline. There was no statistically significant relationship between climacteric syndrome and self-esteem, but there was a relationship between urinary genital syndromes and self-esteem. Fisher’s exact test, P = 0.000.

The main diseases found in the women surveyed were osteoarthritis (22.1%), high blood pressure (15.1%), diabetes (16.8%), low back pain (7.1%) and urinary incontinence (1.8%). However, no disease was found in 33.6% of the women.

There was a statistically significant relationship between night sweat and increased disease frequency. Pearson’s chi-square = 4.660; ddl = 1; P = 0.031, between urinary genital syndromes and increased disease frequency. Fisher’s exact test, P = 0.001; and between joint pain and increased disease frequency. Pearson’s Chi-square = 8.434; ddl = 1; P = 0.004. However, there is no statistically significant relationship between hot flashes and increased disease frequency. Pearson’s Chi-square = 0.516; ddl = 1; P = 0.473.

Our present study on the sociodemographic and clinical aspects of menopausal climacteric syndrome in the city of Kati in Mali is the first of its kind in Mali. It consisted of conducting a household survey to recruit women during this period in order to assess climacteric syndrome. However, menopause is said to be confirmed by the total absence of menstruation for at least twelve months, this accounted for just over half (52.2%) in our series. According to EDSM VI [6] , 8% of women were in menopause. According to Blaise M et al. [11] , 76% of women aged 45 to 65 years reported perimenopause or confirmed menopause. This difference can be explained by the fact that our study covered the city of Kati and only women in perimenopause and already menopausal, unlike the EDSM which covers the entire population of Mali [6] .

The mean age of the women surveyed was 50.5 [41 - 62] years. This result is similar to that of Diarra L.S. [8] , Camara D. [9] and Senouci et al. [12] who found a mean age of onset of menopause of 52 [38 - 67] years and 48.2 [47.8 - 48.6] years, 48 ± 3 years, respectively. These studies were very often carried out in a healthcare setting, unlike ours, which was a household survey. All these results corroborate with some data from the literature where the age of menopause is between 45 and 50 years [1] [2] .

Married women were the most represented with nearly 7 out of 10 cases (69.9%) and were mostly housewives with 43.4%. According to Blaise M et al. [11] , the majority of women (45%) were inactive (without a profession) [11] . The population of the city of Kati is mainly composed of Bambara, this ethnic group accounted for more than half of the cases (53.1%), followed by Malinke (17.7%) and Fulani (13.3%) [13] . Perimenopause or confirmed menopause is a very difficult period for women because of the presence of so-called climacteric disorders, the presence of a spouse could help the woman to bear some of these discomforts especially for a harmonious couple. However, almost half (47.8%) of women were in a couple with their husbands and 30% of women were single. Just over 7 in 10 women lived in a family of more than seven. According to Senouci et al. [12] , out of 131 women interviewed, 81% were married and 62% had more than four children, 47% of women were heads of household, 29% were employed and 71% were housewives. The presence of a significant number of women in the family could improve the woman’s chances of cohabitation.

The prevalence of symptoms in menopause differs between studies depending on several factors such as sample size, conception, hormone status, and country [14] . Hormonal disorders leading to menstrual irregularities during perimenopause were much more observed in our women interviewed, with respectively: joint pain (65.5%), hot flashes (62.8%), night sweats (56.6%). Decreased estradiol levels have significant adverse effects on sexual functioning, desire, and responsiveness (arousal, sexual pleasure, and orgasm). In our series, urinary genital syndromes (42.5%) were dominated by decreased libido (41.7%), followed by urinary disorder (23%) and vaginal dryness (14.6%). Our results can be superimposed on certain studies carried out in sub-Saharan Africa and the Maghreb such as those of Amoussou M. [15] in Cotonou in 2004: hot flashes (82.4%), excessive sweating (74.4%), libido disorders (67%), and joint pain (38.8%). Cissé C.T. et al., [16] in 2006 in Dakar, found hot flashes (83.1%), decreased libido (83%), asthenia (74.3%), arthtralgia (74%), night sweats (73.4%), insomnia (65), dyspareunia (25.6%). According to a comparative overview of menopause in Tunisia and France [17] , in 2012, the most frequent symptoms were hot flashes and pain in muscles and joints (74.4%). For Blaise M et al. [11] in 2013, hot flashes (60%), night sweats (46%), libido disorders (26%) and joint pain (14%). Although our study did not carry out a large-scale study like these, there are hardly any major differences with the data already known in the literature.

Among the changes in marital life that occurred during climacteric syndrome, change in the quality and frequency of sexual intercourse was more represented (44.2%) in our series. Sexuality, being an important element in the couple, is strongly correlated with the change of relationship with the husband (34.5%). According to Cissé C.T. et al. [16] , the dominant symptom was decreased libido and accounted for 83% of women. Marital disagreements and disagreements associated with violence accounted for nearly half (48.7%) of the couples of our women surveyed. Regarding the types of marital disagreements, arguments accounted for 50% of cases and those associated with speech and financial restriction 9.4%. According to Elisabeth Petit [18] , 21% of men living with a woman between the ages of 48 and 60 are affected by their partner’s menopause and feel that it has consequences on their life as a couple.” Since she went through menopause, my wife has been less patient and more irritable, and I can’t explain why. I’d like to help him, but I’m afraid I’m being clumsy unintentionally. What can we do to support them in the best possible way?”

In fact, 97% of spouses said they were satisfied with their relationship with their partner. Nevertheless, 28% believe that menopause has a fair or very significant impact on their sex life, and 2% on their relationship with their partner [19] .

There was only a statistically significant relationship between urinary genital syndrome and marital disagreement. Pearson’s Chi-square = 33.63; ddl = 1; P = 0.001. According to Eloy Moral et al [20] , the majority of women (75%) reported that vaginal atrophy had a negative impact on their lives, including sexual intimacy (64%), romantic relationship with a partner (32%), overall quality of life (32%), feeling healthy (21%), and feeling attractive (21%). In our Malian context, because of the state of their wives, some husbands will be tempted to look for a second wife, especially if they have only one to satisfy their sexual needs. The second wife, who is very often the same age as their daughter, is seen by the husband as a solution to his problem, and is very often the real source of disagreement with the first wife and her children at this age. Other husbands at this age who do not have the courage to remarry will be tempted to look for a “second office” companion and finally many “grins” of men aged 50 and over justify themselves as a solution at this time.

Of the women surveyed, 24.8% said they had changed their work relationship, compared to 75.2% who reported nothing. Of those who reported changes in their employment relationship, these changes mainly concerned increased absenteeism at work (47.1%), more absenteeism and less availability (31.4%), and less attendance at work (21.5%). When it comes to changing relationships with co-workers, only 3.5% of women noticed a change in their relationship with co-workers compared to 96.5% who saw absolutely nothing. The types of change in professional relationships noted by the women surveyed concerned respectively: Dispute (50%); disagreement (25%) and disobedience of their superiors (25%). However, there was no statistically significant relationship between climacteric syndrome and working life. Most of the time, menopause has little to no impact on a person’s ability to do their job, and employers may not notice these changes. However, for others, menopause can have an impact on health, performance and attendance at work [19] .

Among the elements related to self-esteem, 91.1% of women said they were able to play the role of wife, while 39.8% confirmed that they were appreciated by other colleagues. There was no statistically significant relationship between climacteric syndrome and self-esteem, but there was a relationship between urinary genital syndromes and self-esteem. Fisher’s exact test, P = 0.000. Different experiences of menopause are related to social class and degree of male dominance. A certain level of independence and emancipation allows women an identity beyond their reproductive function and a status unaltered by menopause [21] .

Melo et al. [21] found low self-esteem and decreased quality of life in women, causing problems in their personal and professional relationships showing the importance of the role of health professionals, especially nurses, in promoting educational strategies and supporting women at this stage of women’s lives. The assessment of this parameter depends from one study to another depending on the type of study.

Estrogen deficiency during this period can lead to chronic and degenerative diseases, however, in our study osteoarthritis disease, diabetes and high blood pressure were the most common among the women surveyed with: 22.1%, 16.8% and 15.1% respectively. There is a statistically significant relationship between night sweats, urinary genital syndromes and joint pain and increased disease frequency. Women can expect to spend more than a third of their lives after menopause and from the sixth decade onwards, many chronic diseases will begin to appear, affecting both the quality and quantity of a woman’s life. Thus, the onset of menopause paves the way for prevention strategies aimed at improving quality of life and increasing longevity. Obesity, metabolic syndrome and diabetes, cardiovascular disease, osteoporosis and osteoarthritis, cognitive decline, dementia and depression as well as cancer are the main diseases of concern [22] .